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Protein

Keratin, type II cytoskeletal 1b

Gene

KRT77

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei418Stutter1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 1b
Alternative name(s):
Cytokeratin-1B
Short name:
CK-1B
Keratin-77
Short name:
K77
Type-II keratin Kb39
Gene namesi
Name:KRT77
Synonyms:KRT1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000189182.9
HGNCiHGNC:20411 KRT77
MIMi611158 gene
neXtProtiNX_Q7Z794

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189182

Polymorphism and mutation databases

BioMutaiKRT77
DMDMi308153590

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000637111 – 578Keratin, type II cytoskeletal 1bAdd BLAST578

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95Omega-N-methylarginineBy similarity1
Modified residuei523Omega-N-methylarginineBy similarity1

Post-translational modificationi

Undergoes deimination of some arginine residues (citrullination).By similarity

Keywords - PTMi

Citrullination, Methylation

Proteomic databases

EPDiQ7Z794
PaxDbiQ7Z794
PeptideAtlasiQ7Z794
PRIDEiQ7Z794
ProteomicsDBi69492

PTM databases

iPTMnetiQ7Z794
PhosphoSitePlusiQ7Z794
SwissPalmiQ7Z794

Expressioni

Tissue specificityi

Expressed exclusively in skin.1 Publication

Gene expression databases

BgeeiENSG00000189182
CleanExiHS_KRT77
ExpressionAtlasiQ7Z794 baseline and differential
GenevisibleiQ7Z794 HS

Organism-specific databases

HPAiHPA045934

Interactioni

Protein-protein interaction databases

BioGridi131903, 17 interactors
IntActiQ7Z794, 12 interactors
STRINGi9606.ENSP00000342710

Structurei

3D structure databases

ProteinModelPortaliQ7Z794
SMRiQ7Z794
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 477IF rodPROSITE-ProRule annotationAdd BLAST314

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 163HeadAdd BLAST163
Regioni164 – 200Coil 1AAdd BLAST37
Regioni201 – 219Linker 1Add BLAST19
Regioni220 – 311Coil 1BAdd BLAST92
Regioni312 – 335Linker 12Add BLAST24
Regioni336 – 474Coil 2Add BLAST139
Regioni475 – 578TailAdd BLAST104

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IVT1 Eukaryota
ENOG4111ACY LUCA
GeneTreeiENSGT00910000144006
HOGENOMiHOG000230976
HOVERGENiHBG013015
InParanoidiQ7Z794
KOiK07605
OMAiHVSISVQ
OrthoDBiEOG091G09KR
PhylomeDBiQ7Z794
TreeFamiTF317854

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR032444 Keratin_2_head
IPR003054 Keratin_II
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF16208 Keratin_2_head, 1 hit
PRINTSiPR01276 TYPE2KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHQFSSQSA FSSMSRRVYS TSSSAGSGGG SPAVGSVCYA RGRCGGGGYG
60 70 80 90 100
IHGRGFGSRS LYNLGGSRSI SINLMGRSTS GFCQGGGVGG FGGGRGFGVG
110 120 130 140 150
STGAGGFGGG GFGGAGFGTS NFGLGGFGPY CPPGGIQEVT INQSLLEPLH
160 170 180 190 200
LEVDPEIQRI KTQEREQIMV LNNKFASFID KVRFLEQQNQ VLQTKWELLQ
210 220 230 240 250
QVNTSTGTNN LEPLLENYIG DLRRQVDLLS AEQMRQNAEV RSMQDVVEDY
260 270 280 290 300
KSKYEDEINK RTGSENDFVV LKKDVDAAYV SKVDLESRVD TLTGEVNFLK
310 320 330 340 350
YLFLTELSQV QTHISDTNVI LSMDNNRSLD LDSIIDAVRT QYELIAQRSK
360 370 380 390 400
DEAEALYQTK YQELQITAGR HGDDLKNSKM EIAELNRTVQ RLQAEISNVK
410 420 430 440 450
KQIEQMQSLI SDAEERGEQA LQDAWQKLQD LEEALQQSKE ELARLLRDYQ
460 470 480 490 500
AMLGVKLSLD VEIATYRQLL EGEESRMSGE LQSHVSISVQ NSQVSVNGGA
510 520 530 540 550
GGGGSYGSGG YGGGSGGGYG GGRSYRGGGA RGRSGGGYGS GCGGGGGSYG
560 570
GSGRSGRGSS RVQIIQTSTN TSHRRILE
Length:578
Mass (Da):61,901
Last modified:October 5, 2010 - v3
Checksum:i232F92351DF0FDCA
GO

Sequence cautioni

The sequence DAA00402 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti336D → N in CAD91892 (PubMed:15737194).Curated1
Sequence conflicti533R → G in CAD91892 (PubMed:15737194).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05602210A → T. Corresponds to variant dbSNP:rs17118224Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564104 mRNA Translation: CAD91892.1
AC055716 Genomic DNA No translation available.
BK000975 Genomic DNA Translation: DAA00402.1 Sequence problems.
CCDSiCCDS8837.1
RefSeqiNP_778253.2, NM_175078.2
UniGeneiHs.334989

Genome annotation databases

EnsembliENST00000341809; ENSP00000342710; ENSG00000189182
GeneIDi374454
KEGGihsa:374454
UCSCiuc001saw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiK2C1B_HUMAN
AccessioniPrimary (citable) accession number: Q7Z794
Secondary accession number(s): Q7RTS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: October 5, 2010
Last modified: July 18, 2018
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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