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Protein

Centriolin

Gene

CNTRL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-8854518 AURKA Activation by TPX2
SIGNORiQ7Z7A1

Names & Taxonomyi

Protein namesi
Recommended name:
Centriolin
Alternative name(s):
Centrosomal protein 1
Centrosomal protein of 110 kDa
Short name:
Cep110
Gene namesi
Name:CNTRL
Synonyms:CEP1, CEP110
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000119397.16
HGNCiHGNC:1858 CNTRL
MIMi605496 gene
neXtProtiNX_Q7Z7A1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving CEP110 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei2139 – 2140Breakpoint for translocation to form CEP110-FGFR12

Organism-specific databases

DisGeNETi11064
OpenTargetsiENSG00000119397
PharmGKBiPA26414

Polymorphism and mutation databases

BioMutaiCNTRL
DMDMi172045911

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003236751 – 2325CentriolinAdd BLAST2325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei831PhosphoserineCombined sources1
Modified residuei1475PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z7A1
MaxQBiQ7Z7A1
PaxDbiQ7Z7A1
PeptideAtlasiQ7Z7A1
PRIDEiQ7Z7A1
ProteomicsDBi69493
69494 [Q7Z7A1-2]
69495 [Q7Z7A1-3]
69496 [Q7Z7A1-4]
69497 [Q7Z7A1-5]

PTM databases

CarbonylDBiQ7Z7A1
iPTMnetiQ7Z7A1
PhosphoSitePlusiQ7Z7A1

Expressioni

Tissue specificityi

Widely expressed with highest levels in testis and trachea.1 Publication

Gene expression databases

BgeeiENSG00000119397 Expressed in 202 organ(s), highest expression level in testis
CleanExiHS_CEP110
ExpressionAtlasiQ7Z7A1 baseline and differential
GenevisibleiQ7Z7A1 HS

Organism-specific databases

HPAiHPA020468
HPA020480
HPA051583

Interactioni

Subunit structurei

Interacts with HOOK2. Interacts with EXOC6 and SNAPIN. Associates with the exocyst complex.2 Publications

Protein-protein interaction databases

BioGridi116248, 161 interactors
DIPiDIP-47280N
IntActiQ7Z7A1, 173 interactors
MINTiQ7Z7A1
STRINGi9606.ENSP00000238341

Structurei

3D structure databases

ProteinModelPortaliQ7Z7A1
SMRiQ7Z7A1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati126 – 147LRR 1Add BLAST22
Repeati148 – 169LRR 2Add BLAST22
Repeati170 – 191LRR 3Add BLAST22
Repeati194 – 215LRR 4Add BLAST22
Domaini228 – 266LRRCTAdd BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1948 – 2118Required for centrosome localizationAdd BLAST171
Regioni1985 – 2325Sufficient for interaction with HOOK21 PublicationAdd BLAST341

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili267 – 343Sequence analysisAdd BLAST77
Coiled coili435 – 799Sequence analysisAdd BLAST365
Coiled coili851 – 1101Sequence analysisAdd BLAST251
Coiled coili1317 – 2255Sequence analysisAdd BLAST939

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi956 – 959Poly-Lys4
Compositional biasi1147 – 1150Poly-Pro4
Compositional biasi1236 – 1307Pro-richAdd BLAST72

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IJGD Eukaryota
ENOG410ZX4Y LUCA
GeneTreeiENSGT00930000150857
HOVERGENiHBG101203
InParanoidiQ7Z7A1
KOiK16770
OMAiQHDQKVS
OrthoDBiEOG091G0066
PhylomeDBiQ7Z7A1
TreeFamiTF101135

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR028640 CEP110
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PANTHERiPTHR44555 PTHR44555, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 5 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z7A1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKGSQQKIF SKAKIPSSSH SPIPSSMSNM RSRSLSPLIG SETLPFHSGG
60 70 80 90 100
QWCEQVEIAD ENNMLLDYQD HKGADSHAGV RYITEALIKK LTKQDNLALI
110 120 130 140 150
KSLNLSLSKD GGKKFKYIEN LEKCVKLEVL NLSYNLIGKI EKLDKLLKLR
160 170 180 190 200
ELNLSYNKIS KIEGIENMCN LQKLNLAGNE IEHIPVWLGK KLKSLRVLNL
210 220 230 240 250
KGNKISSLQD ISKLKPLQDL ISLILVENPV VTLPHYLQFT IFHLRSLESL
260 270 280 290 300
EGQPVTTQDR QEAFERFSLE EVERLERDLE KKMIETEELK SKQTRFLEEI
310 320 330 340 350
KNQDKLNKSL KEEAMLQKQS CEELKSDLNT KNELLKQKTI ELTRACQKQY
360 370 380 390 400
ELEQELAFYK IDAKFEPLNY YPSEYAEIDK APDESPYIGK SRYKRNMFAT
410 420 430 440 450
ESYIIDSAQA VQIKKMEPDE QLRNDHMNLR GHTPLDTQLE DKEKKISAAQ
460 470 480 490 500
TRLSELHDEI EKAEQQILRA TEEFKQLEEA IQLKKISEAG KDLLYKQLSG
510 520 530 540 550
RLQLVNKLRQ EALDLELQME KQKQEIAGKQ KEIKDLQIAI DSLDSKDPKH
560 570 580 590 600
SHMKAQKSGK EQQLDIMNKQ YQQLESRLDE ILSRIAKETE EIKDLEEQLT
610 620 630 640 650
EGQIAANEAL KKDLEGVISG LQEYLGTIKG QATQAQNECR KLRDEKETLL
660 670 680 690 700
QRLTEVEQER DQLEIVAMDA ENMRKELAEL ESALQEQHEV NASLQQTQGD
710 720 730 740 750
LSAYEAELEA RLNLRDAEAN QLKEELEKVT RLTQLEQSAL QAELEKERQA
760 770 780 790 800
LKNALGKAQF SEEKEQENSE LHAKLKHLQD DNNLLKQQLK DFQNHLNHVV
810 820 830 840 850
DGLVRPEEVA ARVDELRRKL KLGTGEMNIH SPSDVLGKSL ADLQKQFSEI
860 870 880 890 900
LARSKWERDE AQVRERKLQE EMALQQEKLA TGQEEFRQAC ERALEARMNF
910 920 930 940 950
DKRQHEARIQ QMENEIHYLQ ENLKSMEEIQ GLTDLQLQEA DEEKERILAQ
960 970 980 990 1000
LRELEKKKKL EDAKSQEQVF GLDKELKKLK KAVATSDKLA TAELTIAKDQ
1010 1020 1030 1040 1050
LKSLHGTVMK INQERAEELQ EAERFSRKAA QAARDLTRAE AEIELLQNLL
1060 1070 1080 1090 1100
RQKGEQFRLE MEKTGVGTGA NSQVLEIEKL NETMERQRTE IARLQNVLDL
1110 1120 1130 1140 1150
TGSDNKGGFE NVLEEIAELR REVSYQNDYI SSMADPFKRR GYWYFMPPPP
1160 1170 1180 1190 1200
SSKVSSHSSQ ATKDSGVGLK YSASTPVRKP RPGQQDGKEG SQPPPASGYW
1210 1220 1230 1240 1250
VYSPIRSGLH KLFPSRDADS GGDSQEESEL DDQEEPPFVP PPGYMMYTVL
1260 1270 1280 1290 1300
PDGSPVPQGM ALYAPPPPLP NNSRPLTPGT VVYGPPPAGA PMVYGPPPPN
1310 1320 1330 1340 1350
FSIPFIPMGV LHCNVPEHHN LENEVSRLED IMQHLKSKKR EERWMRASKR
1360 1370 1380 1390 1400
QSEKEMEELH HNIDDLLQEK KSLECEVEEL HRTVQKRQQQ KDFIDGNVES
1410 1420 1430 1440 1450
LMTELEIEKS LKHHEDIVDE IECIEKTLLK RRSELREADR LLAEAESELS
1460 1470 1480 1490 1500
CTKEKTKNAV EKFTDAKRSL LQTESDAEEL ERRAQETAVN LVKADQQLRS
1510 1520 1530 1540 1550
LQADAKDLEQ HKIKQEEILK EINKIVAAKD SDFQCLSKKK EKLTEELQKL
1560 1570 1580 1590 1600
QKDIEMAERN EDHHLQVLKE SEVLLQAKRA ELEKLKSQVT SQQQEMAVLD
1610 1620 1630 1640 1650
RQLGHKKEEL HLLQGSMVQA KADLQEALRL GETEVTEKCN HIREVKSLLE
1660 1670 1680 1690 1700
ELSFQKGELN VQISERKTQL TLIKQEIEKE EENLQVVLRQ MSKHKTELKN
1710 1720 1730 1740 1750
ILDMLQLENH ELQGLKLQHD QRVSELEKTQ VAVLEEKLEL ENLQQISQQQ
1760 1770 1780 1790 1800
KGEIEWQKQL LERDKREIER MTAESRALQS CVECLSKEKE DLQEKCDIWE
1810 1820 1830 1840 1850
KKLAQTKRVL AAAEENSKME QSNLEKLELN VRKLQQELDQ LNRDKLSLHN
1860 1870 1880 1890 1900
DISAMQQQLQ EKREAVNSLQ EELANVQDHL NLAKQDLLHT TKHQDVLLSE
1910 1920 1930 1940 1950
QTRLQKDISE WANRFEDCQK EEETKQQQLQ VLQNEIEENK LKLVQQEMMF
1960 1970 1980 1990 2000
QRLQKERESE ESKLETSKVT LKEQQHQLEK ELTDQKSKLD QVLSKVLAAE
2010 2020 2030 2040 2050
ERVRTLQEEE RWCESLEKTL SQTKRQLSER EQQLVEKSGE LLALQKEADS
2060 2070 2080 2090 2100
MRADFSLLRN QFLTERKKAE KQVASLKEAL KIQRSQLEKN LLEQKQENSC
2110 2120 2130 2140 2150
IQKEMATIEL VAQDNHERAR RLMKELNQMQ YEYTELKKQM ANQKDLERRQ
2160 2170 2180 2190 2200
MEISDAMRTL KSEVKDEIRT SLKNLNQFLP ELPADLEAIL ERNENLEGEL
2210 2220 2230 2240 2250
ESLKENLPFT MNEGPFEEKL NFSQVHIMDE HWRGEALREK LRHREDRLKA
2260 2270 2280 2290 2300
QLRHCMSKQA EVLIKGKRQT EGTLHSLRRQ VDALGELVTS TSADSASSPS
2310 2320
LSQLESSLTE DSQLGQNQEK NASAR
Length:2,325
Mass (Da):268,886
Last modified:March 18, 2008 - v2
Checksum:i93DD4CA08B5BD4AF
GO
Isoform 2 (identifier: Q7Z7A1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-552: Missing.

