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Protein

General receptor for phosphoinositides 1-associated scaffold protein

Gene

GRASP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ7Z6J2

Names & Taxonomyi

Protein namesi
Recommended name:
General receptor for phosphoinositides 1-associated scaffold protein
Short name:
GRP1-associated scaffold protein
Gene namesi
Name:GRASP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000161835.10
HGNCiHGNC:18707 GRASP
MIMi612027 gene
neXtProtiNX_Q7Z6J2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi160622
OpenTargetsiENSG00000161835
PharmGKBiPA38651

Polymorphism and mutation databases

DMDMi74738818

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000875841 – 395General receptor for phosphoinositides 1-associated scaffold proteinAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphothreonineBy similarity1
Modified residuei94PhosphoserineBy similarity1
Modified residuei237PhosphotyrosineCombined sources1
Modified residuei270Omega-N-methylarginineBy similarity1
Modified residuei387PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ7Z6J2
PaxDbiQ7Z6J2
PeptideAtlasiQ7Z6J2
PRIDEiQ7Z6J2
ProteomicsDBi69419
69420 [Q7Z6J2-2]

PTM databases

iPTMnetiQ7Z6J2
PhosphoSitePlusiQ7Z6J2

Expressioni

Gene expression databases

BgeeiENSG00000161835
CleanExiHS_GRASP
ExpressionAtlasiQ7Z6J2 baseline and differential
GenevisibleiQ7Z6J2 HS

Organism-specific databases

HPAiHPA040664
HPA062028

Interactioni

Subunit structurei

Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with PSCD3, GRM2, GRM3 and GRM5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127762, 6 interactors
CORUMiQ7Z6J2
IntActiQ7Z6J2, 1 interactor
STRINGi9606.ENSP00000293662

Structurei

Secondary structure

1395
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi98 – 105Combined sources8
Beta strandi114 – 121Combined sources8
Beta strandi130 – 138Combined sources9
Helixi143 – 146Combined sources4
Beta strandi154 – 158Combined sources5
Helixi168 – 177Combined sources10
Turni178 – 180Combined sources3
Beta strandi181 – 188Combined sources8

3D structure databases

ProteinModelPortaliQ7Z6J2
SMRiQ7Z6J2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z6J2

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 190PDZPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 258Interaction with PSCD3By similarityAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi295 – 324Pro-richAdd BLAST30

Phylogenomic databases

eggNOGiKOG3528 Eukaryota
ENOG410ZJVP LUCA
GeneTreeiENSGT00530000063734
HOGENOMiHOG000231871
HOVERGENiHBG053061
InParanoidiQ7Z6J2
OMAiSVEMCTF
OrthoDBiEOG091G0NRM
PhylomeDBiQ7Z6J2
TreeFamiTF316315

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z6J2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLRRLRKLQ QKEEAAATPD PAARTPDSEV APAAPVPTPG PPAAAATPGP
60 70 80 90 100
PADELYAALE DYHPAELYRA LAVSGGTLPR RKGSGFRWKN LSQSPEQQRK
110 120 130 140 150
VLTLEKEDNQ TFGFEIQTYG LHHREEQRVE MVTFVCRVHE SSPAQLAGLT
160 170 180 190 200
PGDTIASVNG LNVEGIRHRE IVDIIKASGN VLRLETLYGT SIRKAELEAR
210 220 230 240 250
LQYLKQTLYE KWGEYRSLMV QEQRLVHGLV VKDPSIYDTL ESVRSCLYGA
260 270 280 290 300
GLLPGSLPFG PLLAVPGRPR GGARRARGDA DDAVYHTCFF GDSEPPALPP
310 320 330 340 350
PPPPARAFGP GPAETPAVGP GPGPRAALSR SASVRCAGPG GGGGGGAPGA
360 370 380 390
LWTEAREQAL CGPGLRKTKY RSFRRRLLKF IPGLNRSLEE EESQL
Length:395
Mass (Da):42,623
Last modified:October 1, 2003 - v1
Checksum:iB042CA2298753CB9
GO
Isoform 2 (identifier: Q7Z6J2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.
     144-151: AQLAGLTP → MTLLPSKG

Note: No experimental confirmation available.
Show »
Length:252
Mass (Da):26,904
Checksum:i8A71C34EA285BE1E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0157071 – 143Missing in isoform 2. 1 PublicationAdd BLAST143
Alternative sequenceiVSP_015708144 – 151AQLAGLTP → MTLLPSKG in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC035500 mRNA Translation: AAH35500.1
BC052967 mRNA Translation: AAH52967.1
BC053666 mRNA Translation: AAH53666.1
CCDSiCCDS61124.1 [Q7Z6J2-2]
CCDS8817.1 [Q7Z6J2-1]
RefSeqiNP_001258785.1, NM_001271856.1 [Q7Z6J2-2]
NP_859062.1, NM_181711.3 [Q7Z6J2-1]
UniGeneiHs.407202

Genome annotation databases

EnsembliENST00000293662; ENSP00000293662; ENSG00000161835 [Q7Z6J2-1]
ENST00000552049; ENSP00000449492; ENSG00000161835 [Q7Z6J2-2]
GeneIDi160622
KEGGihsa:160622
UCSCiuc001rzo.3 human [Q7Z6J2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGRASP_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6J2
Secondary accession number(s): Q6PIF8, Q7Z741
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2003
Last modified: June 20, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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