UniProtKB - Q7Z6K3 (PTAR1_HUMAN)

BLAST

>sp|Q7Z6K3|PTAR1_HUMAN Protein prenyltransferase alpha subunit repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=PTAR1 PE=1 SV=2
MAETSEEVAVLVQRVVKDITNAFRRNPHIDEIGLIPCPEARYNRSPIVLVENKLGVESWC
VKFLLPYVHNKLLLYRTRKQWLNRDELIDVTCTLLLLNPDFTTAWNVRKELILSGTLNPI
KDLHLGKLALTKFPKSPETWIHRRWVLQQLIQETSLPSFVTKGNLGTIPTERAQRLIQEE
MEVCGEAAGRYPSNYNAWSHRIWVLQHLAKLDVKILLDELSSTKHWASMHVSDHSGFHYR
QFLLKSLISQTVIDSSVMEQNPLRSEPALVPPKDEEAAVSTEEPRINLPHLLEEEVEFST
DLIDSYPGHETLWCHRRHIFYLQHHLNAGSQLSQAMEVDGLNDSSKQGYSQETKRLKRTP
VPDSLGLEMEHRFIDQVLSTCRNVEQARFASAYRKWLVTLSQ

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History
Entry version 108 (07 Nov 2018)
Sequence version 2 (05 Feb 2008)
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Protein

Protein prenyltransferase alpha subunit repeat-containing protein 1

Gene

PTAR1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

protein prenyltransferase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein prenylation Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Prenyltransferase, Transferase

Molecular function

Prenyltransferase, Transferase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein prenyltransferase alpha subunit repeat-containing protein 1
Gene namesⁱ	Name:PTAR1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000188647.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30449 PTAR1
neXtProtⁱ	NX_Q7Z6K3

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000188647
PharmGKBⁱ	PA134897041

Polymorphism and mutation databases

BioMutaⁱ	PTAR1
DMDMⁱ	167012004

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000316843	2 – 402	Protein prenyltransferase alpha subunit repeat-containing protein 1Add BLAST		401

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q7Z6K3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7Z6K3
PaxDbⁱ	Q7Z6K3
PeptideAtlas More...PeptideAtlasⁱ	Q7Z6K3
PRIDEⁱ	Q7Z6K3
ProteomicsDBⁱ	69433

PTM databases

iPTMnetⁱ	Q7Z6K3
PhosphoSitePlusⁱ	Q7Z6K3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000188647 Expressed in 205 organ(s), highest expression level in lung
CleanExⁱ	HS_PTAR1
ExpressionAtlasⁱ	Q7Z6K3 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA021248

HPAⁱ

HPA021248

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	131995, 71 interactors
IntActⁱ	Q7Z6K3, 5 interactors
STRINGⁱ	9606.ENSP00000344299

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7Z6K3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	87 – 120	PFTA 1Add BLAST	34
Repeatⁱ	122 – 155	PFTA 2Add BLAST	34
Repeatⁱ	180 – 213	PFTA 3Add BLAST	34
Repeatⁱ	219 – 252	PFTA 4Add BLAST	34
Repeatⁱ	295 – 328	PFTA 5Add BLAST	34

Sequence similaritiesⁱ

Belongs to the protein prenyltransferase subunit alpha family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IGVZ Eukaryota ENOG4110M6X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017892
HOGENOMⁱ	HOG000115755
HOVERGENⁱ	HBG108302
InParanoidⁱ	Q7Z6K3
KEGG Orthology (KO) More...KOⁱ	K14137
OMAⁱ	RHVFYLW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FOG
PhylomeDBⁱ	Q7Z6K3
TreeFamⁱ	TF324310

Family and domain databases

InterProⁱ	View protein in InterPro IPR002088 Prenyl_trans_a
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01239 PPTA, 2 hits
PROSITEⁱ	View protein in PROSITE PS51147 PFTA, 5 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q7Z6K3-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAETSEEVAV LVQRVVKDIT NAFRRNPHID EIGLIPCPEA RYNRSPIVLV 
        60         70         80         90        100
ENKLGVESWC VKFLLPYVHN KLLLYRTRKQ WLNRDELIDV TCTLLLLNPD 
       110        120        130        140        150
FTTAWNVRKE LILSGTLNPI KDLHLGKLAL TKFPKSPETW IHRRWVLQQL 
       160        170        180        190        200
IQETSLPSFV TKGNLGTIPT ERAQRLIQEE MEVCGEAAGR YPSNYNAWSH 
       210        220        230        240        250
RIWVLQHLAK LDVKILLDEL SSTKHWASMH VSDHSGFHYR QFLLKSLISQ 
       260        270        280        290        300
TVIDSSVMEQ NPLRSEPALV PPKDEEAAVS TEEPRINLPH LLEEEVEFST 
       310        320        330        340        350
DLIDSYPGHE TLWCHRRHIF YLQHHLNAGS QLSQAMEVDG LNDSSKQGYS 
       360        370        380        390        400
QETKRLKRTP VPDSLGLEME HRFIDQVLST CRNVEQARFA SAYRKWLVTL 

SQ

Length:402

Mass (Da):46,405

Last modified:February 5, 2008 - v2

Checksum:ⁱBCA832C2F9BEB99F

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

J3KQP8	J3KQP8_HUMAN	Protein prenyltransferase alpha sub... Protein prenyltransferase alpha subunit repeat-containing protein 1	PTAR1	168	Annotation score:
X6R9N0	X6R9N0_HUMAN	Protein prenyltransferase alpha sub... Protein prenyltransferase alpha subunit repeat-containing protein 1	PTAR1	350	Annotation score:
F5GXY1	F5GXY1_HUMAN	Protein prenyltransferase alpha sub... Protein prenyltransferase alpha subunit repeat-containing protein 1	PTAR1	29	Annotation score:

Sequence cautionⁱ

The sequence AAH53622 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL162412 Genomic DNA No translation available. BC053622 mRNA Translation: AAH53622.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47978.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001093136.1, NM_001099666.1
UniGeneⁱ	Hs.744192

Genome annotation databases

Ensemblⁱ	ENST00000340434; ENSP00000344299; ENSG00000188647
GeneIDⁱ	375743
KEGGⁱ	hsa:375743
UCSC genome browser More...UCSCⁱ	uc004ahj.5 human

Protein	Similar proteins		Species	Score	Length	Source
Q7Z6K3	Uncharacterized protein		PROCO		402	UniRef90_Q7Z6K3
Uncharacterized protein		NOMLE		402
Uncharacterized protein		CERAT		402
Uncharacterized protein		RHIRO		402
Uncharacterized protein		RHIBE		402
+39

Protein	Similar proteins		Species	Score	Length	Source
Q7Z6K3	Protein prenyltransferase alpha subunit repeat-containing protein 1-A		XENLA		432	UniRef50_Q7Z6K3
Protein prenyltransferase alpha subunit repeat-containing protein 1		MACMU		402
Uncharacterized protein		MACFA		402
Uncharacterized protein		RHIRO		402
Uncharacterized protein		RHIBE		402
+209

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL162412 Genomic DNA No translation available. BC053622 mRNA Translation: AAH53622.1 Different initiation.
CCDSⁱ	CCDS47978.1
RefSeqⁱ	NP_001093136.1, NM_001099666.1
UniGeneⁱ	Hs.744192

3D structure databases

ProteinModelPortalⁱ	Q7Z6K3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	131995, 71 interactors
IntActⁱ	Q7Z6K3, 5 interactors
STRINGⁱ	9606.ENSP00000344299

PTM databases

iPTMnetⁱ	Q7Z6K3
PhosphoSitePlusⁱ	Q7Z6K3

Polymorphism and mutation databases

BioMutaⁱ	PTAR1
DMDMⁱ	167012004

Proteomic databases

EPDⁱ	Q7Z6K3
MaxQBⁱ	Q7Z6K3
PaxDbⁱ	Q7Z6K3
PeptideAtlasⁱ	Q7Z6K3
PRIDEⁱ	Q7Z6K3
ProteomicsDBⁱ	69433

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000340434; ENSP00000344299; ENSG00000188647
GeneIDⁱ	375743
KEGGⁱ	hsa:375743
UCSCⁱ	uc004ahj.5 human

Organism-specific databases

CTDⁱ	375743
EuPathDBⁱ	HostDB:ENSG00000188647.12
GeneCardsⁱ	PTAR1
HGNCⁱ	HGNC:30449 PTAR1
HPAⁱ	HPA021248
neXtProtⁱ	NX_Q7Z6K3
OpenTargetsⁱ	ENSG00000188647
PharmGKBⁱ	PA134897041
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGVZ Eukaryota ENOG4110M6X LUCA
GeneTreeⁱ	ENSGT00390000017892
HOGENOMⁱ	HOG000115755
HOVERGENⁱ	HBG108302
InParanoidⁱ	Q7Z6K3
KOⁱ	K14137
OMAⁱ	RHVFYLW
OrthoDBⁱ	EOG091G0FOG
PhylomeDBⁱ	Q7Z6K3
TreeFamⁱ	TF324310

Miscellaneous databases

ChiTaRSⁱ	PTAR1 human
GenomeRNAiⁱ	375743
Protein Ontology More...PROⁱ	PR:Q7Z6K3

Gene expression databases

Bgeeⁱ	ENSG00000188647 Expressed in 205 organ(s), highest expression level in lung
CleanExⁱ	HS_PTAR1
ExpressionAtlasⁱ	Q7Z6K3 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR002088 Prenyl_trans_a
Pfamⁱ	View protein in Pfam PF01239 PPTA, 2 hits
PROSITEⁱ	View protein in PROSITE PS51147 PFTA, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTAR1_HUMAN
Accessionⁱ	Q7Z6K3Primary (citable) accession number: Q7Z6K3 Secondary accession number(s): Q5T7V5, Q5T7V6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	February 5, 2008
	Last modified:	November 7, 2018
	This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7Z6K3 (PTAR1_HUMAN)

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Protein prenyltransferase alpha subunit repeat-containing protein 1

PTAR1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