Show »
Length:1,773
Mass (Da):205,172
Checksum:iF430B910E219D5E2
GO
Isoform 3 (identifier: Q7Z7A1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1331: Missing.

Show »
Length:994
Mass (Da):116,799
Checksum:iBFE7F893259BA73D
GO
Isoform 4 (identifier: Q7Z7A1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1818: Missing.
     1962-1986: Missing.

Note: No experimental confirmation available.
Show »
Length:482
Mass (Da):56,587
Checksum:i1B4867D4FEAFE023
GO
Isoform 5 (identifier: Q7Z7A1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1291-1296: Missing.

Note: No experimental confirmation available.
Show »
Length:2,319
Mass (Da):268,241
Checksum:i5C9924F8D58B852A
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JVD3Q5JVD3_HUMAN
Centriolin
CNTRL
460Annotation score:
Q5JVD1Q5JVD1_HUMAN
Centriolin
CNTRL
994Annotation score:
Q5JVD5Q5JVD5_HUMAN
Centriolin
CNTRL
145Annotation score:
Q5JVD6Q5JVD6_HUMAN
Centriolin
CNTRL
346Annotation score:

Sequence cautioni

The sequence AAH02932 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH02932 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH89415 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1389Q → R in AAC32373 (PubMed:10688839).Curated1
Sequence conflicti1699K → Q in AAC32373 (PubMed:10688839).Curated1
Sequence conflicti1828E → D in AAC32373 (PubMed:10688839).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03955956V → I1 PublicationCorresponds to variant dbSNP:rs10818503Ensembl.1
Natural variantiVAR_039560216P → L. Corresponds to variant dbSNP:rs10818504Ensembl.1
Natural variantiVAR_039561889A → T. Corresponds to variant dbSNP:rs17292952Ensembl.1
Natural variantiVAR_0616221146M → V. Corresponds to variant dbSNP:rs35342437Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0320461 – 1818Missing in isoform 4. 1 PublicationAdd BLAST1818
Alternative sequenceiVSP_0320471 – 1331Missing in isoform 3. 1 PublicationAdd BLAST1331
Alternative sequenceiVSP_0320481 – 552Missing in isoform 2. 1 PublicationAdd BLAST552
Alternative sequenceiVSP_0320491291 – 1296Missing in isoform 5. 1 Publication6
Alternative sequenceiVSP_0320501962 – 1986Missing in isoform 4. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083322 mRNA Translation: AAC32373.1
AF513978 mRNA Translation: AAP43846.1
BX640927 mRNA Translation: CAE45965.1
AL137068 Genomic DNA No translation available.
BC002932 mRNA Translation: AAH02932.1 Sequence problems.
BC089415 mRNA Translation: AAH89415.1 Sequence problems.
BC137286 mRNA Translation: AAI37287.1
AY651261 mRNA Translation: AAX35689.1
AK074079 mRNA Translation: BAB84905.1
CCDSiCCDS35118.1 [Q7Z7A1-1]
CCDS83409.1 [Q7Z7A1-2]
RefSeqiNP_001317691.1, NM_001330762.1 [Q7Z7A1-2]
NP_008949.4, NM_007018.4 [Q7Z7A1-1]
XP_005251736.1, XM_005251679.3 [Q7Z7A1-1]
UniGeneiHs.653263

