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Entry version 147 (17 Jun 2020)
Sequence version 1 (01 Oct 2003)
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Protein

PX domain-containing protein kinase-like protein

Gene

PXK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.1 PublicationBy similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • phosphatidylinositol binding Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q7Z7A4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PX domain-containing protein kinase-like protein
Alternative name(s):
Modulator of Na,K-ATPase
Short name:
MONaKA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PXKImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168297.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23326 PXK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611450 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z7A4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi54R → Q: No effect on subcellular location. 1 Publication1
Mutagenesisi56Y → A: Results in redistribution of protein from cytoplasm throughout entire cell. 1 Publication1
Mutagenesisi92R → L: Results in redistribution of protein from cytoplasm throughout entire cell. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
54899

MalaCards human disease database

More...
MalaCardsi
PXK

Open Targets

More...
OpenTargetsi
ENSG00000168297

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
536 Systemic lupus erythematosus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134899496

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z7A4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PXK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74759261

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000865921 – 578PX domain-containing protein kinase-like proteinAdd BLAST578

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z7A4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z7A4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z7A4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z7A4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z7A4

PeptideAtlas

More...
PeptideAtlasi
Q7Z7A4

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z7A4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69499 [Q7Z7A4-1]
69500 [Q7Z7A4-2]
69501 [Q7Z7A4-3]
69502 [Q7Z7A4-4]
69503 [Q7Z7A4-5]
69504 [Q7Z7A4-6]
69505 [Q7Z7A4-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z7A4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z7A4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168297 Expressed in corpus callosum and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z7A4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z7A4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000168297 Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120245, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z7A4, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348472

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z7A4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z7A4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 126PXPROSITE-ProRule annotationAdd BLAST113
Domaini88 – 481Protein kinasePROSITE-ProRule annotationAdd BLAST394
Domaini548 – 567WH2PROSITE-ProRule annotationAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase domain is predicted to be catalytically inactive.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF7B Eukaryota
ENOG410Z20X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017669

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036868_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z7A4

KEGG Orthology (KO)

More...
KOi
K17543

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRFFTQY

Database of Orthologous Groups

More...
OrthoDBi
995721at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z7A4

TreeFam database of animal gene trees

More...
TreeFami
TF324116

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06871 PX_MONaKA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR037903 MONaKA_PX
IPR001683 Phox
IPR000719 Prot_kinase_dom
IPR036871 PX_dom_sf
IPR003124 WH2_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00787 PX, 1 hit
PF02205 WH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00312 PX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50195 PX, 1 hit
PS51082 WH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q7Z7A4-1) [UniParc]FASTAAdd to basket
Also known as: Long1 Publication, v11 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFMEKPPAG KVLLDDTVPL TAAIEASQSL QSHTEYIIRV QRGISVENSW
60 70 80 90 100
QIVRRYSDFD LLNNSLQIAG LSLPLPPKKL IGNMDREFIA ERQKGLQNYL
110 120 130 140 150
NVITTNHILS NCELVKKFLD PNNYSANYTE IALQQVSMFF RSEPKWEVVE
160 170 180 190 200
PLKDIGWRIR KKYFLMKIKN QPKERLVLSW ADLGPDKYLS DKDFQCLIKL
210 220 230 240 250
LPSCLHPYIY RVTFATANES SALLIRMFNE KGTLKDLIYK AKPKDPFLKK
260 270 280 290 300
YCNPKKIQGL ELQQIKTYGR QILEVLKFLH DKGFPYGHLH ASNVMLDGDT
310 320 330 340 350
CRLLDLENSL LGLPSFYRSY FSQFRKINTL ESVDVHCFGH LLYEMTYGRP
360 370 380 390 400
PDSVPVDSFP PAPSMAVVAV LESTLSCEAC KNGMPTISRL LQMPLFSDVL
410 420 430 440 450
LTTSEKPQFK IPTKLKEALR IAKECIEKRL IEEQKQIHQH RRLTRAQSHH
460 470 480 490 500
GSEEERKKRK ILARKKSKRS ALENSEEHSA KYSNSNNSAG SGASSPLTSP
510 520 530 540 550
SSPTPPSTSG ISALPPPPPP PPPPAAPLPP ASTEAPAQLS SQAVNGMSRG
560 570
ALLSSIQNFQ KGTLRKAKTC DHSAPKIG
Length:578
Mass (Da):64,950
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i73523CFC3731FFC8
GO
Isoform 21 Publication (identifier: Q7Z7A4-2) [UniParc]FASTAAdd to basket
Also known as: Short1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     510-515: GISALP → VEHAPF
     516-578: Missing.

Show »
Length:515
Mass (Da):58,732
Checksum:i8115EBC6A5157C97
GO
Isoform 31 Publication (identifier: Q7Z7A4-3) [UniParc]FASTAAdd to basket
Also known as: v31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-226: Missing.

