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Entry version 159 (29 Sep 2021)
Sequence version 2 (04 Jan 2005)
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Protein

Sprouty-related, EVH1 domain-containing protein 1

Gene

SPRED1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity).

Negatively regulates hematopoiesis of bone marrow (By similarity).

Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity).

Attenuates actin stress fiber formation via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:18216281).

Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q7Z699

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-5658442, Regulation of RAS by GAPs
R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling
R-HSA-6802953, RAS signaling downstream of NF1 loss-of-function variants

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 1
Short name:
Spred-1
Short name:
hSpred1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPRED1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:20249, SPRED1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609291, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q7Z699

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000166068

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Legius syndrome (LGSS)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant syndrome characterized mainly by cafe-au-lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities, and features of attention-deficit hyperactivity disorder.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06482731W → C in LGSS. 1 Publication1
Natural variantiVAR_06482844V → D in LGSS. 2 PublicationsCorresponds to variant dbSNP:rs121434318EnsemblClinVar.1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

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DisGeNETi
161742

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
SPRED1

MalaCards human disease database

More...
MalaCardsi
SPRED1
MIMi611431, phenotype

Open Targets

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OpenTargetsi
ENSG00000166068

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
137605, Legius syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134897382

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q7Z699, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SPRED1

Domain mapping of disease mutations (DMDM)

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DMDMi
57013078

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000769072 – 444Sprouty-related, EVH1 domain-containing protein 1Add BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei224N6-methyllysineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei308PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated by ZDHHC17/HIP14.By similarity
Phosphorylated on tyrosine.1 Publication
Ubiquitinated.1 Publication

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-1563

Encyclopedia of Proteome Dynamics

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EPDi
Q7Z699

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7Z699

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q7Z699

MaxQB - The MaxQuant DataBase

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MaxQBi
Q7Z699

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7Z699

PeptideAtlas

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PeptideAtlasi
Q7Z699

PRoteomics IDEntifications database

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PRIDEi
Q7Z699

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
69386

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q7Z699

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q7Z699

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q7Z699

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Weakly expressed in embryonic cell line HEK293.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000166068, Expressed in intestine and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7Z699, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7Z699, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166068, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and heterodimer (PubMed:15683364). Able to interact with SPRED2 to form heterodimers (PubMed:15683364).

Interacts (via C-terminus) with TAOK1/MARKK (via C-terminus); the interaction does not affect TAOK1 kinase activity (PubMed:18216281).

Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction inhibits TESK1 kinase activity (PubMed:18216281).

Interacts with CAV1 (PubMed:16115197).

Interacts with RAS (By similarity).

Interacts with palmitoyltransferase ZDHHC17/HIP14; the interaction leads to palmitoylation of SPRED1 (PubMed:24705354).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q7Z699
With#Exp.IntAct
ABLIM2 - isoform 8 [Q6H8Q1-8]3EBI-5235340,EBI-16436655
ACBD4 - isoform 3 [Q8NC06-3]3EBI-5235340,EBI-12811089
ACD [A0A590TQL1]3EBI-5235340,EBI-23197871
ACRV1 [P26436]3EBI-5235340,EBI-25884472
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-5235340,EBI-10173507
ADAT2 [Q7Z6V5]3EBI-5235340,EBI-2809203
AGO2 [Q9UKV8]3EBI-5235340,EBI-528269
AKR1C1 [Q04828]3EBI-5235340,EBI-2116455
ALOX5 [P09917]3EBI-5235340,EBI-79934
ANKRD13D - isoform 2 [Q6ZTN6-2]3EBI-5235340,EBI-25840993
ANKRD23 [Q86SG2]3EBI-5235340,EBI-5661893
ANKS1A [Q49AR9]3EBI-5235340,EBI-11954519
AP3M2 - isoform 2 [P53677-2]3EBI-5235340,EBI-12177015
APLN [D3DTF8]3EBI-5235340,EBI-22002556
APRT [P07741]3EBI-5235340,EBI-1047565
AQP1 [P29972]3EBI-5235340,EBI-745213
ARHGEF38 - isoform 1 [Q9NXL2-1]3EBI-5235340,EBI-18172597
ARPP21 - isoform 2 [Q9UBL0-2]3EBI-5235340,EBI-25931672
ASB13 [Q8WXK3]3EBI-5235340,EBI-707573
ASB13 - isoform 2 [Q8WXK3-2]3EBI-5235340,EBI-12015080
ASB3 - isoform 3 [Q9Y575-3]3EBI-5235340,EBI-14199987
ASB9 - isoform 3 [Q96DX5-3]3EBI-5235340,EBI-25843552
ASCL4 [Q6XD76]3EBI-5235340,EBI-10254793
ASIC4 - isoform 3 [Q96FT7-4]3EBI-5235340,EBI-9089489
ATL1 [Q8WXF7]3EBI-5235340,EBI-2410266
ATP5IF1 [Q9UII2]3EBI-5235340,EBI-718459
ATXN7L1 - isoform 2 [Q9ULK2-2]3EBI-5235340,EBI-21568482
AXIN1 [O15169]3EBI-5235340,EBI-710484
BAG6 - isoform 2 [P46379-2]3EBI-5235340,EBI-10988864
BAHD1 [Q8TBE0]3EBI-5235340,EBI-742750
BAK1 [Q16611]3EBI-5235340,EBI-519866
BATF [Q16520]3EBI-5235340,EBI-749503
BEX2 [Q9BXY8]3EBI-5235340,EBI-745073
BEX3 [Q00994]3EBI-5235340,EBI-741753
BEX5 [Q5H9J7]3EBI-5235340,EBI-10243741
BLZF1 [Q9H2G9]3EBI-5235340,EBI-2548012
BRK1 [Q8WUW1]3EBI-5235340,EBI-2837444
BRPF3 - isoform 2 [Q9ULD4-2]3EBI-5235340,EBI-23662416
C12orf74 [Q32Q52]3EBI-5235340,EBI-12891828
C1orf216 [Q8TAB5]3EBI-5235340,EBI-747505
C22orf39 [Q6P5X5]3EBI-5235340,EBI-7317823
C2orf68 [Q2NKX9]3EBI-5235340,EBI-11603468
C3orf62 [Q6ZUJ4]3EBI-5235340,EBI-2837036
C8orf48 [Q96LL4]3EBI-5235340,EBI-751596
CAB39L [Q9H9S4]3EBI-5235340,EBI-1047244
CALM3 [P0DP24]3EBI-5235340,EBI-397435
CAPG [P40121]3EBI-5235340,EBI-4291044
CBX2 - isoform 2 [Q14781-2]3EBI-5235340,EBI-11974585
CCDC158 - isoform 2 [Q5M9N0-2]3EBI-5235340,EBI-21796846
CCDC185 [Q8N715]3EBI-5235340,EBI-740814
CCER1 [Q8TC90]3EBI-5235340,EBI-746041
CCNC [P24863]3EBI-5235340,EBI-395261
CD27 [P26842]3EBI-5235340,EBI-520729
CDC23 [Q9UJX2]3EBI-5235340,EBI-396137
CDCA7L - isoform 2 [Q96GN5-2]3EBI-5235340,EBI-9091443
CDKN1A [P38936]4EBI-5235340,EBI-375077
CDS2 [O95674]3EBI-5235340,EBI-3913685
CENPS [Q8N2Z9]3EBI-5235340,EBI-5529649
CENPV [Q7Z7K6]3EBI-5235340,EBI-1210604
CEP41 - isoform 2 [Q9BYV8-2]3EBI-5235340,EBI-25843412
CEP43 - isoform 2 [O95684-2]3EBI-5235340,EBI-1266347
CEP57 [Q86XR8]3EBI-5235340,EBI-308614
CEP70 - isoform 3 [Q8NHQ1-3]3EBI-5235340,EBI-11526150
CFAP100 - isoform 2 [Q494V2-2]3EBI-5235340,EBI-11953200
CHMP7 [Q8WUX9]3EBI-5235340,EBI-749253
CIB1 [Q99828]3EBI-5235340,EBI-372594
CLCN7 [P51798]3EBI-5235340,EBI-4402346
CNPY3 [Q9BT09]3EBI-5235340,EBI-2835965
COA7 [Q96BR5]3EBI-5235340,EBI-6269632
