UniProtKB - Q7Z5Y6 (BMP8A_HUMAN)
Protein
Bone morphogenetic protein 8A
Gene
BMP8A
Organism
Homo sapiens (Human)
Status
Functioni
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT.By similarity1 Publication
Caution
Experiments with human recombinant protein (in mouse system by intracerebroventricular treatment) are reported for BMP8B but the protein is corresponding to BMP8A according sequence data provided by the supplier; related experiments with Bmp8b-/- mice show similar results.1 Publication
GO - Molecular functioni
- BMP receptor binding Source: GO_Central
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
GO - Biological processi
- BMP signaling pathway Source: GO_Central
- cartilage development Source: UniProtKB-KW
- cell differentiation Source: UniProtKB-KW
- diet induced thermogenesis Source: UniProtKB
- energy homeostasis Source: UniProtKB
- negative regulation of insulin secretion Source: UniProtKB
- ossification Source: UniProtKB-KW
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- SMAD protein signal transduction Source: GO_Central
Keywordsi
Molecular function | Cytokine, Developmental protein, Growth factor |
Biological process | Chondrogenesis, Differentiation, Osteogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q7Z5Y6 |
Names & Taxonomyi
Protein namesi | Recommended name: Bone morphogenetic protein 8AShort name: BMP-8A |
Gene namesi | Name:BMP8A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000183682.7 |
HGNCi | HGNC:21650, BMP8A |
neXtProti | NX_Q7Z5Y6 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 353500 |
OpenTargetsi | ENSG00000183682 |
PharmGKBi | PA134894231 |
Miscellaneous databases
Pharosi | Q7Z5Y6, Tbio |
Polymorphism and mutation databases
BioMutai | BMP8A |
DMDMi | 90111975 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
PropeptideiPRO_0000227896 | 20 – 263 | Sequence analysisAdd BLAST | 244 | |
ChainiPRO_0000227897 | 264 – 402 | Bone morphogenetic protein 8AAdd BLAST | 139 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 158 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 301 ↔ 367 | By similarity | ||
Disulfide bondi | 330 ↔ 399 | By similarity | ||
Disulfide bondi | 334 ↔ 401 | By similarity | ||
Glycosylationi | 343 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 366 | InterchainBy similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q7Z5Y6 |
MassIVEi | Q7Z5Y6 |
PaxDbi | Q7Z5Y6 |
PeptideAtlasi | Q7Z5Y6 |
PRIDEi | Q7Z5Y6 |
ProteomicsDBi | 69359 |
PTM databases
GlyGeni | Q7Z5Y6, 2 sites |
iPTMneti | Q7Z5Y6 |
PhosphoSitePlusi | Q7Z5Y6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000183682, Expressed in thyroid gland and 111 other tissues |
Genevisiblei | Q7Z5Y6, HS |
Organism-specific databases
HPAi | ENSG00000183682, Tissue enriched (thyroid) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
By similarityGO - Molecular functioni
- BMP receptor binding Source: GO_Central
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
Protein-protein interaction databases
IntActi | Q7Z5Y6, 1 interactor |
MINTi | Q7Z5Y6 |
STRINGi | 9606.ENSP00000327440 |
Miscellaneous databases
RNActi | Q7Z5Y6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000155272 |
HOGENOMi | CLU_020515_4_1_1 |
InParanoidi | Q7Z5Y6 |
OMAi | GECIYPL |
OrthoDBi | 1063560at2759 |
PhylomeDBi | Q7Z5Y6 |
