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Protein

BTB/POZ domain-containing protein KCTD20

Gene

KCTD20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes the phosphorylation of AKT family members.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD20
Alternative name(s):
Potassium channel tetramerization domain containing 20
Gene namesi
Name:KCTD20
Synonyms:C6orf69
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112078.13
HGNCiHGNC:21052 KCTD20
MIMi615932 gene
neXtProtiNX_Q7Z5Y7

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi222658
OpenTargetsiENSG00000112078
PharmGKBiPA134913479

Polymorphism and mutation databases

BioMutaiKCTD20
DMDMi74750149

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002552481 – 419BTB/POZ domain-containing protein KCTD20Add BLAST419

Proteomic databases

EPDiQ7Z5Y7
MaxQBiQ7Z5Y7
PaxDbiQ7Z5Y7
PeptideAtlasiQ7Z5Y7
PRIDEiQ7Z5Y7
ProteomicsDBi69360
69361 [Q7Z5Y7-2]

PTM databases

iPTMnetiQ7Z5Y7
PhosphoSitePlusiQ7Z5Y7

Expressioni

Gene expression databases

BgeeiENSG00000112078 Expressed in 210 organ(s), highest expression level in amniotic fluid
CleanExiHS_KCTD20
ExpressionAtlasiQ7Z5Y7 baseline and differential
GenevisibleiQ7Z5Y7 HS

Organism-specific databases

HPAiHPA030092

Interactioni

Subunit structurei

Interacts with AKT1; AKT2 and AKT3 (By similarity). Associates with PP2CA (By similarity). Part of a complex containing MARK4 (PubMed:14676191).By similarity1 Publication

Protein-protein interaction databases

BioGridi128809, 10 interactors
IntActiQ7Z5Y7, 5 interactors

Structurei

3D structure databases

ProteinModelPortaliQ7Z5Y7
SMRiQ7Z5Y7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 191BTBAdd BLAST75

Phylogenomic databases

eggNOGiENOG410ISJ3 Eukaryota
ENOG410YA9I LUCA
GeneTreeiENSGT00390000007975
HOGENOMiHOG000261659
HOVERGENiHBG059410
InParanoidiQ7Z5Y7
OMAiYASQPAN
OrthoDBiEOG091G05SP
PhylomeDBiQ7Z5Y7
TreeFamiTF314369

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR039886 BTBD10/KCTD20
IPR039885 BTBD10/KCTD20_BTB/POZ
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR21637 PTHR21637, 1 hit
PfamiView protein in Pfam
PF16017 BTB_3, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z5Y7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNVHRGSDSD RLLRQEASCL VDDTLAVAQE KEANSLASSG PHNLTYPLGP
60 70 80 90 100
RNEDLSLDYA SQPANLQFPH IMPLAEDIKG SCFQSGNKRN HEPFIAPERF
110 120 130 140 150
GNSSVGFGSN SHSQAPEKVT LLVDGTRFVV NPQIFTAHPD TMLGRMFGPG
160 170 180 190 200
REYNFTRPNE KGEYEIAEGI SATVFRTVLD YYKTGIINCP DGISIPDLRD
210 220 230 240 250
TCDYLCINFD FNTIRCQDLS ALLHELSNDG AHKQFDHYLE ELILPIMVGC
260 270 280 290 300
AKKGERECHI VVLTDEDSVD WDEDHPPPMG EEYSQILYSS KLYRFFKYIE
310 320 330 340 350
NRDVAKTVLK ERGLKNIRIG IEGYPTCKEK IKRRPGGRSE VIYNYVQRPF
360 370 380 390 400
IQMSWEKEEG KSRHVDFQCV RSKSLTNLVA AGDDVLEDQE ILMHHPPQVD
410
ELDRLNAPLS QMASNDFQD
Length:419
Mass (Da):47,480
Last modified:October 1, 2003 - v1
Checksum:i71B5D35EA02714EC
GO
Isoform 2 (identifier: Q7Z5Y7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: D → G
     55-220: Missing.

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):28,892
Checksum:iFD685CD0E4995090
GO
Isoform 3 (identifier: Q7Z5Y7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-145: Missing.

