UniProtKB - Q7Z5V6 (PPR32_HUMAN)
Protein
Protein phosphatase 1 regulatory subunit 32
Gene
PPP1R32
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- phosphatase binding Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q7Z5V6 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein phosphatase 1 regulatory subunit 32 |
Gene namesi | Name:PPP1R32 Synonyms:C11orf66 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28869, PPP1R32 |
MIMi | 619047, gene |
neXtProti | NX_Q7Z5V6 |
VEuPathDBi | HostDB:ENSG00000162148.10 |
Subcellular locationi
Cytoskeleton
- ciliary basal body Source: GO_Central
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000162148 |
PharmGKBi | PA144596485 |
Miscellaneous databases
Pharosi | Q7Z5V6, Tdark |
Genetic variation databases
BioMutai | PPP1R32 |
DMDMi | 74738757 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274377 | 1 – 425 | Protein phosphatase 1 regulatory subunit 32Add BLAST | 425 |
Proteomic databases
EPDi | Q7Z5V6 |
MassIVEi | Q7Z5V6 |
PaxDbi | Q7Z5V6 |
PeptideAtlasi | Q7Z5V6 |
PRIDEi | Q7Z5V6 |
ProteomicsDBi | 69355 [Q7Z5V6-1] 69356 [Q7Z5V6-2] |
PTM databases
iPTMneti | Q7Z5V6 |
PhosphoSitePlusi | Q7Z5V6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000162148, Expressed in right uterine tube and 125 other tissues |
ExpressionAtlasi | Q7Z5V6, baseline and differential |
Genevisiblei | Q7Z5V6, HS |
Organism-specific databases
HPAi | ENSG00000162148, Tissue enriched (testis) |
Interactioni
Subunit structurei
Interacts with PPP1CA.
1 PublicationBinary interactionsi
Q7Z5V6
With | #Exp. | IntAct |
---|---|---|
PPP1CA [P62136] | 3 | EBI-4311771,EBI-357253 |
PPP1CC - isoform 2 [P36873-2] | 4 | EBI-4311771,EBI-3964623 |
Isoform 2 [Q7Z5V6-2]
GO - Molecular functioni
- phosphatase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 128618, 77 interactors |
IntActi | Q7Z5V6, 73 interactors |
STRINGi | 9606.ENSP00000344140 |
Miscellaneous databases
RNActi | Q7Z5V6, protein |
Family & Domainsi
Phylogenomic databases
eggNOGi | ENOG502QR8X, Eukaryota |
GeneTreei | ENSGT00390000003127 |
HOGENOMi | CLU_686162_0_0_1 |
InParanoidi | Q7Z5V6 |
OMAi | TVGNKEP |
PhylomeDBi | Q7Z5V6 |
TreeFami | TF328734 |
Family and domain databases
InterProi | View protein in InterPro IPR031410, PPP1R32 |
PANTHERi | PTHR34349, PTHR34349, 1 hit |
Pfami | View protein in Pfam PF15691, PPP1R32, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7Z5V6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMGKLPLGVV SPYVKMSSGG YTDPLKFYAT SYCTAYGRED FKPRVGSHVG
60 70 80 90 100
TGYKSNFQPV VSCQASLEAL DNPARGEQAQ DHFQSVASQS YRPLEVPDGK
110 120 130 140 150
HPLPWSMRQT SSGYGREKPS AGPPTKEVRK VHFDTQEHGP QAITGLEPRE
160 170 180 190 200
VPLLHQQQGQ DPLERENFRH GPRFMTSEYN SKYLRDPLDQ PDFLQKKSIG
210 220 230 240 250
AKEGSGFTKQ SHQSPIVFQP PSQALPGDPA LLPGQSVTKS DFLPKTHLHG
260 270 280 290 300
DEFLPVLARG SKRETAFSRG NERILNPRVP PPCPEPSSVS HQQFQPLHRM
310 320 330 340 350
QQTNVALLGR ETVGKKEPTG FSLNNPMYVR SPCDPDRDQR YLTTYNQGYF
360 370 380 390 400
ENIPKGLDQE GWTRGGIQPQ MPGGYALSQP VSCMEATPNP MESLRHLHPH
410 420
VGRTLTSADP FYQNTPHSSR CVAHS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GZJ9 | F5GZJ9_HUMAN | Protein phosphatase 1 regulatory su... | PPP1R32 | 102 | Annotation score: | ||
F5H272 | F5H272_HUMAN | Protein phosphatase 1 regulatory su... | PPP1R32 | 55 | Annotation score: | ||
H0YF82 | H0YF82_HUMAN | Protein phosphatase 1 regulatory su... | PPP1R32 | 137 | Annotation score: | ||
H0YFZ1 | H0YFZ1_HUMAN | Protein phosphatase 1 regulatory su... | PPP1R32 | 176 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 155 | H → R in BAB71432 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030271 | 238 | T → N. Corresponds to variant dbSNP:rs11230707Ensembl. | 1 | |
Natural variantiVAR_030272 | 382 | S → T1 PublicationCorresponds to variant dbSNP:rs12787061Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_022731 | 230 – 249 | Missing in isoform 2. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057333 mRNA Translation: BAB71432.1 BC043246 mRNA Translation: AAH43246.1 BC053995 mRNA Translation: AAH53995.1 |
CCDSi | CCDS53641.1 [Q7Z5V6-2] CCDS8008.1 [Q7Z5V6-1] |
RefSeqi | NP_001164224.1, NM_001170753.1 [Q7Z5V6-2] NP_659454.2, NM_145017.2 [Q7Z5V6-1] |
Genome annotation databases
Ensembli | ENST00000338608; ENSP00000344140; ENSG00000162148 [Q7Z5V6-1] ENST00000432063; ENSP00000391560; ENSG00000162148 [Q7Z5V6-2] |
GeneIDi | 220004 |
KEGGi | hsa:220004 |
UCSCi | uc001nru.3, human [Q7Z5V6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK057333 mRNA Translation: BAB71432.1 BC043246 mRNA Translation: AAH43246.1 BC053995 mRNA Translation: AAH53995.1 |
CCDSi | CCDS53641.1 [Q7Z5V6-2] CCDS8008.1 [Q7Z5V6-1] |
RefSeqi | NP_001164224.1, NM_001170753.1 [Q7Z5V6-2] NP_659454.2, NM_145017.2 [Q7Z5V6-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 128618, 77 interactors |
IntActi | Q7Z5V6, 73 interactors |
STRINGi | 9606.ENSP00000344140 |
PTM databases
iPTMneti | Q7Z5V6 |
PhosphoSitePlusi | Q7Z5V6 |
Genetic variation databases
BioMutai | PPP1R32 |
DMDMi | 74738757 |
Proteomic databases
EPDi | Q7Z5V6 |
MassIVEi | Q7Z5V6 |
PaxDbi | Q7Z5V6 |
PeptideAtlasi | Q7Z5V6 |
PRIDEi | Q7Z5V6 |
ProteomicsDBi | 69355 [Q7Z5V6-1] 69356 [Q7Z5V6-2] |
Protocols and materials databases
Antibodypediai | 51662, 15 antibodies |
DNASUi | 220004 |
Genome annotation databases
Ensembli | ENST00000338608; ENSP00000344140; ENSG00000162148 [Q7Z5V6-1] ENST00000432063; ENSP00000391560; ENSG00000162148 [Q7Z5V6-2] |
GeneIDi | 220004 |
KEGGi | hsa:220004 |
UCSCi | uc001nru.3, human [Q7Z5V6-1] |
Organism-specific databases
CTDi | 220004 |
GeneCardsi | PPP1R32 |
HGNCi | HGNC:28869, PPP1R32 |
HPAi | ENSG00000162148, Tissue enriched (testis) |
MIMi | 619047, gene |
neXtProti | NX_Q7Z5V6 |
OpenTargetsi | ENSG00000162148 |
PharmGKBi | PA144596485 |
VEuPathDBi | HostDB:ENSG00000162148.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QR8X, Eukaryota |
GeneTreei | ENSGT00390000003127 |
HOGENOMi | CLU_686162_0_0_1 |
InParanoidi | Q7Z5V6 |
OMAi | TVGNKEP |
PhylomeDBi | Q7Z5V6 |
TreeFami | TF328734 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z5V6 |
Miscellaneous databases
BioGRID-ORCSi | 220004, 5 hits in 872 CRISPR screens |
ChiTaRSi | PPP1R32, human |
GenomeRNAii | 220004 |
Pharosi | Q7Z5V6, Tdark |
PROi | PR:Q7Z5V6 |
RNActi | Q7Z5V6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162148, Expressed in right uterine tube and 125 other tissues |
ExpressionAtlasi | Q7Z5V6, baseline and differential |
Genevisiblei | Q7Z5V6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031410, PPP1R32 |
PANTHERi | PTHR34349, PTHR34349, 1 hit |
Pfami | View protein in Pfam PF15691, PPP1R32, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PPR32_HUMAN | |
Accessioni | Q7Z5V6Primary (citable) accession number: Q7Z5V6 Secondary accession number(s): Q4G0P4, Q96M77 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | October 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants