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Protein

Protein prenyltransferase alpha subunit repeat-containing protein 1

Gene

PTAR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPrenyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein prenyltransferase alpha subunit repeat-containing protein 1
Gene namesi
Name:PTAR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000188647.12
HGNCiHGNC:30449 PTAR1
neXtProtiNX_Q7Z6K3

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188647
PharmGKBiPA134897041

Polymorphism and mutation databases

BioMutaiPTAR1
DMDMi167012004

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003168432 – 402Protein prenyltransferase alpha subunit repeat-containing protein 1Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ7Z6K3
MaxQBiQ7Z6K3
PaxDbiQ7Z6K3
PeptideAtlasiQ7Z6K3
PRIDEiQ7Z6K3
ProteomicsDBi69433

PTM databases

iPTMnetiQ7Z6K3
PhosphoSitePlusiQ7Z6K3

Expressioni

Gene expression databases

BgeeiENSG00000188647 Expressed in 205 organ(s), highest expression level in lung
CleanExiHS_PTAR1
ExpressionAtlasiQ7Z6K3 baseline and differential

Organism-specific databases

HPAiHPA021248

Interactioni

Protein-protein interaction databases

BioGridi131995, 71 interactors
IntActiQ7Z6K3, 5 interactors
STRINGi9606.ENSP00000344299

Structurei

3D structure databases

ProteinModelPortaliQ7Z6K3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati87 – 120PFTA 1Add BLAST34
Repeati122 – 155PFTA 2Add BLAST34
Repeati180 – 213PFTA 3Add BLAST34
Repeati219 – 252PFTA 4Add BLAST34
Repeati295 – 328PFTA 5Add BLAST34

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGVZ Eukaryota
ENOG4110M6X LUCA
GeneTreeiENSGT00390000017892
HOGENOMiHOG000115755
HOVERGENiHBG108302
InParanoidiQ7Z6K3
KOiK14137
OMAiRHVFYLW
OrthoDBiEOG091G0FOG
PhylomeDBiQ7Z6K3
TreeFamiTF324310

Family and domain databases

InterProiView protein in InterPro
IPR002088 Prenyl_trans_a
PfamiView protein in Pfam
PF01239 PPTA, 2 hits
PROSITEiView protein in PROSITE
PS51147 PFTA, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q7Z6K3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAETSEEVAV LVQRVVKDIT NAFRRNPHID EIGLIPCPEA RYNRSPIVLV
60 70 80 90 100
ENKLGVESWC VKFLLPYVHN KLLLYRTRKQ WLNRDELIDV TCTLLLLNPD
110 120 130 140 150
FTTAWNVRKE LILSGTLNPI KDLHLGKLAL TKFPKSPETW IHRRWVLQQL
160 170 180 190 200
IQETSLPSFV TKGNLGTIPT ERAQRLIQEE MEVCGEAAGR YPSNYNAWSH
210 220 230 240 250
RIWVLQHLAK LDVKILLDEL SSTKHWASMH VSDHSGFHYR QFLLKSLISQ
260 270 280 290 300
TVIDSSVMEQ NPLRSEPALV PPKDEEAAVS TEEPRINLPH LLEEEVEFST
310 320 330 340 350
DLIDSYPGHE TLWCHRRHIF YLQHHLNAGS QLSQAMEVDG LNDSSKQGYS
360 370 380 390 400
QETKRLKRTP VPDSLGLEME HRFIDQVLST CRNVEQARFA SAYRKWLVTL

SQ
Length:402
Mass (Da):46,405
Last modified:February 5, 2008 - v2
Checksum:iBCA832C2F9BEB99F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KQP8J3KQP8_HUMAN
Protein prenyltransferase alpha sub...
PTAR1
168Annotation score:
X6R9N0X6R9N0_HUMAN
Protein prenyltransferase alpha sub...
PTAR1
350Annotation score:
F5GXY1F5GXY1_HUMAN
Protein prenyltransferase alpha sub...
PTAR1
29Annotation score:

Sequence cautioni

The sequence AAH53622 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162412 Genomic DNA No translation available.
BC053622 mRNA Translation: AAH53622.1 Different initiation.
CCDSiCCDS47978.1
RefSeqiNP_001093136.1, NM_001099666.1
UniGeneiHs.744192

Genome annotation databases

EnsembliENST00000340434; ENSP00000344299; ENSG00000188647
GeneIDi375743
KEGGihsa:375743
UCSCiuc004ahj.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162412 Genomic DNA No translation available.
BC053622 mRNA Translation: AAH53622.1 Different initiation.
CCDSiCCDS47978.1
RefSeqiNP_001093136.1, NM_001099666.1
UniGeneiHs.744192

3D structure databases

ProteinModelPortaliQ7Z6K3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131995, 71 interactors
IntActiQ7Z6K3, 5 interactors
STRINGi9606.ENSP00000344299

PTM databases

iPTMnetiQ7Z6K3
PhosphoSitePlusiQ7Z6K3

Polymorphism and mutation databases

BioMutaiPTAR1
DMDMi167012004

Proteomic databases

EPDiQ7Z6K3
MaxQBiQ7Z6K3
PaxDbiQ7Z6K3
PeptideAtlasiQ7Z6K3
PRIDEiQ7Z6K3
ProteomicsDBi69433

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340434; ENSP00000344299; ENSG00000188647
GeneIDi375743
KEGGihsa:375743
UCSCiuc004ahj.5 human

Organism-specific databases

CTDi375743
EuPathDBiHostDB:ENSG00000188647.12
GeneCardsiPTAR1
HGNCiHGNC:30449 PTAR1
HPAiHPA021248
neXtProtiNX_Q7Z6K3
OpenTargetsiENSG00000188647
PharmGKBiPA134897041
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGVZ Eukaryota
ENOG4110M6X LUCA
GeneTreeiENSGT00390000017892
HOGENOMiHOG000115755
HOVERGENiHBG108302
InParanoidiQ7Z6K3
KOiK14137
OMAiRHVFYLW
OrthoDBiEOG091G0FOG
PhylomeDBiQ7Z6K3
TreeFamiTF324310

Miscellaneous databases

ChiTaRSiPTAR1 human
GenomeRNAii375743
PROiPR:Q7Z6K3

Gene expression databases

BgeeiENSG00000188647 Expressed in 205 organ(s), highest expression level in lung
CleanExiHS_PTAR1
ExpressionAtlasiQ7Z6K3 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002088 Prenyl_trans_a
PfamiView protein in Pfam
PF01239 PPTA, 2 hits
PROSITEiView protein in PROSITE
PS51147 PFTA, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPTAR1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6K3
Secondary accession number(s): Q5T7V5, Q5T7V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 7, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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