UniProtKB - Q7Z5V6 (PPR32_HUMAN)

BLAST

>sp|Q7Z5V6|PPR32_HUMAN Protein phosphatase 1 regulatory subunit 32 OS=Homo sapiens OX=9606 GN=PPP1R32 PE=1 SV=1
MMGKLPLGVVSPYVKMSSGGYTDPLKFYATSYCTAYGREDFKPRVGSHVGTGYKSNFQPV
VSCQASLEALDNPARGEQAQDHFQSVASQSYRPLEVPDGKHPLPWSMRQTSSGYGREKPS
AGPPTKEVRKVHFDTQEHGPQAITGLEPREVPLLHQQQGQDPLERENFRHGPRFMTSEYN
SKYLRDPLDQPDFLQKKSIGAKEGSGFTKQSHQSPIVFQPPSQALPGDPALLPGQSVTKS
DFLPKTHLHGDEFLPVLARGSKRETAFSRGNERILNPRVPPPCPEPSSVSHQQFQPLHRM
QQTNVALLGRETVGKKEPTGFSLNNPMYVRSPCDPDRDQRYLTTYNQGYFENIPKGLDQE
GWTRGGIQPQMPGGYALSQPVSCMEATPNPMESLRHLHPHVGRTLTSADPFYQNTPHSSR
CVAHS

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History
Entry version 103 (12 Sep 2018)
Sequence version 1 (01 Oct 2003)
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Protein

Protein phosphatase 1 regulatory subunit 32

Gene

PPP1R32

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

phosphatase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19389623

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein phosphatase 1 regulatory subunit 32
Gene namesⁱ	Name:PPP1R32 Synonyms:C11orf66
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162148.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28869 PPP1R32
neXtProtⁱ	NX_Q7Z5V6

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000162148
PharmGKBⁱ	PA144596485

Polymorphism and mutation databases

BioMutaⁱ	PPP1R32
DMDMⁱ	74738757

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000274377	1 – 425	Protein phosphatase 1 regulatory subunit 32Add BLAST		425

Proteomic databases

EPDⁱ	Q7Z5V6
PaxDbⁱ	Q7Z5V6
PeptideAtlas More...PeptideAtlasⁱ	Q7Z5V6
PRIDEⁱ	Q7Z5V6
ProteomicsDBⁱ	69355 69356 [Q7Z5V6-2]

PTM databases

iPTMnetⁱ	Q7Z5V6
PhosphoSitePlusⁱ	Q7Z5V6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000162148 Expressed in 102 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_C11orf66
ExpressionAtlasⁱ	Q7Z5V6 baseline and differential
Genevisibleⁱ	Q7Z5V6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039068

HPAⁱ

HPA039068

Interactionⁱ

Subunit structureⁱ

Interacts with PPP1CA.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BAG4	O95429	4	EBI-12000762,EBI-2949658
FKBP6	O75344	4	EBI-12000762,EBI-744771
HGS	O14964	4	EBI-12000762,EBI-740220
PPP1CA	P62136	3	EBI-4311771,EBI-357253
PPP1CC	P36873-2	4	EBI-4311771,EBI-3964623
TEKT4	Q8WW24	4	EBI-12000762,EBI-750487

GO - Molecular functionⁱ

phosphatase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19389623

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	128618, 6 interactors
IntActⁱ	Q7Z5V6, 72 interactors
STRINGⁱ	9606.ENSP00000344140

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7Z5V6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	ENOG410IFQ1 Eukaryota ENOG4110MWW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000003127
HOGENOMⁱ	HOG000007162
HOVERGENⁱ	HBG056750
InParanoidⁱ	Q7Z5V6
KEGG Orthology (KO) More...KOⁱ	K17571
OMAⁱ	TYNQGYF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0E7L
PhylomeDBⁱ	Q7Z5V6
TreeFamⁱ	TF328734

