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Protein

Pleckstrin homology domain-containing family H member 3

Gene

PLEKHH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family H member 3
Short name:
PH domain-containing family H member 3
Gene namesi
Name:PLEKHH3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000068137.14
HGNCiHGNC:26105 PLEKHH3
neXtProtiNX_Q7Z736

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi79990
OpenTargetsiENSG00000068137
PharmGKBiPA143485577

Polymorphism and mutation databases

BioMutaiPLEKHH3
DMDMi296452865

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000031110819 – 793Pleckstrin homology domain-containing family H member 3Add BLAST775

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineCombined sources1
Modified residuei638Omega-N-methylarginineCombined sources1
Modified residuei642Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ7Z736
MaxQBiQ7Z736
PaxDbiQ7Z736
PeptideAtlasiQ7Z736
PRIDEiQ7Z736
ProteomicsDBi69479
69480 [Q7Z736-2]
69481 [Q7Z736-3]
69482 [Q7Z736-4]

PTM databases

iPTMnetiQ7Z736
PhosphoSitePlusiQ7Z736

Expressioni

Gene expression databases

BgeeiENSG00000068137 Expressed in 154 organ(s), highest expression level in body of pancreas
CleanExiHS_PLEKHH3
ExpressionAtlasiQ7Z736 baseline and differential
GenevisibleiQ7Z736 HS

Organism-specific databases

HPAiHPA046234

Interactioni

Protein-protein interaction databases

BioGridi123053, 15 interactors
IntActiQ7Z736, 3 interactors
MINTiQ7Z736

Structurei

3D structure databases

ProteinModelPortaliQ7Z736
SMRiQ7Z736
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 199PHPROSITE-ProRule annotationAdd BLAST105
Domaini237 – 399MyTH4PROSITE-ProRule annotationAdd BLAST163
Domaini404 – 754FERMPROSITE-ProRule annotationAdd BLAST351

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi757 – 760Poly-Ser4

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410ITZM Eukaryota
ENOG410Z45E LUCA
GeneTreeiENSGT00920000149052
HOGENOMiHOG000115561
HOVERGENiHBG052553
InParanoidiQ7Z736
OMAiFNEAVHW
OrthoDBiEOG091G02YB
PhylomeDBiQ7Z736

Family and domain databases

Gene3Di1.20.80.10, 1 hit
1.25.40.530, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00784 MyTH4, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00139 MyTH4, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF47031 SSF47031, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS51016 MYTH4, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z736-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLPGGLWWL LCCRRGFTLL HRDYGDGELS GDGDEDEDEE TFELRTPSPA
60 70 80 90 100
GGGRGPLEVT LTQPVRSGPV SNRLQSWEET WSLIPEKGLP EDDPDIVVKG
110 120 130 140 150
WLYREPRGGG ARPWLPPRRA WFVLTRDSLD QFSSSGKGAR RLGSLVLTSL
160 170 180 190 200
CSVTGPERRR KETGLWSVTV SGRKHSVRLC SPRQAEAERW GVALREVIAS
210 220 230 240 250
KAPLETPTQL LLRDIQESCG DPEAVALIYL RNPILRHTSG ALYAPLLPLP
260 270 280 290 300
YGVSAPGPGY APLREEAVRL FLALQALEGA RRPGPLMQGV LQTCRDLPAL
310 320 330 340 350
RDELFLQLAK QTSGPAGPPG LPATQDPAAL RYWQLLTCMS CTFRPGGAVR
360 370 380 390 400
GHLLGHLERT EQALPDSELA EYARFIRKAL GRTRGRELVP SLAEISALSQ
410 420 430 440 450
RQELLCTVHC PGAGACAVAI DSHTTAGEVA RELVGRLGLA RSRNAFALYE
460 470 480 490 500
QRGAQERALA GGTLVADVLT RFENLAAEEA GLEDSPDSGW RLCLRLHGPL
510 520 530 540 550
HPEGLSPDGH ELPFLFEQAH ALLLRGRPPP PDDTLRALAA LRLQSLQRDF
560 570 580 590 600
SPRVPLPRLD RLLPPPAPPR EDPPRPTPRP PPSAALLAGA LWSPGLAKRR
610 620 630 640 650
AERARRGGAG RTAGSIAREG GGGAGTAAAV LGGWKRLRGM GRAEAMAAYL
660 670 680 690 700
ALAAQCPGFG AARYDVLELS TEPGRGAPQK LCLGLGAKAM SLSRPGETEP
710 720 730 740 750
IHSVSYGHVA ACQLMGPHTL ALRVGESQLL LQSPQVEEIM QLVNAYLANP
760 770 780 790
SPERPCSSSS PPCQDLPDTS PPSQRPGLDE PQGQSGCLGQ LQD
Length:793
Mass (Da):85,317
Last modified:May 18, 2010 - v2
Checksum:i76A85A090F84C4C5
GO
Isoform 2 (identifier: Q7Z736-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     471-474: RFEN → S
     672-736: EPGRGAPQKL...SQLLLQSPQV → VRGRREKGTL...QPPPHTCCES
     737-793: Missing.

Note: No experimental confirmation available.
Show »
Length:733
Mass (Da):79,030
Checksum:i2BC16828BA48A13F
GO
Isoform 3 (identifier: Q7Z736-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     664-705: YDVLELSTEP...GETEPIHSVS → SLVGVLHRSC...SAMAMWPPAS
     706-793: Missing.

Note: No experimental confirmation available.
Show »
Length:705
Mass (Da):76,078
Checksum:i59B3C7223E8F7726
GO
Isoform 4 (identifier: Q7Z736-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     471-474: RFEN → S
     514-531: FLFEQAHALLLRGRPPPP → RGHDFPPACSLGQDCSEI
     532-705: Missing.

Note: No experimental confirmation available.
Show »
Length:616
Mass (Da):66,686
Checksum:iC0CA155F3EF4279D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R3U4X6R3U4_HUMAN
Pleckstrin homology domain-containi...
PLEKHH3
790Annotation score:
K7EK04K7EK04_HUMAN
Pleckstrin homology domain-containi...
PLEKHH3
206Annotation score:

Sequence cautioni

The sequence BAD92176 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117P → L in BAB14956 (PubMed:14702039).Curated1
Sequence conflicti123V → A in BAB14956 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061520547Q → H2 PublicationsCorresponds to variant dbSNP:rs8071056Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029392471 – 474RFEN → S in isoform 2 and isoform 4. 2 Publications4
Alternative sequenceiVSP_029393514 – 531FLFEQ…RPPPP → RGHDFPPACSLGQDCSEI in isoform 4. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_029394532 – 705Missing in isoform 4. 1 PublicationAdd BLAST174
Alternative sequenceiVSP_029395664 – 705YDVLE…IHSVS → SLVGVLHRSCAWAWEPRPCP SPGQGRRSPSTVSAMAMWPP AS in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_029396672 – 736EPGRG…QSPQV → VRGRREKGTLAAQAPHLCPR ATGPTECHVIPHIQNSYPSQ TPGVTSPWALTSLEPQPPPH TCCES in isoform 2. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_029397706 – 793Missing in isoform 3. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_029398737 – 793Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024672 mRNA Translation: BAB14956.1
AB208939 mRNA Translation: BAD92176.1 Different initiation.
AC067852 Genomic DNA No translation available.
BC016062 mRNA Translation: AAH16062.1
BC052978 mRNA Translation: AAH52978.1
AL137584 mRNA Translation: CAB70826.1
CCDSiCCDS11434.1 [Q7Z736-1]
PIRiT46295
RefSeqiNP_079203.3, NM_024927.4
UniGeneiHs.632251

Genome annotation databases

EnsembliENST00000591022; ENSP00000468678; ENSG00000068137 [Q7Z736-1]
ENST00000591196; ENSP00000467824; ENSG00000068137 [Q7Z736-3]
GeneIDi79990
KEGGihsa:79990
UCSCiuc002iau.5 human [Q7Z736-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024672 mRNA Translation: BAB14956.1
AB208939 mRNA Translation: BAD92176.1 Different initiation.
AC067852 Genomic DNA No translation available.
BC016062 mRNA Translation: AAH16062.1
BC052978 mRNA Translation: AAH52978.1
AL137584 mRNA Translation: CAB70826.1
CCDSiCCDS11434.1 [Q7Z736-1]
PIRiT46295
RefSeqiNP_079203.3, NM_024927.4
UniGeneiHs.632251

3D structure databases

ProteinModelPortaliQ7Z736
SMRiQ7Z736
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123053, 15 interactors
IntActiQ7Z736, 3 interactors
MINTiQ7Z736

PTM databases

iPTMnetiQ7Z736
PhosphoSitePlusiQ7Z736

Polymorphism and mutation databases

BioMutaiPLEKHH3
DMDMi296452865

Proteomic databases

EPDiQ7Z736
MaxQBiQ7Z736
PaxDbiQ7Z736
PeptideAtlasiQ7Z736
PRIDEiQ7Z736
ProteomicsDBi69479
69480 [Q7Z736-2]
69481 [Q7Z736-3]
69482 [Q7Z736-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000591022; ENSP00000468678; ENSG00000068137 [Q7Z736-1]
ENST00000591196; ENSP00000467824; ENSG00000068137 [Q7Z736-3]
GeneIDi79990
KEGGihsa:79990
UCSCiuc002iau.5 human [Q7Z736-1]

Organism-specific databases

CTDi79990
DisGeNETi79990
EuPathDBiHostDB:ENSG00000068137.14
GeneCardsiPLEKHH3
HGNCiHGNC:26105 PLEKHH3
HPAiHPA046234
neXtProtiNX_Q7Z736
OpenTargetsiENSG00000068137
PharmGKBiPA143485577
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITZM Eukaryota
ENOG410Z45E LUCA
GeneTreeiENSGT00920000149052
HOGENOMiHOG000115561
HOVERGENiHBG052553
InParanoidiQ7Z736
OMAiFNEAVHW
OrthoDBiEOG091G02YB
PhylomeDBiQ7Z736

Miscellaneous databases

ChiTaRSiPLEKHH3 human
GenomeRNAii79990
PROiPR:Q7Z736

Gene expression databases

BgeeiENSG00000068137 Expressed in 154 organ(s), highest expression level in body of pancreas
CleanExiHS_PLEKHH3
ExpressionAtlasiQ7Z736 baseline and differential
GenevisibleiQ7Z736 HS

Family and domain databases

Gene3Di1.20.80.10, 1 hit
1.25.40.530, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR000299 FERM_domain
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
PfamiView protein in Pfam
PF00373 FERM_M, 1 hit
PF00784 MyTH4, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM00139 MyTH4, 1 hit
SM00233 PH, 1 hit
SUPFAMiSSF47031 SSF47031, 2 hits
PROSITEiView protein in PROSITE
PS50057 FERM_3, 1 hit
PS51016 MYTH4, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPKHH3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z736
Secondary accession number(s): C9JQ76
, Q59H20, Q96B28, Q9H7D6, Q9NT18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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