COMMD2 [Q86X83]3EBI-5235340,EBI-1550220
COX17 [Q14061]3EBI-5235340,EBI-711311
CRACR2A [Q9BSW2]3EBI-5235340,EBI-739773
CREB5 - isoform 3 [Q02930-3]6EBI-5235340,EBI-10192698
CRELD2 - isoform 2 [Q6UXH1-2]3EBI-5235340,EBI-21670927
CRLF3 [Q8IUI8]3EBI-5235340,EBI-2872414
CSTA [P01040]3EBI-5235340,EBI-724303
CTNNB1 [P35222]3EBI-5235340,EBI-491549
CTSC [P53634]3EBI-5235340,EBI-1047323
CXorf38 [Q8TB03]3EBI-5235340,EBI-12024320
CYFIP1 [Q7L576]3EBI-5235340,EBI-1048143
CYTIP [O60759]3EBI-5235340,EBI-997814
DAXX [Q9UER7]3EBI-5235340,EBI-77321
DBF4B - isoform 2 [Q8NFT6-2]3EBI-5235340,EBI-12205861
DCAF8 - isoform 2 [Q5TAQ9-2]3EBI-5235340,EBI-25842815
DCLRE1B [Q9H816]3EBI-5235340,EBI-3508943
DIS3L - isoform 4 [Q8TF46-4]3EBI-5235340,EBI-25933135
DLK1 [P80370]3EBI-5235340,EBI-21555397
DNTTIP1 [Q9H147]3EBI-5235340,EBI-2795449
DPF1 - isoform 2 [Q92782-2]3EBI-5235340,EBI-23669343
DPYSL4 [O14531]3EBI-5235340,EBI-719542
DRG2 [P55039]3EBI-5235340,EBI-750565
DTX3 [Q8N9I9]3EBI-5235340,EBI-2340258
EBF1 [Q9UH73]3EBI-5235340,EBI-765426
EED - isoform 2 [O75530-2]3EBI-5235340,EBI-11132357
EIF3F [O00303]3EBI-5235340,EBI-711990
EIF4ENIF1 [Q9NRA8]3EBI-5235340,EBI-301024
EPHB2 - isoform 3 [P29323-3]3EBI-5235340,EBI-25838727
EPS8L2 [Q9H6S3]3EBI-5235340,EBI-3940939
ERVK3-1 [Q96A10]3EBI-5235340,EBI-10486892
EURL - isoform 3 [Q9NYK6-3]3EBI-5235340,EBI-13371226
EXOC5 [O00471]3EBI-5235340,EBI-949824
EXOC6 [Q8TAG9]3EBI-5235340,EBI-1223394
EXTL2 [Q9UBQ6]3EBI-5235340,EBI-21506125
EZH2 - isoform 2 [Q15910-2]3EBI-5235340,EBI-10699473
FABP7 [O15540]3EBI-5235340,EBI-10697159
FAF1 [Q9UNN5]3EBI-5235340,EBI-718246
FAM161A [Q3B820]3EBI-5235340,EBI-719941
FAM221A [A4D161]3EBI-5235340,EBI-11960181
FAM221B - isoform 3 [A6H8Z2-3]3EBI-5235340,EBI-25843965
FAM90A1 [Q86YD7]3EBI-5235340,EBI-6658203
FAM98C [Q17RN3]3EBI-5235340,EBI-5461838
FAM9A [Q8IZU1]3EBI-5235340,EBI-8468186
FANCG [O15287]3EBI-5235340,EBI-81610
FBLN5 [Q9UBX5]3EBI-5235340,EBI-947897
FHL5 [Q5TD97]3EBI-5235340,EBI-750641
FKBP10 [Q96AY3]3EBI-5235340,EBI-2372475
FNTB [P49356]3EBI-5235340,EBI-602349
FOXA2 - isoform 2 [Q9Y261-2]3EBI-5235340,EBI-25830360
FSTL1 [Q12841]3EBI-5235340,EBI-2349801
FYN - isoform 3 [P06241-3]3EBI-5235340,EBI-10691738
FZD4 [Q9ULV1]3EBI-5235340,EBI-2466380
G2E3 [Q7L622]3EBI-5235340,EBI-751757
GATA1 - isoform 2 [P15976-2]3EBI-5235340,EBI-9090198
GFAP [P14136]3EBI-5235340,EBI-744302
GFOD1 [Q9NXC2]3EBI-5235340,EBI-8799578
GHITM [Q9H3K2]3EBI-5235340,EBI-2868909
GKN1 [Q9NS71]3EBI-5235340,EBI-3933251
GLI4 [P10075]3EBI-5235340,EBI-14061927
GLYCTK [Q8IVS8]3EBI-5235340,EBI-748515
GMCL2 [Q8NEA9]3EBI-5235340,EBI-745707
GNB2 [P62879]3EBI-5235340,EBI-356942
GPATCH2L - isoform 2 [Q9NWQ4-1]3EBI-5235340,EBI-11959863
GPR141 [Q7Z602]3EBI-5235340,EBI-21649723
GPX7 [Q96SL4]3EBI-5235340,EBI-749411
GRN - isoform 2 [P28799-2]3EBI-5235340,EBI-25860013
GUSBP1 [Q15486]3EBI-5235340,EBI-712457
HAND1 [O96004]3EBI-5235340,EBI-11320290
HAUS7 [Q99871]3EBI-5235340,EBI-395719
hCG_2001421 [A8K0U2]3EBI-5235340,EBI-25843825
HEXIM2 [Q96MH2]3EBI-5235340,EBI-5460660
HID1 [Q8IV36]3EBI-5235340,EBI-743438
HMG20B [Q9P0W2]3EBI-5235340,EBI-713401
HOXA1 [P49639]3EBI-5235340,EBI-740785
HOXB7 [P09629]3EBI-5235340,EBI-1248457
HOXC4 [P09017]3EBI-5235340,EBI-3923226
HPCAL1 [P37235]3EBI-5235340,EBI-749311
HPCAL4 [Q9UM19]6EBI-5235340,EBI-744820
