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Protein

Pre-miRNA 5'-monophosphate methyltransferase

Gene

BCDIN3D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

O-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre-miR-145, as well as other pre-miRNAs.1 Publication

GO - Molecular functioni

  • O-methyltransferase activity Source: UniProtKB
  • RNA methyltransferase activity Source: UniProtKB

GO - Biological processi

  • miRNA metabolic process Source: UniProtKB
  • negative regulation of pre-miRNA processing Source: UniProtKB
  • RNA methylation Source: UniProtKB

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-HSA-203927 MicroRNA (miRNA) biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-miRNA 5'-monophosphate methyltransferase (EC:2.1.1.-)
Alternative name(s):
BCDIN3 domain-containing protein
Gene namesi
Name:BCDIN3D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000186666.5
HGNCiHGNC:27050 BCDIN3D
neXtProtiNX_Q7Z5W3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi72 – 74DVG → AVA: Abolishes methyltransferase activity. 1 Publication3

Organism-specific databases

DisGeNETi144233
OpenTargetsiENSG00000186666
PharmGKBiPA162377410

Chemistry databases

ChEMBLiCHEMBL3588740

Polymorphism and mutation databases

BioMutaiBCDIN3D
DMDMi74738762

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892651 – 292Pre-miRNA 5'-monophosphate methyltransferaseAdd BLAST292

Proteomic databases

EPDiQ7Z5W3
MaxQBiQ7Z5W3
PaxDbiQ7Z5W3
PeptideAtlasiQ7Z5W3
PRIDEiQ7Z5W3
ProteomicsDBi69357

PTM databases

iPTMnetiQ7Z5W3
PhosphoSitePlusiQ7Z5W3

Expressioni

Gene expression databases

BgeeiENSG00000186666
CleanExiHS_BCDIN3D
GenevisibleiQ7Z5W3 HS

Organism-specific databases

HPAiHPA039911

Interactioni

Subunit structurei

Interacts with DICER1; the interaction may be mediated by RNA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ZFP2Q6ZN573EBI-10257921,EBI-7236323

Protein-protein interaction databases

BioGridi126839, 4 interactors
IntActiQ7Z5W3, 1 interactor
STRINGi9606.ENSP00000335201

Structurei

3D structure databases

ProteinModelPortaliQ7Z5W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 274Bin3-type SAMPROSITE-ProRule annotationAdd BLAST222

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Phylogenomic databases

eggNOGiKOG2899 Eukaryota
ENOG410XZ7T LUCA
GeneTreeiENSGT00390000014918
HOGENOMiHOG000013152
HOVERGENiHBG057674
OMAiYSITMWI
OrthoDBiEOG091G0KYU
PhylomeDBiQ7Z5W3
TreeFamiTF324061

Family and domain databases

InterProiView protein in InterPro
IPR010675 Bin3_C
IPR024160 BIN3_SAM-bd_dom
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF06859 Bin3, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51515 BIN3_SAM, 1 hit

Sequencei

Sequence statusi: Complete.

Q7Z5W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPTELDGG SVKETAAEEE SRVLAPGAAP FGNFPHYSRF HPPEQRLRLL
60 70 80 90 100
PPELLRQLFP ESPENGPILG LDVGCNSGDL SVALYKHFLS LPDGETCSDA
110 120 130 140 150
SREFRLLCCD IDPVLVKRAE KECPFPDALT FITLDFMNQR TRKVLLSSFL
160 170 180 190 200
SQFGRSVFDI GFCMSITMWI HLNHGDHGLW EFLAHLSSLC HYLLVEPQPW
210 220 230 240 250
KCYRAAARRL RKLGLHDFDH FHSLAIRGDM PNQIVQILTQ DHGMELICCF
260 270 280 290
GNTSWDRSLL LFRAKQTIET HPIPESLIEK GKEKNRLSFQ KQ
Length:292
Mass (Da):33,200
Last modified:October 1, 2003 - v1
Checksum:i361EF0BBAAC0CCAF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032614288S → R. Corresponds to variant dbSNP:rs11169172Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292194 mRNA Translation: BAF84883.1
CH471111 Genomic DNA Translation: EAW58101.1
BC053560 mRNA Translation: AAH53560.1
CCDSiCCDS8790.1
RefSeqiNP_859059.1, NM_181708.2
UniGeneiHs.142736

Genome annotation databases

EnsembliENST00000333924; ENSP00000335201; ENSG00000186666
GeneIDi144233
KEGGihsa:144233
UCSCiuc001rvh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBN3D2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5W3
Secondary accession number(s): A8K829
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2003
Last modified: July 18, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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