Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

FERM domain-containing protein 5

Gene

FRMD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).

GO - Molecular functioni

  • cytoskeletal protein binding Source: InterPro
  • integrin binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • structural constituent of cytoskeleton Source: GO_Central

GO - Biological processi

  • actomyosin structure organization Source: GO_Central
  • negative regulation of cell motility Source: UniProtKB
  • positive regulation of cell adhesion Source: UniProtKB
  • regulation of cell migration Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
FERM domain-containing protein 5
Gene namesi
Name:FRMD5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000171877.19
HGNCiHGNC:28214 FRMD5
MIMi616309 gene
neXtProtiNX_Q7Z6J6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei504 – 524HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84978
OpenTargetsiENSG00000171877
PharmGKBiPA142671751

Polymorphism and mutation databases

DMDMi74738821

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474461 – 570FERM domain-containing protein 5Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei375PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z6J6
MaxQBiQ7Z6J6
PaxDbiQ7Z6J6
PeptideAtlasiQ7Z6J6
PRIDEiQ7Z6J6
ProteomicsDBi69426
69427 [Q7Z6J6-2]

PTM databases

iPTMnetiQ7Z6J6
PhosphoSitePlusiQ7Z6J6

Expressioni

Gene expression databases

BgeeiENSG00000171877
CleanExiHS_FRMD5
ExpressionAtlasiQ7Z6J6 baseline and differential
GenevisibleiQ7Z6J6 HS

Organism-specific databases

HPAiHPA011746
HPA013961

Interactioni

Subunit structurei

Interacts with CTNND1 (PubMed:22846708). Interacts with ITGB5 (via cytoplasmic domain) and ROCK1 (PubMed:25448675).2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • cytoskeletal protein binding Source: InterPro
  • integrin binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi124407, 26 interactors
IntActiQ7Z6J6, 21 interactors
MINTiQ7Z6J6
STRINGi9606.ENSP00000403067

Structurei

3D structure databases

ProteinModelPortaliQ7Z6J6
SMRiQ7Z6J6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 298FERMPROSITE-ProRule annotationAdd BLAST282

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni308 – 353Interaction with ROCK11 PublicationAdd BLAST46

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3530 Eukaryota
ENOG410XSWH LUCA
GeneTreeiENSGT00760000118823
HOGENOMiHOG000231815
HOVERGENiHBG057180
InParanoidiQ7Z6J6
OMAiCQGHGRP
OrthoDBiEOG091G06EA
PhylomeDBiQ7Z6J6
TreeFamiTF343477

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR000798 Ez/rad/moesin-like
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PRINTSiPR00935 BAND41
PR00661 ERMFAMILY
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS50057 FERM_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z6J6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSRLMSGSS RSLEREYSCT VRLLDDSEYT CTIQRDAKGQ YLFDLLCHHL
60 70 80 90 100
NLLEKDYFGI RFVDPDKQRH WLEFTKSVVK QLRSQPPFTM CFRVKFYPAD
110 120 130 140 150
PAALKEEITR YLVFLQIKRD LYHGRLLCKT SDAALLAAYI LQAEIGDYDS
160 170 180 190 200
GKHPEGYSSK FQFFPKHSEK LERKIAEIHK TELSGQTPAT SELNFLRKAQ
210 220 230 240 250
TLETYGVDPH PCKDVSGNAA FLAFTPFGFV VLQGNKRVHF IKWNEVTKLK
260 270 280 290 300
FEGKTFYLYV SQKEEKKIIL TYFAPTPEAC KHLWKCGIEN QAFYKLEKSS
310 320 330 340 350
QVRTVSSSNL FFKGSRFRYS GRVAKEVMES SAKIKREPPE IHRAGMVPSR
360 370 380 390 400
SCPSITHGPR LSSVPRTRRR AVHISIMEGL ESLRDSAHST PVRSTSHGDT
410 420 430 440 450
FLPHVRSSRT DSNERVAVIA DEAYSPADSV LPTPVAEHSL ELMLLSRQIN
460 470 480 490 500
GATCSIEEEK ESEASTPTAT EVEALGGELR ALCQGHSGPE EEQVNKFVLS
510 520 530 540 550
VLRLLLVTMG LLFVLLLLLI ILTESDLDIA FFRDIRQTPE FEQFHYQYFC
560 570
PLRRWFACKI RSVVSLLIDT
Length:570
Mass (Da):65,065
Last modified:October 1, 2003 - v1
Checksum:i8235A774CA2A6DE3
GO
Isoform 2 (identifier: Q7Z6J6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-95: Missing.

Show »
Length:555
Mass (Da):63,244
Checksum:i7D2FB053701EC0D5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01998281 – 95Missing in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090572 mRNA Translation: BAC03480.1
BC053647 mRNA Translation: AAH53647.1
CCDSiCCDS10107.2 [Q7Z6J6-1]
RefSeqiNP_116281.2, NM_032892.4
UniGeneiHs.578544

Genome annotation databases

EnsembliENST00000417257; ENSP00000403067; ENSG00000171877 [Q7Z6J6-1]
GeneIDi84978
KEGGihsa:84978
UCSCiuc001ztl.5 human [Q7Z6J6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFRMD5_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6J6
Secondary accession number(s): Q8NBG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: June 20, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health