HPRT1 [P00492]3EBI-5235340,EBI-748210
HS1BP3 [Q53T59]3EBI-5235340,EBI-11335623
HSD3B2 [P26439]3EBI-5235340,EBI-21761225
HSF2BP [O75031]3EBI-5235340,EBI-7116203
ICA1 - isoform 3 [Q05084-3]3EBI-5235340,EBI-25930511
ID1 [P41134]3EBI-5235340,EBI-1215527
ID3 [Q02535]3EBI-5235340,EBI-1387094
ID4 [P47928]3EBI-5235340,EBI-1754719
IFT20 - isoform 3 [Q8IY31-3]3EBI-5235340,EBI-9091197
IGFBP1 [P08833]3EBI-5235340,EBI-13646303
IGFBP4 [P22692]3EBI-5235340,EBI-2831948
IK [Q13123]3EBI-5235340,EBI-713456
IL16 - isoform 2 [Q14005-2]6EBI-5235340,EBI-17178971
ILF3 [Q9NXX0]3EBI-5235340,EBI-743980
ILKAP [Q9H0C8]3EBI-5235340,EBI-2620298
IMPA1 - isoform 3 [P29218-3]3EBI-5235340,EBI-12330251
ING4 [Q9UNL4]3EBI-5235340,EBI-2866661
ING5 - isoform 2 [Q8WYH8-2]3EBI-5235340,EBI-21602071
INKA1 [Q96EL1]3EBI-5235340,EBI-10285157
IQGAP3 [Q86VI3]3EBI-5235340,EBI-1237354
IQUB [Q8NA54]6EBI-5235340,EBI-10220600
IRAG1 - isoform 3 [Q9Y6F6-3]3EBI-5235340,EBI-25840037
ISCA2 [Q86U28]3EBI-5235340,EBI-10258659
JPH3 [Q8WXH2]3EBI-5235340,EBI-1055254
KAT2B [Q92831]3EBI-5235340,EBI-477430
KAT5 [Q92993]3EBI-5235340,EBI-399080
KAT5 - isoform 1 [Q92993-2]3EBI-5235340,EBI-20795332
KCNIP2 - isoform 2 [Q9NS61-2]3EBI-5235340,EBI-1053003
KCTD17 [Q8N5Z5]3EBI-5235340,EBI-743960
KEAP1 [Q14145]3EBI-5235340,EBI-751001
KIF1A [Q12756]3EBI-5235340,EBI-2679809
KIF2A - isoform 1 [O00139-1]3EBI-5235340,EBI-12197879
KLF6 [Q99612]3EBI-5235340,EBI-714994
KLHL20 [Q9Y2M5]3EBI-5235340,EBI-714379
KRCC1 [Q9NPI7]3EBI-5235340,EBI-2805442
KRT33B [Q14525]3EBI-5235340,EBI-1049638
KRTAP10-7 [P60409]3EBI-5235340,EBI-10172290
KRTAP13-3 [Q3SY46]3EBI-5235340,EBI-10241252
LAPTM4A [Q15012]3EBI-5235340,EBI-723416
LAS2 [Q8IYD9]3EBI-5235340,EBI-749878
LCE2A [Q5TA79]3EBI-5235340,EBI-10246607
LHX5 [Q9H2C1]3EBI-5235340,EBI-25835523
LHX8 [Q68G74]3EBI-5235340,EBI-8474075
LIMS2 - isoform 4 [Q7Z4I7-4]3EBI-5235340,EBI-22000977
LMNA [P02545]3EBI-5235340,EBI-351935
LNX1 [Q8TBB1]3EBI-5235340,EBI-739832
LNX2 [Q8N448]3EBI-5235340,EBI-2340947
LOC401296 [A2RU56]3EBI-5235340,EBI-9088215
LONRF2 [Q1L5Z9]3EBI-5235340,EBI-2510853
LOXL4 [Q96JB6]3EBI-5235340,EBI-749562
LUC7L [Q9NQ29]3EBI-5235340,EBI-473747
LYN [P07948]3EBI-5235340,EBI-79452
MAB21L3 [Q8N8X9]3EBI-5235340,EBI-10268010
MAGEC2 [Q9UBF1]3EBI-5235340,EBI-5651487
MALT1 - isoform 2 [Q9UDY8-2]3EBI-5235340,EBI-12056869
MAOB [P27338]3EBI-5235340,EBI-3911344
MARCHF10 [Q8NA82]3EBI-5235340,EBI-2341554
MEOX1 [P50221]3EBI-5235340,EBI-2864512
MEOX2 [Q6FHY5]3EBI-5235340,EBI-16439278
MESP1 [Q9BRJ9]3EBI-5235340,EBI-21944954
METTL15 - isoform 4 [A6NJ78-4]3EBI-5235340,EBI-10174029
MIIP [Q5JXC2]3EBI-5235340,EBI-2801965
MLH3 - isoform 2 [Q9UHC1-2]3EBI-5235340,EBI-9089845
MOGAT3 - isoform 3 [Q86VF5-3]3EBI-5235340,EBI-25840143
MPND [Q8N594]3EBI-5235340,EBI-2512452
MRFAP1 [Q9Y605]3EBI-5235340,EBI-995714
MSRB3 - isoform 2 [Q8IXL7-2]3EBI-5235340,EBI-10699187
MSX2 [P35548]3EBI-5235340,EBI-6447480
MTF2 - isoform 4 [Q9Y483-4]3EBI-5235340,EBI-10698053
MYLIP [Q8WY64]3EBI-5235340,EBI-6952711
NBL1 - isoform 2 [P41271-2]3EBI-5235340,EBI-12135485
NCALD [P61601]9EBI-5235340,EBI-749635
NDUFA8 [P51970]3EBI-5235340,EBI-1237250
NDUFB10 - isoform 2 [O96000-2]3EBI-5235340,EBI-25930682
NDUFB7 [P17568]3EBI-5235340,EBI-1246238
NDUFV2 [P19404]3EBI-5235340,EBI-713665
