TFAP2D

Functionⁱ

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity).By similarity

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

inferior colliculus development Source: Ensembl
negative regulation of neuron apoptotic process Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Reactomeⁱ

R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transcription factor AP-2-delta Short name: AP2-delta Alternative name(s): Activating enhancer-binding protein 2-delta Transcription factor AP-2-beta-like 1
Gene namesⁱ	Name:TFAP2DImported Synonyms:TFAP2BL11 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000008197.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15581 TFAP2D
MIMⁱ	610161 gene
neXtProtⁱ	NX_Q7Z6R9

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000008197
PharmGKBⁱ	PA37984

Polymorphism and mutation databases

BioMutaⁱ	TFAP2D
DMDMⁱ	74750179

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000309513	1 – 452	Transcription factor AP-2-deltaAdd BLAST		452

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	239	Phosphoserine; by PKABy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q7Z6R9
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7Z6R9
PaxDbⁱ	Q7Z6R9
PeptideAtlas More...PeptideAtlasⁱ	Q7Z6R9
PRIDEⁱ	Q7Z6R9
ProteomicsDBⁱ	69455

PTM databases

iPTMnetⁱ	Q7Z6R9
PhosphoSitePlusⁱ	Q7Z6R9

Expressionⁱ

Tissue specificityⁱ

Highly expressed in brain, placenta, skeletal muscle, thymus, small intestine, and prostate, and expressed at lower levels in leukocyte, spleen, testis, ovary and colon. Barely detectable in heart, kidney, liver, lung or pancreas.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000008197 Expressed in 23 organ(s), highest expression level in oocyte
CleanExⁱ	HS_TFAP2D
Genevisibleⁱ	Q7Z6R9 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA048962

HPAⁱ

HPA048962

Interactionⁱ

Subunit structureⁱ

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	123749, 1 interactor
IntActⁱ	Q7Z6R9, 57 interactors
STRINGⁱ	9606.ENSP00000008391

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7Z6R9
SMRⁱ	Q7Z6R9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	280 – 410	H-S-H (helix-span-helix), dimerizationSequence analysisAdd BLAST		131

Sequence similaritiesⁱ

Belongs to the AP-2 family.Sequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3811 Eukaryota ENOG410XR9E LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074577
HOGENOMⁱ	HOG000231737
HOVERGENⁱ	HBG002455
InParanoidⁱ	Q7Z6R9
KEGG Orthology (KO) More...KOⁱ	K09178
OMAⁱ	YYQQLHH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0PR6
PhylomeDBⁱ	Q7Z6R9
TreeFamⁱ	TF313718

Family and domain databases

InterProⁱ	View protein in InterPro IPR004979 TF_AP2 IPR013854 TF_AP2_C
PANTHERⁱ	PTHR10812 PTHR10812, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03299 TF_AP-2, 1 hit
PRINTSⁱ	PR01748 AP2TNSCPFCT

Sequenceⁱ

Sequence statusⁱ: Complete.

Q7Z6R9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTTFPGLVH DAEIRHDGSN SYRLMQLGCL ESVANSTVAY SSSSPLTYST 
        60         70         80         90        100
TGTEFASPYF STNHQYTPLH HQSFHYEFQH SHPAVTPDAY SLNSLHHSQQ 
       110        120        130        140        150
YYQQIHHGEP TDFINLHNAR ALKSSCLDEQ RRELGCLDAY RRHDLSLMSH 
       160        170        180        190        200
GSQYGMHPDQ RLLPGPSLGL AAAGADDLQG SVEAQCGLVL NGQGGVIRRG 
       210        220        230        240        250
GTCVVNPTDL FCSVPGRLSL LSSTSKYKVT IAEVKRRLSP PECLNASLLG 
       260        270        280        290        300
GILRRAKSKN GGRCLREKLD RLGLNLPAGR RKAANVTLLT SLVEGEALHL 
       310        320        330        340        350
ARDFGYTCET EFPAKAVGEH LARQHMEQKE QTARKKMILA TKQICKEFQD 
       360        370        380        390        400
LLSQDRSPLG SSRPTPILDL DIQRHLTHFS LITHGFGTPA ICAALSTFQT 
       410        420        430        440        450
VLSEMLNYLE KHTTHKNGGA ADSGQGHANS EKAPLRKTSE AAVKEGKTEK 

TD

Length:452

Mass (Da):49,578

Last modified:October 1, 2003 - v1

Checksum:ⁱ6623612B172A59EA

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	16	H → Y in AAK16926 (PubMed:11733187).Curated		1
Sequence conflictⁱ	167	S → N in AAK16926 (PubMed:11733187).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_036975	214	V → F in a breast cancer sample; somatic mutation. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY028376 mRNA Translation: AAK16926.1 AL031224 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04354.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4933.1
NCBI Reference Sequences More...RefSeqⁱ	NP_758438.2, NM_172238.3
UniGeneⁱ	Hs.434107

