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Protein

Notch-regulated ankyrin repeat-containing protein

Gene

NRARP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).By similarity1 Publication2 Publications

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

SIGNORiQ7Z6K4

Names & Taxonomyi

Protein namesi
Recommended name:
Notch-regulated ankyrin repeat-containing protein
Gene namesi
Name:NRARP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000198435.3
HGNCiHGNC:33843 NRARP
neXtProtiNX_Q7Z6K4

Pathology & Biotechi

Organism-specific databases

DisGeNETi441478
OpenTargetsiENSG00000198435
PharmGKBiPA164724205

Polymorphism and mutation databases

BioMutaiNRARP
DMDMi74750170

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003250791 – 114Notch-regulated ankyrin repeat-containing proteinAdd BLAST114

Proteomic databases

PaxDbiQ7Z6K4
PRIDEiQ7Z6K4
ProteomicsDBi69434

Expressioni

Inductioni

In endothelial cells by Notch signaling.1 Publication

Gene expression databases

BgeeiENSG00000198435 Expressed in 195 organ(s), highest expression level in caecum
CleanExiHS_NRARP
GenevisibleiQ7Z6K4 HS

Organism-specific databases

HPAiHPA025729

Interactioni

Subunit structurei

Interacts with LEF1.By similarity

Protein-protein interaction databases

BioGridi137507, 1 interactor
IntActiQ7Z6K4, 2 interactors
STRINGi9606.ENSP00000349041

Structurei

3D structure databases

ProteinModelPortaliQ7Z6K4
SMRiQ7Z6K4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati50 – 79ANK 1Add BLAST30
Repeati83 – 112ANK 2Add BLAST30

Sequence similaritiesi

Belongs to the NRARP family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150998
HOGENOMiHOG000082661
HOVERGENiHBG097373
InParanoidiQ7Z6K4
OMAiHQDIALY
OrthoDBiEOG091G0WZR
PhylomeDBiQ7Z6K4

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

Q7Z6K4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQAELSTCS APQTQRIFQE AVRKGNTQEL QSLLQNMTNC EFNVNSFGPE
60 70 80 90 100
GQTALHQSVI DGNLELVKLL VKFGADIRLA NRDGWSALHI AAFGGHQDIV
110
LYLITKAKYA ASGR
Length:114
Mass (Da):12,492
Last modified:October 1, 2003 - v1
Checksum:iC8B84B648DB47F4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255925 Genomic DNA No translation available.
BC053618 mRNA Translation: AAH53618.1
CCDSiCCDS35188.1
RefSeqiNP_001004354.1, NM_001004354.2
UniGeneiHs.535075
Hs.732282

Genome annotation databases

EnsembliENST00000356628; ENSP00000349041; ENSG00000198435
GeneIDi441478
KEGGihsa:441478
UCSCiuc004cmo.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX255925 Genomic DNA No translation available.
BC053618 mRNA Translation: AAH53618.1
CCDSiCCDS35188.1
RefSeqiNP_001004354.1, NM_001004354.2
UniGeneiHs.535075
Hs.732282

3D structure databases

ProteinModelPortaliQ7Z6K4
SMRiQ7Z6K4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137507, 1 interactor
IntActiQ7Z6K4, 2 interactors
STRINGi9606.ENSP00000349041

Polymorphism and mutation databases

BioMutaiNRARP
DMDMi74750170

Proteomic databases

PaxDbiQ7Z6K4
PRIDEiQ7Z6K4
ProteomicsDBi69434

Protocols and materials databases

DNASUi441478
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356628; ENSP00000349041; ENSG00000198435
GeneIDi441478
KEGGihsa:441478
UCSCiuc004cmo.3 human

Organism-specific databases

CTDi441478
DisGeNETi441478
EuPathDBiHostDB:ENSG00000198435.3
GeneCardsiNRARP
HGNCiHGNC:33843 NRARP
HPAiHPA025729
neXtProtiNX_Q7Z6K4
OpenTargetsiENSG00000198435
PharmGKBiPA164724205
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00930000150998
HOGENOMiHOG000082661
HOVERGENiHBG097373
InParanoidiQ7Z6K4
OMAiHQDIALY
OrthoDBiEOG091G0WZR
PhylomeDBiQ7Z6K4

Enzyme and pathway databases

SIGNORiQ7Z6K4

Miscellaneous databases

GenomeRNAii441478
PROiPR:Q7Z6K4

Gene expression databases

BgeeiENSG00000198435 Expressed in 195 organ(s), highest expression level in caecum
CleanExiHS_NRARP
GenevisibleiQ7Z6K4 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNRARP_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6K4
Secondary accession number(s): B8A4K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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