NEBL [O76041]3EBI-5235340,EBI-2880203
NELFCD [Q8IXH7]3EBI-5235340,EBI-536725
NETO2 - isoform 2 [Q8NC67-2]3EBI-5235340,EBI-25852289
NF1 [P21359]6EBI-5235340,EBI-1172917
NFE2 [Q16621]3EBI-5235340,EBI-726369
NFKBIB [Q15653]3EBI-5235340,EBI-352889
NFX1 [Q12986]3EBI-5235340,EBI-2130062
NGFR [P08138]3EBI-5235340,EBI-1387782
NOD1 [Q9Y239]3EBI-5235340,EBI-1051262
NOL3 [O60936]3EBI-5235340,EBI-740992
NOS3 [P29474]3EBI-5235340,EBI-1391623
NR1D2 [Q14995]3EBI-5235340,EBI-6144053
NR1H2 [F1D8P7]3EBI-5235340,EBI-10177172
NR1H3 - isoform 3 [Q13133-3]3EBI-5235340,EBI-11952806
NSD3 - isoform 3 [Q9BZ95-3]3EBI-5235340,EBI-22002759
NSMCE2 [Q96MF7]3EBI-5235340,EBI-2557388
NSMF - isoform 6 [Q6X4W1-6]3EBI-5235340,EBI-25842707
NUFIP2 [Q7Z417]3EBI-5235340,EBI-1210753
OBI1 [Q5W0B1]3EBI-5235340,EBI-2562035
ODAD3 [A5D8V7]3EBI-5235340,EBI-8466445
ODF2 - isoform 2 [Q5BJF6-2]3EBI-5235340,EBI-9090919
ODF3L2 [Q3SX64]3EBI-5235340,EBI-6660184
OLIG3 [Q7RTU3]3EBI-5235340,EBI-10225049
OTUB1 [Q96FW1]3EBI-5235340,EBI-1058491
OTUD7B - isoform 2 [Q6GQQ9-2]3EBI-5235340,EBI-25830200
P3H3 - isoform 2 [Q8IVL6-2]3EBI-5235340,EBI-12149899
PACRGL - isoform 2 [Q8N7B6-2]3EBI-5235340,EBI-10694433
PALM [O75781]3EBI-5235340,EBI-6448827
PARP11 - isoform 4 [Q9NR21-5]3EBI-5235340,EBI-17159452
PARVG [Q9HBI0]3EBI-5235340,EBI-3921217
PCDHGC3 [Q9BR81]3EBI-5235340,EBI-22012354
PCMT1 - isoform 2 [P22061-2]3EBI-5235340,EBI-12386584
PCMTD2 [Q9NV79]3EBI-5235340,EBI-6309018
PDS5A - isoform 2 [Q29RF7-3]3EBI-5235340,EBI-12067280
PHF5A [Q7RTV0]3EBI-5235340,EBI-2555365
PHF7 [Q9BWX1]3EBI-5235340,EBI-4307517
PHKA2 [P46019]3EBI-5235340,EBI-1642846
PIAS1 [O75925]3EBI-5235340,EBI-629434
PIH1D2 [Q8WWB5]8EBI-5235340,EBI-10232538
PIK3R2 [O00459]3EBI-5235340,EBI-346930
PKM [P14618]3EBI-5235340,EBI-353408
PLA2G10 [O15496]3EBI-5235340,EBI-726466
PLAUR - isoform 2 [Q03405-2]3EBI-5235340,EBI-11028203
PMF1 [Q6P1K2]3EBI-5235340,EBI-713832
PMF1 - isoform 3 [Q6P1K2-3]3EBI-5235340,EBI-12906008
PPARA [Q07869]3EBI-5235340,EBI-78615
PPARD - isoform 2 [Q03181-2]3EBI-5235340,EBI-10223258
PPP1CA [P62136]4EBI-5235340,EBI-357253
PPP1CB [P62140]3EBI-5235340,EBI-352350
PPP2R5A [Q15172]3EBI-5235340,EBI-641666
PPTC7 [Q8NI37]3EBI-5235340,EBI-9089276
PRIM2 [P49643]3EBI-5235340,EBI-850004
PRKAB2 [O43741]3EBI-5235340,EBI-1053424
PRKN - isoform 5 [O60260-5]3EBI-5235340,EBI-21251460
PRPF18 [Q99633]3EBI-5235340,EBI-2798416
PRR15 [Q8IV56]3EBI-5235340,EBI-8787485
PSMB10 [P40306]3EBI-5235340,EBI-603329
PTBP2 - isoform 2 [Q9UKA9-2]3EBI-5235340,EBI-12255608
PXN [Q7Z7K5]3EBI-5235340,EBI-25841978
RAB11B [Q15907]3EBI-5235340,EBI-722234
RAB3IP - isoform 7 [Q96QF0-7]3EBI-5235340,EBI-11984839
RAN [P62826]3EBI-5235340,EBI-286642
RASSF1 - isoform C [Q9NS23-4]3EBI-5235340,EBI-438710
RCHY1 [Q96PM5]3EBI-5235340,EBI-947779
RCHY1 - isoform 4 [Q96PM5-4]3EBI-5235340,EBI-21252376
RCN1 [Q15293]3EBI-5235340,EBI-948278
RCOR3 - isoform 2 [Q9P2K3-2]3EBI-5235340,EBI-1504830
REX1BD [Q96EN9]3EBI-5235340,EBI-745810
RGR - isoform 3 [P47804-3]3EBI-5235340,EBI-25834767
RGS17 [Q9UGC6]3EBI-5235340,EBI-3918154
RHEBL1 [Q8TAI7]3EBI-5235340,EBI-746555
RHOJ [Q9H4E5]3EBI-5235340,EBI-6285694
RHPN1 [Q8TCX5]3EBI-5235340,EBI-746325
RILP [Q96NA2]3EBI-5235340,EBI-2856119
RIN1 [Q13671]3EBI-5235340,EBI-366017
RING1 [Q06587]3EBI-5235340,EBI-752313
