UniProtKB - Q7Z6V5 (ADAT2_HUMAN)
Protein
tRNA-specific adenosine deaminase 2
Gene
ADAT2
Organism
Homo sapiens (Human)
Status
Functioni
Probably participates in deamination of adenosine-34 to inosine in many tRNAs.By similarity
Catalytic activityi
- EC:3.5.4.33Curated
Cofactori
Zn2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 71 | Zinc; catalytic1 Publication | 1 | |
Active sitei | 73 | Proton donorBy similarity | 1 | |
Metal bindingi | 107 | Zinc; catalytic1 Publication | 1 | |
Metal bindingi | 110 | Zinc; catalytic1 Publication | 1 |
GO - Molecular functioni
- tRNA-specific adenosine-34 deaminase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- tRNA modification Source: Reactome
- tRNA wobble adenosine to inosine editing Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Biological process | tRNA processing |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q7Z6V5 |
Reactomei | R-HSA-6782315, tRNA modification in the nucleus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA-specific adenosine deaminase 2 (EC:3.5.4.33Curated)Alternative name(s): Deaminase domain-containing protein 1 tRNA-specific adenosine-34 deaminase subunit ADAT2 |
Gene namesi | Name:ADAT2 Synonyms:DEADC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21172, ADAT2 |
MIMi | 615388, gene |
neXtProti | NX_Q7Z6V5 |
VEuPathDBi | HostDB:ENSG00000189007.15 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 134637 |
OpenTargetsi | ENSG00000189007 |
PharmGKBi | PA162375592 |
Miscellaneous databases
Pharosi | Q7Z6V5, Tbio |
Genetic variation databases
BioMutai | ADAT2 |
DMDMi | 74750199 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287653 | 1 – 191 | tRNA-specific adenosine deaminase 2Add BLAST | 191 |
Proteomic databases
EPDi | Q7Z6V5 |
jPOSTi | Q7Z6V5 |
MassIVEi | Q7Z6V5 |
MaxQBi | Q7Z6V5 |
PaxDbi | Q7Z6V5 |
PeptideAtlasi | Q7Z6V5 |
PRIDEi | Q7Z6V5 |
ProteomicsDBi | 69466 [Q7Z6V5-1] 69467 [Q7Z6V5-2] |
PTM databases
iPTMneti | Q7Z6V5 |
MetOSitei | Q7Z6V5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000189007, Expressed in zone of skin and 166 other tissues |
Genevisiblei | Q7Z6V5, HS |
Organism-specific databases
HPAi | ENSG00000189007, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ7Z6V5
With | #Exp. | IntAct |
---|---|---|
NAV2 [Q8IVL1] | 3 | EBI-2809203,EBI-741200 |
SGTB [Q96EQ0] | 3 | EBI-2809203,EBI-744081 |
SMARCD1 [Q96GM5] | 3 | EBI-2809203,EBI-358489 |
SPRED1 [Q7Z699] | 3 | EBI-2809203,EBI-5235340 |
Protein-protein interaction databases
BioGRIDi | 126410, 11 interactors |
IntActi | Q7Z6V5, 6 interactors |
STRINGi | 9606.ENSP00000237283 |
Miscellaneous databases
RNActi | Q7Z6V5, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q7Z6V5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q7Z6V5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 145 | CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST | 126 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1018, Eukaryota |
GeneTreei | ENSGT00390000000280 |
HOGENOMi | CLU_025810_8_3_1 |
InParanoidi | Q7Z6V5 |
OMAi | LEPCQMC |
OrthoDBi | 1616309at2759 |
PhylomeDBi | Q7Z6V5 |
TreeFami | TF313782 |
Family and domain databases
HAMAPi | MF_00972, tRNA_aden_deaminase, 1 hit |
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR016193, Cytidine_deaminase-like IPR028883, tRNA_aden_deaminase |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q7Z6V5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAKAAPKPA ASGACSVSAE ETEKWMEEAM HMAKEALENT EVPVGCLMVY
60 70 80 90 100
NNEVVGKGRN EVNQTKNATR HAEMVAIDQV LDWCRQSGKS PSEVFEHTVL
110 120 130 140 150
YVTVEPCIMC AAALRLMKIP LVVYGCQNER FGGCGSVLNI ASADLPNTGR
160 170 180 190
PFQCIPGYRA EEAVEMLKTF YKQENPNAPK SKVRKKECQK S
Sequence cautioni
The sequence AAH37955 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025582 | 1 – 47 | Missing in isoform 2. 2 PublicationsAdd BLAST | 47 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126201 mRNA Translation: BAG54295.1 BX538182 mRNA Translation: CAD98054.1 AL031320 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47868.1 BC037955 mRNA Translation: AAH37955.2 Different initiation. |
