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UniProtKB - Q7Z614 (SNX20_HUMAN)
Protein
Sorting nexin-20
Gene
SNX20
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 116 | Phosphatidylinositol 3-phosphateBy similarity | 1 | |
Binding sitei | 118 | Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity | 1 | |
Binding sitei | 143 | Phosphatidylinositol 3-phosphateBy similarity | 1 | |
Binding sitei | 157 | Phosphatidylinositol 3-phosphateBy similarity | 1 |
GO - Molecular functioni
- phosphatidylinositol-3-phosphate binding Source: UniProtKB
- phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
- phosphatidylinositol phosphate binding Source: GO_Central
GO - Biological processi
- protein transport Source: UniProtKB-KW
Keywordsi
Biological process | Protein transport, Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q7Z614 |
SignaLinki | Q7Z614 |
Names & Taxonomyi
Protein namesi | Recommended name: Sorting nexin-20Alternative name(s): Selectin ligand-interactor cytoplasmic 11 Publication Short name: SLIC-11 Publication |
Gene namesi | Name:SNX20 Synonyms:SLIC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30390, SNX20 |
MIMi | 613281, gene |
neXtProti | NX_Q7Z614 |
VEuPathDBi | HostDB:ENSG00000167208 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus 1 Publication
Endosome
- Early endosome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Endosome
- early endosome membrane Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Endosome, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 116 | R → Q: Decreased binding activity to all phospholipids. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 124460 |
OpenTargetsi | ENSG00000167208 |
PharmGKBi | PA162404311 |
Miscellaneous databases
Pharosi | Q7Z614, Tdark |
Genetic variation databases
BioMutai | SNX20 |
DMDMi | 74713704 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000325820 | 1 – 316 | Sorting nexin-20Add BLAST | 316 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 3 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q7Z614 |
MassIVEi | Q7Z614 |
PaxDbi | Q7Z614 |
PeptideAtlasi | Q7Z614 |
PRIDEi | Q7Z614 |
ProteomicsDBi | 69364 [Q7Z614-1] 69365 [Q7Z614-2] 69366 [Q7Z614-3] 69367 [Q7Z614-4] |
PTM databases
iPTMneti | Q7Z614 |
PhosphoSitePlusi | Q7Z614 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167208, Expressed in granulocyte and 156 other tissues |
ExpressionAtlasi | Q7Z614, baseline and differential |
Genevisiblei | Q7Z614, HS |
Organism-specific databases
HPAi | ENSG00000167208, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Interacts with SELPLG (PubMed:18196517). Interaction with SELPLG is controversial.
Curated1 PublicationBinary interactionsi
Q7Z614
Isoform 3 [Q7Z614-3]
Protein-protein interaction databases
BioGRIDi | 125867, 25 interactors |
IntActi | Q7Z614, 23 interactors |
STRINGi | 9606.ENSP00000332062 |
Miscellaneous databases
RNActi | Q7Z614, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 74 – 191 | PXPROSITE-ProRule annotationAdd BLAST | 118 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 54 | DisorderedSequence analysisAdd BLAST | 32 |
Domaini
The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes.1 Publication
Sequence similaritiesi
Belongs to the sorting nexin family.Curated
Phylogenomic databases
eggNOGi | KOG2101, Eukaryota |
GeneTreei | ENSGT00530000063759 |
HOGENOMi | CLU_160093_0_0_1 |
InParanoidi | Q7Z614 |
OMAi | ATRCVRH |
OrthoDBi | 1322681at2759 |
PhylomeDBi | Q7Z614 |
TreeFami | TF326807 |
Family and domain databases
Gene3Di | 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR001683, PX_dom IPR036871, PX_dom_sf IPR039937, SNX20/SNX21 |
PANTHERi | PTHR20939, PTHR20939, 1 hit |
Pfami | View protein in Pfam PF00787, PX, 1 hit |
SMARTi | View protein in SMART SM00312, PX, 1 hit |
SUPFAMi | SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50195, PX, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q7Z614-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASPEHPGSP GCMGPITQCT ARTQQEAPAT GPDLPHPGPD GHLDTHSGLS
60 70 80 90 100
SNSSMTTREL QQYWQNQKCR WKHVKLLFEI ASARIEERKV SKFVVYQIIV
110 120 130 140 150
IQTGSFDNNK AVLERRYSDF AKLQKALLKT FREEIEDVEF PRKHLTGNFA
160 170 180 190 200
EEMICERRRA LQEYLGLLYA IRCVRRSREF LDFLTRPELR EAFGCLRAGQ
210 220 230 240 250
YPRALELLLR VLPLQEKLTA HCPAAAVPAL CAVLLCHRDL DRPAEAFAAG
260 270 280 290 300
ERALQRLQAR EGHRYYAPLL DAMVRLAYAL GKDFVTLQER LEESQLRRPT
310
PRGITLKELT VREYLH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039927 | 35 | P → L1 PublicationCorresponds to variant dbSNP:rs1131716Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032425 | 95 – 129 | VYQII…KALLK → MGKSRPGEMTYPGSRGETGT APEPDPRCPRQSDML in isoform 3. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_032426 | 95 – 102 | VYQIIVIQ → APAPDATP in isoform 4. 2 Publications | 8 | |
