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Entry version 127 (18 Sep 2019)
Sequence version 3 (18 May 2010)
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Protein

Maestro heat-like repeat-containing protein family member 2B

Gene

MROH2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the process of sperm capacitation.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Maestro heat-like repeat-containing protein family member 2BImported
Alternative name(s):
HEAT repeat-containing protein 7B2
Sperm PKA-interacting factorBy similarity
Short name:
SPIFBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MROH2BImported
Synonyms:HEATR7B2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26857 MROH2B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z745

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Flagellum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
133558

Open Targets

More...
OpenTargetsi
ENSG00000171495

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164720440

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MROH2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296453066

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003322431 – 1585Maestro heat-like repeat-containing protein family member 2BAdd BLAST1585

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Constitutively phosphorylated on serine and threonine residues in acrosomal region of the sperm head, midpiece and flagellar regions of noncapacitated spermatozoa. Phosphorylation on tyrosine residues increases upon sperm capacitation within the acrosomal and tail regions in a protein kinase A (PKA)-dependent signaling pathway.By similarity

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z745

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z745

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z745

PeptideAtlas

More...
PeptideAtlasi
Q7Z745

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z745

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69484 [Q7Z745-1]
69485 [Q7Z745-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z745

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z745

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171495 Expressed in 56 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z745 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z745 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA059457

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Found in a complex at least composed of MROH2B, PRKACA isoform 2 and TCP11.

Interacts with PRKACA.

Interacts with TCP11.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126362, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q7Z745, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000382476

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati28 – 65HEAT 1Add BLAST38
Repeati228 – 263HEAT 2Add BLAST36
Repeati272 – 309HEAT 3Add BLAST38
Repeati310 – 346HEAT 4Add BLAST37
Repeati405 – 445HEAT 5Add BLAST41
Repeati531 – 569HEAT 6Add BLAST39
Repeati572 – 611HEAT 7Add BLAST40
Repeati662 – 699HEAT 8Add BLAST38
Repeati777 – 819HEAT 9Add BLAST43
Repeati964 – 1001HEAT 10Add BLAST38
Repeati1021 – 1059HEAT 11Add BLAST39
Repeati1112 – 1151HEAT 12Add BLAST40
Repeati1157 – 1195HEAT 13Add BLAST39
Repeati1258 – 1295HEAT 14Add BLAST38
Repeati1363 – 1402HEAT 15Add BLAST40

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2032 Eukaryota
ENOG410XQE8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161231

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168416

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z745

Identification of Orthologs from Complete Genome Data

More...
OMAi
GRRWKIF

Database of Orthologous Groups

More...
OrthoDBi
31329at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z745