RIPPLY2 [Q5TAB7]3EBI-5235340,EBI-10246897
RMND5B [Q96G75]3EBI-5235340,EBI-745055
RNF10 [Q8N5U6]3EBI-5235340,EBI-714023
RNF138 [Q8WVD3]3EBI-5235340,EBI-749039
RNF183 [Q96D59]3EBI-5235340,EBI-743938
RNF208 [Q9H0X6]3EBI-5235340,EBI-751555
RNF34 [Q969K3]3EBI-5235340,EBI-2340642
RPS4X [P62701]3EBI-5235340,EBI-354303
RPUSD1 [Q9UJJ7]3EBI-5235340,EBI-3922794
RSPO2 - isoform 2 [Q6UXX9-2]3EBI-5235340,EBI-12009390
RUFY4 [Q6ZNE9]3EBI-5235340,EBI-10181525
RXRG [P48443]3EBI-5235340,EBI-712405
RYBP [Q8N488]3EBI-5235340,EBI-752324
SAMD3 - isoform 2 [Q8N6K7-2]3EBI-5235340,EBI-11528848
SCAPER - isoform 3 [Q9BY12-3]3EBI-5235340,EBI-25837959
SCNM1 [Q9BWG6]3EBI-5235340,EBI-748391
SDC2 [P34741]3EBI-5235340,EBI-1172957
SDCBP [O00560]3EBI-5235340,EBI-727004
SELE [P16581]3EBI-5235340,EBI-8007671
SENP3 [Q9H4L4]3EBI-5235340,EBI-2880236
SET - isoform 2 [Q01105-2]3EBI-5235340,EBI-7481343
SHFL - isoform 3 [Q9NUL5-3]3EBI-5235340,EBI-22000547
SHLD1 [Q8IYI0]3EBI-5235340,EBI-2560428
SKIL [P12757]3EBI-5235340,EBI-2902468
SKP1 - isoform 2 [P63208-2]3EBI-5235340,EBI-25930963
SLC27A4 - isoform 2 [Q6P1M0-2]3EBI-5235340,EBI-12898981
SLFN12 [Q8IYM2]3EBI-5235340,EBI-2822550
SMARCB1 [Q12824]3EBI-5235340,EBI-358419
SMIM14 [Q96QK8]3EBI-5235340,EBI-373430
SMURF1 - isoform Short [Q9HCE7-2]3EBI-5235340,EBI-9845742
SNAP91 - isoform 3 [O60641-3]3EBI-5235340,EBI-12854506
SNRNP48 [Q6IEG0]3EBI-5235340,EBI-2876632
SNW1 [Q13573]3EBI-5235340,EBI-632715
SOCS4 [Q8WXH5]3EBI-5235340,EBI-3942425
SOX5 - isoform 5 [P35711-5]3EBI-5235340,EBI-25930989
SPAG8 - isoform 2 [Q99932-2]3EBI-5235340,EBI-11959123
SPATA24 - isoform 2 [Q86W54-2]3EBI-5235340,EBI-12041693
SPATA3 [A0A024R4B0]3EBI-5235340,EBI-14123856
SPG21 [Q9NZD8]3EBI-5235340,EBI-742688
SPRED2 [Q7Z698]3EBI-5235340,EBI-7082156
SPRY4 [Q9C004]3EBI-5235340,EBI-354861
SRGAP3 [Q8IXS7]3EBI-5235340,EBI-18616594
SSX2B [Q16385]3EBI-5235340,EBI-2210673
STK36 [Q9NRP7]3EBI-5235340,EBI-863797
STRC [A1L378]3EBI-5235340,EBI-22013242
STUB1 [Q9UNE7]3EBI-5235340,EBI-357085
STX11 [O75558]3EBI-5235340,EBI-714135
STX19 [Q8N4C7]3EBI-5235340,EBI-8484990
TADA3 [O75528]3EBI-5235340,EBI-473249
TASOR2 [Q5VWN6]3EBI-5235340,EBI-745958
TBC1D23 - isoform 2 [Q9NUY8-2]3EBI-5235340,EBI-10314276
TCEAL8 [Q8IYN2]3EBI-5235340,EBI-2116184
TERF1 - isoform 2 [P54274-2]3EBI-5235340,EBI-711018
TES [Q9UGI8]3EBI-5235340,EBI-2561654
TEX35 - isoform 2 [Q5T0J7-2]3EBI-5235340,EBI-12833746
TGM2 - isoform 2 [P21980-2]3EBI-5235340,EBI-25842075
THEM4 [Q5T1C6]3EBI-5235340,EBI-7684443
TIMM8A [O60220]3EBI-5235340,EBI-1049822
TIPIN [Q9BVW5]3EBI-5235340,EBI-2515360
TMEM61 [Q8N0U2]3EBI-5235340,EBI-25830583
TMUB2 - isoform 4 [Q71RG4-4]3EBI-5235340,EBI-25831574
TNIP3 [Q96KP6]3EBI-5235340,EBI-2509913
TP53BP1 [Q12888]3EBI-5235340,EBI-396540
TRAF5 [O00463]3EBI-5235340,EBI-523498
TRIB2 [Q92519]3EBI-5235340,EBI-947178
TRIB3 [Q96RU7]4EBI-5235340,EBI-492476
TRIM35 - isoform 2 [Q9UPQ4-2]3EBI-5235340,EBI-17716262
TRIM42 [Q8IWZ5]3EBI-5235340,EBI-5235829
TRIM69 - isoform 2 [Q86WT6-2]3EBI-5235340,EBI-11525489
TRIM74 - isoform 2 [Q86UV6-2]3EBI-5235340,EBI-10259086
TRIT1 - isoform 5 [Q9H3H1-5]3EBI-5235340,EBI-25932209
TSC1 [Q86WV8]3EBI-5235340,EBI-12806590
TUT7 - isoform 5 [Q5VYS8-5]3EBI-5235340,EBI-9088812
TXN [P10599]3EBI-5235340,EBI-594644
U2AF1 [Q7Z780]3EBI-5235340,EBI-25833730
