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Protein

Protein phosphatase 1 regulatory subunit 32

Gene

PPP1R32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 32
Gene namesi
Name:PPP1R32
Synonyms:C11orf66
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000162148.10
HGNCiHGNC:28869 PPP1R32
neXtProtiNX_Q7Z5V6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162148
PharmGKBiPA144596485

Polymorphism and mutation databases

BioMutaiPPP1R32
DMDMi74738757

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743771 – 425Protein phosphatase 1 regulatory subunit 32Add BLAST425

Proteomic databases

EPDiQ7Z5V6
PaxDbiQ7Z5V6
PeptideAtlasiQ7Z5V6
PRIDEiQ7Z5V6
ProteomicsDBi69355
69356 [Q7Z5V6-2]

PTM databases

iPTMnetiQ7Z5V6
PhosphoSitePlusiQ7Z5V6

Expressioni

Gene expression databases

BgeeiENSG00000162148
CleanExiHS_C11orf66
ExpressionAtlasiQ7Z5V6 baseline and differential
GenevisibleiQ7Z5V6 HS

Organism-specific databases

HPAiHPA039068

Interactioni

Subunit structurei

Interacts with PPP1CA.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi128618, 6 interactors
IntActiQ7Z5V6, 72 interactors
STRINGi9606.ENSP00000344140

Structurei

3D structure databases

ProteinModelPortaliQ7Z5V6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFQ1 Eukaryota
ENOG4110MWW LUCA
GeneTreeiENSGT00390000003127
HOGENOMiHOG000007162
HOVERGENiHBG056750
InParanoidiQ7Z5V6
KOiK17571
OMAiTYNQGYF
OrthoDBiEOG091G0E7L
PhylomeDBiQ7Z5V6
TreeFamiTF328734

Family and domain databases

InterProiView protein in InterPro
IPR031410 PPP1R32
PANTHERiPTHR34349 PTHR34349, 1 hit
PfamiView protein in Pfam
PF15691 PPP1R32, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5V6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGKLPLGVV SPYVKMSSGG YTDPLKFYAT SYCTAYGRED FKPRVGSHVG
60 70 80 90 100
TGYKSNFQPV VSCQASLEAL DNPARGEQAQ DHFQSVASQS YRPLEVPDGK
110 120 130 140 150
HPLPWSMRQT SSGYGREKPS AGPPTKEVRK VHFDTQEHGP QAITGLEPRE
160 170 180 190 200
VPLLHQQQGQ DPLERENFRH GPRFMTSEYN SKYLRDPLDQ PDFLQKKSIG
210 220 230 240 250
AKEGSGFTKQ SHQSPIVFQP PSQALPGDPA LLPGQSVTKS DFLPKTHLHG
260 270 280 290 300
DEFLPVLARG SKRETAFSRG NERILNPRVP PPCPEPSSVS HQQFQPLHRM
310 320 330 340 350
QQTNVALLGR ETVGKKEPTG FSLNNPMYVR SPCDPDRDQR YLTTYNQGYF
360 370 380 390 400
ENIPKGLDQE GWTRGGIQPQ MPGGYALSQP VSCMEATPNP MESLRHLHPH
410 420
VGRTLTSADP FYQNTPHSSR CVAHS
Length:425
Mass (Da):47,295
Last modified:October 1, 2003 - v1
Checksum:i61020C5A4F14563F
GO
Isoform 2 (identifier: Q7Z5V6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-249: Missing.

Note: No experimental confirmation available.
Show »
Length:405
Mass (Da):45,123
Checksum:iFA14F2D08D1B617E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155H → R in BAB71432 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030271238T → N. Corresponds to variant dbSNP:rs11230707Ensembl.1
Natural variantiVAR_030272382S → T1 PublicationCorresponds to variant dbSNP:rs12787061Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022731230 – 249Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057333 mRNA Translation: BAB71432.1
BC043246 mRNA Translation: AAH43246.1
BC053995 mRNA Translation: AAH53995.1
CCDSiCCDS53641.1 [Q7Z5V6-2]
CCDS8008.1 [Q7Z5V6-1]
RefSeqiNP_001164224.1, NM_001170753.1 [Q7Z5V6-2]
NP_659454.2, NM_145017.2 [Q7Z5V6-1]
UniGeneiHs.729003

Genome annotation databases

EnsembliENST00000338608; ENSP00000344140; ENSG00000162148 [Q7Z5V6-1]
ENST00000432063; ENSP00000391560; ENSG00000162148 [Q7Z5V6-2]
GeneIDi220004
KEGGihsa:220004
UCSCiuc001nru.3 human [Q7Z5V6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPPR32_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5V6
Secondary accession number(s): Q4G0P4, Q96M77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2003
Last modified: July 18, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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