Note: No experimental confirmation available.
Show »
Length:274
Mass (Da):31,669
Checksum:i6C4ABB9B0D986630
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXH0H7BXH0_HUMAN
BTB/POZ domain-containing protein K...
KCTD20
127Annotation score:
F8WF75F8WF75_HUMAN
BTB/POZ domain-containing protein K...
KCTD20
92Annotation score:
C9JY11C9JY11_HUMAN
BTB/POZ domain-containing protein K...
KCTD20
109Annotation score:
C9J624C9J624_HUMAN
BTB/POZ domain-containing protein K...
KCTD20
97Annotation score:
C9J5B3C9J5B3_HUMAN
BTB/POZ domain-containing protein K...
KCTD20
87Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70H → R in CAH10583 (PubMed:17974005).Curated1
Sequence conflicti205L → P in CAH10583 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028854171S → T1 PublicationCorresponds to variant dbSNP:rs2239808Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0556691 – 145Missing in isoform 3. 1 PublicationAdd BLAST145
Alternative sequenceiVSP_02127754D → G in isoform 2. 1 Publication1
Alternative sequenceiVSP_02127855 – 220Missing in isoform 2. 1 PublicationAdd BLAST166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY305862 mRNA Translation: AAP74385.1
AK302861 mRNA Translation: BAG64045.1
AK304377 mRNA Translation: BAG65215.1
AL136135 Genomic DNA No translation available.
Z85986 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03892.1
BC023525 mRNA Translation: AAH23525.1
AL832381 mRNA Translation: CAH10583.1
CCDSiCCDS4821.1 [Q7Z5Y7-1]
CCDS69096.1 [Q7Z5Y7-2]
CCDS69097.1 [Q7Z5Y7-3]
RefSeqiNP_001273508.1, NM_001286579.1 [Q7Z5Y7-2]
NP_001273509.1, NM_001286580.1 [Q7Z5Y7-3]
NP_775833.2, NM_173562.4 [Q7Z5Y7-1]
XP_005248997.1, XM_005248940.4 [Q7Z5Y7-1]
XP_006715086.1, XM_006715023.2 [Q7Z5Y7-1]
XP_011512700.1, XM_011514398.2 [Q7Z5Y7-1]
UniGeneiHs.188757

Genome annotation databases

EnsembliENST00000373731; ENSP00000362836; ENSG00000112078 [Q7Z5Y7-1]
ENST00000449081; ENSP00000412205; ENSG00000112078 [Q7Z5Y7-2]
ENST00000536244; ENSP00000439118; ENSG00000112078 [Q7Z5Y7-3]
GeneIDi222658
KEGGihsa:222658
UCSCiuc003ome.4 human [Q7Z5Y7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY305862 mRNA Translation: AAP74385.1
AK302861 mRNA Translation: BAG64045.1
AK304377 mRNA Translation: BAG65215.1
AL136135 Genomic DNA No translation available.
Z85986 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03892.1
BC023525 mRNA Translation: AAH23525.1
AL832381 mRNA Translation: CAH10583.1
CCDSiCCDS4821.1 [Q7Z5Y7-1]
CCDS69096.1 [Q7Z5Y7-2]
CCDS69097.1 [Q7Z5Y7-3]
RefSeqiNP_001273508.1, NM_001286579.1 [Q7Z5Y7-2]
NP_001273509.1, NM_001286580.1 [Q7Z5Y7-3]
NP_775833.2, NM_173562.4 [Q7Z5Y7-1]
XP_005248997.1, XM_005248940.4 [Q7Z5Y7-1]
XP_006715086.1, XM_006715023.2 [Q7Z5Y7-1]
XP_011512700.1, XM_011514398.2 [Q7Z5Y7-1]
UniGeneiHs.188757

3D structure databases

ProteinModelPortaliQ7Z5Y7
SMRiQ7Z5Y7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128809, 10 interactors
IntActiQ7Z5Y7, 5 interactors

PTM databases

iPTMnetiQ7Z5Y7
PhosphoSitePlusiQ7Z5Y7

Polymorphism and mutation databases

BioMutaiKCTD20
DMDMi74750149

Proteomic databases

EPDiQ7Z5Y7
MaxQBiQ7Z5Y7
PaxDbiQ7Z5Y7
PeptideAtlasiQ7Z5Y7
PRIDEiQ7Z5Y7
ProteomicsDBi69360
69361 [Q7Z5Y7-2]

Protocols and materials databases

DNASUi222658
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373731; ENSP00000362836; ENSG00000112078 [Q7Z5Y7-1]
ENST00000449081; ENSP00000412205; ENSG00000112078 [Q7Z5Y7-2]
ENST00000536244; ENSP00000439118; ENSG00000112078 [Q7Z5Y7-3]
GeneIDi222658
KEGGihsa:222658
UCSCiuc003ome.4 human [Q7Z5Y7-1]

Organism-specific databases

CTDi222658
DisGeNETi222658
EuPathDBiHostDB:ENSG00000112078.13
GeneCardsiKCTD20
HGNCiHGNC:21052 KCTD20
HPAiHPA030092
MIMi615932 gene
neXtProtiNX_Q7Z5Y7
OpenTargetsiENSG00000112078
PharmGKBiPA134913479
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISJ3 Eukaryota
ENOG410YA9I LUCA
GeneTreeiENSGT00390000007975
HOGENOMiHOG000261659
HOVERGENiHBG059410
InParanoidiQ7Z5Y7
OMAiYASQPAN
OrthoDBiEOG091G05SP
PhylomeDBiQ7Z5Y7
TreeFamiTF314369

Miscellaneous databases

ChiTaRSiKCTD20 human
GenomeRNAii222658
PROiPR:Q7Z5Y7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112078 Expressed in 210 organ(s), highest expression level in amniotic fluid
CleanExiHS_KCTD20
ExpressionAtlasiQ7Z5Y7 baseline and differential
GenevisibleiQ7Z5Y7 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR039886 BTBD10/KCTD20
IPR039885 BTBD10/KCTD20_BTB/POZ
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR21637 PTHR21637, 1 hit
PfamiView protein in Pfam
PF16017 BTB_3, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCD20_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5Y7
Secondary accession number(s): B4DZD3
, B4E2Q3, F5H3T3, Q5W105, Q69YQ7, Q8IZ55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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