Family and domain databases

InterProⁱ	View protein in InterPro IPR031410 PPP1R32
PANTHERⁱ	PTHR34349 PTHR34349, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15691 PPP1R32, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q7Z5V6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGKLPLGVV SPYVKMSSGG YTDPLKFYAT SYCTAYGRED FKPRVGSHVG 
        60         70         80         90        100
TGYKSNFQPV VSCQASLEAL DNPARGEQAQ DHFQSVASQS YRPLEVPDGK 
       110        120        130        140        150
HPLPWSMRQT SSGYGREKPS AGPPTKEVRK VHFDTQEHGP QAITGLEPRE 
       160        170        180        190        200
VPLLHQQQGQ DPLERENFRH GPRFMTSEYN SKYLRDPLDQ PDFLQKKSIG 
       210        220        230        240        250
AKEGSGFTKQ SHQSPIVFQP PSQALPGDPA LLPGQSVTKS DFLPKTHLHG 
       260        270        280        290        300
DEFLPVLARG SKRETAFSRG NERILNPRVP PPCPEPSSVS HQQFQPLHRM 
       310        320        330        340        350
QQTNVALLGR ETVGKKEPTG FSLNNPMYVR SPCDPDRDQR YLTTYNQGYF 
       360        370        380        390        400
ENIPKGLDQE GWTRGGIQPQ MPGGYALSQP VSCMEATPNP MESLRHLHPH 
       410        420 
VGRTLTSADP FYQNTPHSSR CVAHS

Length:425

Mass (Da):47,295

Last modified:October 1, 2003 - v1

Checksum:ⁱ61020C5A4F14563F

Isoform 2 (identifier: Q7Z5V6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
230-249: Missing.

« Hide

        10         20         30         40         50
MMGKLPLGVV SPYVKMSSGG YTDPLKFYAT SYCTAYGRED FKPRVGSHVG 
        60         70         80         90        100
TGYKSNFQPV VSCQASLEAL DNPARGEQAQ DHFQSVASQS YRPLEVPDGK 
       110        120        130        140        150
HPLPWSMRQT SSGYGREKPS AGPPTKEVRK VHFDTQEHGP QAITGLEPRE 
       160        170        180        190        200
VPLLHQQQGQ DPLERENFRH GPRFMTSEYN SKYLRDPLDQ PDFLQKKSIG 
       210        220        230        240        250
AKEGSGFTKQ SHQSPIVFQP PSQALPGDPG DEFLPVLARG SKRETAFSRG 
       260        270        280        290        300
NERILNPRVP PPCPEPSSVS HQQFQPLHRM QQTNVALLGR ETVGKKEPTG 
       310        320        330        340        350
FSLNNPMYVR SPCDPDRDQR YLTTYNQGYF ENIPKGLDQE GWTRGGIQPQ 
       360        370        380        390        400
MPGGYALSQP VSCMEATPNP MESLRHLHPH VGRTLTSADP FYQNTPHSSR 

CVAHS

Note: No experimental confirmation available.

Show »

Length:405

Mass (Da):45,123

Checksum:ⁱFA14F2D08D1B617E

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5GZJ9	F5GZJ9_HUMAN	Protein phosphatase 1 regulatory su... Protein phosphatase 1 regulatory subunit 32	PPP1R32	102	Annotation score:
H0YFZ1	H0YFZ1_HUMAN	Protein phosphatase 1 regulatory su... Protein phosphatase 1 regulatory subunit 32	PPP1R32	176	Annotation score:
F5H272	F5H272_HUMAN	Protein phosphatase 1 regulatory su... Protein phosphatase 1 regulatory subunit 32	PPP1R32	55	Annotation score:
H0YF82	H0YF82_HUMAN	Protein phosphatase 1 regulatory su... Protein phosphatase 1 regulatory subunit 32	PPP1R32	137	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	155	H → R in BAB71432 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_030271	238	T → N. Corresponds to variant dbSNP:rs11230707Ensembl.		1
Natural variantⁱVAR_030272	382	S → T1 PublicationCorresponds to variant dbSNP:rs12787061Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_022731	230 – 249	Missing in isoform 2. 1 PublicationAdd BLAST		20

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057333 mRNA Translation: BAB71432.1 BC043246 mRNA Translation: AAH43246.1 BC053995 mRNA Translation: AAH53995.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53641.1 [Q7Z5V6-2] CCDS8008.1 [Q7Z5V6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001164224.1, NM_001170753.1 [Q7Z5V6-2] NP_659454.2, NM_145017.2 [Q7Z5V6-1]
UniGeneⁱ	Hs.729003

Genome annotation databases

Ensemblⁱ	ENST00000338608; ENSP00000344140; ENSG00000162148 [Q7Z5V6-1] ENST00000432063; ENSP00000391560; ENSG00000162148 [Q7Z5V6-2]
GeneIDⁱ	220004
KEGGⁱ	hsa:220004
UCSC genome browser More...UCSCⁱ	uc001nru.3 human [Q7Z5V6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q7Z5V6	C11ORF66s		HUMAN		425	UniRef100_Q7Z5V6

Protein	Similar proteins		Species	Score	Length	Source
Q7Z5V6	C11ORF66s		HUMAN		425	UniRef90_Q7Z5V6
Uncharacterized protein		CHLSB		425
Uncharacterized protein		PAPAN		425
Uncharacterized protein		MACNE		425
IIIG9 protein		PANTR		425
+24
Q7Z5V6-2	Protein phosphatase 1 regulatory subunit 32		GORGO		405	UniRef90_Q7Z5V6-2
Uncharacterized protein		NOMLE		405
Uncharacterized protein		MANLE		405
Uncharacterized protein		COLAP		405
Uncharacterized protein		PANPA		405
+12

Protein	Similar proteins		Species	Score	Length	Source
Q7Z5V6	C11ORF66s		HUMAN		425	UniRef50_Q7Z5V6
IIIG9 protein		PANTR		425
Uncharacterized protein		MACFA		425
Uncharacterized protein		RHIBE		425
Uncharacterized protein		RHIRO		425
+33
Q7Z5V6-2	Uncharacterized protein		PANPA		405	UniRef50_Q7Z5V6-2
Uncharacterized protein		MACNE		405
Uncharacterized protein		MACFA		405
Uncharacterized protein		COLAP		405
Protein phosphatase 1 regulatory subunit 32		GORGO		405
+34

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK057333 mRNA Translation: BAB71432.1 BC043246 mRNA Translation: AAH43246.1 BC053995 mRNA Translation: AAH53995.1
CCDSⁱ	CCDS53641.1 [Q7Z5V6-2] CCDS8008.1 [Q7Z5V6-1]
RefSeqⁱ	NP_001164224.1, NM_001170753.1 [Q7Z5V6-2] NP_659454.2, NM_145017.2 [Q7Z5V6-1]
UniGeneⁱ	Hs.729003

3D structure databases

ProteinModelPortalⁱ	Q7Z5V6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	128618, 6 interactors
IntActⁱ	Q7Z5V6, 72 interactors
STRINGⁱ	9606.ENSP00000344140

PTM databases

iPTMnetⁱ	Q7Z5V6
PhosphoSitePlusⁱ	Q7Z5V6

Polymorphism and mutation databases

BioMutaⁱ	PPP1R32
DMDMⁱ	74738757

Proteomic databases

EPDⁱ	Q7Z5V6
PaxDbⁱ	Q7Z5V6
PeptideAtlasⁱ	Q7Z5V6
PRIDEⁱ	Q7Z5V6
ProteomicsDBⁱ	69355 69356 [Q7Z5V6-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	220004
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000338608; ENSP00000344140; ENSG00000162148 [Q7Z5V6-1] ENST00000432063; ENSP00000391560; ENSG00000162148 [Q7Z5V6-2]
GeneIDⁱ	220004
KEGGⁱ	hsa:220004
UCSCⁱ	uc001nru.3 human [Q7Z5V6-1]

Organism-specific databases

CTDⁱ	220004
EuPathDBⁱ	HostDB:ENSG00000162148.10
GeneCardsⁱ	PPP1R32
HGNCⁱ	HGNC:28869 PPP1R32
HPAⁱ	HPA039068
neXtProtⁱ	NX_Q7Z5V6
OpenTargetsⁱ	ENSG00000162148
PharmGKBⁱ	PA144596485
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFQ1 Eukaryota ENOG4110MWW LUCA
GeneTreeⁱ	ENSGT00390000003127
HOGENOMⁱ	HOG000007162
HOVERGENⁱ	HBG056750
InParanoidⁱ	Q7Z5V6
KOⁱ	K17571
OMAⁱ	TYNQGYF
OrthoDBⁱ	EOG091G0E7L
PhylomeDBⁱ	Q7Z5V6
TreeFamⁱ	TF328734

Miscellaneous databases

ChiTaRSⁱ	PPP1R32 human
GenomeRNAiⁱ	220004
Protein Ontology More...PROⁱ	PR:Q7Z5V6

Gene expression databases

Bgeeⁱ	ENSG00000162148 Expressed in 102 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_C11orf66
ExpressionAtlasⁱ	Q7Z5V6 baseline and differential
Genevisibleⁱ	Q7Z5V6 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR031410 PPP1R32
PANTHERⁱ	PTHR34349 PTHR34349, 1 hit
Pfamⁱ	View protein in Pfam PF15691 PPP1R32, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPR32_HUMAN
Accessionⁱ	Q7Z5V6Primary (citable) accession number: Q7Z5V6 Secondary accession number(s): Q4G0P4, Q96M77
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
	Last sequence update:	October 1, 2003
	Last modified:	September 12, 2018
	This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - Q7Z5V6 (PPR32_HUMAN)

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Protein phosphatase 1 regulatory subunit 32

PPP1R32

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