SNX20

Functionⁱ

May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	116	Phosphatidylinositol 3-phosphateBy similarity	1
Binding siteⁱ	118	Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity	1
Binding siteⁱ	143	Phosphatidylinositol 3-phosphateBy similarity	1
Binding siteⁱ	157	Phosphatidylinositol 3-phosphateBy similarity	1

GO - Molecular functionⁱ

phosphatidylinositol-3-phosphate binding Source: UniProtKB
phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport
Ligand	Lipid-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sorting nexin-20 Alternative name(s): Selectin ligand-interactor cytoplasmic 11 Publication Short name: SLIC-11 Publication
Gene namesⁱ	Name:SNX20 Synonyms:SLIC1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000167208.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30390 SNX20
MIMⁱ	613281 gene
neXtProtⁱ	NX_Q7Z614

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Endosome, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	116	R → Q: Decreased binding activity to all phospholipids. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	124460
Open Targets More...OpenTargetsⁱ	ENSG00000167208
PharmGKBⁱ	PA162404311

Polymorphism and mutation databases

BioMutaⁱ	SNX20
DMDMⁱ	74713704

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000325820	1 – 316	Sorting nexin-20Add BLAST		316

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	3	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q7Z614
PeptideAtlas More...PeptideAtlasⁱ	Q7Z614
PRIDEⁱ	Q7Z614
ProteomicsDBⁱ	69364 69365 [Q7Z614-2] 69366 [Q7Z614-3] 69367 [Q7Z614-4]

PTM databases

iPTMnetⁱ	Q7Z614
PhosphoSitePlusⁱ	Q7Z614

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000167208 Expressed in 137 organ(s), highest expression level in blood
CleanExⁱ	HS_SNX20
ExpressionAtlasⁱ	Q7Z614 baseline and differential
Genevisibleⁱ	Q7Z614 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043649

HPAⁱ

HPA043649

Interactionⁱ

Subunit structureⁱ

Interacts with SELPLG (PubMed:18196517). Interaction with SELPLG is controversial.Curated1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ALAS1	P13196	3	EBI-744896,EBI-3905054
FAM9B	Q8IZU0	3	EBI-744896,EBI-10175124
FLJ13057	Q53SE7	3	EBI-744896,EBI-10172181
KLHL12	Q53G59	4	EBI-744896,EBI-740929
MAGEA11	P43364-2	3	EBI-744896,EBI-10178634
SELPLG	Q14242	5	EBI-744896,EBI-1030190
TACC3	Q9Y6A5	3	EBI-744896,EBI-2554984
TFIP11	Q9UBB9	3	EBI-744896,EBI-1105213

Protein-protein interaction databases

BioGridⁱ	125867, 19 interactors
IntActⁱ	Q7Z614, 9 interactors
STRINGⁱ	9606.ENSP00000332062

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7Z614
SMRⁱ	Q7Z614
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	74 – 191	PXPROSITE-ProRule annotationAdd BLAST		118

Domainⁱ

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for localization to the endosomes.1 Publication

Sequence similaritiesⁱ

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IMHU Eukaryota ENOG41114JN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063759
HOGENOMⁱ	HOG000154363
HOVERGENⁱ	HBG108497
InParanoidⁱ	Q7Z614
KEGG Orthology (KO) More...KOⁱ	K17931
OMAⁱ	CLRAGQY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0S8F
PhylomeDBⁱ	Q7Z614
TreeFamⁱ	TF326807

Family and domain databases

Gene3Dⁱ	1.25.40.10, 1 hit 3.30.1520.10, 1 hit
InterProⁱ	View protein in InterPro IPR001683 Phox IPR036871 PX_dom_sf IPR011990 TPR-like_helical_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00787 PX, 1 hit
SMARTⁱ	View protein in SMART SM00312 PX, 1 hit
SUPFAMⁱ	SSF64268 SSF64268, 1 hit
PROSITEⁱ	View protein in PROSITE PS50195 PX, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.ⁱShow all

