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UniProtKB - Q7Z6M1 (RABEK_HUMAN)

Entry version 145 (10 Feb 2021)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
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Protein

Rab9 effector protein with kelch motifs

Gene

RABEPK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rab9 effector required for endosome to trans-Golgi network (TGN) transport.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7Z6M1

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q7Z6M1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rab9 effector protein with kelch motifsCurated
Alternative name(s):
40 kDa Rab9 effector protein
p40
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RABEPKImported
Synonyms:RAB9P40
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16896, RABEPK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605962, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z6M1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000136933.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10244

Open Targets

More...OpenTargetsi		ENSG00000136933

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671100

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z6M1, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RABEPK

Domain mapping of disease mutations (DMDM)

More...DMDMi		74750172

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002806161 – 372Rab9 effector protein with kelch motifsAdd BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei133PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser residues by PIKFYVE.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7Z6M1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z6M1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z6M1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7Z6M1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z6M1

PeptideAtlas

More...PeptideAtlasi		Q7Z6M1

PRoteomics IDEntifications database

More...PRIDEi		Q7Z6M1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69444 [Q7Z6M1-1]
69445 [Q7Z6M1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z6M1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z6M1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136933, Expressed in right lobe of liver and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7Z6M1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z6M1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000136933, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PIKFYVE; the interaction recruits RABEPK to the endosomal membrane (PubMed:14530284).

Interacts with RAB9 in its GTP-bound conformation (PubMed:16769818, PubMed:9230071).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115538, 17 interactors

Protein interaction database and analysis system

More...IntActi		Q7Z6M1, 10 interactors

Molecular INTeraction database

More...MINTi		Q7Z6M1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362639

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z6M1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7Z6M1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati49 – 95Kelch 1Add BLAST47
Repeati100 – 146Kelch 2Add BLAST47
Repeati151 – 200Kelch 3Add BLAST50
Repeati204 – 250Kelch 4Add BLAST47
Repeati254 – 303Kelch 5Add BLAST50

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0379, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158763

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_045313_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z6M1

Identification of Orthologs from Complete Genome Data

More...OMAi		LGTHRWD

Database of Orthologous Groups

More...OrthoDBi		933937at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z6M1

TreeFam database of animal gene trees

More...TreeFami		TF329153

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.120.10.80, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
IPR011498, Kelch_2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01344, Kelch_1, 1 hit
PF07646, Kelch_2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF117281, SSF117281, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z6M1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKQLPVLEPG DKPRKATWYT LTVPGDSPCA RVGHSCSYLP PVGNAKRGKV 
        60         70         80         90        100
FIVGGANPNR SFSDVHTMDL GKHQWDLDTC KGLLPRYEHA SFIPSCTPDR 
       110        120        130        140        150
IWVFGGANQS GNRNCLQVLN PETRTWTTPE VTSPPPSPRT FHTSSAAIGN 
       160        170        180        190        200
QLYVFGGGER GAQPVQDTKL HVFDANTLTW SQPETLGNPP SPRHGHVMVA 
       210        220        230        240        250
AGTKLFIHGG LAGDRFYDDL HCIDISDMKW QKLNPTGAAP AGCAAHSAVA 
       260        270        280        290        300
MGKHVYIFGG MTPAGALDTM YQYHTEEQHW TLLKFDTLLP PGRLDHSMCI 
       310        320        330        340        350
IPWPVTCASE KEDSNSLTLN HEAEKEDSAD KVMSHSGDSH EESQTATLLC 
       360        370 
LVFGGMNTEG EIYDDCIVTV VD
Length:372
Mass (Da):40,565
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFBB17B9C6260C62E
GO
Isoform 2 (identifier: Q7Z6M1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-121: Missing.

Show »
Length:321
Mass (Da):34,841
Checksum:i92ACDAAD554F818F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T1S5Q5T1S5_HUMAN
Rab9 effector protein with kelch mo...
RABEPK
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T1S4Q5T1S4_HUMAN
Rab9 effector protein with kelch mo...
RABEPK
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8E → K in CAG46649 (Ref. 3) Curated1
Sequence conflicti329A → V in CAB09808 (PubMed:9230071).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05005858P → A. Corresponds to variant dbSNP:rs13302059Ensembl.1
Natural variantiVAR_03117560R → G1 PublicationCorresponds to variant dbSNP:rs17855990Ensembl.1
Natural variantiVAR_03117667T → P. Corresponds to variant dbSNP:rs13302050Ensembl.1
Natural variantiVAR_03117773H → Y2 PublicationsCorresponds to variant dbSNP:rs1128362Ensembl.1
Natural variantiVAR_05005995S → C. Corresponds to variant dbSNP:rs34991596Ensembl.1
Natural variantiVAR_031178313D → G1 PublicationCorresponds to variant dbSNP:rs17849326Ensembl.1
Natural variantiVAR_031179333M → I. Corresponds to variant dbSNP:rs15233Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02382871 – 121Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z97074 mRNA Translation: CAB09808.1
AK290768 mRNA Translation: BAF83457.1
CR456837 mRNA Translation: CAG33118.1
CR541851 mRNA Translation: CAG46649.1
AL354710 Genomic DNA No translation available.
AL445930 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87616.1
BC000503 mRNA Translation: AAH00503.1
BC047023 mRNA Translation: AAH47023.1
BC053541 mRNA Translation: AAH53541.1
BC065725 mRNA Translation: AAH65725.1
AL832249 mRNA Translation: CAH10393.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS55341.1 [Q7Z6M1-2]
CCDS6862.1 [Q7Z6M1-1]

