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Protein

Transmembrane and coiled-coil domain-containing protein 2

Gene

TMCO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane and coiled-coil domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMCO2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000188800.5

Human Gene Nomenclature Database

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HGNCi
HGNC:23312 TMCO2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z6W1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei51 – 71HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000188800

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142670793

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMCO2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750201

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002494351 – 182Transmembrane and coiled-coil domain-containing protein 2Add BLAST182

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7Z6W1

PeptideAtlas

More...
PeptideAtlasi
Q7Z6W1

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z6W1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69468

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q7Z6W1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z6W1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000188800 Expressed in 55 organ(s), highest expression level in sperm

CleanEx database of gene expression profiles

More...
CleanExi
HS_TMCO2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z6W1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z6W1 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q7Z6W1, 6 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000361852

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q7Z6W1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7Z6W1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili124 – 151Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 8Poly-Ser7

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JA7Q Eukaryota
ENOG4111526 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001528

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000154635

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080208

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z6W1

Identification of Orthologs from Complete Genome Data

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OMAi
LWKRSVR

Database of Orthologous Groups

More...
OrthoDBi
1551363at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z6W1

TreeFam database of animal gene trees

More...
TreeFami
TF337575

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR031697 TMCCDC2

The PANTHER Classification System

More...
PANTHERi
PTHR38496 PTHR38496, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15844 TMCCDC2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7Z6W1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTSSSSSWD NLLESLSLST VWNWIQASFL GETSAPQQTS LGLLDNLAPA
60 70 80 90 100
VQIILRISFL ILLGIGIYAL WKRSIQSIQK TLLFVITLYK LYKKGSHIFE
110 120 130 140 150
ALLANPEGSG LRIQDNNNLF LSLGLQEKIL KKLKTVENKM KNLEGIIVAQ
160 170 180
KPATKRDCSS EPYCSCSDCQ SPLSTSGFTS PI
Length:182
Mass (Da):20,071
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA0A64E52CBF8462
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL050341 Genomic DNA No translation available.
BC108666 mRNA Translation: AAI08667.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS30684.1

NCBI Reference Sequences

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RefSeqi
NP_001008740.1, NM_001008740.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.406265

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372766; ENSP00000361852; ENSG00000188800

Database of genes from NCBI RefSeq genomes

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GeneIDi
127391

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:127391

UCSC genome browser

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UCSCi
uc001cfe.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050341 Genomic DNA No translation available.
BC108666 mRNA Translation: AAI08667.1
CCDSiCCDS30684.1
RefSeqiNP_001008740.1, NM_001008740.3
UniGeneiHs.406265

3D structure databases

ProteinModelPortaliQ7Z6W1
SMRiQ7Z6W1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7Z6W1, 6 interactors
STRINGi9606.ENSP00000361852

PTM databases

iPTMnetiQ7Z6W1
PhosphoSitePlusiQ7Z6W1

Polymorphism and mutation databases

BioMutaiTMCO2
DMDMi74750201

Proteomic databases

PaxDbiQ7Z6W1
PeptideAtlasiQ7Z6W1
PRIDEiQ7Z6W1
ProteomicsDBi69468

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372766; ENSP00000361852; ENSG00000188800
GeneIDi127391
KEGGihsa:127391
UCSCiuc001cfe.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
127391
EuPathDBiHostDB:ENSG00000188800.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMCO2
HGNCiHGNC:23312 TMCO2
neXtProtiNX_Q7Z6W1
OpenTargetsiENSG00000188800
PharmGKBiPA142670793

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JA7Q Eukaryota
ENOG4111526 LUCA
GeneTreeiENSGT00390000001528
HOGENOMiHOG000154635
HOVERGENiHBG080208
InParanoidiQ7Z6W1
OMAiLWKRSVR
OrthoDBi1551363at2759
PhylomeDBiQ7Z6W1
TreeFamiTF337575

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
127391

Protein Ontology

More...
PROi
PR:Q7Z6W1

Gene expression databases

BgeeiENSG00000188800 Expressed in 55 organ(s), highest expression level in sperm
CleanExiHS_TMCO2
ExpressionAtlasiQ7Z6W1 baseline and differential
GenevisibleiQ7Z6W1 HS

Family and domain databases

InterProiView protein in InterPro
IPR031697 TMCCDC2
PANTHERiPTHR38496 PTHR38496, 1 hit
PfamiView protein in Pfam
PF15844 TMCCDC2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMCO2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z6W1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 1, 2003
Last modified: January 16, 2019
This is version 101 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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