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Entry version 149 (29 Sep 2021)
Sequence version 2 (18 May 2010)
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Protein

Pleckstrin homology domain-containing family H member 3

Gene

PLEKHH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7Z736

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family H member 3
Short name:
PH domain-containing family H member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLEKHH3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26105, PLEKHH3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z736

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000068137

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79990

Open Targets

More...
OpenTargetsi
ENSG00000068137

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485577

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z736, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLEKHH3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452865

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031110819 – 793Pleckstrin homology domain-containing family H member 3Add BLAST775

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei30PhosphoserineCombined sources1
Modified residuei638Omega-N-methylarginineCombined sources1
Modified residuei642Omega-N-methylarginineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z736

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z736

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z736

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z736

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z736

PeptideAtlas

More...
PeptideAtlasi
Q7Z736

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z736

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69479 [Q7Z736-1]
69480 [Q7Z736-2]
69481 [Q7Z736-3]
69482 [Q7Z736-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z736

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z736

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7Z736

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000068137, Expressed in pancreas and 174 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z736, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z736, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000068137, Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123053, 16 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z736, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000468678

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z736, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z736

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini95 – 199PHPROSITE-ProRule annotationAdd BLAST105
Domaini237 – 399MyTH4PROSITE-ProRule annotationAdd BLAST163
Domaini404 – 754FERMPROSITE-ProRule annotationAdd BLAST351

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 62DisorderedSequence analysisAdd BLAST35
Regioni554 – 586DisorderedSequence analysisAdd BLAST33
Regioni598 – 622DisorderedSequence analysisAdd BLAST25
Regioni750 – 793DisorderedSequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi558 – 583Pro residuesSequence analysisAdd BLAST26
Compositional biasi775 – 793Polar residuesSequence analysisAdd BLAST19

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4229, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159764

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001626_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z736

Identification of Orthologs from Complete Genome Data

More...
OMAi
SRQEMLC

Database of Orthologous Groups

More...
OrthoDBi
478730at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z736

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
1.25.40.530, 1 hit
2.30.29.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000159, RA_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00373, FERM_M, 1 hit
PF00784, MyTH4, 1 hit
PF00788, RA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 1 hit
SM00139, MyTH4, 1 hit
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031, SSF47031, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057, FERM_3, 1 hit
PS51016, MYTH4, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z736-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLPGGLWWL LCCRRGFTLL HRDYGDGELS GDGDEDEDEE TFELRTPSPA
60 70 80 90 100
GGGRGPLEVT LTQPVRSGPV SNRLQSWEET WSLIPEKGLP EDDPDIVVKG
110 120 130 140 150
WLYREPRGGG ARPWLPPRRA WFVLTRDSLD QFSSSGKGAR RLGSLVLTSL
160 170 180 190 200
CSVTGPERRR KETGLWSVTV SGRKHSVRLC SPRQAEAERW GVALREVIAS
210 220 230 240 250
KAPLETPTQL LLRDIQESCG DPEAVALIYL RNPILRHTSG ALYAPLLPLP
260 270 280 290 300
YGVSAPGPGY APLREEAVRL FLALQALEGA RRPGPLMQGV LQTCRDLPAL
310 320 330 340 350
RDELFLQLAK QTSGPAGPPG LPATQDPAAL RYWQLLTCMS CTFRPGGAVR
360 370 380 390 400
GHLLGHLERT EQALPDSELA EYARFIRKAL GRTRGRELVP SLAEISALSQ
410 420 430 440 450
RQELLCTVHC PGAGACAVAI DSHTTAGEVA RELVGRLGLA RSRNAFALYE
460 470 480 490 500
QRGAQERALA GGTLVADVLT RFENLAAEEA GLEDSPDSGW RLCLRLHGPL
510 520 530 540 550
HPEGLSPDGH ELPFLFEQAH ALLLRGRPPP PDDTLRALAA LRLQSLQRDF
560 570 580 590 600
SPRVPLPRLD RLLPPPAPPR EDPPRPTPRP PPSAALLAGA LWSPGLAKRR
610 620 630 640 650
AERARRGGAG RTAGSIAREG GGGAGTAAAV LGGWKRLRGM GRAEAMAAYL
660 670 680 690 700
ALAAQCPGFG AARYDVLELS TEPGRGAPQK LCLGLGAKAM SLSRPGETEP
710 720 730 740 750
IHSVSYGHVA ACQLMGPHTL ALRVGESQLL LQSPQVEEIM QLVNAYLANP
760 770 780 790
SPERPCSSSS PPCQDLPDTS PPSQRPGLDE PQGQSGCLGQ LQD
Length:793
Mass (Da):85,317
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76A85A090F84C4C5
GO
Isoform 2 (identifier: Q7Z736-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     471-474: RFEN → S
     672-736: EPGRGAPQKL...SQLLLQSPQV → VRGRREKGTL...QPPPHTCCES
     737-793: Missing.

Show »
Length:733
Mass (Da):79,030
Checksum:i2BC16828BA48A13F
GO
Isoform 3 (identifier: Q7Z736-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     664-705: YDVLELSTEP...GETEPIHSVS → SLVGVLHRSC...SAMAMWPPAS
     706-793: Missing.

Show »
Length:705
Mass (Da):76,078
Checksum:i59B3C7223E8F7726
GO
Isoform 4 (identifier: Q7Z736-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     471-474: RFEN → S
     514-531: FLFEQAHALLLRGRPPPP → RGHDFPPACSLGQDCSEI
     532-705: Missing.