Genome annotation databases

EnsembliENST00000238341; ENSP00000238341; ENSG00000119397 [Q7Z7A1-1]
ENST00000373850; ENSP00000362956; ENSG00000119397 [Q7Z7A1-2]
ENST00000373855; ENSP00000362962; ENSG00000119397 [Q7Z7A1-1]
ENST00000613863; ENSP00000481072; ENSG00000119397 [Q7Z7A1-4]
GeneIDi11064
KEGGihsa:11064
UCSCiuc004bkx.1 human [Q7Z7A1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083322 mRNA Translation: AAC32373.1
AF513978 mRNA Translation: AAP43846.1
BX640927 mRNA Translation: CAE45965.1
AL137068 Genomic DNA No translation available.
BC002932 mRNA Translation: AAH02932.1 Sequence problems.
BC089415 mRNA Translation: AAH89415.1 Sequence problems.
BC137286 mRNA Translation: AAI37287.1
AY651261 mRNA Translation: AAX35689.1
AK074079 mRNA Translation: BAB84905.1
CCDSiCCDS35118.1 [Q7Z7A1-1]
CCDS83409.1 [Q7Z7A1-2]
RefSeqiNP_001317691.1, NM_001330762.1 [Q7Z7A1-2]
NP_008949.4, NM_007018.4 [Q7Z7A1-1]
XP_005251736.1, XM_005251679.3 [Q7Z7A1-1]
UniGeneiHs.653263

3D structure databases

ProteinModelPortaliQ7Z7A1
SMRiQ7Z7A1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116248, 161 interactors
DIPiDIP-47280N
IntActiQ7Z7A1, 173 interactors
MINTiQ7Z7A1
STRINGi9606.ENSP00000238341

PTM databases

CarbonylDBiQ7Z7A1
iPTMnetiQ7Z7A1
PhosphoSitePlusiQ7Z7A1

Polymorphism and mutation databases

BioMutaiCNTRL
DMDMi172045911

Proteomic databases

EPDiQ7Z7A1
MaxQBiQ7Z7A1
PaxDbiQ7Z7A1
PeptideAtlasiQ7Z7A1
PRIDEiQ7Z7A1
ProteomicsDBi69493
69494 [Q7Z7A1-2]
69495 [Q7Z7A1-3]
69496 [Q7Z7A1-4]
69497 [Q7Z7A1-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238341; ENSP00000238341; ENSG00000119397 [Q7Z7A1-1]
ENST00000373850; ENSP00000362956; ENSG00000119397 [Q7Z7A1-2]
ENST00000373855; ENSP00000362962; ENSG00000119397 [Q7Z7A1-1]
ENST00000613863; ENSP00000481072; ENSG00000119397 [Q7Z7A1-4]
GeneIDi11064
KEGGihsa:11064
UCSCiuc004bkx.1 human [Q7Z7A1-1]

Organism-specific databases

CTDi11064
DisGeNETi11064
EuPathDBiHostDB:ENSG00000119397.16
GeneCardsiCNTRL
H-InvDBiHIX0008344
HGNCiHGNC:1858 CNTRL
HPAiHPA020468
HPA020480
HPA051583
MIMi605496 gene
neXtProtiNX_Q7Z7A1
OpenTargetsiENSG00000119397
PharmGKBiPA26414
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJGD Eukaryota
ENOG410ZX4Y LUCA
GeneTreeiENSGT00930000150857
HOVERGENiHBG101203
InParanoidiQ7Z7A1
KOiK16770
OMAiQHDQKVS
OrthoDBiEOG091G0066
PhylomeDBiQ7Z7A1
TreeFamiTF101135

Enzyme and pathway databases

ReactomeiR-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-8854518 AURKA Activation by TPX2
SIGNORiQ7Z7A1

Miscellaneous databases

ChiTaRSiCNTRL human
GeneWikiiCNTRL
GenomeRNAii11064
PROiPR:Q7Z7A1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119397 Expressed in 202 organ(s), highest expression level in testis
CleanExiHS_CEP110
ExpressionAtlasiQ7Z7A1 baseline and differential
GenevisibleiQ7Z7A1 HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR028640 CEP110
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PANTHERiPTHR44555 PTHR44555, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 3 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCNTRL_HUMAN
AccessioniPrimary (citable) accession number: Q7Z7A1
Secondary accession number(s): A2A2Y1
, B2RP67, Q3MN79, Q5FWF8, Q5JVD0, Q6MZR3, Q6PKC1, Q8TEP3, Q9Y489
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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