UniProtKB - Q7Z602 (GP141_HUMAN)
Protein
Probable G-protein coupled receptor 141
Gene
GPR141
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 141Alternative name(s): G-protein coupled receptor PGR13 |
Gene namesi | Name:GPR141 Synonyms:PGR13 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000187037.8 |
HGNCi | HGNC:19997 GPR141 |
MIMi | 609045 gene |
neXtProti | NX_Q7Z602 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 22 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 23 – 43 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 44 – 50 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 51 – 71 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 72 – 89 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 90 – 110 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 111 – 131 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 132 – 152 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 153 – 183 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 184 – 204 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 205 – 227 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 228 – 248 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 249 – 267 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 268 – 288 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 289 – 305 | CytoplasmicSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 353345 |
OpenTargetsi | ENSG00000187037 |
PharmGKBi | PA134923895 |
Polymorphism and mutation databases
BioMutai | GPR141 |
DMDMi | 62900364 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069618 | 1 – 305 | Probable G-protein coupled receptor 141Add BLAST | 305 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 9 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q7Z602 |
PeptideAtlasi | Q7Z602 |
PRIDEi | Q7Z602 |
ProteomicsDBi | 69363 |
PTM databases
iPTMneti | Q7Z602 |
PhosphoSitePlusi | Q7Z602 |
Expressioni
Gene expression databases
Bgeei | ENSG00000187037 Expressed in 81 organ(s), highest expression level in blood |
ExpressionAtlasi | Q7Z602 baseline and differential |
Interactioni
Protein-protein interaction databases
BioGridi | 131689, 13 interactors |
STRINGi | 9606.ENSP00000334540 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IN12 Eukaryota ENOG410Y9TY LUCA |
GeneTreei | ENSGT00940000154241 |
HOGENOMi | HOG000090258 |
HOVERGENi | HBG051782 |
InParanoidi | Q7Z602 |
KOi | K08429 |
OMAi | VINYMIV |
OrthoDBi | 1432969at2759 |
PhylomeDBi | Q7Z602 |
TreeFami | TF333221 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7Z602-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGHNTSRNS SCDPIVTPHL ISLYFIVLIG GLVGVISILF LLVKMNTRSV
60 70 80 90 100
TTMAVINLVV VHSVFLLTVP FRLTYLIKKT WMFGLPFCKF VSAMLHIHMY
110 120 130 140 150
LTFLFYVVIL VTRYLIFFKC KDKVEFYRKL HAVAASAGMW TLVIVIVVPL
160 170 180 190 200
VVSRYGIHEE YNEEHCFKFH KELAYTYVKI INYMIVIFVI AVAVILLVFQ
210 220 230 240 250
VFIIMLMVQK LRHSLLSHQE FWAQLKNLFF IGVILVCFLP YQFFRIYYLN
260 270 280 290 300
VVTHSNACNS KVAFYNEIFL SVTAISCYDL LLFVFGGSHW FKQKIIGLWN
CVLCR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JDP7 | C9JDP7_HUMAN | Probable G-protein-coupled receptor... | GPR141 | 104 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_074185 | 72 | R → H1 PublicationCorresponds to variant dbSNP:rs772202718Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY288420 mRNA Translation: AAP72129.1 CH236951 Genomic DNA Translation: EAL23980.1 BC120951 mRNA Translation: AAI20952.1 BC120952 mRNA Translation: AAI20953.1 AY255538 mRNA Translation: AAO85050.1 |
CCDSi | CCDS5451.1 |
RefSeqi | NP_001316922.1, NM_001329993.1 NP_001316923.1, NM_001329994.1 NP_861456.1, NM_181791.2 XP_011513687.1, XM_011515385.2 XP_011513688.1, XM_011515386.2 XP_011513690.1, XM_011515388.2 XP_011513691.1, XM_011515389.2 XP_016867654.1, XM_017012165.1 XP_016867655.1, XM_017012166.1 |
UniGenei | Hs.563492 Hs.688230 |
Genome annotation databases
Ensembli | ENST00000334425; ENSP00000334540; ENSG00000187037 ENST00000447769; ENSP00000390410; ENSG00000187037 |
GeneIDi | 353345 |
KEGGi | hsa:353345 |
UCSCi | uc003tfm.1 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY288420 mRNA Translation: AAP72129.1 CH236951 Genomic DNA Translation: EAL23980.1 BC120951 mRNA Translation: AAI20952.1 BC120952 mRNA Translation: AAI20953.1 AY255538 mRNA Translation: AAO85050.1 |
CCDSi | CCDS5451.1 |
RefSeqi | NP_001316922.1, NM_001329993.1 NP_001316923.1, NM_001329994.1 NP_861456.1, NM_181791.2 XP_011513687.1, XM_011515385.2 XP_011513688.1, XM_011515386.2 XP_011513690.1, XM_011515388.2 XP_011513691.1, XM_011515389.2 XP_016867654.1, XM_017012165.1 XP_016867655.1, XM_017012166.1 |
UniGenei | Hs.563492 Hs.688230 |
3D structure databases
ProteinModelPortali | Q7Z602 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 131689, 13 interactors |
STRINGi | 9606.ENSP00000334540 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q7Z602 |
PhosphoSitePlusi | Q7Z602 |
Polymorphism and mutation databases
BioMutai | GPR141 |
DMDMi | 62900364 |
Proteomic databases
PaxDbi | Q7Z602 |
PeptideAtlasi | Q7Z602 |
PRIDEi | Q7Z602 |
ProteomicsDBi | 69363 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000334425; ENSP00000334540; ENSG00000187037 ENST00000447769; ENSP00000390410; ENSG00000187037 |
GeneIDi | 353345 |
KEGGi | hsa:353345 |
UCSCi | uc003tfm.1 human |
Organism-specific databases
CTDi | 353345 |
DisGeNETi | 353345 |
EuPathDBi | HostDB:ENSG00000187037.8 |
GeneCardsi | GPR141 |
HGNCi | HGNC:19997 GPR141 |
MIMi | 609045 gene |
neXtProti | NX_Q7Z602 |
OpenTargetsi | ENSG00000187037 |
PharmGKBi | PA134923895 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IN12 Eukaryota ENOG410Y9TY LUCA |
GeneTreei | ENSGT00940000154241 |
HOGENOMi | HOG000090258 |
HOVERGENi | HBG051782 |
InParanoidi | Q7Z602 |
KOi | K08429 |
OMAi | VINYMIV |
OrthoDBi | 1432969at2759 |
PhylomeDBi | Q7Z602 |
TreeFami | TF333221 |
Miscellaneous databases
ChiTaRSi | GPR141 human |
GeneWikii | GPR141 |
GenomeRNAii | 353345 |
PROi | PR:Q7Z602 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000187037 Expressed in 81 organ(s), highest expression level in blood |
ExpressionAtlasi | Q7Z602 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | GP141_HUMAN | |
Accessioni | Q7Z602Primary (citable) accession number: Q7Z602 Secondary accession number(s): A4D1X7, Q0VAR5, Q86SP3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | October 1, 2003 | |
Last modified: | February 13, 2019 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries