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UniProtKB - Q7Z6V5 (ADAT2_HUMAN)

Entry version 131 (22 Apr 2020)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
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Protein

tRNA-specific adenosine deaminase 2

Gene

ADAT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably participates in deamination of adenosine-34 to inosine in many tRNAs.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi71Zinc; catalytic1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei73Proton donorBy similarity1
Metal bindingi107Zinc; catalytic1 Publication1
Metal bindingi110Zinc; catalytic1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processtRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6782315 tRNA modification in the nucleus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA-specific adenosine deaminase 2 (EC:3.5.4.33Curated)
Alternative name(s):
Deaminase domain-containing protein 1
tRNA-specific adenosine-34 deaminase subunit ADAT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADAT2
Synonyms:DEADC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21172 ADAT2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615388 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z6V5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		134637

Open Targets

More...OpenTargetsi		ENSG00000189007

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162375592

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z6V5 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADAT2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74750199

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002876531 – 191tRNA-specific adenosine deaminase 2Add BLAST191

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7Z6V5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z6V5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z6V5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7Z6V5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z6V5

PeptideAtlas

More...PeptideAtlasi		Q7Z6V5

PRoteomics IDEntifications database

More...PRIDEi		Q7Z6V5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69466 [Q7Z6V5-1]
69467 [Q7Z6V5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z6V5

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q7Z6V5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000189007 Expressed in body of pancreas and 151 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z6V5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000189007 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		126410, 9 interactors

Protein interaction database and analysis system

More...IntActi		Q7Z6V5, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000237283

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z6V5 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7Z6V5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q7Z6V5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 145CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST126

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1018 Eukaryota
COG0590 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000280

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_025810_8_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z6V5

KEGG Orthology (KO)

More...KOi		K15441

Identification of Orthologs from Complete Genome Data

More...OMAi		LEPCQMC

Database of Orthologous Groups

More...OrthoDBi		1616309at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z6V5

TreeFam database of animal gene trees

More...TreeFami		TF313782

Family and domain databases

HAMAP database of protein families

More...HAMAPi		MF_00972 tRNA_aden_deaminase, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
IPR028883 tRNA_aden_deaminase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14437 MafB19-deam, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53927 SSF53927, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z6V5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAKAAPKPA ASGACSVSAE ETEKWMEEAM HMAKEALENT EVPVGCLMVY 
        60         70         80         90        100
NNEVVGKGRN EVNQTKNATR HAEMVAIDQV LDWCRQSGKS PSEVFEHTVL 
       110        120        130        140        150
YVTVEPCIMC AAALRLMKIP LVVYGCQNER FGGCGSVLNI ASADLPNTGR 
       160        170        180        190 
PFQCIPGYRA EEAVEMLKTF YKQENPNAPK SKVRKKECQK S
Length:191
Mass (Da):21,046
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F2881A100A1782E
GO
Isoform 2 (identifier: Q7Z6V5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Show »
Length:144
Mass (Da):16,100
Checksum:i4A697F09E3651358
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH37955 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0255821 – 47Missing in isoform 2. 2 PublicationsAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK126201 mRNA Translation: BAG54295.1
BX538182 mRNA Translation: CAD98054.1
AL031320 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47868.1
BC037955 mRNA Translation: AAH37955.2 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43511.1 [Q7Z6V5-1]
CCDS69219.1 [Q7Z6V5-2]

NCBI Reference Sequences

More...RefSeqi		NP_001273188.1, NM_001286259.1 [Q7Z6V5-2]
NP_872309.2, NM_182503.2 [Q7Z6V5-1]
XP_011533742.1, XM_011535440.1
XP_011533746.1, XM_011535444.2 [Q7Z6V5-2]
XP_016865749.1, XM_017010260.1 [Q7Z6V5-2]
XP_016865750.1, XM_017010261.1
XP_016865751.1, XM_017010262.1 [Q7Z6V5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000237283; ENSP00000237283; ENSG00000189007 [Q7Z6V5-1]
ENST00000606514; ENSP00000475651; ENSG00000189007 [Q7Z6V5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		134637

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:134637

UCSC genome browser

More...UCSCi		uc003qjj.4 human [Q7Z6V5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126201 mRNA Translation: BAG54295.1
BX538182 mRNA Translation: CAD98054.1
AL031320 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47868.1
BC037955 mRNA Translation: AAH37955.2 Different initiation.
CCDSiCCDS43511.1 [Q7Z6V5-1]
CCDS69219.1 [Q7Z6V5-2]
RefSeqiNP_001273188.1, NM_001286259.1 [Q7Z6V5-2]
NP_872309.2, NM_182503.2 [Q7Z6V5-1]
XP_011533742.1, XM_011535440.1
XP_011533746.1, XM_011535444.2 [Q7Z6V5-2]
XP_016865749.1, XM_017010260.1 [Q7Z6V5-2]
XP_016865750.1, XM_017010261.1
XP_016865751.1, XM_017010262.1 [Q7Z6V5-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DH1X-ray2.80A/B/C/D20-185[»]
SMRiQ7Z6V5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi126410, 9 interactors
IntActiQ7Z6V5, 5 interactors
STRINGi9606.ENSP00000237283

PTM databases

iPTMnetiQ7Z6V5
MetOSiteiQ7Z6V5

Polymorphism and mutation databases

BioMutaiADAT2
DMDMi74750199

Proteomic databases

EPDiQ7Z6V5
jPOSTiQ7Z6V5
MassIVEiQ7Z6V5
MaxQBiQ7Z6V5
PaxDbiQ7Z6V5
PeptideAtlasiQ7Z6V5
PRIDEiQ7Z6V5
ProteomicsDBi69466 [Q7Z6V5-1]
69467 [Q7Z6V5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33139 58 antibodies

The DNASU plasmid repository

More...DNASUi		134637

Genome annotation databases

EnsembliENST00000237283; ENSP00000237283; ENSG00000189007 [Q7Z6V5-1]
ENST00000606514; ENSP00000475651; ENSG00000189007 [Q7Z6V5-2]
GeneIDi134637
KEGGihsa:134637
UCSCiuc003qjj.4 human [Q7Z6V5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		134637
DisGeNETi134637

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADAT2
HGNCiHGNC:21172 ADAT2
HPAiENSG00000189007 Low tissue specificity
MIMi615388 gene
neXtProtiNX_Q7Z6V5
OpenTargetsiENSG00000189007
PharmGKBiPA162375592

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1018 Eukaryota
COG0590 LUCA
GeneTreeiENSGT00390000000280
HOGENOMiCLU_025810_8_3_1
InParanoidiQ7Z6V5
KOiK15441
OMAiLEPCQMC
OrthoDBi1616309at2759
PhylomeDBiQ7Z6V5
TreeFamiTF313782

Enzyme and pathway databases

ReactomeiR-HSA-6782315 tRNA modification in the nucleus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ADAT2 human
EvolutionaryTraceiQ7Z6V5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		134637
PharosiQ7Z6V5 Tbio

Protein Ontology

More...PROi		PR:Q7Z6V5
RNActiQ7Z6V5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000189007 Expressed in body of pancreas and 151 other tissues
GenevisibleiQ7Z6V5 HS

Family and domain databases

HAMAPiMF_00972 tRNA_aden_deaminase, 1 hit
InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
IPR028883 tRNA_aden_deaminase
PfamiView protein in Pfam
PF14437 MafB19-deam, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 1 hit
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADAT2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z6V5
Secondary accession number(s): A6NL12
, B3KWY3, Q7Z327, Q8IY39
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2003
Last modified: April 22, 2020
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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