Show »
Length:616
Mass (Da):66,686
Checksum:iC0CA155F3EF4279D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R3U4X6R3U4_HUMAN
Pleckstrin homology domain-containi...
PLEKHH3
790Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EK04K7EK04_HUMAN
Pleckstrin homology domain-containi...
PLEKHH3
206Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92176 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti117P → L in BAB14956 (PubMed:14702039).Curated1
Sequence conflicti123V → A in BAB14956 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061520547Q → H2 PublicationsCorresponds to variant dbSNP:rs8071056Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029392471 – 474RFEN → S in isoform 2 and isoform 4. 2 Publications4
Alternative sequenceiVSP_029393514 – 531FLFEQ…RPPPP → RGHDFPPACSLGQDCSEI in isoform 4. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_029394532 – 705Missing in isoform 4. 1 PublicationAdd BLAST174
Alternative sequenceiVSP_029395664 – 705YDVLE…IHSVS → SLVGVLHRSCAWAWEPRPCP SPGQGRRSPSTVSAMAMWPP AS in isoform 3. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_029396672 – 736EPGRG…QSPQV → VRGRREKGTLAAQAPHLCPR ATGPTECHVIPHIQNSYPSQ TPGVTSPWALTSLEPQPPPH TCCES in isoform 2. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_029397706 – 793Missing in isoform 3. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_029398737 – 793Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK024672 mRNA Translation: BAB14956.1
AB208939 mRNA Translation: BAD92176.1 Different initiation.
AC067852 Genomic DNA No translation available.
BC016062 mRNA Translation: AAH16062.1
BC052978 mRNA Translation: AAH52978.1
AL137584 mRNA Translation: CAB70826.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11434.1 [Q7Z736-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46295

NCBI Reference Sequences

More...
RefSeqi
NP_079203.3, NM_024927.4 [Q7Z736-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000591022; ENSP00000468678; ENSG00000068137 [Q7Z736-1]
ENST00000591196; ENSP00000467824; ENSG00000068137 [Q7Z736-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79990

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79990

UCSC genome browser

More...
UCSCi
uc002iau.5, human [Q7Z736-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024672 mRNA Translation: BAB14956.1
AB208939 mRNA Translation: BAD92176.1 Different initiation.
AC067852 Genomic DNA No translation available.
BC016062 mRNA Translation: AAH16062.1
BC052978 mRNA Translation: AAH52978.1
AL137584 mRNA Translation: CAB70826.1
CCDSiCCDS11434.1 [Q7Z736-1]
PIRiT46295
RefSeqiNP_079203.3, NM_024927.4 [Q7Z736-1]

3D structure databases

SMRiQ7Z736
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123053, 16 interactors
IntActiQ7Z736, 10 interactors
STRINGi9606.ENSP00000468678

PTM databases

iPTMnetiQ7Z736
PhosphoSitePlusiQ7Z736
SwissPalmiQ7Z736

Genetic variation databases

BioMutaiPLEKHH3
DMDMi296452865

Proteomic databases

EPDiQ7Z736
jPOSTiQ7Z736
MassIVEiQ7Z736
MaxQBiQ7Z736
PaxDbiQ7Z736
PeptideAtlasiQ7Z736
PRIDEiQ7Z736
ProteomicsDBi69479 [Q7Z736-1]
69480 [Q7Z736-2]
69481 [Q7Z736-3]
69482 [Q7Z736-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29328, 32 antibodies

The DNASU plasmid repository

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DNASUi
79990

Genome annotation databases

EnsembliENST00000591022; ENSP00000468678; ENSG00000068137 [Q7Z736-1]
ENST00000591196; ENSP00000467824; ENSG00000068137 [Q7Z736-3]
GeneIDi79990
KEGGihsa:79990
UCSCiuc002iau.5, human [Q7Z736-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79990
DisGeNETi79990

GeneCards: human genes, protein and diseases

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GeneCardsi
PLEKHH3
HGNCiHGNC:26105, PLEKHH3
HPAiENSG00000068137, Tissue enhanced (pancreas)
neXtProtiNX_Q7Z736
OpenTargetsiENSG00000068137
PharmGKBiPA143485577
VEuPathDBiHostDB:ENSG00000068137

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4229, Eukaryota
GeneTreeiENSGT00940000159764
HOGENOMiCLU_001626_4_0_1
InParanoidiQ7Z736
OMAiSRQEMLC
OrthoDBi478730at2759
PhylomeDBiQ7Z736

Enzyme and pathway databases

PathwayCommonsiQ7Z736

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
79990, 13 hits in 1017 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PLEKHH3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79990
PharosiQ7Z736, Tdark

Protein Ontology

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PROi
PR:Q7Z736
RNActiQ7Z736, protein

Gene expression databases

BgeeiENSG00000068137, Expressed in pancreas and 174 other tissues
ExpressionAtlasiQ7Z736, baseline and differential
GenevisibleiQ7Z736, HS

Family and domain databases

Gene3Di1.20.80.10, 1 hit
1.25.40.530, 1 hit
2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR000159, RA_dom
PfamiView protein in Pfam
PF00373, FERM_M, 1 hit
PF00784, MyTH4, 1 hit
PF00788, RA, 1 hit
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM00139, MyTH4, 1 hit
SM00233, PH, 1 hit
SUPFAMiSSF47031, SSF47031, 1 hit
PROSITEiView protein in PROSITE
PS50057, FERM_3, 1 hit
PS51016, MYTH4, 1 hit
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHH3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z736
Secondary accession number(s): C9JQ76
, Q59H20, Q96B28, Q9H7D6, Q9NT18
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 18, 2010
Last modified: September 29, 2021
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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