UBR1 [Q8IWV7]3EBI-5235340,EBI-711736
UBR4 [Q5T4S7]3EBI-5235340,EBI-1995940
UCHL3 [P15374]3EBI-5235340,EBI-954554
USP15 - isoform 2 [Q9Y4E8-2]3EBI-5235340,EBI-12041225
USP2 - isoform 3 [O75604-3]3EBI-5235340,EBI-10696113
USP54 - isoform 6 [Q70EL1-9]3EBI-5235340,EBI-11975223
VAMP4 - isoform 2 [O75379-2]3EBI-5235340,EBI-10187996
VHL - isoform 2 [P40337-2]3EBI-5235340,EBI-12157263
VPS11 [Q9H270]3EBI-5235340,EBI-373380
VPS37A [Q8NEZ2]3EBI-5235340,EBI-2850578
VPS37A - isoform 2 [Q8NEZ2-2]3EBI-5235340,EBI-10270911
VSNL1 [P62760]5EBI-5235340,EBI-740943
WASF2 [Q9Y6W5]3EBI-5235340,EBI-4290615
WDR61 [Q9GZS3]3EBI-5235340,EBI-358545
WDR83 [Q9BRX9]3EBI-5235340,EBI-7705033
WWOX - isoform 5 [Q9NZC7-5]3EBI-5235340,EBI-12040603
YAF2 - isoform 2 [Q8IY57-5]3EBI-5235340,EBI-12111538
YY1 [P25490]3EBI-5235340,EBI-765538
ZBTB24 - isoform 2 [O43167-2]3EBI-5235340,EBI-25842419
ZBTB25 [P24278]3EBI-5235340,EBI-739899
ZC3HC1 - isoform 2 [Q86WB0-2]3EBI-5235340,EBI-25894765
ZDHHC17 [Q8IUH5]3EBI-5235340,EBI-524753
ZFP2 [Q6ZN57]3EBI-5235340,EBI-7236323
ZFPM2 [Q8WW38]3EBI-5235340,EBI-947213
ZIK1 [Q3SY52]3EBI-5235340,EBI-20857691
ZKSCAN5 [Q9Y2L8]3EBI-5235340,EBI-2876965
ZKSCAN8 [Q15776]3EBI-5235340,EBI-2602314
ZMYND12 [Q9H0C1]3EBI-5235340,EBI-12030590
ZNF124 [Q15973]3EBI-5235340,EBI-2555767
ZNF138 [P52744]3EBI-5235340,EBI-10746567
ZNF165 [P49910]3EBI-5235340,EBI-741694
ZNF180 - isoform 4 [Q9UJW8-4]3EBI-5235340,EBI-12055755
ZNF20 [P17024]3EBI-5235340,EBI-717634
ZNF23 [P17027]3EBI-5235340,EBI-5657766
ZNF239 [Q16600]3EBI-5235340,EBI-8787052
ZNF24 [A0A024RC47]3EBI-5235340,EBI-25830832
ZNF286A [Q9HBT8]3EBI-5235340,EBI-10754950
ZNF343 - isoform 3 [Q6P1L6-3]3EBI-5235340,EBI-25932668
ZNF345 [Q14585]3EBI-5235340,EBI-2818408
ZNF366 [Q8N895]3EBI-5235340,EBI-2813661
ZNF408 [Q9H9D4]3EBI-5235340,EBI-347633
ZNF414 [Q96IQ9]3EBI-5235340,EBI-744257
ZNF417 [Q8TAU3]3EBI-5235340,EBI-740727
ZNF436 [Q9C0F3]3EBI-5235340,EBI-8489702
ZNF444 - isoform 2 [Q8N0Y2-2]3EBI-5235340,EBI-12010736
ZNF460 [Q14592]3EBI-5235340,EBI-2555738
ZNF488 - isoform 2 [Q96MN9-2]3EBI-5235340,EBI-25831733
ZNF496 [Q96IT1]3EBI-5235340,EBI-743906
ZNF497 [Q6ZNH5]3EBI-5235340,EBI-10486136
ZNF500 [O60304]3EBI-5235340,EBI-18234077
ZNF524 [Q96C55]3EBI-5235340,EBI-10283126
ZNF566 [Q969W8]3EBI-5235340,EBI-2555762
ZNF57 [Q68EA5]3EBI-5235340,EBI-8490788
ZNF572 [Q7Z3I7]3EBI-5235340,EBI-10172590
ZNF581 [Q9P0T4]3EBI-5235340,EBI-745520
ZNF587 [Q96SQ5]3EBI-5235340,EBI-6427977
ZNF597 [Q96LX8]3EBI-5235340,EBI-9091553
ZNF607 - isoform 3 [Q96SK3-3]3EBI-5235340,EBI-25932974
ZNF625 - isoform 2 [Q96I27-2]3EBI-5235340,EBI-12038525
ZNF641 - isoform 2 [Q96N77-2]3EBI-5235340,EBI-12939666
ZNF649 [Q9BS31]3EBI-5235340,EBI-4395789
ZNF655 [Q8N720]3EBI-5235340,EBI-625509
ZNF670 [Q9BS34]3EBI-5235340,EBI-745276
ZNF696 [Q9H7X3]3EBI-5235340,EBI-11090299
ZNF774 [Q6NX45]3EBI-5235340,EBI-10251462
ZNF829 - isoform 3 [Q3KNS6-3]3EBI-5235340,EBI-18036029
ZSCAN12 [O43309]3EBI-5235340,EBI-1210440
ZSCAN16 [Q9H4T2]3EBI-5235340,EBI-723596
ZSCAN22 [P10073]3EBI-5235340,EBI-10178224
ZSCAN31 - isoform 2 [Q96LW9-2]3EBI-5235340,EBI-25932549
ZSCAN9 [O15535]3EBI-5235340,EBI-751531
Q7L8T73EBI-5235340,EBI-25831943
Q7Z7833EBI-5235340,EBI-9088990
Q86V283EBI-5235340,EBI-10259496
Q96FU43EBI-5235340,EBI-25933855

