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Entry version 158 (13 Feb 2019)
Sequence version 1 (01 Oct 2003)
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Protein

E3 ubiquitin-protein ligase RBBP6

Gene

RBBP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri159 – 176CCHC-typePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri259 – 300RING-type; degeneratePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processDNA damage, DNA replication, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RBBP6 (EC:2.3.2.27)
Alternative name(s):
Proliferation potential-related protein
Protein P2P-R
RING-type E3 ubiquitin transferase RBBP6Curated
Retinoblastoma-binding Q protein 1
Short name:
RBQ-1
Retinoblastoma-binding protein 6
p53-associated cellular protein of testis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBBP6
Synonyms:P2PR, PACT, RBQ1
ORF Names:My038
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000122257.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9889 RBBP6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
600938 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z6E9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5930

Open Targets

More...
OpenTargetsi
ENSG00000122257

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34253

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RBBP6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762440

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002343541 – 1792E3 ubiquitin-protein ligase RBBP6Add BLAST1792

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei130N6-acetyllysineBy similarity1
Modified residuei244PhosphoserineCombined sources1
Modified residuei245PhosphoserineCombined sources1
Modified residuei246PhosphoserineCombined sources1
Modified residuei247PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei516PhosphoserineCombined sources1
Modified residuei768PhosphoserineCombined sources1
Modified residuei770PhosphoserineCombined sources1
Modified residuei772PhosphoserineCombined sources1
Modified residuei780PhosphoserineCombined sources1
Modified residuei815PhosphoserineCombined sources1
Modified residuei861PhosphoserineCombined sources1
Modified residuei873PhosphoserineCombined sources1
Modified residuei957PhosphoserineCombined sources1
Modified residuei984PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki1106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki1169Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1179PhosphoserineCombined sources1
Modified residuei1221PhosphoserineCombined sources1
Modified residuei1271PhosphothreonineBy similarity1
Modified residuei1277PhosphoserineCombined sources1
Modified residuei1328PhosphoserineCombined sources1
Modified residuei1341PhosphoserineCombined sources1
Modified residuei1347PhosphoserineCombined sources1
Modified residuei1468PhosphothreonineCombined sources1
Modified residuei1646PhosphoserineCombined sources1
Modified residuei1648PhosphoserineCombined sources1
Modified residuei1651PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by NEK6.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q7Z6E9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7Z6E9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q7Z6E9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z6E9

PeptideAtlas

More...
PeptideAtlasi
Q7Z6E9

PRoteomics IDEntifications database

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PRIDEi
Q7Z6E9

ProteomicsDB human proteome resource

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ProteomicsDBi
69396
69397 [Q7Z6E9-2]
69398 [Q7Z6E9-3]
69399 [Q7Z6E9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q7Z6E9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q7Z6E9

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
Q7Z6E9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the placenta and testis. Expressed at lower levels in the brain, heart, kidney, liver and lung. Overexpressed in esophageal cancer.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000122257 Expressed in 229 organ(s), highest expression level in placenta

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7Z6E9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7Z6E9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB032866
HPA041725
HPA043544

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with p53/TP53 and RB1 (By similarity). Interacts also with MDM2 and YBX1. Interacts with NEK6. Interacts with ZBTB38.By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SRSF7Q166293EBI-2117026,EBI-398885

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111865, 103 interactors

Database of interacting proteins

More...
DIPi
DIP-46897N

Protein interaction database and analysis system

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IntActi
Q7Z6E9, 37 interactors

Molecular INTeraction database

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MINTi
Q7Z6E9

STRING: functional protein association networks

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STRINGi
9606.ENSP00000317872

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11792
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C7HNMR-A1-81[»]
2YSANMR-A159-206[»]
2YURNMR-A249-309[»]
3ZTGNMR-A/B249-335[»]
6E5XX-ray1.50B554-568[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q7Z6E9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7Z6E9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7Z6E9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 76DWNNPROSITE-ProRule annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni982 – 1139Interaction with RB1By similarityAdd BLAST158
Regioni1433 – 1544Interaction with p53By similarityAdd BLAST112