Isoform 1 (identifier: Q7Z614-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASPEHPGSP GCMGPITQCT ARTQQEAPAT GPDLPHPGPD GHLDTHSGLS 
        60         70         80         90        100
SNSSMTTREL QQYWQNQKCR WKHVKLLFEI ASARIEERKV SKFVVYQIIV 
       110        120        130        140        150
IQTGSFDNNK AVLERRYSDF AKLQKALLKT FREEIEDVEF PRKHLTGNFA 
       160        170        180        190        200
EEMICERRRA LQEYLGLLYA IRCVRRSREF LDFLTRPELR EAFGCLRAGQ 
       210        220        230        240        250
YPRALELLLR VLPLQEKLTA HCPAAAVPAL CAVLLCHRDL DRPAEAFAAG 
       260        270        280        290        300
ERALQRLQAR EGHRYYAPLL DAMVRLAYAL GKDFVTLQER LEESQLRRPT 
       310 
PRGITLKELT VREYLH

Length:316

Mass (Da):36,178

Last modified:October 1, 2003 - v1

Checksum:ⁱ48D06CF4490907F4

GO

Isoform 2 (identifier: Q7Z614-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
121-284: Missing.

« Hide

        10         20         30         40         50
MASPEHPGSP GCMGPITQCT ARTQQEAPAT GPDLPHPGPD GHLDTHSGLS 
        60         70         80         90        100
SNSSMTTREL QQYWQNQKCR WKHVKLLFEI ASARIEERKV SKFVVYQIIV 
       110        120        130        140        150
IQTGSFDNNK AVLERRYSDF VTLQERLEES QLRRPTPRGI TLKELTVREY 

LH

Show »

Length:152

Mass (Da):17,314

Checksum:ⁱE9E2EE4EDE3AAC46

GO

Isoform 3 (identifier: Q7Z614-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
95-129: VYQIIVIQTGSFDNNKAVLERRYSDFAKLQKALLK → MGKSRPGEMTYPGSRGETGTAPEPDPRCPRQSDML
130-316: Missing.

« Hide

        10         20         30         40         50
MASPEHPGSP GCMGPITQCT ARTQQEAPAT GPDLPHPGPD GHLDTHSGLS 
        60         70         80         90        100
SNSSMTTREL QQYWQNQKCR WKHVKLLFEI ASARIEERKV SKFVMGKSRP 
       110        120 
GEMTYPGSRG ETGTAPEPDP RCPRQSDML

Show »

Length:129

Mass (Da):14,186

Checksum:ⁱ7037F3ABC0033C43

GO

Isoform 4 (identifier: Q7Z614-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
95-102: VYQIIVIQ → APAPDATP
103-316: Missing.

« Hide

        10         20         30         40         50
MASPEHPGSP GCMGPITQCT ARTQQEAPAT GPDLPHPGPD GHLDTHSGLS 
        60         70         80         90        100
SNSSMTTREL QQYWQNQKCR WKHVKLLFEI ASARIEERKV SKFVAPAPDA 

TP

Show »

Length:102

Mass (Da):11,131

Checksum:ⁱ47D9A565C2C63833

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	A0A087X2C1	A0A087X2C1_HUMAN		Sorting nexin-20 Sorting nexin-20	SNX20	152	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_039927	35	P → L1 PublicationCorresponds to variant dbSNP:rs1131716Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_032425	95 – 129	VYQII…KALLK → MGKSRPGEMTYPGSRGETGT APEPDPRCPRQSDML in isoform 3. 1 PublicationAdd BLAST	35
Alternative sequenceⁱVSP_032426	95 – 102	VYQIIVIQ → APAPDATP in isoform 4. 2 Publications	8
Alternative sequenceⁱVSP_032427	103 – 316	Missing in isoform 4. 2 PublicationsAdd BLAST	214
Alternative sequenceⁱVSP_032428	121 – 284	Missing in isoform 2. 1 PublicationAdd BLAST	164
Alternative sequenceⁱVSP_032429	130 – 316	Missing in isoform 3. 1 PublicationAdd BLAST	187

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY302441 mRNA Translation: AAP58362.1 AK292650 mRNA Translation: BAF85339.1 AK292705 mRNA Translation: BAF85394.1 CH471092 Genomic DNA Translation: EAW82763.1 BC063423 mRNA Translation: AAH63423.1 BC119626 mRNA Translation: AAI19627.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10744.1 [Q7Z614-3] CCDS10745.1 [Q7Z614-1] CCDS45481.1 [Q7Z614-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001138444.1, NM_001144972.1 [Q7Z614-4] NP_699168.1, NM_153337.2 [Q7Z614-3] NP_878274.1, NM_182854.3 [Q7Z614-1]
UniGeneⁱ	Hs.460777 Hs.660456 Hs.715778

Genome annotation databases

Ensemblⁱ	ENST00000300590; ENSP00000300590; ENSG00000167208 [Q7Z614-3] ENST00000330943; ENSP00000332062; ENSG00000167208 [Q7Z614-1] ENST00000423026; ENSP00000388875; ENSG00000167208 [Q7Z614-4] ENST00000568993; ENSP00000454863; ENSG00000167208 [Q7Z614-3]
GeneIDⁱ	124460
KEGGⁱ	hsa:124460
UCSC genome browser More...UCSCⁱ	uc002egi.4 human [Q7Z614-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7Z614	SNX20 isoform 2		PANTR		316	UniRef90_Q7Z614
Sorting nexin-20 isoform 1		MACMU		316
Sorting nexin 20		MANLE		316
Sorting nexin 20		MACFA		316
Sorting nexin 20		MACNE		316
+20
Q7Z614-2	Sorting nexin-20		MACMU		153	UniRef90_Q7Z614-2
Sorting nexin 20		MANLE		153
Sorting nexin 20		MACFA		153
Sorting nexin 20		MACNE		153
Sorting nexin 20		PANTR		153
+6
Q7Z614-3	Uncharacterized protein		AOTNA		130	UniRef90_Q7Z614-3
Sorting nexin 20		CALJA		130
Sorting nexin-20		MACMU		129
Sorting nexin 20		MACFA		129
Sorting nexin 20		MACNE		129
+3
Q7Z614-4	SNX20 isoform 3		PANTR		102	UniRef90_Q7Z614-4
Sorting nexin-20		MACMU		102
Sorting nexin 20		MANLE		102
Sorting nexin 20		MACFA		102
Sorting nexin 20		MACNE		102
+10

Protein	Similar proteins		Species	Score	Length	Source
Q7Z614	Sorting nexin 20		CHLSB		316	UniRef50_Q7Z614
Sorting nexin 20		RHIRO		316
Sorting nexin 20		RHIBE		316
Sorting nexin 20		PAPAN		316
Sorting nexin 20		Cebus capucinus imitator		316
+120
Q7Z614-2	Sorting nexin-20		MACMU		153	UniRef50_Q7Z614-2
Sorting nexin 20		MANLE		153
Sorting nexin 20		MACFA		153
Sorting nexin 20		MACNE		153
Uncharacterized protein		AOTNA		153
+10
Q7Z614-3	Uncharacterized protein		AOTNA		130	UniRef50_Q7Z614-3
Sorting nexin 20		CALJA		130
Sorting nexin-20		MACMU		129
Sorting nexin 20		MACFA		129
Sorting nexin 20		MACNE		129
+5
Q7Z614-4	Sorting nexin 20		Cebus capucinus imitator		102	UniRef50_Q7Z614-4
SNX20 isoform 3		PANTR		102
Sorting nexin 20		PANPA		102
SNX20 isoform 1		PONAB		102
Uncharacterized protein		AOTNA		102
+14

Entry informationⁱ

Entry nameⁱ	SNX20_HUMAN
Accessionⁱ	Q7Z614Primary (citable) accession number: Q7Z614 Secondary accession number(s): A8K9D5 , Q08E98, Q6P4H2, Q8IV59
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
	Last sequence update:	October 1, 2003
	Last modified:	September 12, 2018
	This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7Z614 (SNX20_HUMAN)

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Sorting nexin-20

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Nucleus

Other locations

Endosome

Nucleus

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