UniProtKB - Q7Z6R9 (AP2D_HUMAN)
Transcription factor AP-2-delta
TFAP2D
Functioni
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity).
By similarityGO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anatomical structure development Source: GO_Central
- inferior colliculus development Source: Ensembl
- negative regulation of neuron apoptotic process Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of cell population proliferation Source: GO_Central
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q7Z6R9 |
Reactomei | R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
SignaLinki | Q7Z6R9 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor AP-2-deltaShort name: AP2-delta Alternative name(s): Activating enhancer-binding protein 2-delta Transcription factor AP-2-beta-like 1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15581, TFAP2D |
MIMi | 610161, gene |
neXtProti | NX_Q7Z6R9 |
VEuPathDBi | HostDB:ENSG00000008197 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Other locations
- chromatin Source: NTNU_SB
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 83741 |
OpenTargetsi | ENSG00000008197 |
PharmGKBi | PA37984 |
Miscellaneous databases
Pharosi | Q7Z6R9, Tdark |
Genetic variation databases
BioMutai | TFAP2D |
DMDMi | 74750179 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309513 | 1 – 452 | Transcription factor AP-2-deltaAdd BLAST | 452 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 239 | Phosphoserine; by PKABy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q7Z6R9 |
MassIVEi | Q7Z6R9 |
MaxQBi | Q7Z6R9 |
PaxDbi | Q7Z6R9 |
PeptideAtlasi | Q7Z6R9 |
PRIDEi | Q7Z6R9 |
ProteomicsDBi | 69455 |
PTM databases
iPTMneti | Q7Z6R9 |
PhosphoSitePlusi | Q7Z6R9 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000008197, Expressed in oocyte and 30 other tissues |
Genevisiblei | Q7Z6R9, HS |
Organism-specific databases
HPAi | ENSG00000008197, Tissue enriched (brain) |
Interactioni
Subunit structurei
Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity).
By similarityBinary interactionsi
Q7Z6R9
Protein-protein interaction databases
BioGRIDi | 123749, 74 interactors |
IntActi | Q7Z6R9, 60 interactors |
STRINGi | 9606.ENSP00000008391 |
Miscellaneous databases
RNActi | Q7Z6R9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 280 – 410 | H-S-H (helix-span-helix), dimerizationSequence analysisAdd BLAST | 131 | |
Regioni | 416 – 452 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 433 – 452 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
HOGENOMi | CLU_035175_5_0_1 |
InParanoidi | Q7Z6R9 |
OMAi | YYQQLHH |
OrthoDBi | 641707at2759 |
PhylomeDBi | Q7Z6R9 |
TreeFami | TF313718 |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR013854, TF_AP2_C |
PANTHERi | PTHR10812, PTHR10812, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01748, AP2TNSCPFCT |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSTTFPGLVH DAEIRHDGSN SYRLMQLGCL ESVANSTVAY SSSSPLTYST
60 70 80 90 100
TGTEFASPYF STNHQYTPLH HQSFHYEFQH SHPAVTPDAY SLNSLHHSQQ
110 120 130 140 150
YYQQIHHGEP TDFINLHNAR ALKSSCLDEQ RRELGCLDAY RRHDLSLMSH
160 170 180 190 200
GSQYGMHPDQ RLLPGPSLGL AAAGADDLQG SVEAQCGLVL NGQGGVIRRG
210 220 230 240 250
GTCVVNPTDL FCSVPGRLSL LSSTSKYKVT IAEVKRRLSP PECLNASLLG
260 270 280 290 300
GILRRAKSKN GGRCLREKLD RLGLNLPAGR RKAANVTLLT SLVEGEALHL
310 320 330 340 350
ARDFGYTCET EFPAKAVGEH LARQHMEQKE QTARKKMILA TKQICKEFQD
360 370 380 390 400
LLSQDRSPLG SSRPTPILDL DIQRHLTHFS LITHGFGTPA ICAALSTFQT
