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Entry version 134 (10 Apr 2019)
Sequence version 1 (01 Oct 2003)
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Protein

N-terminal EF-hand calcium-binding protein 2

Gene

NECAB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi73 – 841PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi107 – 1182PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-terminal EF-hand calcium-binding protein 2
Short name:
EF-hand calcium-binding protein 2
Alternative name(s):
Neuronal calcium-binding protein 2
Synaptotagmin-interacting protein 2
Short name:
Stip-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NECAB2
Synonyms:EFCBP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000103154.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23746 NECAB2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618130 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z6G3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54550

Open Targets

More...
OpenTargetsi
ENSG00000103154

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162397412

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NECAB2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762441

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002826131 – 386N-terminal EF-hand calcium-binding protein 2Add BLAST386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10Omega-N-methylarginineBy similarity1
Modified residuei42Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z6G3

PeptideAtlas

More...
PeptideAtlasi
Q7Z6G3

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z6G3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69400

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z6G3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain. Expressed in the spinal dorsal horn with especially strong expression in lamina IIi; found in excitory synaptic boutons and in ependymal cells (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103154 Expressed in 139 organ(s), highest expression level in amygdala

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z6G3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z6G3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB068211
HPA013998
HPA014144

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (calcium-dependent) with ADORA2A and GRM5.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120035, 80 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z6G3, 82 interactors

Molecular INTeraction database

More...
MINTi
Q7Z6G3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000307449

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q7Z6G3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z6G3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 95EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini94 – 129EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini286 – 375ABMAdd BLAST90

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili170 – 201Sequence analysisAdd BLAST32

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH3U Eukaryota
ENOG4111GJU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183131

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008120

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050433

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z6G3

Identification of Orthologs from Complete Genome Data

More...
OMAi
RDCFHVT

Database of Orthologous Groups

More...
OrthoDBi
924307at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z6G3

TreeFam database of animal gene trees

More...
TreeFami
TF331029

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051 EFh, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007138 ABM_dom
IPR011008 Dimeric_a/b-barrel
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR039862 NECAB1/2/3

The PANTHER Classification System

More...
PANTHERi
PTHR12178 PTHR12178, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03992 ABM, 1 hit
PF13833 EF-hand_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF54909 SSF54909, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51725 ABM, 1 hit
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z6G3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCERAARLCR AGAHRLLREP PQQGRALGGL LRWVGARMGE PRESLAPAAP
60 70 80 90 100
ADPGPASPRG GTAVILDIFR RADKNDDGKL SLEEFQLFFA DGVLNEKELE
110 120 130 140 150
DLFHTIDSDN TNHVDTKELC DYFVDHMGDY EDVLASLETL NHSVLKAMGY
160 170 180 190 200
TKKVYEGGSN VDQFVTRFLL KETANQIQSL LSSVESAVEA IEEQTSQLRQ
210 220 230 240 250
NHIKPSHSAA QTWCGSPTPA SAPNHKLMAM EQGKTLPSAT EDAKEEGLEA
260 270 280 290 300
QISRLAELIG RLESKALWFD LQQRLSDEDG TNMHLQLVRQ EMAVCPEQLS
310 320 330 340 350
EFLDSLRQYL RGTTGVRNCF HITAVRLSDG FTFVIYEFWE TEEAWKRHLQ
360 370 380
SPLCKAFRHV KVDTLSQPEA LSRILVPAAW CTVGRD
Length:386
Mass (Da):43,194
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5F32B9AACF1A1C1
GO
Isoform 2 (identifier: Q7Z6G3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: MCERAARLCR...NHVDTKELCD → MMMGSCPWRN...FTRLTLTTPN

Show »
Length:303
Mass (Da):34,322
Checksum:i0D700F56055354EF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPH6H3BPH6_HUMAN
N-terminal EF-hand calcium-binding ...
NECAB2
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQC7H3BQC7_HUMAN
N-terminal EF-hand calcium-binding ...
NECAB2
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI31616 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC86948 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048639233G → S. Corresponds to variant dbSNP:rs2292323Ensembl.1
Natural variantiVAR_048640235T → S. Corresponds to variant dbSNP:rs2292324Ensembl.1
Natural variantiVAR_048641308Q → H. Corresponds to variant dbSNP:rs2292329Ensembl.1
Natural variantiVAR_048642353L → V. Corresponds to variant dbSNP:rs2271298Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0589361 – 121MCERA…KELCD → MMMGSCPWRNSSSSLQMASL MRKNWRISFTRLTLTTPN in isoform 2. Add BLAST121

