APBB1IP

Functionⁱ

Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.2 Publications

GO - Biological processⁱ

positive regulation of cell adhesion Source: Ensembl
signal transduction Source: InterPro
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-354192 Integrin alphaIIb beta3 signaling R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708 p130Cas linkage to MAPK signaling for integrins R-HSA-5674135 MAP2K and MAPK activation R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF

Reactomeⁱ

R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein Alternative name(s): APBB1-interacting protein 1 Proline-rich EVH1 ligand 1 Short name: PREL-1 Proline-rich protein 73 Rap1-GTP-interacting adapter molecule Short name: RIAM Retinoic acid-responsive proline-rich protein 1 Short name: RARP-1
Gene namesⁱ	Name:APBB1IP Synonyms:PREL1, RARP1, RIAM
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000077420.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17379 APBB1IP
MIMⁱ	609036 gene
neXtProtⁱ	NX_Q7Z5R6

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	54518
Open Targets More...OpenTargetsⁱ	ENSG00000077420
PharmGKBⁱ	PA134933955

Polymorphism and mutation databases

BioMutaⁱ	APBB1IP
DMDMⁱ	74750143

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000181347	1 – 666	Amyloid beta A4 precursor protein-binding family B member 1-interacting proteinAdd BLAST		666

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	55	PhosphoserineCombined sources	1
Modified residueⁱ	526	PhosphoserineCombined sources	1
Modified residueⁱ	528	PhosphothreonineBy similarity	1
Modified residueⁱ	531	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q7Z5R6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7Z5R6
PaxDbⁱ	Q7Z5R6
PeptideAtlas More...PeptideAtlasⁱ	Q7Z5R6
PRIDEⁱ	Q7Z5R6
ProteomicsDBⁱ	69350

PTM databases

iPTMnetⁱ	Q7Z5R6
PhosphoSitePlusⁱ	Q7Z5R6

Expressionⁱ

Tissue specificityⁱ

Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.2 Publications

Inductionⁱ

By all-trans-retinoic acid (ATRA).

Gene expression databases

Bgeeⁱ	ENSG00000077420 Expressed in 194 organ(s), highest expression level in blood
CleanExⁱ	HS_APBB1IP
Genevisibleⁱ	Q7Z5R6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA017009 HPA063903

HPAⁱ

HPA017009
HPA063903

Interactionⁱ

Subunit structureⁱ

Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, TLN1, VASP, VCL and ENAH.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ZDHHC17	Q8IUH5	2	EBI-2818084,EBI-524753

With

Entry

#Exp.

IntAct

Notes

ZDHHC17

Q8IUH5

2

EBI-2818084,EBI-524753

Protein-protein interaction databases

BioGridⁱ	120012, 10 interactors
CORUMⁱ	Q7Z5R6
IntActⁱ	Q7Z5R6, 12 interactors
Molecular INTeraction database More...MINTⁱ	Q7Z5R6
STRINGⁱ	9606.ENSP00000365411

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	8 – 25	Combined sources		18
Turnⁱ	26 – 31	Combined sources		6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q7Z5R6
SMRⁱ	Q7Z5R6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	176 – 263	Ras-associatingPROSITE-ProRule annotationAdd BLAST		88
Domainⁱ	310 – 419	PHPROSITE-ProRule annotationAdd BLAST		110

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	129 – 148	Pro-richAdd BLAST	20
Compositional biasⁱ	152 – 155	Poly-Glu	4
Compositional biasⁱ	503 – 640	Pro-richAdd BLAST	138

Domainⁱ

The two Pro-rich regions are required for the suppression of AP1 transcription activity.

Sequence similaritiesⁱ

Belongs to the MRL family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3751 Eukaryota ENOG410XXC8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074537
HOGENOMⁱ	HOG000033749
HOVERGENⁱ	HBG080806
InParanoidⁱ	Q7Z5R6
KEGG Orthology (KO) More...KOⁱ	K17704
OMAⁱ	KVKYKAP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05PM
PhylomeDBⁱ	Q7Z5R6
TreeFamⁱ	TF317511

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01259 PH_APBB1IP, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR039664 GRB/APBB1IP IPR011993 PH-like_dom_sf IPR039665 PH_APBB1IP IPR001849 PH_domain IPR000159 RA_dom IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR11243 PTHR11243, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00169 PH, 1 hit PF00788 RA, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit SM00314 RA, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50003 PH_DOMAIN, 1 hit PS50200 RA, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q7Z5R6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGESSEDIDQ MFSTLLGEMD LLTQSLGVDT LPPPDPNPPR AEFNYSVGFK 
        60         70         80         90        100
DLNESLNALE DQDLDALMAD LVADISEAEQ RTIQAQKESL QNQHHSASLQ 
       110        120        130        140        150
ASIFSGAASL GYGTNVAATG ISQYEDDLPP PPADPVLDLP LPPPPPEPLS 
       160        170        180        190        200
QEEEEAQAKA DKIKLALEKL KEAKVKKLVV KVHMNDNSTK SLMVDERQLA 
       210        220        230        240        250
RDVLDNLFEK THCDCNVDWC LYEIYPELQI ERFFEDHENV VEVLSDWTRD 
       260        270        280        290        300
TENKILFLEK EEKYAVFKNP QNFYLDNRGK KESKETNEKM NAKNKESLLE 
       310        320        330        340        350
ESFCGTSIIV PELEGALYLK EDGKKSWKRR YFLLRASGIY YVPKGKTKTS 
       360        370        380        390        400
RDLACFIQFE NVNIYYGTQH KMKYKAPTDY CFVLKHPQIQ KESQYIKYLC 
       410        420        430        440        450
CDDTRTLNQW VMGIRIAKYG KTLYDNYQRA VAKAGLASRW TNLGTVNAAA 
       460        470        480        490        500
PAQPSTGPKT GTTQPNGQIP QATHSVSAVL QEAQRHAETS KDKKPALGNH 
       510        520        530        540        550
HDPAVPRAPH APKSSLPPPP PVRRSSDTSG SPATPLKAKG TGGGGLPAPP 
       560        570        580        590        600
DDFLPPPPPP PPLDDPELPP PPPDFMEPPP DFVPPPPPSY AGIAGSELPP 
       610        620        630        640        650
PPPPPPAPAP APVPDSARPP PAVAKRPPVP PKRQENPGHP GGAGGGEQDF 
       660 
MSDLMKALQK KRGNVS

Length:666

Mass (Da):73,183

Last modified:October 1, 2003 - v1

Checksum:ⁱ525C906C490D8D97

GO

Isoform 2 (identifier: Q7Z5R6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
152-172: EEEEAQAKADKIKLALEKLKE → VSMWDQRWQDHQPLLPITDVP
173-666: Missing.

« Hide

        10         20         30         40         50
MGESSEDIDQ MFSTLLGEMD LLTQSLGVDT LPPPDPNPPR AEFNYSVGFK 
        60         70         80         90        100
DLNESLNALE DQDLDALMAD LVADISEAEQ RTIQAQKESL QNQHHSASLQ 
       110        120        130        140        150
ASIFSGAASL GYGTNVAATG ISQYEDDLPP PPADPVLDLP LPPPPPEPLS 
       160        170 
QVSMWDQRWQ DHQPLLPITD VP

Note: No experimental confirmation available.

Show »

Length:172

Mass (Da):18,686

Checksum:ⁱ21314883C4E8C7B9

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	423	L → F in BAC41256 (PubMed:14530287).Curated		1
Sequence conflictⁱ	599	Missing in AAN75525 (PubMed:15469846).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_050098	404	T → A. Corresponds to variant dbSNP:rs34081356Ensembl.		1
Natural variantⁱVAR_059447	617	A → T. Corresponds to variant dbSNP:rs7903226Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056542	152 – 172	EEEEA…EKLKE → VSMWDQRWQDHQPLLPITDV P in isoform 2. 1 PublicationAdd BLAST		21
Alternative sequenceⁱVSP_056543	173 – 666	Missing in isoform 2. 1 PublicationAdd BLAST		494

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB085852 mRNA Translation: BAC41256.1 AY152730 mRNA Translation: AAN75525.1 AL160287 Genomic DNA No translation available. AL355798 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86097.1 BC035636 mRNA Translation: AAH35636.1 BC054516 mRNA Translation: AAH54516.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31167.1 [Q7Z5R6-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_061916.3, NM_019043.3 [Q7Z5R6-1] XP_006717514.1, XM_006717451.2 [Q7Z5R6-1]
UniGeneⁱ	Hs.310421

Genome annotation databases

Ensemblⁱ	ENST00000356785; ENSP00000349237; ENSG00000077420 [Q7Z5R6-2] ENST00000376236; ENSP00000365411; ENSG00000077420 [Q7Z5R6-1]
GeneIDⁱ	54518
KEGGⁱ	hsa:54518
UCSC genome browser More...UCSCⁱ	uc001isr.4 human [Q7Z5R6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7Z5R6	Uncharacterized protein		MACMU		671	UniRef90_Q7Z5R6
Uncharacterized protein		NOMLE		667
Uncharacterized protein		Cebus capucinus imitator		666
APBB1IP isoform 1		PANTR		665
Uncharacterized protein		CERAT		665
+23
Q7Z5R6-2	APBB1IP isoform 4		PONAB		172	UniRef90_Q7Z5R6-2
Uncharacterized protein		COLAP		172
APBB1IP isoform 4		PANTR		172
Uncharacterized protein		RHIBE		172
Uncharacterized protein		AOTNA		170
+1

Protein	Similar proteins		Species	Score	Length	Source
Q7Z5R6	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein		DANRE		646	UniRef50_Q7Z5R6
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein	)	MOUSE		670
Uncharacterized protein		MACMU		671
Uncharacterized protein		NOMLE		667
Uncharacterized protein		Cebus capucinus imitator		666
+204
Q7Z5R6-2	APBB1IP isoform 4		PANTR		172	UniRef50_Q7Z5R6-2
Uncharacterized protein		COLAP		172
Uncharacterized protein		RHIBE		172
APBB1IP isoform 4		PONAB		172
Amyloid beta precursor protein binding family B member 1 interacting protein		SAIBB		170
+4

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB085852 mRNA Translation: BAC41256.1 AY152730 mRNA Translation: AAN75525.1 AL160287 Genomic DNA No translation available. AL355798 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86097.1 BC035636 mRNA Translation: AAH35636.1 BC054516 mRNA Translation: AAH54516.1
CCDSⁱ	CCDS31167.1 [Q7Z5R6-1]
RefSeqⁱ	NP_061916.3, NM_019043.3 [Q7Z5R6-1] XP_006717514.1, XM_006717451.2 [Q7Z5R6-1]
UniGeneⁱ	Hs.310421

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2MWN	NMR	-	A	7-30	[»]
	3ZDL	X-ray	2.30	B	1-31	[»]
ProteinModelPortalⁱ	Q7Z5R6
SMRⁱ	Q7Z5R6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120012, 10 interactors
CORUMⁱ	Q7Z5R6
IntActⁱ	Q7Z5R6, 12 interactors
MINTⁱ	Q7Z5R6
STRINGⁱ	9606.ENSP00000365411

PTM databases

iPTMnetⁱ	Q7Z5R6
PhosphoSitePlusⁱ	Q7Z5R6

Polymorphism and mutation databases

BioMutaⁱ	APBB1IP
DMDMⁱ	74750143

Proteomic databases

EPDⁱ	Q7Z5R6
MaxQBⁱ	Q7Z5R6
PaxDbⁱ	Q7Z5R6
PeptideAtlasⁱ	Q7Z5R6
PRIDEⁱ	Q7Z5R6
ProteomicsDBⁱ	69350

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000356785; ENSP00000349237; ENSG00000077420 [Q7Z5R6-2] ENST00000376236; ENSP00000365411; ENSG00000077420 [Q7Z5R6-1]
GeneIDⁱ	54518
KEGGⁱ	hsa:54518
UCSCⁱ	uc001isr.4 human [Q7Z5R6-1]

Organism-specific databases

CTDⁱ	54518
DisGeNETⁱ	54518
EuPathDBⁱ	HostDB:ENSG00000077420.15
GeneCardsⁱ	APBB1IP
H-InvDBⁱ	HIX0008723 HIX0035713
HGNCⁱ	HGNC:17379 APBB1IP
HPAⁱ	HPA017009 HPA063903
MIMⁱ	609036 gene
neXtProtⁱ	NX_Q7Z5R6
OpenTargetsⁱ	ENSG00000077420
PharmGKBⁱ	PA134933955
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3751 Eukaryota ENOG410XXC8 LUCA
GeneTreeⁱ	ENSGT00550000074537
HOGENOMⁱ	HOG000033749
HOVERGENⁱ	HBG080806
InParanoidⁱ	Q7Z5R6
KOⁱ	K17704
OMAⁱ	KVKYKAP
OrthoDBⁱ	EOG091G05PM
PhylomeDBⁱ	Q7Z5R6
TreeFamⁱ	TF317511

Enzyme and pathway databases

Reactomeⁱ	R-HSA-354192 Integrin alphaIIb beta3 signaling R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708 p130Cas linkage to MAPK signaling for integrins R-HSA-5674135 MAP2K and MAPK activation R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants R-HSA-6802948 Signaling by high-kinase activity BRAF mutants R-HSA-6802949 Signaling by RAS mutants R-HSA-6802952 Signaling by BRAF and RAF fusions R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF

Reactomeⁱ

R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF

Miscellaneous databases

ChiTaRSⁱ	APBB1IP human
GeneWikiⁱ	APBB1IP
GenomeRNAiⁱ	54518
Protein Ontology More...PROⁱ	PR:Q7Z5R6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000077420 Expressed in 194 organ(s), highest expression level in blood
CleanExⁱ	HS_APBB1IP
Genevisibleⁱ	Q7Z5R6 HS

Family and domain databases

CDDⁱ	cd01259 PH_APBB1IP, 1 hit
Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR039664 GRB/APBB1IP IPR011993 PH-like_dom_sf IPR039665 PH_APBB1IP IPR001849 PH_domain IPR000159 RA_dom IPR029071 Ubiquitin-like_domsf
PANTHERⁱ	PTHR11243 PTHR11243, 1 hit
Pfamⁱ	View protein in Pfam PF00169 PH, 1 hit PF00788 RA, 1 hit
SMARTⁱ	View protein in SMART SM00233 PH, 1 hit SM00314 RA, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50003 PH_DOMAIN, 1 hit PS50200 RA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AB1IP_HUMAN
Accessionⁱ	Q7Z5R6Primary (citable) accession number: Q7Z5R6 Secondary accession number(s): Q8IWS8, Q8IYL7, Q8IZZ7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
	Last sequence update:	October 1, 2003
	Last modified:	November 7, 2018
	This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - Q7Z5R6 (AB1IP_HUMAN)

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Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