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UniProtKB - Q7Z698 (SPRE2_HUMAN)

Entry version 154 (10 Feb 2021)
Sequence version 2 (25 Jul 2006)
Previous versions | rss
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Protein

Sprouty-related, EVH1 domain-containing protein 2

Gene

SPRED2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:15683364). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7Z698

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5658442, Regulation of RAS by GAPs
R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling
R-HSA-6802953, RAS signaling downstream of NF1 loss-of-function variants

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sprouty-related, EVH1 domain-containing protein 2
Short name:
Spred-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPRED2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17722, SPRED2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609292, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z698

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198369.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi228Y → F: Reduces ubiquitination and CBL-induced phosphorylation; when associated with F-231. 1 Publication1
Mutagenesisi231Y → F: Reduces ubiquitination and CBL-induced phosphorylation; when associated with F-228. 1 Publication1
Mutagenesisi240Y → F: No affect on phosphorylation or ubiquitination. 1 Publication1
Mutagenesisi251Y → F: No affect on phosphorylation or ubiquitination. 1 Publication1
Mutagenesisi264Y → F: No affect on phosphorylation or ubiquitination; when associated with F-266. 1 Publication1
Mutagenesisi266Y → F: No affect on phosphorylation or ubiquitination; when associated with F-264. 1 Publication1
Mutagenesisi268Y → F: No affect on phosphorylation or ubiquitination. 1 Publication1
Mutagenesisi311Y → F: No affect on phosphorylation or ubiquitination. 1 Publication1
Mutagenesisi351Y → F: No affect on phosphorylation or ubiquitination. 1 Publication1
Mutagenesisi394Y → F: No affect on phosphorylation or ubiquitination. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		200734

Open Targets

More...OpenTargetsi		ENSG00000198369

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134956365

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z698, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SPRED2

Domain mapping of disease mutations (DMDM)

More...DMDMi		110825745

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000769101 – 418Sprouty-related, EVH1 domain-containing protein 2Add BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei206PhosphoserineCombined sources1
Modified residuei228Phosphotyrosine1 Publication1
Modified residuei231Phosphotyrosine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine and threonine residues (PubMed:15683364). Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination (PubMed:17094949).2 Publications
Ubiquitinated; leading to degradation by the proteasome.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7Z698

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z698

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z698

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7Z698

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z698

PeptideAtlas

More...PeptideAtlasi		Q7Z698

PRoteomics IDEntifications database

More...PRIDEi		Q7Z698

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69384 [Q7Z698-1]
69385 [Q7Z698-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z698

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z698

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q7Z698

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver, skin, small intestine, salivary gland and prostate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198369, Expressed in forebrain and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7Z698, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z698, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198369, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and heterodimer (PubMed:15683364). Able to interact with SPRED1 to form heterodimers (PubMed:15683364).

Interacts with RAS (By similarity). May interact with ZDHHC13 (via ANK repeats) and ZDHHC17 (via ANK repeats) (By similarity).

Interacts with TESK1 (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q7Z698
With#Exp.IntAct
APBB2 - isoform 2 [Q92870-2]3EBI-7082156,EBI-21535880
AQP1 [P29972]3EBI-7082156,EBI-745213
CALR [P27797]3EBI-7082156,EBI-1049597
CHAT - isoform R [P28329-3]3EBI-7082156,EBI-25837549
DLST [P36957]3EBI-7082156,EBI-351007
DMWD [G5E9A7]3EBI-7082156,EBI-10976677
DNM2 - isoform 2 [P50570-2]3EBI-7082156,EBI-10968534
FGFR3 [P22607]3EBI-7082156,EBI-348399
GFAP [P14136]3EBI-7082156,EBI-744302
GLE1 [Q53GS7]3EBI-7082156,EBI-1955541
GRN [P28799]3EBI-7082156,EBI-747754
hCG_1987119 [A0A024R8L2]3EBI-7082156,EBI-14103818
HTT [P42858]6EBI-7082156,EBI-466029
KCNIP1 - isoform 2 [Q9NZI2-2]3EBI-7082156,EBI-22452746
KIF1B - isoform 2 [O60333-2]3EBI-7082156,EBI-10975473
KPRP [Q5T749]3EBI-7082156,EBI-10981970
KRTAP12-2 [P59991]3EBI-7082156,EBI-10176379
KRTAP2-4 [Q9BYR9]3EBI-7082156,EBI-14065470
LCE1C [Q5T751]3EBI-7082156,EBI-12224199
LCE2B [O14633]3EBI-7082156,EBI-11478468
LCE5A [Q5TCM9]3EBI-7082156,EBI-11955689
LMNA [P02545]3EBI-7082156,EBI-351935
MDFI [Q99750]3EBI-7082156,EBI-724076
NCS1 [P62166]3EBI-7082156,EBI-746987
NDUFB7 [P17568]3EBI-7082156,EBI-1246238
NDUFV2 [P19404]3EBI-7082156,EBI-713665
NEK7 [Q8TDX7]3EBI-7082156,EBI-1055945
NOS3 [P29474]3EBI-7082156,EBI-1391623
PMP22 [D3DTS7]3EBI-7082156,EBI-25882629
PRPS1 [P60891]3EBI-7082156,EBI-749195
QARS1 [P47897]3EBI-7082156,EBI-347462
RBM48 [Q5RL73]3EBI-7082156,EBI-473821
RNF11 [Q9Y3C5]3EBI-7082156,EBI-396669
RPS6KA3 [P51812]4EBI-7082156,EBI-1046616
RPS6KA6 [Q9UK32]3EBI-7082156,EBI-722467
SPG21 [Q9NZD8]10EBI-7082156,EBI-742688
SPRED1 [Q7Z699]3EBI-7082156,EBI-5235340
TOP3B [O95985]4EBI-7082156,EBI-373403
TSNAX [Q99598]3EBI-7082156,EBI-742638
VSNL1 [P62760]3EBI-7082156,EBI-740943
WFS1 [O76024]3EBI-7082156,EBI-720609
ZDHHC17 [Q8IUH5]3EBI-7082156,EBI-524753
ZNF250 - isoform 3 [P15622-3]3EBI-7082156,EBI-10177272
ZNF414 [Q96IQ9]3EBI-7082156,EBI-744257
ZNF417 [Q8TAU3]3EBI-7082156,EBI-740727
ZNF575 [Q86XF7]3EBI-7082156,EBI-14069183
ZNF837 [Q96EG3]6EBI-7082156,EBI-11962574

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128344, 50 interactors

Protein interaction database and analysis system

More...IntActi		Q7Z698, 56 interactors

Molecular INTeraction database

More...MINTi		Q7Z698

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000348753

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z698, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1418
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q7Z698

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7Z698

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q7Z698

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 122WH1PROSITE-ProRule annotationAdd BLAST118
Domaini201 – 257KBDPROSITE-ProRule annotationAdd BLAST57
Domaini308 – 416SPRPROSITE-ProRule annotationAdd BLAST109

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4590, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156841

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_038867_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z698

Database of Orthologous Groups

More...OrthoDBi		1094638at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z698

TreeFam database of animal gene trees

More...TreeFami		TF321411

Family and domain databases

Conserved Domains Database

More...CDDi		cd10574, EVH1_SPRED-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023337, KBD
IPR011993, PH-like_dom_sf
IPR041937, SPRE_EVH1
IPR007875, Sprouty
IPR000697, WH1/EVH1_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05210, Sprouty, 1 hit
PF00568, WH1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00461, WH1, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51488, KBD, 1 hit
PS51227, SPR, 1 hit
PS50229, WH1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z698-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTEETHPDDD SYIVRVKAVV MTRDDSSGGW FPQEGGGISR VGVCKVMHPE 
        60         70         80         90        100
GNGRSGFLIH GERQKDKLVV LECYVRKDLV YTKANPTFHH WKVDNRKFGL 
       110        120        130        140        150
TFQSPADARA FDRGVRKAIE DLIEGSTTSS STIHNEAELG DDDVFTTATD 
       160        170        180        190        200
SSSNSSQKRE QPTRTISSPT SCEHRRIYTL GHLHDSYPTD HYHLDQPMPR 
       210        220        230        240        250
PYRQVSFPDD DEEIVRINPR EKIWMTGYED YRHAPVRGKY PDPSEDADSS 
       260        270        280        290        300
YVRFAKGEVP KHDYNYPYVD SSDFGLGEDP KGRGGSVIKT QPSRGKSRRR 
       310        320        330        340        350
KEDGERSRCV YCRDMFNHEE NRRGHCQDAP DSVRTCIRRV SCMWCADSML 
       360        370        380        390        400
YHCMSDPEGD YTDPCSCDTS DEKFCLRWMA LIALSFLAPC MCCYLPLRAC 
       410 
YHCGVMCRCC GGKHKAAA
Length:418
Mass (Da):47,558
Last modified:July 25, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA4FE80C45008851
GO
Isoform 2 (identifier: Q7Z698-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MTEETHPDD → MASPGS

Show »
Length:415
Mass (Da):47,033
Checksum:i2E6F7236B9F0FB3C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JG63C9JG63_HUMAN
Sprouty-related, EVH1 domain-contai...
SPRED2
432Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2T4H7C2T4_HUMAN
Sprouty-related, EVH1 domain-contai...
SPRED2
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J623C9J623_HUMAN
Sprouty-related, EVH1 domain-contai...
SPRED2
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3Y6H7C3Y6_HUMAN
Sprouty-related, EVH1 domain-contai...
SPRED2
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C065H7C065_HUMAN
Sprouty-related, EVH1 domain-contai...
SPRED2
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33Q → R in BAH12943 (PubMed:14702039).Curated1
Sequence conflicti202Y → C in AAP59415 (PubMed:15683364).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0437551 – 9MTEETHPDD → MASPGS in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY299090 mRNA Translation: AAP59415.1
AK299079 mRNA Translation: BAH12943.1
AC012370 Genomic DNA No translation available.
AC097503 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99905.1
CH471053 Genomic DNA Translation: EAW99906.1
BC111495 mRNA Translation: AAI11496.1
BC130292 mRNA Translation: AAI30293.1
BC136334 mRNA Translation: AAI36335.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS33211.1 [Q7Z698-1]
CCDS46308.1 [Q7Z698-2]

NCBI Reference Sequences

More...RefSeqi		NP_001121682.1, NM_001128210.1 [Q7Z698-2]
NP_861449.2, NM_181784.2 [Q7Z698-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356388; ENSP00000348753; ENSG00000198369 [Q7Z698-1]
ENST00000443619; ENSP00000393697; ENSG00000198369 [Q7Z698-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		200734

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:200734

UCSC genome browser

More...UCSCi		uc002sdr.5, human [Q7Z698-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299090 mRNA Translation: AAP59415.1
AK299079 mRNA Translation: BAH12943.1
AC012370 Genomic DNA No translation available.
AC097503 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99905.1
CH471053 Genomic DNA Translation: EAW99906.1
BC111495 mRNA Translation: AAI11496.1
BC130292 mRNA Translation: AAI30293.1
BC136334 mRNA Translation: AAI36335.1
CCDSiCCDS33211.1 [Q7Z698-1]
CCDS46308.1 [Q7Z698-2]
RefSeqiNP_001121682.1, NM_001128210.1 [Q7Z698-2]
NP_861449.2, NM_181784.2 [Q7Z698-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JP2NMR-A1-124[»]
BMRBiQ7Z698
SMRiQ7Z698
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi128344, 50 interactors
IntActiQ7Z698, 56 interactors
MINTiQ7Z698
STRINGi9606.ENSP00000348753

PTM databases

iPTMnetiQ7Z698
PhosphoSitePlusiQ7Z698
SwissPalmiQ7Z698

Genetic variation databases

BioMutaiSPRED2
DMDMi110825745

Proteomic databases

EPDiQ7Z698
jPOSTiQ7Z698
MassIVEiQ7Z698
MaxQBiQ7Z698
PaxDbiQ7Z698
PeptideAtlasiQ7Z698
PRIDEiQ7Z698
ProteomicsDBi69384 [Q7Z698-1]
69385 [Q7Z698-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30873, 141 antibodies

The DNASU plasmid repository

More...DNASUi		200734

Genome annotation databases

EnsembliENST00000356388; ENSP00000348753; ENSG00000198369 [Q7Z698-1]
ENST00000443619; ENSP00000393697; ENSG00000198369 [Q7Z698-2]
GeneIDi200734
KEGGihsa:200734
UCSCiuc002sdr.5, human [Q7Z698-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		200734
DisGeNETi200734

GeneCards: human genes, protein and diseases

More...GeneCardsi		SPRED2
HGNCiHGNC:17722, SPRED2
HPAiENSG00000198369, Low tissue specificity
MIMi609292, gene
neXtProtiNX_Q7Z698
OpenTargetsiENSG00000198369
PharmGKBiPA134956365
VEuPathDBiHostDB:ENSG00000198369.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4590, Eukaryota
GeneTreeiENSGT00940000156841
HOGENOMiCLU_038867_1_1_1
InParanoidiQ7Z698
OrthoDBi1094638at2759
PhylomeDBiQ7Z698
TreeFamiTF321411

Enzyme and pathway databases

PathwayCommonsiQ7Z698
ReactomeiR-HSA-5658442, Regulation of RAS by GAPs
R-HSA-5658623, FGFRL1 modulation of FGFR1 signaling
R-HSA-6802953, RAS signaling downstream of NF1 loss-of-function variants

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		200734, 15 hits in 880 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SPRED2, human
EvolutionaryTraceiQ7Z698

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SPRED2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		200734
PharosiQ7Z698, Tbio

Protein Ontology

More...PROi		PR:Q7Z698
RNActiQ7Z698, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198369, Expressed in forebrain and 220 other tissues
ExpressionAtlasiQ7Z698, baseline and differential
GenevisibleiQ7Z698, HS

Family and domain databases

CDDicd10574, EVH1_SPRED-like, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR023337, KBD
IPR011993, PH-like_dom_sf
IPR041937, SPRE_EVH1
IPR007875, Sprouty
IPR000697, WH1/EVH1_dom
PfamiView protein in Pfam
PF05210, Sprouty, 1 hit
PF00568, WH1, 1 hit
SMARTiView protein in SMART
SM00461, WH1, 1 hit
PROSITEiView protein in PROSITE
PS51488, KBD, 1 hit
PS51227, SPR, 1 hit
PS50229, WH1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPRE2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z698
Secondary accession number(s): A1L3V4
, B7Z5K7, D6W5F7, E9PEP0, Q2NKX6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 25, 2006
Last modified: February 10, 2021
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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