Show »
Length:352
Mass (Da):38,875
Checksum:iDE5F73819ABBB77C
GO
Isoform 4Curated (identifier: Q7Z7A4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-51: Missing.

Show »
Length:561
Mass (Da):62,891
Checksum:i615A342917403DCD
GO
Isoform 51 Publication (identifier: Q7Z7A4-5) [UniParc]FASTAAdd to basket
Also known as: v41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.

Show »
Length:441
Mass (Da):49,491
Checksum:iF1D219D8C6988D86
GO
Isoform 61 Publication (identifier: Q7Z7A4-6) [UniParc]FASTAAdd to basket
Also known as: v21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     35-67: Missing.

Show »
Length:545
Mass (Da):60,956
Checksum:iA1F5BED8AEAFF293
GO
Isoform 71 Publication (identifier: Q7Z7A4-7) [UniParc]FASTAAdd to basket
Also known as: v51 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:495
Mass (Da):55,762
Checksum:iE5BA2969CBC9E57D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
W5RWE6W5RWE6_HUMAN
PX domain-containing protein kinase...
PXK
557Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PD56E9PD56_HUMAN
PX domain-containing protein kinase...
PXK
482Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DG95A0A0C4DG95_HUMAN
PX domain-containing protein kinase...
PXK
563Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BYG4H7BYG4_HUMAN
PX domain-containing protein kinase...
PXK
498Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4V0H7C4V0_HUMAN
PX domain-containing protein kinase...
PXK
312Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQS4U3KQS4_HUMAN
PX domain-containing protein kinase...
PXK
203Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C4W2H7C4W2_HUMAN
PX domain-containing protein kinase...
PXK
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C529H7C529_HUMAN
PX domain-containing protein kinase...
PXK
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9IYJ2C9IYJ2_HUMAN
PX domain-containing protein kinase...
PXK
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDF7F8WDF7_HUMAN
PX domain-containing protein kinase...
PXK
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH14479 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAA91097 differs from that shown. Reason: Frameshift.Curated
The sequence BAD18536 differs from that shown. Reason: Frameshift.Curated
The sequence BAD92925 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti42R → G in AAK94455 (Ref. 3) Curated1
Sequence conflicti42R → G in BAA91097 (PubMed:14702039).Curated1
Sequence conflicti459R → K in AAR98521 (PubMed:16142408).Curated1
Sequence conflicti489Missing in BAD18536 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_041362426I → V1 PublicationCorresponds to variant dbSNP:rs55973253Ensembl.1
Natural variantiVAR_041363481K → R2 PublicationsCorresponds to variant dbSNP:rs56384862Ensembl.1
Natural variantiVAR_033911525A → V. Corresponds to variant dbSNP:rs34579268Ensembl.1
Natural variantiVAR_033912535A → V. Corresponds to variant dbSNP:rs34579268Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0519071 – 226Missing in isoform 3. 1 PublicationAdd BLAST226
Alternative sequenceiVSP_0519081 – 137Missing in isoform 5. 1 PublicationAdd BLAST137
Alternative sequenceiVSP_0519091 – 83Missing in isoform 7. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_05191035 – 67Missing in isoform 6. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_05191135 – 51Missing in isoform 4. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_051912510 – 515GISALP → VEHAPF in isoform 2. 3 Publications6
Alternative sequenceiVSP_051913516 – 578Missing in isoform 2. 3 PublicationsAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ124707 mRNA Translation: AAZ38821.1
DQ124708 mRNA Translation: AAZ38822.1
AY437879 mRNA Translation: AAR98521.1
AY847222 mRNA Translation: AAX73354.1
AY847220 mRNA Translation: AAX73352.1
AY847221 mRNA Translation: AAX73353.1
AF399753 mRNA Translation: AAK94455.1
AY274811 mRNA Translation: AAP42076.1
AB209688 mRNA Translation: BAD92925.1 Frameshift.
AK000342 mRNA Translation: BAA91097.1 Frameshift.
AK131385 mRNA Translation: BAD18536.1 Frameshift.
BC008943 mRNA Translation: AAH08943.1
BC014479 mRNA Translation: AAH14479.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2889.1 [Q7Z7A4-1]
CCDS74952.1 [Q7Z7A4-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001276024.1, NM_001289095.1
NP_001276025.1, NM_001289096.1 [Q7Z7A4-6]
NP_001276027.1, NM_001289098.1 [Q7Z7A4-2]
NP_001276028.1, NM_001289099.1 [Q7Z7A4-7]
NP_001276029.1, NM_001289100.1
NP_001276030.1, NM_001289101.1 [Q7Z7A4-5]
NP_060241.2, NM_017771.4 [Q7Z7A4-1]
XP_016862160.1, XM_017006671.1
XP_016862164.1, XM_017006675.1
XP_016862175.1, XM_017006686.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356151; ENSP00000348472; ENSG00000168297 [Q7Z7A4-1]
ENST00000383716; ENSP00000373222; ENSG00000168297 [Q7Z7A4-2]
ENST00000484288; ENSP00000417915; ENSG00000168297 [Q7Z7A4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54899

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54899

UCSC genome browser

More...
UCSCi
uc003djx.2 human [Q7Z7A4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ124707 mRNA Translation: AAZ38821.1
DQ124708 mRNA Translation: AAZ38822.1
AY437879 mRNA Translation: AAR98521.1
AY847222 mRNA Translation: AAX73354.1
AY847220 mRNA Translation: AAX73352.1
AY847221 mRNA Translation: AAX73353.1
AF399753 mRNA Translation: AAK94455.1
AY274811 mRNA Translation: AAP42076.1
AB209688 mRNA Translation: BAD92925.1 Frameshift.
AK000342 mRNA Translation: BAA91097.1 Frameshift.
AK131385 mRNA Translation: BAD18536.1 Frameshift.
BC008943 mRNA Translation: AAH08943.1
BC014479 mRNA Translation: AAH14479.1 Sequence problems.
CCDSiCCDS2889.1 [Q7Z7A4-1]
CCDS74952.1 [Q7Z7A4-2]
RefSeqiNP_001276024.1, NM_001289095.1
NP_001276025.1, NM_001289096.1 [Q7Z7A4-6]
NP_001276027.1, NM_001289098.1 [Q7Z7A4-2]
NP_001276028.1, NM_001289099.1 [Q7Z7A4-7]
NP_001276029.1, NM_001289100.1
NP_001276030.1, NM_001289101.1 [Q7Z7A4-5]
NP_060241.2, NM_017771.4 [Q7Z7A4-1]
XP_016862160.1, XM_017006671.1
XP_016862164.1, XM_017006675.1
XP_016862175.1, XM_017006686.1

3D structure databases

SMRiQ7Z7A4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120245, 15 interactors
IntActiQ7Z7A4, 10 interactors
STRINGi9606.ENSP00000348472

PTM databases

iPTMnetiQ7Z7A4
PhosphoSitePlusiQ7Z7A4

Polymorphism and mutation databases

BioMutaiPXK
DMDMi74759261

Proteomic databases

EPDiQ7Z7A4
jPOSTiQ7Z7A4
MassIVEiQ7Z7A4
MaxQBiQ7Z7A4
PaxDbiQ7Z7A4
PeptideAtlasiQ7Z7A4
PRIDEiQ7Z7A4
ProteomicsDBi69499 [Q7Z7A4-1]
69500 [Q7Z7A4-2]
69501 [Q7Z7A4-3]
69502 [Q7Z7A4-4]
69503 [Q7Z7A4-5]
69504 [Q7Z7A4-6]
69505 [Q7Z7A4-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
15176 160 antibodies

The DNASU plasmid repository

More...
DNASUi
54899

Genome annotation databases

EnsembliENST00000356151; ENSP00000348472; ENSG00000168297 [Q7Z7A4-1]
ENST00000383716; ENSP00000373222; ENSG00000168297 [Q7Z7A4-2]
ENST00000484288; ENSP00000417915; ENSG00000168297 [Q7Z7A4-2]
GeneIDi54899
KEGGihsa:54899
UCSCiuc003djx.2 human [Q7Z7A4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54899
DisGeNETi54899
EuPathDBiHostDB:ENSG00000168297.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PXK
HGNCiHGNC:23326 PXK
HPAiENSG00000168297 Tissue enhanced (brain)
MalaCardsiPXK
MIMi611450 gene
neXtProtiNX_Q7Z7A4
OpenTargetsiENSG00000168297
Orphaneti536 Systemic lupus erythematosus
PharmGKBiPA134899496

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF7B Eukaryota
ENOG410Z20X LUCA
GeneTreeiENSGT00390000017669
HOGENOMiCLU_036868_0_0_1
InParanoidiQ7Z7A4
KOiK17543
OMAiHRFFTQY
OrthoDBi995721at2759
PhylomeDBiQ7Z7A4
TreeFamiTF324116

Enzyme and pathway databases

SignaLinkiQ7Z7A4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
54899 3 hits in 792 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PXK human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54899
PharosiQ7Z7A4 Tbio

Protein Ontology

More...
PROi
PR:Q7Z7A4
RNActiQ7Z7A4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168297 Expressed in corpus callosum and 197 other tissues
ExpressionAtlasiQ7Z7A4 baseline and differential
GenevisibleiQ7Z7A4 HS

Family and domain databases

CDDicd06871 PX_MONaKA, 1 hit
Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR037903 MONaKA_PX
IPR001683 Phox
IPR000719 Prot_kinase_dom
IPR036871 PX_dom_sf
IPR003124 WH2_dom
PfamiView protein in Pfam
PF00787 PX, 1 hit
PF02205 WH2, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50195 PX, 1 hit
PS51082 WH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPXK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z7A4
Secondary accession number(s): Q3BCH4
, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2003
Last modified: June 17, 2020
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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