TreeFam database of animal gene trees

More...
TreeFami
TF315201

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z745-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLSTEESIE MFGDINLTLG MLNKEDIVNK EDIYSHLTSV IQNTDILDDA
60 70 80 90 100
IVQRLIYYAS KDMRDNNMLR EIRMLAGEVL VSLAAHDFNS VMYEVQSNFR
110 120 130 140 150
ILELPDEFVV LALAELATSY VSQSIPFMMM TLLTMQTMLR LAEDERMKGT
160 170 180 190 200
FCIALEKFSK AIYKYVNHWR DFPYPRLDAN RLSDKIFMLF WYIMEKWAPL
210 220 230 240 250
ASPMQTLSIV KAHGPTVSLL LHREDFRGYA LGQVPWLLNQ YKDKEIDFHV
260 270 280 290 300
TQSLKQILTA AVLYDIGLPR SLRRSIFINL LQQICRAPEP PVKENEMKAS
310 320 330 340 350
SCFLILAHSN PGELMEFFDE QVRSNNEAIR VGILTLLRLA VNADEPRLRD
360 370 380 390 400
HIISIERTVK IVMGDLSTKV RNSVLLLIQT MCEKSYIEAR EGWPLIDYVF
410 420 430 440 450
SQFATLNRNL EKPVKTNFHE NEKEEESVRE TSLEVLKTLD PLVIGMPQVL
460 470 480 490 500
WPRILTFVVP AEYTEALEPL FSIIRILIMA EEKKQHSAKE STALVVSTGA
510 520 530 540 550
VKLPSPQQLL ARLLVISMPA SLGELRGAGA IGLLKILPEI IHPKLVDLWK
560 570 580 590 600
TRLPELLQPL EGKNISTVLW ETMLLQLLKE SLWKISDVAW TIQLTQDFKQ
610 620 630 640 650
QMGSYSNNST EKKFLWKALG TTLACCQDSD FVNSQIKEFL TAPNQLGDQR
660 670 680 690 700
QGITSILGYC AENHLDIVLK VLKTFQNQEK FFMNRCKSLF SGKKSLTKTD
710 720 730 740 750
VMVIYGAVAL HAPKKQLLSR LNQDIISQVL SLHGQCSQVL GMSVMNKDMD
760 770 780 790 800
LQMSFTRSIT EIGIAVQDAE DQGFQFSYKE MLIGYMLDFI RDEPLDSLAS
810 820 830 840 850
PIRWKALIAI RYLSKLKPQL SLQDHLNILE ENIRRLLPLP PLENLKSEGQ
860 870 880 890 900
TDKDKEHIQF LYERSMDALG KLLKTMMWDN VNAEDCQEMF NLLQMWLVSQ
910 920 930 940 950
KEWERERAFQ ITAKVLTNDI EAPENFKIGS LLGLLAPHSC DTLPTIRQAA
960 970 980 990 1000
ASSTIGLFYI KGIHLEVERL QGLQEGLESD DVQVQIKISS KIAKIVSKFI
1010 1020 1030 1040 1050
PNEEILMFLE EMLDGLESLN PTCTKACGIW MITVLKQQGA ALEDQLLEIL
1060 1070 1080 1090 1100
GTIYHHMPVL RQKEESFQFI LEAISQIASF HMDTVVVNLL QKPLPFDRDT
1110 1120 1130 1140 1150
KTLWKALAEK PASSGKLLQA LIDKLETELE DDIARVEAIS VACAMYEVIS
1160 1170 1180 1190 1200
MGTSVTGLYP ELFTLLLKLV SCTLGQKMLT CPWSHRRHVM QQGEQQQIPD
1210 1220 1230 1240 1250
PCRLSTATLK CLQAQAMREG LAKESDEGDN LWTLLSSPST HHIGVCSLAR
1260 1270 1280 1290 1300
SMAVWQHGVI LDIMEQLLSS LTSSSENYRI TGAAFFSELM KEPILWKHGN
1310 1320 1330 1340 1350
LRNVLILMDQ SAWDSNATLR QMAIRGLGNT ASGAPHKVKK HKQLMLESII
1360 1370 1380 1390 1400
RGLYHLARTE VVCESLKALK KILELLTDRD VSFYFKEIVL QTRTFFEDEQ
1410 1420 1430 1440 1450
DDVRLTAIFL FEDLAPLTGR RWKIFFAEEI KKSLISFLLH LWDPNPKIGV
1460 1470 1480 1490 1500
ACRDVLMVCI PFLGLQELYG VLDRLLDQDL PRARDFYRQF CVKLAKKNQE
1510 1520 1530 1540 1550
ILWILHTHSF TFFTSTWEVI RSAAVKLTDA VVLNLTSQYV ELLDREQLTT
1560 1570 1580
RLQALRQDPC ISVQRAAEAA LQTLLRRCKE TSIPL
Length:1,585
Mass (Da):180,781
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA57EF4E9DC182FAD
GO
Isoform 2 (identifier: Q7Z745-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-296: Missing.