410 420 430 440 450
VLSEMLNYLE KHTTHKNGGA ADSGQGHANS EKAPLRKTSE AAVKEGKTEK
TD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 16 | H → Y in AAK16926 (PubMed:11733187).Curated | 1 | |
Sequence conflicti | 167 | S → N in AAK16926 (PubMed:11733187).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036975 | 214 | V → F in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY028376 mRNA Translation: AAK16926.1 AL031224 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04354.1 |
CCDSi | CCDS4933.1 |
RefSeqi | NP_758438.2, NM_172238.3 |
Genome annotation databases
Ensembli | ENST00000008391; ENSP00000008391; ENSG00000008197 |
GeneIDi | 83741 |
KEGGi | hsa:83741 |
MANE-Selecti | ENST00000008391.4; ENSP00000008391.4; NM_172238.4; NP_758438.2 |
UCSCi | uc003paf.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Activating protein 2 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY028376 mRNA Translation: AAK16926.1 AL031224 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04354.1 |
CCDSi | CCDS4933.1 |
RefSeqi | NP_758438.2, NM_172238.3 |
3D structure databases
SMRi | Q7Z6R9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123749, 74 interactors |
IntActi | Q7Z6R9, 60 interactors |
STRINGi | 9606.ENSP00000008391 |
PTM databases
iPTMneti | Q7Z6R9 |
PhosphoSitePlusi | Q7Z6R9 |
Genetic variation databases
BioMutai | TFAP2D |
DMDMi | 74750179 |
Proteomic databases
EPDi | Q7Z6R9 |
MassIVEi | Q7Z6R9 |
MaxQBi | Q7Z6R9 |
PaxDbi | Q7Z6R9 |
PeptideAtlasi | Q7Z6R9 |
PRIDEi | Q7Z6R9 |
ProteomicsDBi | 69455 |
Protocols and materials databases
Antibodypediai | 30864, 141 antibodies from 25 providers |
DNASUi | 83741 |
Genome annotation databases
Ensembli | ENST00000008391; ENSP00000008391; ENSG00000008197 |
GeneIDi | 83741 |
KEGGi | hsa:83741 |
MANE-Selecti | ENST00000008391.4; ENSP00000008391.4; NM_172238.4; NP_758438.2 |
UCSCi | uc003paf.4, human |
Organism-specific databases
CTDi | 83741 |
DisGeNETi | 83741 |
GeneCardsi | TFAP2D |
HGNCi | HGNC:15581, TFAP2D |
HPAi | ENSG00000008197, Tissue enriched (brain) |
MIMi | 610161, gene |
neXtProti | NX_Q7Z6R9 |
OpenTargetsi | ENSG00000008197 |
PharmGKBi | PA37984 |
VEuPathDBi | HostDB:ENSG00000008197 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3811, Eukaryota |
GeneTreei | ENSGT00950000182848 |
HOGENOMi | CLU_035175_5_0_1 |
InParanoidi | Q7Z6R9 |
OMAi | YYQQLHH |
OrthoDBi | 641707at2759 |
PhylomeDBi | Q7Z6R9 |
TreeFami | TF313718 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z6R9 |
Reactomei | R-HSA-8866904, Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866907, Activation of the TFAP2 (AP-2) family of transcription factors |
SignaLinki | Q7Z6R9 |
Miscellaneous databases
BioGRID-ORCSi | 83741, 8 hits in 999 CRISPR screens |
GenomeRNAii | 83741 |
Pharosi | Q7Z6R9, Tdark |
PROi | PR:Q7Z6R9 |
RNActi | Q7Z6R9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000008197, Expressed in oocyte and 30 other tissues |
Genevisiblei | Q7Z6R9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004979, TF_AP2 IPR013854, TF_AP2_C |
PANTHERi | PTHR10812, PTHR10812, 1 hit |
Pfami | View protein in Pfam PF03299, TF_AP-2, 1 hit |
PRINTSi | PR01748, AP2TNSCPFCT |
MobiDBi | Search... |
Entry informationi
Entry namei | AP2D_HUMAN | |
Accessioni | Q7Z6R9Primary (citable) accession number: Q7Z6R9 Secondary accession number(s): Q8IWX0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | October 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families