Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 141 (12 Aug 2020)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Tectonin beta-propeller repeat-containing protein 1

Gene

TECPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns3P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phosphatidylinositol-3-phosphate binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy
LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7Z6L1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tectonin beta-propeller repeat-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TECPR1
Synonyms:KIAA1358
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000205356.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:22214, TECPR1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614781, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z6L1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
25851

Open Targets

More...
OpenTargetsi
ENSG00000205356

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164726436

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z6L1, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TECPR1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74738829

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003370601 – 1165Tectonin beta-propeller repeat-containing protein 1Add BLAST1165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei386PhosphoserineBy similarity1
Modified residuei388PhosphoserineBy similarity1
Modified residuei391PhosphoserineBy similarity1
Modified residuei412PhosphoserineBy similarity1
Modified residuei417PhosphoserineBy similarity1
Modified residuei938PhosphoserineCombined sources1
Modified residuei949PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z6L1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z6L1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z6L1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z6L1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z6L1

PeptideAtlas

More...
PeptideAtlasi
Q7Z6L1

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z6L1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69439 [Q7Z6L1-1]
69440 [Q7Z6L1-2]
69441 [Q7Z6L1-3]
69442 [Q7Z6L1-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z6L1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z6L1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000205356, Expressed in parotid gland and 214 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z6L1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z6L1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000205356, Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ATG5; the interaction is direct.

Interacts with WIPI2.

Interacts with the ATG5-ATG12 conjugate, the interaction is however mutually exclusive with ATG16, since it does not interact with ATG12-ATG5-ATG16 complex.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117375, 9 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-358, ATG5-ATG12-TECPR1 complex

Protein interaction database and analysis system

More...
IntActi
Q7Z6L1, 15 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000404923

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z6L1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z6L1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati209 – 240TECPR 1Add BLAST32
Repeati254 – 285TECPR 2Add BLAST32
Repeati301 – 332TECPR 3Add BLAST32
Repeati344 – 376TECPR 4Add BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini611 – 717PHAdd BLAST107
Repeati729 – 756TECPR 5Add BLAST28
Repeati953 – 984TECPR 6Add BLAST32
Repeati998 – 1029TECPR 7Add BLAST32
Repeati1044 – 1075TECPR 8Add BLAST32
Repeati1087 – 1127TECPR 9Add BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi384 – 391Poly-Ser8

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH domain mediates the binding to phosphatidylinositol-3-phosphate (PtdIns3P). While full-length protein is unable to bind PtdIns3P in vitro, it is assumed that the binding to the ATG5-ATG12 conjugate exposes the PH domain, allowing the association with PtdIns3P (PubMed:22342342).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TECPR1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3669, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047886

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008303_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z6L1

KEGG Orthology (KO)

More...
KOi
K17988

Identification of Orthologs from Complete Genome Data

More...
OMAi
MAWQWDG

Database of Orthologous Groups

More...
OrthoDBi
119234at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z6L1

TreeFam database of animal gene trees

More...
TreeFami
TF323648

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006624, Beta-propeller_rpt_TECPR
IPR010482, Peroxin
IPR006614, Peroxin/Ferlin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06462, Hyd_WA, 8 hits
PF06398, Pex24p, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00694, DysFC, 2 hits
SM00693, DysFN, 2 hits
SM00706, TECPR, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z6L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPNSVLWAVD LFGRVYTLST AGQYWEMCKD SQLEFKRVSA TTQCCWGIAC
60 70 80 90 100
DNQVYVYVCA SDVPIRRREE AYENQRWNPM GGFCEKLLLS DRWGWSDVSG
110 120 130 140 150
LQHRPLDRVA LPSPHWEWES DWYVDENFGG EPTEKGGWTY AIDFPATYTK
160 170 180 190 200
DKKWNSCVRR RKWIRYRRYK SRDIWAKIPS KDDPKELPDP FNDLSVGGWE
210 220 230 240 250
ITEEPVGRLS VWAVSLQGKV WYREDVSHSN PEGSSWSLLD TPGEVVQISC
260 270 280 290 300
GPHDLLWATL WEGQALVREG INRSNPKGSS WSIVEPPGSE NGVMHISVGV
310 320 330 340 350
SVVWAVTKDW KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GMNDQVWGIG
360 370 380 390 400
CEDRAVYFRQ GVTPSELSGK TWKAIIAARE CDRSHSGSSS SLLSAGCFFG
410 420 430 440 450
DEVRGSGESA PSDTDASSEV ERPGPGQILP AEPLDDSKNA TGNSASGLGA
460 470 480 490 500
GRTAEDTVED ACPAEGSREA RPNTHPGPAP TPAELPWTNI DLKEAKKVPS
510 520 530 540 550
HSAAGFPETT SLSSLGLLPL GLEEPYGVDD HPLWAWVSGG GCVVEACAMP
560 570 580 590 600
RWFTVQAGLS SSVHMLSLSI TPAQTAAWRK QIFQQLTERT KRELENFRHY
610 620 630 640 650
EQAVEQSVWV KTGALQWWCD WKPHKWVDVR LALEQFTGHD GVRDSILFIY
660 670 680 690 700
YVVHEEKKYI HIFLNEVVAL VPVLNETKHS FALYTPERTR QRWPVRLAAA
710 720 730 740 750
TEQDMNDWLA LLSLSCCESR KVQGRPSPQA IWSITCKGDI FVSEPSPDLE
760 770 780 790 800
AHEHPLPCDQ MFWRQMGGHL RMVEANSRGV VWGIGYDHTA WVYTGGYGGG
810 820 830 840 850
CFQGLASSTS NIYTQSDVKC VHIYENQRWN PVTGYTSRGL PTDRYMWSDA
860 870 880 890 900
SGLQECTKAG TKPPSLQWAW VSDWFVDFSV PGGTDQEGWQ YASDFPASYH
910 920 930 940 950
GSKTMKDFVR RRCWARKCKL VTSGPWLEVP PIALRDVSII PESPGAEGSG
960 970 980 990 1000
HSIALWAVSD KGDVLCRLGV SELNPAGSSW LHVGTDQPFA SISIGACYQV
1010 1020 1030 1040 1050
WAVARDGSAF YRGSVYPSQP AGDCWYHIPS PPRQRLKQVS AGQTSVYALD
1060 1070 1080 1090 1100
ENGNLWYRQG ITPSYPQGSS WEHVSNNVCR VSVGPLDQVW VIANKVQGSH
1110 1120 1130 1140 1150
SLSRGTVCHR TGVQPHEPKG HGWDYGIGGG WDHISVRANA TRAPRSSSQE
1160
QEPSAPPEAH GPVCC
Length:1,165
Mass (Da):129,696
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD396F4128710062D
GO
Isoform 2 (identifier: Q7Z6L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-557: A → AG

Show »
Length:1,166
Mass (Da):129,753
Checksum:i514CB3EE46C887D6
GO
Isoform 3 (identifier: Q7Z6L1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     219-219: K → KVLCPCLASQ
     838-1165: RGLPTDRYMW...PPEAHGPVCC → SRDRISPCW

Show »
Length:776
Mass (Da):86,697
Checksum:iCCBCAB81F92A970A
GO
Isoform 4 (identifier: Q7Z6L1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     556-556: Q → QA
     836-836: T → TS

Show »
Length:1,167
Mass (Da):129,854
Checksum:i5E69B7980D8A5297
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JUV4C9JUV4_HUMAN
Tectonin beta-propeller repeat-cont...
TECPR1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2A1C9J2A1_HUMAN
Tectonin beta-propeller repeat-cont...
TECPR1
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEV4C9JEV4_HUMAN
Tectonin beta-propeller repeat-cont...
TECPR1
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti116W → R in BAF85685 (PubMed:14702039).Curated1
Sequence conflicti151D → Y in BAG51853 (PubMed:14702039).Curated1
Sequence conflicti464A → T in BAF85685 (PubMed:14702039).Curated1
Sequence conflicti746S → T in CAB55961 (PubMed:17974005).Curated1
Sequence conflicti953I → T in BAF85685 (PubMed:14702039).Curated1
Sequence conflicti988P → L in CAB55961 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060190733S → Y. Corresponds to variant dbSNP:rs35623371Ensembl.1
Natural variantiVAR_062238944P → L. Corresponds to variant dbSNP:rs11762014Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0429691 – 79Missing in isoform 3. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_042970219K → KVLCPCLASQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_042971556Q → QA in isoform 4. Curated1
Alternative sequenceiVSP_033861557A → AG in isoform 2. 1 Publication1
Alternative sequenceiVSP_042972836T → TS in isoform 4. Curated1
Alternative sequenceiVSP_042973838 – 1165RGLPT…GPVCC → SRDRISPCW in isoform 3. 1 PublicationAdd BLAST328

