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Protein

B- and T-lymphocyte attenuator

Gene

BTLA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-388841 Costimulation by the CD28 family

Names & Taxonomyi

Protein namesi
Recommended name:
B- and T-lymphocyte attenuator
Alternative name(s):
B- and T-lymphocyte-associated protein
CD_antigen: CD272
Gene namesi
Name:BTLA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000186265.9
HGNCiHGNC:21087 BTLA
MIMi607925 gene
neXtProtiNX_Q7Z6A9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 157ExtracellularSequence analysisAdd BLAST127
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 289CytoplasmicSequence analysisAdd BLAST111

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi226Y → F: No change of phosphorylation implicated in interaction with PTPN6 and PTPN11. Severe reduction of phosphorylation; when associated with F-257 and/or F-282. 2 Publications1
Mutagenesisi257Y → F: No change of phosphorylation implicated in interaction with PTPN6 and PTPN11. Severe reduction of phosphorylation; when associated with F-226 and/or F-282. 2 Publications1
Mutagenesisi282Y → F: No change of phosphorylation implicated in interaction with PTPN6 and PTPN11. Severe reduction of phosphorylation; when associated with F-226 and/or F-257. 2 Publications1

Organism-specific databases

DisGeNETi151888
OpenTargetsiENSG00000186265
PharmGKBiPA134968341

Polymorphism and mutation databases

BioMutaiBTLA
DMDMi296439425

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001452331 – 289B- and T-lymphocyte attenuatorAdd BLAST259

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 63PROSITE-ProRule annotation1 Publication
Disulfide bondi58 ↔ 115PROSITE-ProRule annotation1 Publication
Disulfide bondi72 ↔ 79PROSITE-ProRule annotation1 Publication
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.1 Publication
N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ7Z6A9
PeptideAtlasiQ7Z6A9
PRIDEiQ7Z6A9
ProteomicsDBi69387
69388 [Q7Z6A9-2]
TopDownProteomicsiQ7Z6A9-1 [Q7Z6A9-1]
Q7Z6A9-2 [Q7Z6A9-2]

PTM databases

iPTMnetiQ7Z6A9
PhosphoSitePlusiQ7Z6A9
SwissPalmiQ7Z6A9

Expressioni

Gene expression databases

BgeeiENSG00000186265 Expressed in 95 organ(s), highest expression level in leukocyte
CleanExiHS_BTLA
GenevisibleiQ7Z6A9 HS

Organism-specific databases

HPAiHPA047211
HPA062029

Interactioni

Subunit structurei

Interacts with tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Interacts with TNFRSF14/HVEM.4 Publications

Protein-protein interaction databases

BioGridi127411, 7 interactors
DIPiDIP-48795N
IntActiQ7Z6A9, 3 interactors
MINTiQ7Z6A9
STRINGi9606.ENSP00000333919

Structurei

Secondary structure

1289
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ7Z6A9
SMRiQ7Z6A9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z6A9

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 132Ig-like V-typeAdd BLAST102

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYZD Eukaryota
ENOG410ZATJ LUCA
GeneTreeiENSGT00390000017390
HOGENOMiHOG000168895
HOVERGENiHBG080937
InParanoidiQ7Z6A9
KOiK06707
OMAiCFYLFCC
OrthoDBiEOG091G0I5G
PhylomeDBiQ7Z6A9
TreeFamiTF337694

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR039257 BTLA
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PANTHERiPTHR37996 PTHR37996, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z6A9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKTLPAMLGT GKLFWVFFLI PYLDIWNIHG KESCDVQLYI KRQSEHSILA
60 70 80 90 100
GDPFELECPV KYCANRPHVT WCKLNGTTCV KLEDRQTSWK EEKNISFFIL
110 120 130 140 150
HFEPVLPNDN GSYRCSANFQ SNLIESHSTT LYVTDVKSAS ERPSKDEMAS
160 170 180 190 200
RPWLLYRLLP LGGLPLLITT CFCLFCCLRR HQGKQNELSD TAGREINLVD
210 220 230 240 250
AHLKSEQTEA STRQNSQVLL SETGIYDNDP DLCFRMQEGS EVYSNPCLEE
260 270 280
NKPGIVYASL NHSVIGPNSR LARNVKEAPT EYASICVRS
Length:289
Mass (Da):32,834
Last modified:May 18, 2010 - v3
Checksum:iF4D1FF775D7D33F3
GO
Isoform 2 (identifier: Q7Z6A9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-182: Missing.

Show »
Length:241
Mass (Da):27,317
Checksum:i991AFF2495C3F612
GO

Sequence cautioni

The sequence BAD18396 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti105V → M in AAP44003 (PubMed:12796776).Curated1
Sequence conflicti138S → G in AAP44003 (PubMed:12796776).Curated1
Sequence conflicti148M → V in AAP44003 (PubMed:12796776).Curated1
Sequence conflicti171C → W in AAP44003 (PubMed:12796776).Curated1
Sequence conflicti219L → P in BAD18396 (PubMed:14702039).Curated1
Sequence conflicti223T → A in AAP44003 (PubMed:12796776).Curated1
Sequence conflicti243Y → C in AAP44003 (PubMed:12796776).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056027124I → V. Corresponds to variant dbSNP:rs16859633Ensembl.1
Natural variantiVAR_027607157R → S3 PublicationsCorresponds to variant dbSNP:rs2931761Ensembl.1
Natural variantiVAR_027608267P → L5 PublicationsCorresponds to variant dbSNP:rs9288952Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040305135 – 182Missing in isoform 2. 3 PublicationsAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY293286 mRNA Translation: AAP44003.1
AY599411 mRNA Translation: AAT44901.1
DQ198368 mRNA Translation: ABA54407.1
AC092894 Genomic DNA No translation available.
BC107091 mRNA Translation: AAI07092.1
BC107092 mRNA Translation: AAI07093.1
AK131204 mRNA Translation: BAD18396.1 Different initiation.
CCDSiCCDS33819.1 [Q7Z6A9-1]
CCDS43130.1 [Q7Z6A9-2]
RefSeqiNP_001078826.1, NM_001085357.1 [Q7Z6A9-2]
NP_861445.3, NM_181780.3
XP_016861237.1, XM_017005748.1 [Q7Z6A9-1]
UniGeneiHs.445162

Genome annotation databases

EnsembliENST00000334529; ENSP00000333919; ENSG00000186265 [Q7Z6A9-1]
ENST00000383680; ENSP00000373178; ENSG00000186265 [Q7Z6A9-2]
GeneIDi151888
KEGGihsa:151888
UCSCiuc003dza.5 human [Q7Z6A9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY293286 mRNA Translation: AAP44003.1
AY599411 mRNA Translation: AAT44901.1
DQ198368 mRNA Translation: ABA54407.1
AC092894 Genomic DNA No translation available.
BC107091 mRNA Translation: AAI07092.1
BC107092 mRNA Translation: AAI07093.1
AK131204 mRNA Translation: BAD18396.1 Different initiation.
CCDSiCCDS33819.1 [Q7Z6A9-1]
CCDS43130.1 [Q7Z6A9-2]
RefSeqiNP_001078826.1, NM_001085357.1 [Q7Z6A9-2]
NP_861445.3, NM_181780.3
XP_016861237.1, XM_017005748.1 [Q7Z6A9-1]
UniGeneiHs.445162

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AW2X-ray2.80A/X26-137[»]
ProteinModelPortaliQ7Z6A9
SMRiQ7Z6A9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127411, 7 interactors
DIPiDIP-48795N
IntActiQ7Z6A9, 3 interactors
MINTiQ7Z6A9
STRINGi9606.ENSP00000333919

PTM databases

iPTMnetiQ7Z6A9
PhosphoSitePlusiQ7Z6A9
SwissPalmiQ7Z6A9

Polymorphism and mutation databases

BioMutaiBTLA
DMDMi296439425

Proteomic databases

PaxDbiQ7Z6A9
PeptideAtlasiQ7Z6A9
PRIDEiQ7Z6A9
ProteomicsDBi69387
69388 [Q7Z6A9-2]
TopDownProteomicsiQ7Z6A9-1 [Q7Z6A9-1]
Q7Z6A9-2 [Q7Z6A9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334529; ENSP00000333919; ENSG00000186265 [Q7Z6A9-1]
ENST00000383680; ENSP00000373178; ENSG00000186265 [Q7Z6A9-2]
GeneIDi151888
KEGGihsa:151888
UCSCiuc003dza.5 human [Q7Z6A9-1]

Organism-specific databases

CTDi151888
DisGeNETi151888
EuPathDBiHostDB:ENSG00000186265.9
GeneCardsiBTLA
HGNCiHGNC:21087 BTLA
HPAiHPA047211
HPA062029
MIMi607925 gene
neXtProtiNX_Q7Z6A9
OpenTargetsiENSG00000186265
PharmGKBiPA134968341
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYZD Eukaryota
ENOG410ZATJ LUCA
GeneTreeiENSGT00390000017390
HOGENOMiHOG000168895
HOVERGENiHBG080937
InParanoidiQ7Z6A9
KOiK06707
OMAiCFYLFCC
OrthoDBiEOG091G0I5G
PhylomeDBiQ7Z6A9
TreeFamiTF337694

Enzyme and pathway databases

ReactomeiR-HSA-388841 Costimulation by the CD28 family

Miscellaneous databases

EvolutionaryTraceiQ7Z6A9
GeneWikiiBTLA
GenomeRNAii151888
PROiPR:Q7Z6A9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186265 Expressed in 95 organ(s), highest expression level in leukocyte
CleanExiHS_BTLA
GenevisibleiQ7Z6A9 HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR039257 BTLA
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013151 Immunoglobulin
PANTHERiPTHR37996 PTHR37996, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBTLA_HUMAN
AccessioniPrimary (citable) accession number: Q7Z6A9
Secondary accession number(s): Q3B831, Q3HS85, Q6ZNH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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