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri159 – 176CCHC-typePROSITE-ProRule annotationAdd BLAST18
Zinc fingeri259 – 300RING-type; degeneratePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0314 Eukaryota
COG5222 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157561

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG093889

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z6E9

KEGG Orthology (KO)

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KOi
K10624

Identification of Orthologs from Complete Genome Data

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OMAi
TYDTKRP

Database of Orthologous Groups

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OrthoDBi
81368at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z6E9

TreeFam database of animal gene trees

More...
TreeFami
TF350543

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014891 DWNN_domain
IPR033489 RBBP6
IPR003613 Ubox_domain
IPR025829 Zn_knuckle_CX2CX3GHX4C
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

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PANTHERi
PTHR15439:SF3 PTHR15439:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08783 DWNN, 1 hit
PF04564 U-box, 1 hit
PF13696 zf-CCHC_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01180 DWNN, 1 hit
SM00184 RING, 1 hit
SM00343 ZnF_C2HC, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57756 SSF57756, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51282 DWNN, 1 hit
PS50158 ZF_CCHC, 1 hit
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z6E9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSCVHYKFSS KLNYDTVTFD GLHISLCDLK KQIMGREKLK AADCDLQITN
60 70 80 90 100
AQTKEEYTDD NALIPKNSSV IVRRIPIGGV KSTSKTYVIS RTEPAMATTK
110 120 130 140 150
AIDDSSASIS LAQLTKTANL AEANASEEDK IKAMMSQSGH EYDPINYMKK
160 170 180 190 200
PLGPPPPSYT CFRCGKPGHY IKNCPTNGDK NFESGPRIKK STGIPRSFMM
210 220 230 240 250
EVKDPNMKGA MLTNTGKYAI PTIDAEAYAI GKKEKPPFLP EEPSSSSEED
260 270 280 290 300
DPIPDELLCL ICKDIMTDAV VIPCCGNSYC DECIRTALLE SDEHTCPTCH
310 320 330 340 350
QNDVSPDALI ANKFLRQAVN NFKNETGYTK RLRKQLPPPP PPIPPPRPLI
360 370 380 390 400
QRNLQPLMRS PISRQQDPLM IPVTSSSTHP APSISSLTSN QSSLAPPVSG
410 420 430 440 450
NPSSAPAPVP DITATVSISV HSEKSDGPFR DSDNKILPAA ALASEHSKGT
460 470 480 490 500