Genome annotation databases

Ensemblⁱ	ENST00000008391; ENSP00000008391; ENSG00000008197
GeneIDⁱ	83741
KEGGⁱ	hsa:83741
UCSC genome browser More...UCSCⁱ	uc003paf.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7Z6R9	TFAP2D isoform 1		PANTR		452	UniRef100_Q7Z6R9
Transcription factor AP-2 delta		MACFA		452
TFAP2D isoform 1		PONAB		452
Uncharacterized protein		PROCO		452
Uncharacterized protein		MACMU		452
+16

Protein	Similar proteins		Species	Score	Length	Source
Q7Z6R9	Transcription factor AP-2-delta		DANRE		450	UniRef90_Q7Z6R9
TFAP2D isoform 1		PANTR		452
Transcription factor AP-2 delta		MACFA		452
TFAP2D isoform 1		PONAB		452
Uncharacterized protein		PROCO		452
+88

Protein	Similar proteins		Species	Score	Length	Source
Q7Z6R9	Transcription factor AP-2-delta		MOUSE		452	UniRef50_Q91ZK0
Transcription factor AP-2-delta		DANRE		450
Transcription factor AP-2 delta		PTEAL		536
transcription factor AP-2-delta isoform X1		MESAU		456
Transcription factor AP-2-delta		MYODS		456
+225

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Activating protein 2 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY028376 mRNA Translation: AAK16926.1 AL031224 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04354.1
CCDSⁱ	CCDS4933.1
RefSeqⁱ	NP_758438.2, NM_172238.3
UniGeneⁱ	Hs.434107

3D structure databases

ProteinModelPortalⁱ	Q7Z6R9
SMRⁱ	Q7Z6R9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123749, 1 interactor
IntActⁱ	Q7Z6R9, 57 interactors
STRINGⁱ	9606.ENSP00000008391

PTM databases

iPTMnetⁱ	Q7Z6R9
PhosphoSitePlusⁱ	Q7Z6R9

Polymorphism and mutation databases

BioMutaⁱ	TFAP2D
DMDMⁱ	74750179

Proteomic databases

EPDⁱ	Q7Z6R9
MaxQBⁱ	Q7Z6R9
PaxDbⁱ	Q7Z6R9
PeptideAtlasⁱ	Q7Z6R9
PRIDEⁱ	Q7Z6R9
ProteomicsDBⁱ	69455

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	83741
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000008391; ENSP00000008391; ENSG00000008197
GeneIDⁱ	83741
KEGGⁱ	hsa:83741
UCSCⁱ	uc003paf.4 human

Organism-specific databases

CTDⁱ	83741
EuPathDBⁱ	HostDB:ENSG00000008197.4
GeneCardsⁱ	TFAP2D
H-InvDBⁱ	HIX0032849
HGNCⁱ	HGNC:15581 TFAP2D
HPAⁱ	HPA048962
MIMⁱ	610161 gene
neXtProtⁱ	NX_Q7Z6R9
OpenTargetsⁱ	ENSG00000008197
PharmGKBⁱ	PA37984
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3811 Eukaryota ENOG410XR9E LUCA
GeneTreeⁱ	ENSGT00550000074577
HOGENOMⁱ	HOG000231737
HOVERGENⁱ	HBG002455
InParanoidⁱ	Q7Z6R9
KOⁱ	K09178
OMAⁱ	YYQQLHH
OrthoDBⁱ	EOG091G0PR6
PhylomeDBⁱ	Q7Z6R9
TreeFamⁱ	TF313718

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Reactomeⁱ

R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Miscellaneous databases

GenomeRNAiⁱ	83741
Protein Ontology More...PROⁱ	PR:Q7Z6R9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000008197 Expressed in 23 organ(s), highest expression level in oocyte
CleanExⁱ	HS_TFAP2D
Genevisibleⁱ	Q7Z6R9 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR004979 TF_AP2 IPR013854 TF_AP2_C
PANTHERⁱ	PTHR10812 PTHR10812, 1 hit
Pfamⁱ	View protein in Pfam PF03299 TF_AP-2, 1 hit
PRINTSⁱ	PR01748 AP2TNSCPFCT
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AP2D_HUMAN
Accessionⁱ	Q7Z6R9Primary (citable) accession number: Q7Z6R9 Secondary accession number(s): Q8IWX0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
	Last sequence update:	October 1, 2003
	Last modified:	November 7, 2018
	This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniRef

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Supporting data

UniProtKB - Q7Z6R9 (AP2D_HUMAN)

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Transcription factor AP-2-delta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