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127800, 45 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z699, 455 interactors

Molecular INTeraction database

More...
MINTi
Q7Z699

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299084

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z699, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1444
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z699

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 123WH1PROSITE-ProRule annotationAdd BLAST118
Domaini233 – 285KBDPROSITE-ProRule annotationAdd BLAST53
Domaini334 – 442SPRPROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni123 – 151DisorderedSequence analysisAdd BLAST29
Regioni333 – 444Required for interaction with TESK1By similarityAdd BLAST112

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4590, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159180

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_038867_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z699

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLFQHET

Database of Orthologous Groups

More...
OrthoDBi
759156at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z699

TreeFam database of animal gene trees

More...
TreeFami
TF321411

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10574, EVH1_SPRED-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023337, KBD
IPR011993, PH-like_dom_sf
IPR041937, SPRE_EVH1
IPR007875, Sprouty
IPR000697, WH1/EVH1_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05210, Sprouty, 1 hit
PF00568, WH1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00461, WH1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51488, KBD, 1 hit
PS51227, SPR, 1 hit
PS50229, WH1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7Z699-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEETATSDN DNSYARVRAV VMTRDDSSGG WLPLGGSGLS SVTVFKVPHQ
60 70 80 90 100
EENGCADFFI RGERLRDKMV VLECMLKKDL IYNKVTPTFH HWKIDDKKFG
110 120 130 140 150
LTFQSPADAR AFDRGIRRAI EDISQGCPES KNEAEGADDL QANEEDSSSS
160 170 180 190 200
LVKDHLFQQE TVVTSEPYRS SNIRPSPFED LNARRVYMQS QANQITFGQP
210 220 230 240 250
GLDIQSRSME YVQRQISKEC GSLKSQNRVP LKSIRHVSFQ DEDEIVRINP
260 270 280 290 300
RDILIRRYAD YRHPDMWKND LERDDADSSI QFSKPDSKKS DYLYSCGDET
310 320 330 340 350
KLSSPKDSVV FKTQPSSLKI KKSKRRKEDG ERSRCVYCQE RFNHEENVRG
360 370 380 390 400
KCQDAPDPIK RCIYQVSCML CAESMLYHCM SDSEGDFSDP CSCDTSDDKF
410 420 430 440
CLRWLALVAL SFIVPCMCCY VPLRMCHRCG EACGCCGGKH KAAG
Length:444
Mass (Da):50,477
Last modified:January 4, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FFDECCE590DB311
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMN8H0YMN8_HUMAN
Sprouty-related, EVH1 domain-contai...
SPRED1
131Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH18015 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6 – 7AT → GL in AAP59414 (PubMed:15683364).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06482731W → C in LGSS. 1 Publication1
Natural variantiVAR_06482844V → D in LGSS. 2 PublicationsCorresponds to variant dbSNP:rs121434318EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY299089 mRNA Translation: AAP59414.1
AK091222 mRNA Translation: BAC03614.1
CH471125 Genomic DNA Translation: EAW92368.1
BC018015 mRNA Translation: AAH18015.1 Sequence problems.
BC137480 mRNA Translation: AAI37481.1
BC137481 mRNA Translation: AAI37482.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32193.1

NCBI Reference Sequences

More...
RefSeqi
NP_689807.1, NM_152594.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299084; ENSP00000299084; ENSG00000166068

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
161742

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:161742

UCSC genome browser

More...
UCSCi
uc001zka.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299089 mRNA Translation: AAP59414.1
AK091222 mRNA Translation: BAC03614.1
CH471125 Genomic DNA Translation: EAW92368.1
BC018015 mRNA Translation: AAH18015.1 Sequence problems.
BC137480 mRNA Translation: AAI37481.1
BC137481 mRNA Translation: AAI37482.1
CCDSiCCDS32193.1
RefSeqiNP_689807.1, NM_152594.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SYXX-ray2.45A13-131[»]
6V65X-ray2.76A13-125[»]
6V6FX-ray2.54A13-125[»]
SMRiQ7Z699
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi127800, 45 interactors
IntActiQ7Z699, 455 interactors
MINTiQ7Z699
STRINGi9606.ENSP00000299084

PTM databases

iPTMnetiQ7Z699
PhosphoSitePlusiQ7Z699
SwissPalmiQ7Z699

Genetic variation databases

BioMutaiSPRED1
DMDMi57013078

Proteomic databases

CPTACiCPTAC-1563
EPDiQ7Z699
jPOSTiQ7Z699
MassIVEiQ7Z699
MaxQBiQ7Z699
PaxDbiQ7Z699
PeptideAtlasiQ7Z699
PRIDEiQ7Z699
ProteomicsDBi69386

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22853, 384 antibodies

The DNASU plasmid repository

More...
DNASUi
161742

Genome annotation databases

EnsembliENST00000299084; ENSP00000299084; ENSG00000166068
GeneIDi161742
KEGGihsa:161742
UCSCiuc001zka.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
161742
DisGeNETi161742

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPRED1
GeneReviewsiSPRED1
HGNCiHGNC:20249, SPRED1
HPAiENSG00000166068, Low tissue specificity
MalaCardsiSPRED1
MIMi609291, gene
611431, phenotype
neXtProtiNX_Q7Z699
OpenTargetsiENSG00000166068
Orphaneti137605, Legius syndrome
PharmGKBiPA134897382
VEuPathDBiHostDB:ENSG00000166068

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4590, Eukaryota
GeneTreeiENSGT00940000159180
HOGENOMiCLU_038867_1_1_1
InParanoidiQ7Z699
OMAiHLFQHET
OrthoDBi759156at2759
PhylomeDBiQ7Z699
TreeFamiTF321411

Enzyme and pathway databases

PathwayCommonsiQ7Z699
ReactomeiR-HSA-5658442, Regulation of RAS by GAPs
R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling
R-HSA-6802953, RAS signaling downstream of NF1 loss-of-function variants

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
161742, 15 hits in 1039 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPRED1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SPRED1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
161742
PharosiQ7Z699, Tbio

Protein Ontology

More...
PROi
PR:Q7Z699
RNActiQ7Z699, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166068, Expressed in intestine and 217 other tissues
ExpressionAtlasiQ7Z699, baseline and differential
GenevisibleiQ7Z699, HS

Family and domain databases

CDDicd10574, EVH1_SPRED-like, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR023337, KBD
IPR011993, PH-like_dom_sf
IPR041937, SPRE_EVH1
IPR007875, Sprouty
IPR000697, WH1/EVH1_dom
PfamiView protein in Pfam
PF05210, Sprouty, 1 hit
PF00568, WH1, 1 hit
SMARTiView protein in SMART
SM00461, WH1, 1 hit
PROSITEiView protein in PROSITE
PS51488, KBD, 1 hit
PS51227, SPR, 1 hit
PS50229, WH1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPRE1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z699
Secondary accession number(s): B2RPJ8, Q05D53, Q8N256
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: September 29, 2021
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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