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Protein

E3 ubiquitin-protein ligase E3D

Gene

UBE3D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.1 Publication

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • cyclin binding Source: UniProtKB
  • ubiquitin-like protein conjugating enzyme binding Source: UniProtKB
  • ubiquitin protein ligase activity Source: UniProtKB

GO - Biological processi

  • protein autoubiquitination Source: UniProtKB
  • protein monoubiquitination Source: UniProtKB
  • protein polyubiquitination Source: UniProtKB

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase E3D (EC:2.3.2.26)
Alternative name(s):
HECT-type E3 ubiquitin transferase E3DCurated
UbcH10-binding protein with a HECT-like domain
Ubiquitin-conjugating enzyme E2C-binding protein
Gene namesi
Name:UBE3D
Synonyms:C6orf157, H10BH, UBE2CBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000118420.16
HGNCiHGNC:21381 UBE3D
MIMi612495 gene
neXtProtiNX_Q7Z6J8

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi90025
OpenTargetsiENSG00000118420
PharmGKBiPA162407873

Polymorphism and mutation databases

BioMutaiUBE3D
DMDMi160395569

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003111902 – 389E3 ubiquitin-protein ligase E3DAdd BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Post-translational modificationi

Ubiquitinated by UBCH10 (E2 ubiquitin-conjugating enzyme).

Keywords - PTMi

Acetylation, Ubl conjugation

Proteomic databases

EPDiQ7Z6J8
MaxQBiQ7Z6J8
PaxDbiQ7Z6J8
PeptideAtlasiQ7Z6J8
PRIDEiQ7Z6J8
ProteomicsDBi69428

PTM databases

iPTMnetiQ7Z6J8
PhosphoSitePlusiQ7Z6J8

Expressioni

Gene expression databases

BgeeiENSG00000118420
CleanExiHS_UBE2CBP
ExpressionAtlasiQ7Z6J8 baseline and differential
GenevisibleiQ7Z6J8 HS

Organism-specific databases

HPAiHPA027231

Interactioni

Subunit structurei

Interacts with UBE2C/UbcH10 (E2 ubiquitin-conjugating enzyme). In vitro, interacts with cyclin-B.1 Publication

GO - Molecular functioni

  • cyclin binding Source: UniProtKB
  • ubiquitin-like protein conjugating enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124656, 23 interactors
IntActiQ7Z6J8, 4 interactors
STRINGi9606.ENSP00000358762

Structurei

3D structure databases

ProteinModelPortaliQ7Z6J8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 257Interaction with UBE2C1 PublicationAdd BLAST23
Regioni353 – 389HECT-likeAdd BLAST37

Domaini

The C-terminal half (AA 188-389) is able to bind cyclin-B and shows a self-ubiquitination activity (mono-, poly, or multi-ubiquitination) in a HECT-like sequence dependent manner.

Phylogenomic databases

eggNOGiKOG4784 Eukaryota
ENOG4111HHQ LUCA
GeneTreeiENSGT00390000003986
HOVERGENiHBG056762
InParanoidiQ7Z6J8
KOiK20803
OMAiETTKFYM
OrthoDBiEOG091G09U8
PhylomeDBiQ7Z6J8
TreeFamiTF324684

Family and domain databases

InterProiView protein in InterPro
IPR019193 UBQ-conj_enz_E2-bd_prot
PANTHERiPTHR31531 PTHR31531, 1 hit
PfamiView protein in Pfam
PF09814 HECT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z6J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAAETRV FLEVRGQLQS ALLILGEPKE GGMPMNISIM PSSLQMKTPE
60 70 80 90 100
GCTEIQLPAE VRLVPSSCRG LQFVVGDGLH LRLQTQAKLG TKLISMFNQS
110 120 130 140 150
SQTQECCTFY CQSCGEVIIK DRKLLRVLPL PSENWGALVG EWCCHPDPFA
160 170 180 190 200
NKSLHPQEND CFIGDSFFLV NLRTSLWQQR PELSPVEMCC VSSDNHCKLE
210 220 230 240 250
PKANTKVICK RCKVMLGETV SSETTKFYMT EIIIQSSERS FPIIPRSWFV
260 270 280 290 300
QSVIAQCLVQ LSSARSTFRF TIQGQDDKVY ILLWLLNSDS LVIESLRNSK
310 320 330 340 350
YIKKFPLLEN TFKADSSSAW SAVKVLYQPC IKSRNEKLVS LWESDISVHP
360 370 380
LTLPSATCLE LLLILSKSNA NLPSSLRRVN SFQVAFLKM
Length:389
Mass (Da):43,657
Last modified:November 13, 2007 - v2
Checksum:i5F72BE6670863E2B
GO

Sequence cautioni

The sequence AAH53645 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI13740 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI15282 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM28304 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223 – 226ETTK → ARSC in CAB70802 (PubMed:17974005).Curated4
Sequence conflicti340S → G in AAH71763 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037152174T → P. Corresponds to variant dbSNP:rs12528542Ensembl.1
Natural variantiVAR_037153379V → M. Corresponds to variant dbSNP:rs7739323Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126062 mRNA Translation: BAD01604.1
AK298205 mRNA Translation: BAG60475.1
AL034377
, AL139333, AL357121, AL355613 Genomic DNA Translation: CAM28304.1 Sequence problems.
AL139333
, AL034377, AL357121, AL355613 Genomic DNA Translation: CAI15282.2 Sequence problems.
AL357121
, AL034377, AL139333, AL355613 Genomic DNA Translation: CAI13740.2 Sequence problems.
CH471051 Genomic DNA Translation: EAW48681.1
BC053645 mRNA Translation: AAH53645.1 Different initiation.
BC071763 mRNA Translation: AAH71763.1
BC101512 mRNA Translation: AAI01513.1
BC101538 mRNA Translation: AAI01539.1
AL137544 mRNA Translation: CAB70802.1
CCDSiCCDS34491.1
PIRiT46387
RefSeqiNP_001291366.1, NM_001304437.1
NP_944602.1, NM_198920.2
UniGeneiHs.148609

Genome annotation databases

EnsembliENST00000369747; ENSP00000358762; ENSG00000118420
GeneIDi90025
KEGGihsa:90025
UCSCiuc003pjp.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUBE3D_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6J8
Secondary accession number(s): B4DP63
, Q5T4W2, Q6IPR4, Q75UG0, Q9NT42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 20, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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