SSIAITALME EKGYQVPVLG TPSLLGQSLL HGQLIPTTGP VRINTARPGG
510 520 530 540 550
GRPGWEHSNK LGYLVSPPQQ IRRGERSCYR SINRGRHHSE RSQRTQGPSL
560 570 580 590 600
PATPVFVPVP PPPLYPPPPH TLPLPPGVPP PQFSPQFPPG QPPPAGYSVP
610 620 630 640 650
PPGFPPAPAN LSTPWVSSGV QTAHSNTIPT TQAPPLSREE FYREQRRLKE
660 670 680 690 700
EEKKKSKLDE FTNDFAKELM EYKKIQKERR RSFSRSKSPY SGSSYSRSSY
710 720 730 740 750
TYSKSRSGST RSRSYSRSFS RSHSRSYSRS PPYPRRGRGK SRNYRSRSRS
760 770 780 790 800
HGYHRSRSRS PPYRRYHSRS RSPQAFRGQS PNKRNVPQGE TEREYFNRYR
810 820 830 840 850
EVPPPYDMKA YYGRSVDFRD PFEKERYREW ERKYREWYEK YYKGYAAGAQ
860 870 880 890 900
PRPSANRENF SPERFLPLNI RNSPFTRGRR EDYVGGQSHR SRNIGSNYPE
910 920 930 940 950
KLSARDGHNQ KDNTKSKEKE SENAPGDGKG NKHKKHRKRR KGEESEGFLN
960 970 980 990 1000
PELLETSRKS REPTGVEENK TDSLFVLPSR DDATPVRDEP MDAESITFKS
1010 1020 1030 1040 1050
VSEKDKRERD KPKAKGDKTK RKNDGSAVSK KENIVKPAKG PQEKVDGERE
1060 1070 1080 1090 1100
RSPRSEPPIK KAKEETPKTD NTKSSSSSQK DEKITGTPRK AHSKSAKEHQ
1110 1120 1130 1140 1150
ETKPVKEEKV KKDYSKDVKS EKLTTKEEKA KKPNEKNKPL DNKGEKRKRK
1160 1170 1180 1190 1200
TEEKGVDKDF ESSSMKISKL EVTEIVKPSP KRKMEPDTEK MDRTPEKDKI
1210 1220 1230 1240 1250
SLSAPAKKIK LNRETGKKIG STENISNTKE PSEKLESTSS KVKQEKVKGK
1260 1270 1280 1290 1300
VRRKVTGTEG SSSTLVDYTS TSSTGGSPVR KSEEKTDTKR TVIKTMEEYN
1310 1320 1330 1340 1350
NDNTAPAEDV IIMIQVPQSK WDKDDFESEE EDVKSTQPIS SVGKPASVIK
1360 1370 1380 1390 1400
NVSTKPSNIV KYPEKESEPS EKIQKFTKDV SHEIIQHEVK SSKNSASSEK
1410 1420 1430 1440 1450
GKTKDRDYSV LEKENPEKRK NSTQPEKESN LDRLNEQGNF KSLSQSSKEA
1460 1470 1480 1490 1500
RTSDKHDSTR ASSNKDFTPN RDKKTDYDTR EYSSSKRRDE KNELTRRKDS
1510 1520 1530 1540 1550
PSRNKDSASG QKNKPREERD LPKKGTGDSK KSNSSPSRDR KPHDHKATYD
1560 1570 1580 1590 1600
TKRPNEETKS VDKNPCKDRE KHVLEARNNK ESSGNKLLYI LNPPETQVEK
1610 1620 1630 1640 1650
EQITGQIDKS TVKPKPQLSH SSRLSSDLTR ETDEAAFEPD YNESDSESNV
1660 1670 1680 1690 1700
SVKEEESSGN ISKDLKDKIV EKAKESLDTA AVVQVGISRN QSHSSPSVSP
1710 1720 1730 1740 1750
SRSHSPSGSQ TRSHSSSASS AESQDSKKKK KKKEKKKHKK HKKHKKHKKH
1760 1770 1780 1790
AGTEVELEKS QKHKHKKKKS KKNKDKEKEK EKDDQKVKSV TV
Length:1,792
Mass (Da):201,564
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i550F7BBA5125DA06
GO
Isoform 2 (identifier: Q7Z6E9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     652-685: Missing.

Show »
Length:1,758
Mass (Da):197,287
Checksum:i5062A3FBA5BB5255
GO
Isoform 3 (identifier: Q7Z6E9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-117: IDDSSASISLAQLTKT → VCKNTISHFFYTLLLPL
     118-1792: Missing.

Note: No experimental confirmation available.
Show »
Length:118
Mass (Da):13,235
Checksum:i18B6431D0D740828
GO
Isoform 4 (identifier: Q7Z6E9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-1270: Missing.

Note: No experimental confirmation available.
Show »
Length:952
Mass (Da):106,037
Checksum:iBC28F8CCB1EED8E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSK8H3BSK8_HUMAN
E3 ubiquitin-protein ligase RBBP6
RBBP6
1,008Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUN0H3BUN0_HUMAN
E3 ubiquitin-protein ligase RBBP6
RBBP6
300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY32A0A087WY32_HUMAN
E3 ubiquitin-protein ligase RBBP6
RBBP6
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y880A0A2R8Y880_HUMAN
E3 ubiquitin-protein ligase RBBP6
RBBP6
1,759Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3Y2I3L3Y2_HUMAN
E3 ubiquitin-protein ligase RBBP6
RBBP6
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG43155 differs from that shown. Intron retention.Curated
The sequence AAH63524 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAL05625 differs from that shown. Reason: Frameshift at position 198.Curated
The sequence AAL68925 differs from that shown. Intron retention.Curated
The sequence CAA59445 differs from that shown. Reason: Frameshift at positions 198, 1048 and 1098.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti223I → T in AAL68925 (Ref. 5) Curated1
Sequence conflicti1633D → H in AAL68925 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05130643D → H. Corresponds to variant dbSNP:rs16973796Ensembl.1
Natural variantiVAR_026216555V → A. Corresponds to variant dbSNP:rs16973840Ensembl.1
Natural variantiVAR_0513071208K → I. Corresponds to variant dbSNP:rs3743968Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_018281102 – 117IDDSS…QLTKT → VCKNTISHFFYTLLLPL in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_018282118 – 1792Missing in isoform 3. 1 PublicationAdd BLAST1675
Alternative sequenceiVSP_018283431 – 1270Missing in isoform 4. 1 PublicationAdd BLAST840
Alternative sequenceiVSP_018284652 – 685Missing in isoform 2. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB112074 mRNA Translation: BAC77636.1
AB112075 mRNA Translation: BAC77637.1
CH471145 Genomic DNA Translation: EAW55789.1
BC029352 mRNA Translation: AAH29352.1
BC063524 mRNA Translation: AAH63524.1 Sequence problems.
BC073938 mRNA Translation: AAH73938.1
BC101139 mRNA Translation: AAI01140.1
BC101140 mRNA Translation: AAI01141.1
BC101141 mRNA Translation: AAI01142.1
BC101142 mRNA Translation: AAI01143.1
BC114353 mRNA Translation: AAI14354.1
BC114354 mRNA Translation: AAI14355.1
BC118667 mRNA Translation: AAI18668.1
BC139830 mRNA Translation: AAI39831.1
AF063596 mRNA Translation: AAG43155.1 Sequence problems.
AY072922 mRNA Translation: AAL68925.1 Sequence problems.
AF352051 mRNA Translation: AAL05625.1 Frameshift.
X85133 mRNA Translation: CAA59445.1 Frameshift.
AK026954 mRNA Translation: BAB15600.1
AL359564 mRNA Translation: CAB94869.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10621.1 [Q7Z6E9-1]
CCDS10622.1 [Q7Z6E9-2]
CCDS45444.1 [Q7Z6E9-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
A57640
T50609

NCBI Reference Sequences

More...
RefSeqi
NP_008841.2, NM_006910.4 [Q7Z6E9-1]
NP_061173.1, NM_018703.3 [Q7Z6E9-2]
NP_116015.2, NM_032626.5 [Q7Z6E9-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.188553

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319715; ENSP00000317872; ENSG00000122257 [Q7Z6E9-1]
ENST00000348022; ENSP00000316291; ENSG00000122257 [Q7Z6E9-2]
ENST00000381039; ENSP00000370427; ENSG00000122257 [Q7Z6E9-4]
ENST00000452655; ENSP00000390537; ENSG00000122257 [Q7Z6E9-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5930

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5930

UCSC genome browser

More...
UCSCi
uc002dmg.4 human [Q7Z6E9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB112074 mRNA Translation: BAC77636.1
AB112075 mRNA Translation: BAC77637.1
CH471145 Genomic DNA Translation: EAW55789.1
BC029352 mRNA Translation: AAH29352.1
BC063524 mRNA Translation: AAH63524.1 Sequence problems.
BC073938 mRNA Translation: AAH73938.1
BC101139 mRNA Translation: AAI01140.1
BC101140 mRNA Translation: AAI01141.1
BC101141 mRNA Translation: AAI01142.1
BC101142 mRNA Translation: AAI01143.1
BC114353 mRNA Translation: AAI14354.1
BC114354 mRNA Translation: AAI14355.1
BC118667 mRNA Translation: AAI18668.1
BC139830 mRNA Translation: AAI39831.1
AF063596 mRNA Translation: AAG43155.1 Sequence problems.
AY072922 mRNA Translation: AAL68925.1 Sequence problems.
AF352051 mRNA Translation: AAL05625.1 Frameshift.
X85133 mRNA Translation: CAA59445.1 Frameshift.
AK026954 mRNA Translation: BAB15600.1
AL359564 mRNA Translation: CAB94869.1
CCDSiCCDS10621.1 [Q7Z6E9-1]
CCDS10622.1 [Q7Z6E9-2]
CCDS45444.1 [Q7Z6E9-3]
PIRiA57640
T50609
RefSeqiNP_008841.2, NM_006910.4 [Q7Z6E9-1]
NP_061173.1, NM_018703.3 [Q7Z6E9-2]
NP_116015.2, NM_032626.5 [Q7Z6E9-3]
UniGeneiHs.188553

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C7HNMR-A1-81[»]
2YSANMR-A159-206[»]
2YURNMR-A249-309[»]
3ZTGNMR-A/B249-335[»]
6E5XX-ray1.50B554-568[»]
ProteinModelPortaliQ7Z6E9
SMRiQ7Z6E9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111865, 103 interactors
DIPiDIP-46897N
IntActiQ7Z6E9, 37 interactors
MINTiQ7Z6E9
STRINGi9606.ENSP00000317872

PTM databases

iPTMnetiQ7Z6E9
PhosphoSitePlusiQ7Z6E9

Polymorphism and mutation databases

BioMutaiRBBP6
DMDMi74762440

Proteomic databases

EPDiQ7Z6E9
jPOSTiQ7Z6E9
MaxQBiQ7Z6E9
PaxDbiQ7Z6E9
PeptideAtlasiQ7Z6E9
PRIDEiQ7Z6E9
ProteomicsDBi69396
69397 [Q7Z6E9-2]
69398 [Q7Z6E9-3]
69399 [Q7Z6E9-4]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5930
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319715; ENSP00000317872; ENSG00000122257 [Q7Z6E9-1]
ENST00000348022; ENSP00000316291; ENSG00000122257 [Q7Z6E9-2]
ENST00000381039; ENSP00000370427; ENSG00000122257 [Q7Z6E9-4]
ENST00000452655; ENSP00000390537; ENSG00000122257 [Q7Z6E9-3]
GeneIDi5930
KEGGihsa:5930
UCSCiuc002dmg.4 human [Q7Z6E9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5930
DisGeNETi5930
EuPathDBiHostDB:ENSG00000122257.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RBBP6
HGNCiHGNC:9889 RBBP6
HPAiCAB032866
HPA041725
HPA043544
MIMi600938 gene
neXtProtiNX_Q7Z6E9
OpenTargetsiENSG00000122257
PharmGKBiPA34253

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0314 Eukaryota
COG5222 LUCA
GeneTreeiENSGT00940000157561
HOVERGENiHBG093889
InParanoidiQ7Z6E9
KOiK10624
OMAiTYDTKRP
OrthoDBi81368at2759
PhylomeDBiQ7Z6E9
TreeFamiTF350543

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
RBBP6 human
EvolutionaryTraceiQ7Z6E9

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RBBP6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5930
PMAP-CutDBiQ7Z6E9

Protein Ontology

More...
PROi
PR:Q7Z6E9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000122257 Expressed in 229 organ(s), highest expression level in placenta
ExpressionAtlasiQ7Z6E9 baseline and differential
GenevisibleiQ7Z6E9 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR014891 DWNN_domain
IPR033489 RBBP6
IPR003613 Ubox_domain
IPR025829 Zn_knuckle_CX2CX3GHX4C
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR15439:SF3 PTHR15439:SF3, 1 hit
PfamiView protein in Pfam
PF08783 DWNN, 1 hit
PF04564 U-box, 1 hit
PF13696 zf-CCHC_2, 1 hit
SMARTiView protein in SMART
SM01180 DWNN, 1 hit
SM00184 RING, 1 hit
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS51282 DWNN, 1 hit
PS50158 ZF_CCHC, 1 hit
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBBP6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z6E9
Secondary accession number(s): Q147T5
, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2003
Last modified: February 13, 2019
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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