TreeFami | TF316134 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q7Z5Y6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAARPGPLWL LGLTLCALGG GGPGLRPPPG CPQRRLGARE RRDVQREILA
60 70 80 90 100
VLGLPGRPRP RAPPAASRLP ASAPLFMLDL YHAMAGDDDE DGAPAEQRLG
110 120 130 140 150
RADLVMSFVN MVERDRALGH QEPHWKEFRF DLTQIPAGEA VTAAEFRIYK
160 170 180 190 200
VPSIHLLNRT LHVSMFQVVQ EQSNRESDLF FLDLQTLRAG DEGWLVLDVT
210 220 230 240 250
AASDCWLLKR HKDLGLRLYV ETEDGHSVDP GLAGLLGQRA PRSQQPFVVT
260 270 280 290 300
FFRASPSPIR TPRAVRPLRR RQPKKSNELP QANRLPGIFD DVRGSHGRQV
310 320 330 340 350
CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL
360 370 380 390 400
QSLVHLMKPN AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG
CH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059859 | 84 | M → V. Corresponds to variant dbSNP:rs4660269Ensembl. | 1 | |
Natural variantiVAR_052571 | 293 | R → H1 PublicationCorresponds to variant dbSNP:rs6525EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY303954 mRNA Translation: AAP74559.1 AL365277 Genomic DNA No translation available. |
CCDSi | CCDS437.1 |
RefSeqi | NP_861525.2, NM_181809.3 |
Genome annotation databases
Ensembli | ENST00000331593; ENSP00000327440; ENSG00000183682 |
GeneIDi | 353500 |
KEGGi | hsa:353500 |
UCSCi | uc001cdi.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Bone morphogenetic protein 8A entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY303954 mRNA Translation: AAP74559.1 AL365277 Genomic DNA No translation available. |
CCDSi | CCDS437.1 |
RefSeqi | NP_861525.2, NM_181809.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q7Z5Y6, 1 interactor |
MINTi | Q7Z5Y6 |
STRINGi | 9606.ENSP00000327440 |
PTM databases
GlyGeni | Q7Z5Y6, 2 sites |
iPTMneti | Q7Z5Y6 |
PhosphoSitePlusi | Q7Z5Y6 |
Polymorphism and mutation databases
BioMutai | BMP8A |
DMDMi | 90111975 |
Proteomic databases
jPOSTi | Q7Z5Y6 |
MassIVEi | Q7Z5Y6 |
PaxDbi | Q7Z5Y6 |
PeptideAtlasi | Q7Z5Y6 |
PRIDEi | Q7Z5Y6 |
ProteomicsDBi | 69359 |
Protocols and materials databases
Antibodypediai | 31907, 169 antibodies |
Genome annotation databases
Ensembli | ENST00000331593; ENSP00000327440; ENSG00000183682 |
GeneIDi | 353500 |
KEGGi | hsa:353500 |
UCSCi | uc001cdi.4, human |
Organism-specific databases
CTDi | 353500 |
DisGeNETi | 353500 |
EuPathDBi | HostDB:ENSG00000183682.7 |
GeneCardsi | BMP8A |
HGNCi | HGNC:21650, BMP8A |
HPAi | ENSG00000183682, Tissue enriched (thyroid) |
neXtProti | NX_Q7Z5Y6 |
OpenTargetsi | ENSG00000183682 |
PharmGKBi | PA134894231 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000155272 |
HOGENOMi | CLU_020515_4_1_1 |
InParanoidi | Q7Z5Y6 |
OMAi | GECIYPL |
OrthoDBi | 1063560at2759 |
PhylomeDBi | Q7Z5Y6 |
TreeFami | TF316134 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z5Y6 |
Miscellaneous databases
BioGRID-ORCSi | 353500, 16 hits in 843 CRISPR screens |
ChiTaRSi | BMP8A, human |
GeneWikii | Bone_morphogenetic_protein_8A |
GenomeRNAii | 353500 |
Pharosi | Q7Z5Y6, Tbio |
PROi | PR:Q7Z5Y6 |
RNActi | Q7Z5Y6, protein |
Gene expression databases
Bgeei | ENSG00000183682, Expressed in thyroid gland and 111 other tissues |
Genevisiblei | Q7Z5Y6, HS |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BMP8A_HUMAN | |
Accessioni | Q7Z5Y6Primary (citable) accession number: Q7Z5Y6 Secondary accession number(s): Q5T3A5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | March 21, 2006 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations