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UniProtKB - Q7Z6R9 (AP2D_HUMAN)

Entry version 130 (23 Feb 2022)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
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Protein

Transcription factor AP-2-delta

Gene

TFAP2D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7Z6R9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q7Z6R9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor AP-2-delta
Short name:
AP2-delta
Alternative name(s):
Activating enhancer-binding protein 2-delta
Transcription factor AP-2-beta-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFAP2DImported
Synonyms:TFAP2BL11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15581, TFAP2D

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610161, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z6R9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000008197

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		83741

Open Targets

More...OpenTargetsi		ENSG00000008197

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37984

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z6R9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TFAP2D

Domain mapping of disease mutations (DMDM)

More...DMDMi		74750179

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003095131 – 452Transcription factor AP-2-deltaAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei239Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7Z6R9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z6R9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7Z6R9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z6R9

PeptideAtlas

More...PeptideAtlasi		Q7Z6R9

PRoteomics IDEntifications database

More...PRIDEi		Q7Z6R9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69455

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z6R9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z6R9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, placenta, skeletal muscle, thymus, small intestine, and prostate, and expressed at lower levels in leukocyte, spleen, testis, ovary and colon. Barely detectable in heart, kidney, liver, lung or pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000008197, Expressed in oocyte and 30 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z6R9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000008197, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q7Z6R9
With#Exp.IntAct
ADAM12 - isoform 4 [O43184-4]3EBI-11952651,EBI-12006944
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-11952651,EBI-10173507
AGR2 [O95994]3EBI-11952651,EBI-712648
AKAP8L [Q9ULX6]3EBI-11952651,EBI-357530
BAG4 [O95429]5EBI-11952651,EBI-2949658
CAMK2A [Q9UQM7]3EBI-11952651,EBI-1383687
CARD10 [Q9BWT7]3EBI-11952651,EBI-3866279
CDPF1 [Q6NVV7]3EBI-11952651,EBI-2802782
CEP76 [Q8TAP6]3EBI-11952651,EBI-742887
CNFN [Q9BYD5]3EBI-11952651,EBI-12819063
CSNK2B [P67870]3EBI-11952651,EBI-348169
CYSRT1 [A8MQ03]3EBI-11952651,EBI-3867333
FAM166B - isoform 2 [A8MTA8-2]3EBI-11952651,EBI-12160437
FAM168A - isoform 2 [Q92567-2]3EBI-11952651,EBI-11978259
GUCD1 - isoform 2 [Q96NT3-2]5EBI-11952651,EBI-11978177
GYS1 [P13807]3EBI-11952651,EBI-740553
HOXD12 - isoform 2 [P35452-2]3EBI-11952651,EBI-17244356
IKZF3 [Q9UKT9]3EBI-11952651,EBI-747204
INCA1 [Q0VD86]5EBI-11952651,EBI-6509505
KLHL20 [Q9BS75]3EBI-11952651,EBI-10693436
KPRP [Q5T749]3EBI-11952651,EBI-10981970
KRT31 [Q15323]3EBI-11952651,EBI-948001
KRT34 [O76011]3EBI-11952651,EBI-1047093
KRTAP1-1 [Q07627]3EBI-11952651,EBI-11959885
KRTAP10-7 [P60409]5EBI-11952651,EBI-10172290
KRTAP10-8 [P60410]5EBI-11952651,EBI-10171774
KRTAP11-1 [Q8IUC1]3EBI-11952651,EBI-1052037
KRTAP12-3 [P60328]3EBI-11952651,EBI-11953334
KRTAP15-1 [Q3LI76]3EBI-11952651,EBI-11992140
KRTAP19-2 [Q3LHN2]3EBI-11952651,EBI-12196745
KRTAP19-6 [Q3LI70]3EBI-11952651,EBI-12805508
KRTAP19-7 [Q3SYF9]3EBI-11952651,EBI-10241353
KRTAP2-4 [Q9BYR9]3EBI-11952651,EBI-14065470
KRTAP26-1 [Q6PEX3]3EBI-11952651,EBI-3957672
KRTAP6-1 [Q3LI64]3EBI-11952651,EBI-12111050
KRTAP6-2 [Q3LI66]5EBI-11952651,EBI-11962084
KRTAP7-1 [Q8IUC3]3EBI-11952651,EBI-18394498
KRTAP9-2 [Q9BYQ4]5EBI-11952651,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-11952651,EBI-1043191
MLH1 [P40692]5EBI-11952651,EBI-744248
OIP5 [O43482]5EBI-11952651,EBI-536879
PITX1 [P78337]3EBI-11952651,EBI-748265
PLEKHG4 [Q58EX7]3EBI-11952651,EBI-949255
PSMB4 [P28070]3EBI-11952651,EBI-603350
RAD54L2 [Q9Y4B4]3EBI-11952651,EBI-948156
SIVA1 - isoform 2 [O15304-2]3EBI-11952651,EBI-12372219
SLAIN1 [Q8ND83]3EBI-11952651,EBI-10269374
SPRY1 [O43609]3EBI-11952651,EBI-3866665
TEPSIN [Q96N21]3EBI-11952651,EBI-11139477
TEX37 [Q96LM6]3EBI-11952651,EBI-743976
TLE5 - isoform 2 [Q08117-2]5EBI-11952651,EBI-11741437
TNS2 [Q63HR2]3EBI-11952651,EBI-949753
TRAF1 [Q13077]3EBI-11952651,EBI-359224
TRIM42 [Q8IWZ5]3EBI-11952651,EBI-5235829
TSC1 [Q86WV8]3EBI-11952651,EBI-12806590
USP54 - isoform 6 [Q70EL1-9]3EBI-11952651,EBI-11975223
VPS37C [A5D8V6]3EBI-11952651,EBI-2559305
ZBTB32 [A0A0C4DGF1]3EBI-11952651,EBI-10188476
ZMYND12 [Q9H0C1]3EBI-11952651,EBI-12030590

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123749, 74 interactors

Protein interaction database and analysis system

More...IntActi		Q7Z6R9, 60 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000008391

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z6R9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7Z6R9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni280 – 410H-S-H (helix-span-helix), dimerizationSequence analysisAdd BLAST131
Regioni416 – 452DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi433 – 452Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AP-2 family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3811, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182848

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035175_5_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z6R9

Identification of Orthologs from Complete Genome Data

More...OMAi		YYQQLHH

Database of Orthologous Groups

More...OrthoDBi		641707at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z6R9

TreeFam database of animal gene trees

More...TreeFami		TF313718

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004979, TF_AP2
IPR013854, TF_AP2_C

The PANTHER Classification System

More...PANTHERi		PTHR10812, PTHR10812, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03299, TF_AP-2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01748, AP2TNSCPFCT

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7Z6R9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTTFPGLVH DAEIRHDGSN SYRLMQLGCL ESVANSTVAY SSSSPLTYST 
        60         70         80         90        100
TGTEFASPYF STNHQYTPLH HQSFHYEFQH SHPAVTPDAY SLNSLHHSQQ 
       110        120        130        140        150
YYQQIHHGEP TDFINLHNAR ALKSSCLDEQ RRELGCLDAY RRHDLSLMSH 
       160        170        180        190        200
GSQYGMHPDQ RLLPGPSLGL AAAGADDLQG SVEAQCGLVL NGQGGVIRRG 
       210        220        230        240        250
GTCVVNPTDL FCSVPGRLSL LSSTSKYKVT IAEVKRRLSP PECLNASLLG 
       260        270        280        290        300
GILRRAKSKN GGRCLREKLD RLGLNLPAGR RKAANVTLLT SLVEGEALHL 
       310        320        330        340        350
ARDFGYTCET EFPAKAVGEH LARQHMEQKE QTARKKMILA TKQICKEFQD 
       360        370        380        390        400
LLSQDRSPLG SSRPTPILDL DIQRHLTHFS LITHGFGTPA ICAALSTFQT 
       410        420        430        440        450
VLSEMLNYLE KHTTHKNGGA ADSGQGHANS EKAPLRKTSE AAVKEGKTEK 

TD
Length:452
Mass (Da):49,578
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6623612B172A59EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16H → Y in AAK16926 (PubMed:11733187).Curated1
Sequence conflicti167S → N in AAK16926 (PubMed:11733187).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036975214V → F in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY028376 mRNA Translation: AAK16926.1
AL031224 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04354.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4933.1

NCBI Reference Sequences

More...RefSeqi		NP_758438.2, NM_172238.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000008391; ENSP00000008391; ENSG00000008197

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83741

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:83741

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000008391.4; ENSP00000008391.4; NM_172238.4; NP_758438.2

UCSC genome browser

More...UCSCi		uc003paf.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Activating protein 2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY028376 mRNA Translation: AAK16926.1
AL031224 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04354.1
CCDSiCCDS4933.1
RefSeqiNP_758438.2, NM_172238.3

3D structure databases

SMRiQ7Z6R9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123749, 74 interactors
IntActiQ7Z6R9, 60 interactors
STRINGi9606.ENSP00000008391

PTM databases

iPTMnetiQ7Z6R9
PhosphoSitePlusiQ7Z6R9

Genetic variation databases

BioMutaiTFAP2D
DMDMi74750179

Proteomic databases

EPDiQ7Z6R9
MassIVEiQ7Z6R9
MaxQBiQ7Z6R9
PaxDbiQ7Z6R9
PeptideAtlasiQ7Z6R9
PRIDEiQ7Z6R9
ProteomicsDBi69455

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30864, 141 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		83741

Genome annotation databases

EnsembliENST00000008391; ENSP00000008391; ENSG00000008197
GeneIDi83741
KEGGihsa:83741
MANE-SelectiENST00000008391.4; ENSP00000008391.4; NM_172238.4; NP_758438.2
UCSCiuc003paf.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83741
DisGeNETi83741

GeneCards: human genes, protein and diseases

More...GeneCardsi		TFAP2D
HGNCiHGNC:15581, TFAP2D
HPAiENSG00000008197, Tissue enriched (brain)
MIMi610161, gene
neXtProtiNX_Q7Z6R9
OpenTargetsiENSG00000008197
PharmGKBiPA37984
VEuPathDBiHostDB:ENSG00000008197

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3811, Eukaryota
GeneTreeiENSGT00950000182848
HOGENOMiCLU_035175_5_0_1
InParanoidiQ7Z6R9
OMAiYYQQLHH
OrthoDBi641707at2759
PhylomeDBiQ7Z6R9
TreeFamiTF313718

Enzyme and pathway databases

PathwayCommonsiQ7Z6R9
ReactomeiR-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors
SignaLinkiQ7Z6R9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		83741, 8 hits in 999 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		83741
PharosiQ7Z6R9, Tdark

Protein Ontology

More...PROi		PR:Q7Z6R9
RNActiQ7Z6R9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000008197, Expressed in oocyte and 30 other tissues
GenevisibleiQ7Z6R9, HS

Family and domain databases

InterProiView protein in InterPro
IPR004979, TF_AP2
IPR013854, TF_AP2_C
PANTHERiPTHR10812, PTHR10812, 1 hit
PfamiView protein in Pfam
PF03299, TF_AP-2, 1 hit
PRINTSiPR01748, AP2TNSCPFCT

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP2D_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z6R9
Secondary accession number(s): Q8IWX0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2003
Last modified: February 23, 2022
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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