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057048 mRNA Translation: BAG51853.1
AK292996 mRNA Translation: BAF85685.1
AC091654 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23891.1
CH471091 Genomic DNA Translation: EAW76717.1
BC012529 mRNA Translation: AAH12529.2
BC053591 mRNA Translation: AAH53591.1
AB037779 mRNA Translation: BAA92596.1
AL117495 mRNA Translation: CAB55961.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47648.1 [Q7Z6L1-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T17271

NCBI Reference Sequences

More...
RefSeqi
NP_056210.1, NM_015395.2 [Q7Z6L1-1]
XP_005250310.1, XM_005250253.3 [Q7Z6L1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000447648; ENSP00000404923; ENSG00000205356 [Q7Z6L1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25851

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25851

UCSC genome browser

More...
UCSCi
uc003upg.5, human [Q7Z6L1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057048 mRNA Translation: BAG51853.1
AK292996 mRNA Translation: BAF85685.1
AC091654 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23891.1
CH471091 Genomic DNA Translation: EAW76717.1
BC012529 mRNA Translation: AAH12529.2
BC053591 mRNA Translation: AAH53591.1
AB037779 mRNA Translation: BAA92596.1
AL117495 mRNA Translation: CAB55961.2
CCDSiCCDS47648.1 [Q7Z6L1-1]
PIRiT17271
RefSeqiNP_056210.1, NM_015395.2 [Q7Z6L1-1]
XP_005250310.1, XM_005250253.3 [Q7Z6L1-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4TQ1X-ray1.80B573-610[»]
SMRiQ7Z6L1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117375, 9 interactors
ComplexPortaliCPX-358, ATG5-ATG12-TECPR1 complex
IntActiQ7Z6L1, 15 interactors
STRINGi9606.ENSP00000404923

PTM databases

iPTMnetiQ7Z6L1
PhosphoSitePlusiQ7Z6L1

Polymorphism and mutation databases

BioMutaiTECPR1
DMDMi74738829

Proteomic databases

EPDiQ7Z6L1
jPOSTiQ7Z6L1
MassIVEiQ7Z6L1
MaxQBiQ7Z6L1
PaxDbiQ7Z6L1
PeptideAtlasiQ7Z6L1
PRIDEiQ7Z6L1
ProteomicsDBi69439 [Q7Z6L1-1]
69440 [Q7Z6L1-2]
69441 [Q7Z6L1-3]
69442 [Q7Z6L1-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
8742, 118 antibodies

Genome annotation databases

EnsembliENST00000447648; ENSP00000404923; ENSG00000205356 [Q7Z6L1-1]
GeneIDi25851
KEGGihsa:25851
UCSCiuc003upg.5, human [Q7Z6L1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25851
DisGeNETi25851
EuPathDBiHostDB:ENSG00000205356.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TECPR1
HGNCiHGNC:22214, TECPR1
HPAiENSG00000205356, Tissue enhanced (pancreas)
MIMi614781, gene
neXtProtiNX_Q7Z6L1
OpenTargetsiENSG00000205356
PharmGKBiPA164726436

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3669, Eukaryota
GeneTreeiENSGT00510000047886
HOGENOMiCLU_008303_0_0_1
InParanoidiQ7Z6L1
KOiK17988
OMAiMAWQWDG
OrthoDBi119234at2759
PhylomeDBiQ7Z6L1
TreeFamiTF323648

Enzyme and pathway databases

PathwayCommonsiQ7Z6L1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
25851, 4 hits in 868 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TECPR1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25851
PharosiQ7Z6L1, Tbio

Protein Ontology

More...
PROi
PR:Q7Z6L1
RNActiQ7Z6L1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000205356, Expressed in parotid gland and 214 other tissues
ExpressionAtlasiQ7Z6L1, baseline and differential
GenevisibleiQ7Z6L1, HS

Family and domain databases

InterProiView protein in InterPro
IPR006624, Beta-propeller_rpt_TECPR
IPR010482, Peroxin
IPR006614, Peroxin/Ferlin
PfamiView protein in Pfam
PF06462, Hyd_WA, 8 hits
PF06398, Pex24p, 2 hits
SMARTiView protein in SMART
SM00694, DysFC, 2 hits
SM00693, DysFN, 2 hits
SM00706, TECPR, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTCPR1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z6L1
Secondary accession number(s): A8KAD1
, B3KPZ1, C9J024, F5GX57, Q96EB0, Q9P2I9, Q9UFR6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2003
Last modified: August 12, 2020
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again