Note: No experimental confirmation available.
Show »
Length:1,289
Mass (Da):146,438
Checksum:iCD1E87E04BB82DDD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GZ06F5GZ06_HUMAN
Maestro heat-like repeat-containing...
MROH2B
1,140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAP97306 differs from that shown. Reason: Frameshift at positions 1063 and 1080.Curated
The sequence BAC05103 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti624A → V in CAH18199 (PubMed:17974005).Curated1
Sequence conflicti897L → P in BAC05103 (PubMed:14702039).Curated1
Sequence conflicti1059V → L in AAP97306 (Ref. 5) Curated1
Sequence conflicti1072E → D in AAP97306 (Ref. 5) Curated1
Sequence conflicti1424I → T in CAH18199 (PubMed:17974005).Curated1
Sequence conflicti1424I → T in AAP97306 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04298311M → V1 PublicationCorresponds to variant dbSNP:rs13174484Ensembl.1
Natural variantiVAR_042984191W → R1 PublicationCorresponds to variant dbSNP:rs865093Ensembl.1
Natural variantiVAR_042985263L → I. Corresponds to variant dbSNP:rs10045243Ensembl.1
Natural variantiVAR_042986468E → V. Corresponds to variant dbSNP:rs17198125Ensembl.1
Natural variantiVAR_042987496V → I2 PublicationsCorresponds to variant dbSNP:rs325864Ensembl.1
Natural variantiVAR_042988526R → H2 PublicationsCorresponds to variant dbSNP:rs13173930Ensembl.1
Natural variantiVAR_042989617K → N1 PublicationCorresponds to variant dbSNP:rs17854768Ensembl.1
Natural variantiVAR_042990648D → V. Corresponds to variant dbSNP:rs16870720Ensembl.1
Natural variantiVAR_042991781M → V. Corresponds to variant dbSNP:rs10067611Ensembl.1
Natural variantiVAR_042992918N → K. Corresponds to variant dbSNP:rs10054110Ensembl.1
Natural variantiVAR_0429931179L → P4 PublicationsCorresponds to variant dbSNP:rs2271704Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0333611 – 296Missing in isoform 2. 1 PublicationAdd BLAST296

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR749346 mRNA Translation: CAH18199.1
AC114967 Genomic DNA No translation available.
BC052962 mRNA Translation: AAH52962.1
AK097562 mRNA Translation: BAC05103.1 Different initiation.
AF432068 mRNA Translation: AAP97306.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47202.1 [Q7Z745-1]

NCBI Reference Sequences

More...
RefSeqi
NP_775760.3, NM_173489.4 [Q7Z745-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000399564; ENSP00000382476; ENSG00000171495 [Q7Z745-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
133558

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:133558

UCSC genome browser

More...
UCSCi
uc003jmj.5 human [Q7Z745-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749346 mRNA Translation: CAH18199.1
AC114967 Genomic DNA No translation available.
BC052962 mRNA Translation: AAH52962.1
AK097562 mRNA Translation: BAC05103.1 Different initiation.
AF432068 mRNA Translation: AAP97306.1 Frameshift.
CCDSiCCDS47202.1 [Q7Z745-1]
RefSeqiNP_775760.3, NM_173489.4 [Q7Z745-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126362, 1 interactor
IntActiQ7Z745, 2 interactors
STRINGi9606.ENSP00000382476

PTM databases

iPTMnetiQ7Z745
PhosphoSitePlusiQ7Z745

Polymorphism and mutation databases

BioMutaiMROH2B
DMDMi296453066

Proteomic databases

jPOSTiQ7Z745
MassIVEiQ7Z745
PaxDbiQ7Z745
PeptideAtlasiQ7Z745
PRIDEiQ7Z745
ProteomicsDBi69484 [Q7Z745-1]
69485 [Q7Z745-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399564; ENSP00000382476; ENSG00000171495 [Q7Z745-1]
GeneIDi133558
KEGGihsa:133558
UCSCiuc003jmj.5 human [Q7Z745-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
133558
DisGeNETi133558

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MROH2B
HGNCiHGNC:26857 MROH2B
HPAiHPA059457
neXtProtiNX_Q7Z745
OpenTargetsiENSG00000171495
PharmGKBiPA164720440

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2032 Eukaryota
ENOG410XQE8 LUCA
GeneTreeiENSGT00940000161231
HOGENOMiHOG000168416
InParanoidiQ7Z745
OMAiGRRWKIF
OrthoDBi31329at2759
PhylomeDBiQ7Z745
TreeFamiTF315201

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
133558

Pharos

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Pharosi
Q7Z745

Protein Ontology

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PROi
PR:Q7Z745

Gene expression databases

BgeeiENSG00000171495 Expressed in 56 organ(s), highest expression level in testis
ExpressionAtlasiQ7Z745 baseline and differential
GenevisibleiQ7Z745 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRO2B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z745
Secondary accession number(s): Q68DM1, Q7Z4U4, Q8N7X3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 18, 2010
Last modified: September 18, 2019
This is version 127 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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