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Protein

Sprouty-related, EVH1 domain-containing protein 1

Gene

SPRED1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).By similarity

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB
  • protein kinase binding Source: ARUK-UCL
  • protein serine/threonine kinase inhibitor activity Source: BHF-UCL
  • stem cell factor receptor binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-6802949 Signaling by RAS mutants

Names & Taxonomyi

Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 1
Short name:
Spred-1
Short name:
hSpred1
Gene namesi
Name:SPRED1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166068.12
HGNCiHGNC:20249 SPRED1
MIMi609291 gene
neXtProtiNX_Q7Z699

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Neurofibromatosis 1-like syndrome (NFLS)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity.
See also OMIM:611431
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06482731W → C in NFLS. 1 Publication1
Natural variantiVAR_06482844V → D in NFLS. 2 PublicationsCorresponds to variant dbSNP:rs121434318EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi161742
GeneReviewsiSPRED1
MalaCardsiSPRED1
MIMi611431 phenotype
OpenTargetsiENSG00000166068
Orphaneti137605 Legius syndrome
PharmGKBiPA134897382

Polymorphism and mutation databases

BioMutaiSPRED1
DMDMi57013078

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000769072 – 444Sprouty-related, EVH1 domain-containing protein 1Add BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei224N6-methyllysineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei308PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ7Z699
MaxQBiQ7Z699
PaxDbiQ7Z699
PeptideAtlasiQ7Z699
PRIDEiQ7Z699
ProteomicsDBi69386

PTM databases

iPTMnetiQ7Z699
PhosphoSitePlusiQ7Z699
SwissPalmiQ7Z699

Expressioni

Tissue specificityi

Weakly expressed in embryonic cell line HEK293.1 Publication

Gene expression databases

BgeeiENSG00000166068 Expressed in 203 organ(s), highest expression level in intestine
CleanExiHS_SPRED1
ExpressionAtlasiQ7Z699 baseline and differential
GenevisibleiQ7Z699 HS

Organism-specific databases

HPAiHPA042193
HPA061805

Interactioni

Subunit structurei

Interacts with Ras. Interacts with TAOK2 and TESK1 (By similarity). Homodimer and heterodimer. Interacts with CAV1. Able to interact with SPRED2 to form heterodimers.By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127800, 17 interactors
IntActiQ7Z699, 37 interactors
MINTiQ7Z699
STRINGi9606.ENSP00000299084

Structurei

Secondary structure

1444
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ7Z699
SMRiQ7Z699
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 123WH1PROSITE-ProRule annotationAdd BLAST118
Domaini233 – 285KBDPROSITE-ProRule annotationAdd BLAST53
Domaini334 – 442SPRPROSITE-ProRule annotationAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi147 – 150Poly-Ser4

Phylogenomic databases

eggNOGiENOG410IQ20 Eukaryota
ENOG4112CZ7 LUCA
GeneTreeiENSGT00730000110272
HOGENOMiHOG000220886
HOVERGENiHBG057556
InParanoidiQ7Z699
KOiK04703
OMAiTDSNIQF
OrthoDBiEOG091G0OE8
PhylomeDBiQ7Z699
TreeFamiTF321411

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR023337 KBD
IPR011993 PH-like_dom_sf
IPR007875 Sprouty
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS51488 KBD, 1 hit
PS51227 SPR, 1 hit
PS50229 WH1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7Z699-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEETATSDN DNSYARVRAV VMTRDDSSGG WLPLGGSGLS SVTVFKVPHQ
60 70 80 90 100
EENGCADFFI RGERLRDKMV VLECMLKKDL IYNKVTPTFH HWKIDDKKFG
110 120 130 140 150
LTFQSPADAR AFDRGIRRAI EDISQGCPES KNEAEGADDL QANEEDSSSS
160 170 180 190 200
LVKDHLFQQE TVVTSEPYRS SNIRPSPFED LNARRVYMQS QANQITFGQP
210 220 230 240 250
GLDIQSRSME YVQRQISKEC GSLKSQNRVP LKSIRHVSFQ DEDEIVRINP
260 270 280 290 300
RDILIRRYAD YRHPDMWKND LERDDADSSI QFSKPDSKKS DYLYSCGDET
310 320 330 340 350
KLSSPKDSVV FKTQPSSLKI KKSKRRKEDG ERSRCVYCQE RFNHEENVRG
360 370 380 390 400
KCQDAPDPIK RCIYQVSCML CAESMLYHCM SDSEGDFSDP CSCDTSDDKF
410 420 430 440
CLRWLALVAL SFIVPCMCCY VPLRMCHRCG EACGCCGGKH KAAG
Length:444
Mass (Da):50,477
Last modified:January 4, 2005 - v2
Checksum:i6FFDECCE590DB311
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMN8H0YMN8_HUMAN
Sprouty-related, EVH1 domain-contai...
SPRED1
131Annotation score:

Sequence cautioni

The sequence AAH18015 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6 – 7AT → GL in AAP59414 (PubMed:15683364).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06482731W → C in NFLS. 1 Publication1
Natural variantiVAR_06482844V → D in NFLS. 2 PublicationsCorresponds to variant dbSNP:rs121434318EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299089 mRNA Translation: AAP59414.1
AK091222 mRNA Translation: BAC03614.1
CH471125 Genomic DNA Translation: EAW92368.1
BC018015 mRNA Translation: AAH18015.1 Sequence problems.
BC137480 mRNA Translation: AAI37481.1
BC137481 mRNA Translation: AAI37482.1
CCDSiCCDS32193.1
RefSeqiNP_689807.1, NM_152594.2
UniGeneiHs.525781

Genome annotation databases

EnsembliENST00000299084; ENSP00000299084; ENSG00000166068
GeneIDi161742
KEGGihsa:161742
UCSCiuc001zka.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299089 mRNA Translation: AAP59414.1
AK091222 mRNA Translation: BAC03614.1
CH471125 Genomic DNA Translation: EAW92368.1
BC018015 mRNA Translation: AAH18015.1 Sequence problems.
BC137480 mRNA Translation: AAI37481.1
BC137481 mRNA Translation: AAI37482.1
CCDSiCCDS32193.1
RefSeqiNP_689807.1, NM_152594.2
UniGeneiHs.525781

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3SYXX-ray2.45A13-131[»]
ProteinModelPortaliQ7Z699
SMRiQ7Z699
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127800, 17 interactors
IntActiQ7Z699, 37 interactors
MINTiQ7Z699
STRINGi9606.ENSP00000299084

PTM databases

iPTMnetiQ7Z699
PhosphoSitePlusiQ7Z699
SwissPalmiQ7Z699

Polymorphism and mutation databases

BioMutaiSPRED1
DMDMi57013078

Proteomic databases

EPDiQ7Z699
MaxQBiQ7Z699
PaxDbiQ7Z699
PeptideAtlasiQ7Z699
PRIDEiQ7Z699
ProteomicsDBi69386

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299084; ENSP00000299084; ENSG00000166068
GeneIDi161742
KEGGihsa:161742
UCSCiuc001zka.5 human

Organism-specific databases

CTDi161742
DisGeNETi161742
EuPathDBiHostDB:ENSG00000166068.12
GeneCardsiSPRED1
GeneReviewsiSPRED1
HGNCiHGNC:20249 SPRED1
HPAiHPA042193
HPA061805
MalaCardsiSPRED1
MIMi609291 gene
611431 phenotype
neXtProtiNX_Q7Z699
OpenTargetsiENSG00000166068
Orphaneti137605 Legius syndrome
PharmGKBiPA134897382
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQ20 Eukaryota
ENOG4112CZ7 LUCA
GeneTreeiENSGT00730000110272
HOGENOMiHOG000220886
HOVERGENiHBG057556
InParanoidiQ7Z699
KOiK04703
OMAiTDSNIQF
OrthoDBiEOG091G0OE8
PhylomeDBiQ7Z699
TreeFamiTF321411

Enzyme and pathway databases

ReactomeiR-HSA-5658442 Regulation of RAS by GAPs
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-6802949 Signaling by RAS mutants

Miscellaneous databases

ChiTaRSiSPRED1 human
GeneWikiiSPRED1
GenomeRNAii161742
PROiPR:Q7Z699
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166068 Expressed in 203 organ(s), highest expression level in intestine
CleanExiHS_SPRED1
ExpressionAtlasiQ7Z699 baseline and differential
GenevisibleiQ7Z699 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR023337 KBD
IPR011993 PH-like_dom_sf
IPR007875 Sprouty
IPR000697 WH1/EVH1_dom
PfamiView protein in Pfam
PF05210 Sprouty, 1 hit
PF00568 WH1, 1 hit
SMARTiView protein in SMART
SM00461 WH1, 1 hit
PROSITEiView protein in PROSITE
PS51488 KBD, 1 hit
PS51227 SPR, 1 hit
PS50229 WH1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPRE1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z699
Secondary accession number(s): B2RPJ8, Q05D53, Q8N256
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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