NCBI Reference Sequences

More...RefSeqi		NP_001167623.1, NM_001174152.1 [Q7Z6M1-1]
NP_001167624.1, NM_001174153.1 [Q7Z6M1-2]
NP_005824.2, NM_005833.3 [Q7Z6M1-1]
XP_016869666.1, XM_017014177.1 [Q7Z6M1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000259460; ENSP00000259460; ENSG00000136933 [Q7Z6M1-2]
ENST00000373538; ENSP00000362639; ENSG00000136933 [Q7Z6M1-1]
ENST00000394125; ENSP00000377683; ENSG00000136933 [Q7Z6M1-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10244

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10244

UCSC genome browser

More...UCSCi		uc004bpi.4, human [Q7Z6M1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97074 mRNA Translation: CAB09808.1
AK290768 mRNA Translation: BAF83457.1
CR456837 mRNA Translation: CAG33118.1
CR541851 mRNA Translation: CAG46649.1
AL354710 Genomic DNA No translation available.
AL445930 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87616.1
BC000503 mRNA Translation: AAH00503.1
BC047023 mRNA Translation: AAH47023.1
BC053541 mRNA Translation: AAH53541.1
BC065725 mRNA Translation: AAH65725.1
AL832249 mRNA Translation: CAH10393.1
CCDSiCCDS55341.1 [Q7Z6M1-2]
CCDS6862.1 [Q7Z6M1-1]
RefSeqiNP_001167623.1, NM_001174152.1 [Q7Z6M1-1]
NP_001167624.1, NM_001174153.1 [Q7Z6M1-2]
NP_005824.2, NM_005833.3 [Q7Z6M1-1]
XP_016869666.1, XM_017014177.1 [Q7Z6M1-1]

3D structure databases

SMRiQ7Z6M1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115538, 17 interactors
IntActiQ7Z6M1, 10 interactors
MINTiQ7Z6M1
STRINGi9606.ENSP00000362639

PTM databases

iPTMnetiQ7Z6M1
PhosphoSitePlusiQ7Z6M1

Genetic variation databases

BioMutaiRABEPK
DMDMi74750172

Proteomic databases

EPDiQ7Z6M1
jPOSTiQ7Z6M1
MassIVEiQ7Z6M1
MaxQBiQ7Z6M1
PaxDbiQ7Z6M1
PeptideAtlasiQ7Z6M1
PRIDEiQ7Z6M1
ProteomicsDBi69444 [Q7Z6M1-1]
69445 [Q7Z6M1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16386, 212 antibodies

The DNASU plasmid repository

More...DNASUi		10244

Genome annotation databases

EnsembliENST00000259460; ENSP00000259460; ENSG00000136933 [Q7Z6M1-2]
ENST00000373538; ENSP00000362639; ENSG00000136933 [Q7Z6M1-1]
ENST00000394125; ENSP00000377683; ENSG00000136933 [Q7Z6M1-1]
GeneIDi10244
KEGGihsa:10244
UCSCiuc004bpi.4, human [Q7Z6M1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10244
DisGeNETi10244

GeneCards: human genes, protein and diseases

More...GeneCardsi		RABEPK
HGNCiHGNC:16896, RABEPK
HPAiENSG00000136933, Low tissue specificity
MIMi605962, gene
neXtProtiNX_Q7Z6M1
OpenTargetsiENSG00000136933
PharmGKBiPA142671100
VEuPathDBiHostDB:ENSG00000136933.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0379, Eukaryota
GeneTreeiENSGT00940000158763
HOGENOMiCLU_045313_0_0_1
InParanoidiQ7Z6M1
OMAiLGTHRWD
OrthoDBi933937at2759
PhylomeDBiQ7Z6M1
TreeFamiTF329153

Enzyme and pathway databases

PathwayCommonsiQ7Z6M1
ReactomeiR-HSA-6811440, Retrograde transport at the Trans-Golgi-Network
SIGNORiQ7Z6M1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10244, 2 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RABEPK, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RABEPK

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10244
PharosiQ7Z6M1, Tdark

Protein Ontology

More...PROi		PR:Q7Z6M1
RNActiQ7Z6M1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136933, Expressed in right lobe of liver and 236 other tissues
ExpressionAtlasiQ7Z6M1, baseline and differential
GenevisibleiQ7Z6M1, HS

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR015915, Kelch-typ_b-propeller
IPR006652, Kelch_1
IPR011498, Kelch_2
PfamiView protein in Pfam
PF01344, Kelch_1, 1 hit
PF07646, Kelch_2, 1 hit
SUPFAMiSSF117281, SSF117281, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRABEK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z6M1
Secondary accession number(s): A8K403
, O00568, Q69YR2, Q6FHA4, Q6IBG7, Q6P092, Q86Y76, Q9BWB1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2003
Last modified: February 10, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with genetic variants
    List of human entries with genetic variants
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