Alternative sequenceiVSP_032427 | 103 – 316 | Missing in isoform 4. 2 PublicationsAdd BLAST | 214 | |
Alternative sequenceiVSP_032428 | 121 – 284 | Missing in isoform 2. 1 PublicationAdd BLAST | 164 | |
Alternative sequenceiVSP_032429 | 130 – 316 | Missing in isoform 3. 1 PublicationAdd BLAST | 187 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY302441 mRNA Translation: AAP58362.1 AK292650 mRNA Translation: BAF85339.1 AK292705 mRNA Translation: BAF85394.1 CH471092 Genomic DNA Translation: EAW82763.1 BC063423 mRNA Translation: AAH63423.1 BC119626 mRNA Translation: AAI19627.1 |
CCDSi | CCDS10744.1 [Q7Z614-3] CCDS10745.1 [Q7Z614-1] CCDS45481.1 [Q7Z614-4] |
RefSeqi | NP_001138444.1, NM_001144972.1 [Q7Z614-4] NP_699168.1, NM_153337.2 [Q7Z614-3] NP_878274.1, NM_182854.3 [Q7Z614-1] |
Genome annotation databases
Ensembli | ENST00000300590.7; ENSP00000300590.3; ENSG00000167208.16 [Q7Z614-3] ENST00000330943.9; ENSP00000332062.4; ENSG00000167208.16 ENST00000423026.6; ENSP00000388875.2; ENSG00000167208.16 [Q7Z614-4] ENST00000568993.5; ENSP00000454863.1; ENSG00000167208.16 [Q7Z614-3] |
GeneIDi | 124460 |
KEGGi | hsa:124460 |
MANE-Selecti | ENST00000330943.9; ENSP00000332062.4; NM_182854.4; NP_878274.1 |
UCSCi | uc002egi.4, human [Q7Z614-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY302441 mRNA Translation: AAP58362.1 AK292650 mRNA Translation: BAF85339.1 AK292705 mRNA Translation: BAF85394.1 CH471092 Genomic DNA Translation: EAW82763.1 BC063423 mRNA Translation: AAH63423.1 BC119626 mRNA Translation: AAI19627.1 |
CCDSi | CCDS10744.1 [Q7Z614-3] CCDS10745.1 [Q7Z614-1] CCDS45481.1 [Q7Z614-4] |
RefSeqi | NP_001138444.1, NM_001144972.1 [Q7Z614-4] NP_699168.1, NM_153337.2 [Q7Z614-3] NP_878274.1, NM_182854.3 [Q7Z614-1] |
3D structure databases
AlphaFoldDBi | Q7Z614 |
SMRi | Q7Z614 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125867, 25 interactors |
IntActi | Q7Z614, 23 interactors |
STRINGi | 9606.ENSP00000332062 |
PTM databases
iPTMneti | Q7Z614 |
PhosphoSitePlusi | Q7Z614 |
Genetic variation databases
BioMutai | SNX20 |
DMDMi | 74713704 |
Proteomic databases
jPOSTi | Q7Z614 |
MassIVEi | Q7Z614 |
PaxDbi | Q7Z614 |
PeptideAtlasi | Q7Z614 |
PRIDEi | Q7Z614 |
ProteomicsDBi | 69364 [Q7Z614-1] 69365 [Q7Z614-2] 69366 [Q7Z614-3] 69367 [Q7Z614-4] |
Protocols and materials databases
Antibodypediai | 28297, 93 antibodies from 18 providers |
DNASUi | 124460 |
Genome annotation databases
Ensembli | ENST00000300590.7; ENSP00000300590.3; ENSG00000167208.16 [Q7Z614-3] ENST00000330943.9; ENSP00000332062.4; ENSG00000167208.16 ENST00000423026.6; ENSP00000388875.2; ENSG00000167208.16 [Q7Z614-4] ENST00000568993.5; ENSP00000454863.1; ENSG00000167208.16 [Q7Z614-3] |
GeneIDi | 124460 |
KEGGi | hsa:124460 |
MANE-Selecti | ENST00000330943.9; ENSP00000332062.4; NM_182854.4; NP_878274.1 |
UCSCi | uc002egi.4, human [Q7Z614-1] |
Organism-specific databases
CTDi | 124460 |
DisGeNETi | 124460 |
GeneCardsi | SNX20 |
HGNCi | HGNC:30390, SNX20 |
HPAi | ENSG00000167208, Tissue enhanced (bone marrow, lymphoid tissue) |
MIMi | 613281, gene |
neXtProti | NX_Q7Z614 |
OpenTargetsi | ENSG00000167208 |
PharmGKBi | PA162404311 |
VEuPathDBi | HostDB:ENSG00000167208 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2101, Eukaryota |
GeneTreei | ENSGT00530000063759 |
HOGENOMi | CLU_160093_0_0_1 |
InParanoidi | Q7Z614 |
OMAi | ATRCVRH |
OrthoDBi | 1322681at2759 |
PhylomeDBi | Q7Z614 |
TreeFami | TF326807 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z614 |
SignaLinki | Q7Z614 |
Miscellaneous databases
BioGRID-ORCSi | 124460, 7 hits in 1071 CRISPR screens |
ChiTaRSi | SNX20, human |
GenomeRNAii | 124460 |
Pharosi | Q7Z614, Tdark |
PROi | PR:Q7Z614 |
RNActi | Q7Z614, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167208, Expressed in granulocyte and 156 other tissues |
ExpressionAtlasi | Q7Z614, baseline and differential |
Genevisiblei | Q7Z614, HS |
Family and domain databases
Gene3Di | 3.30.1520.10, 1 hit |
InterProi | View protein in InterPro IPR001683, PX_dom IPR036871, PX_dom_sf IPR039937, SNX20/SNX21 |
PANTHERi | PTHR20939, PTHR20939, 1 hit |
Pfami | View protein in Pfam PF00787, PX, 1 hit |
SMARTi | View protein in SMART SM00312, PX, 1 hit |
SUPFAMi | SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS50195, PX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SNX20_HUMAN | |
Accessioni | Q7Z614Primary (citable) accession number: Q7Z614 Secondary accession number(s): A8K9D5 Q8IV59 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | October 1, 2003 | |
Last modified: | May 25, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families