CCDSi | CCDS43511.1 [Q7Z6V5-1] CCDS69219.1 [Q7Z6V5-2] |
RefSeqi | NP_001273188.1, NM_001286259.1 [Q7Z6V5-2] NP_872309.2, NM_182503.2 [Q7Z6V5-1] XP_011533742.1, XM_011535440.1 XP_011533746.1, XM_011535444.2 [Q7Z6V5-2] XP_016865749.1, XM_017010260.1 [Q7Z6V5-2] XP_016865750.1, XM_017010261.1 XP_016865751.1, XM_017010262.1 [Q7Z6V5-2] |
Genome annotation databases
Ensembli | ENST00000237283; ENSP00000237283; ENSG00000189007 [Q7Z6V5-1] ENST00000606514; ENSP00000475651; ENSG00000189007 [Q7Z6V5-2] |
GeneIDi | 134637 |
KEGGi | hsa:134637 |
UCSCi | uc003qjj.4, human [Q7Z6V5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126201 mRNA Translation: BAG54295.1 BX538182 mRNA Translation: CAD98054.1 AL031320 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47868.1 BC037955 mRNA Translation: AAH37955.2 Different initiation. |
CCDSi | CCDS43511.1 [Q7Z6V5-1] CCDS69219.1 [Q7Z6V5-2] |
RefSeqi | NP_001273188.1, NM_001286259.1 [Q7Z6V5-2] NP_872309.2, NM_182503.2 [Q7Z6V5-1] XP_011533742.1, XM_011535440.1 XP_011533746.1, XM_011535444.2 [Q7Z6V5-2] XP_016865749.1, XM_017010260.1 [Q7Z6V5-2] XP_016865750.1, XM_017010261.1 XP_016865751.1, XM_017010262.1 [Q7Z6V5-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3DH1 | X-ray | 2.80 | A/B/C/D | 20-185 | [»] | |
SMRi | Q7Z6V5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 126410, 11 interactors |
IntActi | Q7Z6V5, 6 interactors |
STRINGi | 9606.ENSP00000237283 |
PTM databases
iPTMneti | Q7Z6V5 |
MetOSitei | Q7Z6V5 |
Genetic variation databases
BioMutai | ADAT2 |
DMDMi | 74750199 |
Proteomic databases
EPDi | Q7Z6V5 |
jPOSTi | Q7Z6V5 |
MassIVEi | Q7Z6V5 |
MaxQBi | Q7Z6V5 |
PaxDbi | Q7Z6V5 |
PeptideAtlasi | Q7Z6V5 |
PRIDEi | Q7Z6V5 |
ProteomicsDBi | 69466 [Q7Z6V5-1] 69467 [Q7Z6V5-2] |
Protocols and materials databases
Antibodypediai | 33139, 61 antibodies |
DNASUi | 134637 |
Genome annotation databases
Ensembli | ENST00000237283; ENSP00000237283; ENSG00000189007 [Q7Z6V5-1] ENST00000606514; ENSP00000475651; ENSG00000189007 [Q7Z6V5-2] |
GeneIDi | 134637 |
KEGGi | hsa:134637 |
UCSCi | uc003qjj.4, human [Q7Z6V5-1] |
Organism-specific databases
CTDi | 134637 |
DisGeNETi | 134637 |
GeneCardsi | ADAT2 |
HGNCi | HGNC:21172, ADAT2 |
HPAi | ENSG00000189007, Low tissue specificity |
MIMi | 615388, gene |
neXtProti | NX_Q7Z6V5 |
OpenTargetsi | ENSG00000189007 |
PharmGKBi | PA162375592 |
VEuPathDBi | HostDB:ENSG00000189007.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1018, Eukaryota |
GeneTreei | ENSGT00390000000280 |
HOGENOMi | CLU_025810_8_3_1 |
InParanoidi | Q7Z6V5 |
OMAi | LEPCQMC |
OrthoDBi | 1616309at2759 |
PhylomeDBi | Q7Z6V5 |
TreeFami | TF313782 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z6V5 |
Reactomei | R-HSA-6782315, tRNA modification in the nucleus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 134637, 322 hits in 995 CRISPR screens |
ChiTaRSi | ADAT2, human |
EvolutionaryTracei | Q7Z6V5 |
GenomeRNAii | 134637 |
Pharosi | Q7Z6V5, Tbio |
PROi | PR:Q7Z6V5 |
RNActi | Q7Z6V5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000189007, Expressed in zone of skin and 166 other tissues |
Genevisiblei | Q7Z6V5, HS |
Family and domain databases
HAMAPi | MF_00972, tRNA_aden_deaminase, 1 hit |
InterProi | View protein in InterPro IPR016192, APOBEC/CMP_deaminase_Zn-bd IPR002125, CMP_dCMP_dom IPR016193, Cytidine_deaminase-like IPR028883, tRNA_aden_deaminase |
Pfami | View protein in Pfam PF00383, dCMP_cyt_deam_1, 1 hit |
SUPFAMi | SSF53927, SSF53927, 1 hit |
PROSITEi | View protein in PROSITE PS00903, CYT_DCMP_DEAMINASES_1, 1 hit PS51747, CYT_DCMP_DEAMINASES_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADAT2_HUMAN | |
Accessioni | Q7Z6V5Primary (citable) accession number: Q7Z6V5 Secondary accession number(s): A6NL12 Q8IY39 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | October 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families