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY299331 mRNA Translation: AAP57260.1
AK127376 mRNA Translation: BAC86948.1 Different initiation.
AC040169 Genomic DNA No translation available.
BC016979 mRNA No translation available.
BC131615 mRNA Translation: AAI31616.1 Different initiation.
AF193758 mRNA Translation: AAG28414.1
AF070637 mRNA Translation: AAC25392.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10940.1 [Q7Z6G3-1]
CCDS82019.1 [Q7Z6G3-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001316678.1, NM_001329749.1 [Q7Z6G3-2]
NP_061938.2, NM_019065.2 [Q7Z6G3-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.140950

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305202; ENSP00000307449; ENSG00000103154 [Q7Z6G3-1]
ENST00000565691; ENSP00000457354; ENSG00000103154 [Q7Z6G3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
54550

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54550

UCSC genome browser

More...
UCSCi
uc002fhd.4 human [Q7Z6G3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299331 mRNA Translation: AAP57260.1
AK127376 mRNA Translation: BAC86948.1 Different initiation.
AC040169 Genomic DNA No translation available.
BC016979 mRNA No translation available.
BC131615 mRNA Translation: AAI31616.1 Different initiation.
AF193758 mRNA Translation: AAG28414.1
AF070637 mRNA Translation: AAC25392.1
CCDSiCCDS10940.1 [Q7Z6G3-1]
CCDS82019.1 [Q7Z6G3-2]
RefSeqiNP_001316678.1, NM_001329749.1 [Q7Z6G3-2]
NP_061938.2, NM_019065.2 [Q7Z6G3-1]
UniGeneiHs.140950

3D structure databases

ProteinModelPortaliQ7Z6G3
SMRiQ7Z6G3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120035, 80 interactors
IntActiQ7Z6G3, 82 interactors
MINTiQ7Z6G3
STRINGi9606.ENSP00000307449

PTM databases

PhosphoSitePlusiQ7Z6G3

Polymorphism and mutation databases

BioMutaiNECAB2
DMDMi74762441

Proteomic databases

PaxDbiQ7Z6G3
PeptideAtlasiQ7Z6G3
PRIDEiQ7Z6G3
ProteomicsDBi69400

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
54550
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305202; ENSP00000307449; ENSG00000103154 [Q7Z6G3-1]
ENST00000565691; ENSP00000457354; ENSG00000103154 [Q7Z6G3-2]
GeneIDi54550
KEGGihsa:54550
UCSCiuc002fhd.4 human [Q7Z6G3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54550
DisGeNETi54550
EuPathDBiHostDB:ENSG00000103154.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NECAB2
HGNCiHGNC:23746 NECAB2
HPAiCAB068211
HPA013998
HPA014144
MIMi618130 gene
neXtProtiNX_Q7Z6G3
OpenTargetsiENSG00000103154
PharmGKBiPA162397412

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH3U Eukaryota
ENOG4111GJU LUCA
GeneTreeiENSGT00950000183131
HOGENOMiHOG000008120
HOVERGENiHBG050433
InParanoidiQ7Z6G3
OMAiRDCFHVT
OrthoDBi924307at2759
PhylomeDBiQ7Z6G3
TreeFamiTF331029

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NECAB2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
EFCBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54550

Protein Ontology

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PROi
PR:Q7Z6G3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000103154 Expressed in 139 organ(s), highest expression level in amygdala
ExpressionAtlasiQ7Z6G3 baseline and differential
GenevisibleiQ7Z6G3 HS

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR007138 ABM_dom
IPR011008 Dimeric_a/b-barrel
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR039862 NECAB1/2/3
PANTHERiPTHR12178 PTHR12178, 1 hit
PfamiView protein in Pfam
PF03992 ABM, 1 hit
PF13833 EF-hand_8, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF54909 SSF54909, 1 hit
PROSITEiView protein in PROSITE
PS51725 ABM, 1 hit
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNECA2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z6G3
Secondary accession number(s): A2RRG3
, H3BTW2, O75547, Q6ZSK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2003
Last modified: April 10, 2019
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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