UniProtKB - Q7Z6K3 (PTAR1_HUMAN)
Protein
Protein prenyltransferase alpha subunit repeat-containing protein 1
Gene
PTAR1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- protein prenyltransferase activity Source: InterPro
GO - Biological processi
- protein prenylation Source: GO_Central
Keywordsi
Molecular function | Prenyltransferase, Transferase |
Enzyme and pathway databases
PathwayCommonsi | Q7Z6K3 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein prenyltransferase alpha subunit repeat-containing protein 1 |
Gene namesi | Name:PTAR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000188647.12 |
HGNCi | HGNC:30449, PTAR1 |
neXtProti | NX_Q7Z6K3 |
Subcellular locationi
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000188647 |
PharmGKBi | PA134897041 |
Miscellaneous databases
Pharosi | Q7Z6K3, Tdark |
Polymorphism and mutation databases
BioMutai | PTAR1 |
DMDMi | 167012004 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000316843 | 2 – 402 | Protein prenyltransferase alpha subunit repeat-containing protein 1Add BLAST | 401 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q7Z6K3 |
jPOSTi | Q7Z6K3 |
MassIVEi | Q7Z6K3 |
MaxQBi | Q7Z6K3 |
PaxDbi | Q7Z6K3 |
PeptideAtlasi | Q7Z6K3 |
PRIDEi | Q7Z6K3 |
ProteomicsDBi | 69433 |
PTM databases
iPTMneti | Q7Z6K3 |
MetOSitei | Q7Z6K3 |
PhosphoSitePlusi | Q7Z6K3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000188647, Expressed in lung and 220 other tissues |
ExpressionAtlasi | Q7Z6K3, baseline and differential |
Organism-specific databases
HPAi | ENSG00000188647, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 131995, 72 interactors |
IntActi | Q7Z6K3, 10 interactors |
STRINGi | 9606.ENSP00000344299 |
Miscellaneous databases
RNActi | Q7Z6K3, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q7Z6K3 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 87 – 120 | PFTA 1Add BLAST | 34 | |
Repeati | 122 – 155 | PFTA 2Add BLAST | 34 | |
Repeati | 180 – 213 | PFTA 3Add BLAST | 34 | |
Repeati | 219 – 252 | PFTA 4Add BLAST | 34 | |
Repeati | 295 – 328 | PFTA 5Add BLAST | 34 |
Sequence similaritiesi
Belongs to the protein prenyltransferase subunit alpha family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QQUP, Eukaryota |
GeneTreei | ENSGT00390000017892 |
HOGENOMi | CLU_048186_2_0_1 |
InParanoidi | Q7Z6K3 |
OMAi | EMELCTD |
OrthoDBi | 1527547at2759 |
PhylomeDBi | Q7Z6K3 |
TreeFami | TF324310 |
Family and domain databases
InterProi | View protein in InterPro IPR002088, Prenyl_trans_a |
Pfami | View protein in Pfam PF01239, PPTA, 4 hits |
PROSITEi | View protein in PROSITE PS51147, PFTA, 5 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q7Z6K3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAETSEEVAV LVQRVVKDIT NAFRRNPHID EIGLIPCPEA RYNRSPIVLV
60 70 80 90 100
ENKLGVESWC VKFLLPYVHN KLLLYRTRKQ WLNRDELIDV TCTLLLLNPD
110 120 130 140 150
FTTAWNVRKE LILSGTLNPI KDLHLGKLAL TKFPKSPETW IHRRWVLQQL
160 170 180 190 200
IQETSLPSFV TKGNLGTIPT ERAQRLIQEE MEVCGEAAGR YPSNYNAWSH
210 220 230 240 250
RIWVLQHLAK LDVKILLDEL SSTKHWASMH VSDHSGFHYR QFLLKSLISQ
260 270 280 290 300
TVIDSSVMEQ NPLRSEPALV PPKDEEAAVS TEEPRINLPH LLEEEVEFST
310 320 330 340 350
DLIDSYPGHE TLWCHRRHIF YLQHHLNAGS QLSQAMEVDG LNDSSKQGYS
360 370 380 390 400
QETKRLKRTP VPDSLGLEME HRFIDQVLST CRNVEQARFA SAYRKWLVTL
SQ
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketX6R9N0 | X6R9N0_HUMAN | Protein prenyltransferase alpha sub... | PTAR1 | 350 | Annotation score: | ||
J3KQP8 | J3KQP8_HUMAN | Protein prenyltransferase alpha sub... | PTAR1 | 168 | Annotation score: | ||
F5GXY1 | F5GXY1_HUMAN | Protein prenyltransferase alpha sub... | PTAR1 | 29 | Annotation score: |
Sequence cautioni
The sequence AAH53622 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL162412 Genomic DNA No translation available. BC053622 mRNA Translation: AAH53622.1 Different initiation. |
CCDSi | CCDS47978.1 |
RefSeqi | NP_001093136.1, NM_001099666.1 |
Genome annotation databases
Ensembli | ENST00000340434; ENSP00000344299; ENSG00000188647 |
GeneIDi | 375743 |
KEGGi | hsa:375743 |
UCSCi | uc004ahj.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL162412 Genomic DNA No translation available. BC053622 mRNA Translation: AAH53622.1 Different initiation. |
CCDSi | CCDS47978.1 |
RefSeqi | NP_001093136.1, NM_001099666.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6J6X | X-ray | 2.96 | A | 1-339 | [»] | |
6J74 | X-ray | 3.21 | A | 1-327 | [»] | |
6J7F | X-ray | 2.88 | A | 1-327 | [»] | |
6J7X | X-ray | 2.75 | A | 1-327 | [»] | |
6O60 | X-ray | 2.50 | A | 1-402 | [»] | |
SMRi | Q7Z6K3 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 131995, 72 interactors |
IntActi | Q7Z6K3, 10 interactors |
STRINGi | 9606.ENSP00000344299 |
PTM databases
iPTMneti | Q7Z6K3 |
MetOSitei | Q7Z6K3 |
PhosphoSitePlusi | Q7Z6K3 |
Polymorphism and mutation databases
BioMutai | PTAR1 |
DMDMi | 167012004 |
Proteomic databases
EPDi | Q7Z6K3 |
jPOSTi | Q7Z6K3 |
MassIVEi | Q7Z6K3 |
MaxQBi | Q7Z6K3 |
PaxDbi | Q7Z6K3 |
PeptideAtlasi | Q7Z6K3 |
PRIDEi | Q7Z6K3 |
ProteomicsDBi | 69433 |
Protocols and materials databases
Antibodypediai | 6448, 77 antibodies |
Genome annotation databases
Ensembli | ENST00000340434; ENSP00000344299; ENSG00000188647 |
GeneIDi | 375743 |
KEGGi | hsa:375743 |
UCSCi | uc004ahj.5, human |
Organism-specific databases
CTDi | 375743 |
EuPathDBi | HostDB:ENSG00000188647.12 |
GeneCardsi | PTAR1 |
HGNCi | HGNC:30449, PTAR1 |
HPAi | ENSG00000188647, Low tissue specificity |
neXtProti | NX_Q7Z6K3 |
OpenTargetsi | ENSG00000188647 |
PharmGKBi | PA134897041 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQUP, Eukaryota |
GeneTreei | ENSGT00390000017892 |
HOGENOMi | CLU_048186_2_0_1 |
InParanoidi | Q7Z6K3 |
OMAi | EMELCTD |
OrthoDBi | 1527547at2759 |
PhylomeDBi | Q7Z6K3 |
TreeFami | TF324310 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z6K3 |
Miscellaneous databases
BioGRID-ORCSi | 375743, 158 hits in 851 CRISPR screens |
ChiTaRSi | PTAR1, human |
GenomeRNAii | 375743 |
Pharosi | Q7Z6K3, Tdark |
PROi | PR:Q7Z6K3 |
RNActi | Q7Z6K3, protein |
Gene expression databases
Bgeei | ENSG00000188647, Expressed in lung and 220 other tissues |
ExpressionAtlasi | Q7Z6K3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR002088, Prenyl_trans_a |
Pfami | View protein in Pfam PF01239, PPTA, 4 hits |
PROSITEi | View protein in PROSITE PS51147, PFTA, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTAR1_HUMAN | |
Accessioni | Q7Z6K3Primary (citable) accession number: Q7Z6K3 Secondary accession number(s): Q5T7V5, Q5T7V6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | December 2, 2020 | |
This is version 120 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families