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Protein

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

Gene

APBB1IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.2 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708 p130Cas linkage to MAPK signaling for integrins
R-HSA-5674135 MAP2K and MAPK activation
R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948 Signaling by high-kinase activity BRAF mutants
R-HSA-6802949 Signaling by RAS mutants
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Alternative name(s):
APBB1-interacting protein 1
Proline-rich EVH1 ligand 1
Short name:
PREL-1
Proline-rich protein 73
Rap1-GTP-interacting adapter molecule
Short name:
RIAM
Retinoic acid-responsive proline-rich protein 1
Short name:
RARP-1
Gene namesi
Name:APBB1IP
Synonyms:PREL1, RARP1, RIAM
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000077420.15
HGNCiHGNC:17379 APBB1IP
MIMi609036 gene
neXtProtiNX_Q7Z5R6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54518
OpenTargetsiENSG00000077420
PharmGKBiPA134933955

Polymorphism and mutation databases

BioMutaiAPBB1IP
DMDMi74750143

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001813471 – 666Amyloid beta A4 precursor protein-binding family B member 1-interacting proteinAdd BLAST666

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei55PhosphoserineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei528PhosphothreonineBy similarity1
Modified residuei531PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z5R6
MaxQBiQ7Z5R6
PaxDbiQ7Z5R6
PeptideAtlasiQ7Z5R6
PRIDEiQ7Z5R6
ProteomicsDBi69350

PTM databases

iPTMnetiQ7Z5R6
PhosphoSitePlusiQ7Z5R6

Expressioni

Tissue specificityi

Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.2 Publications

Inductioni

By all-trans-retinoic acid (ATRA).

Gene expression databases

BgeeiENSG00000077420
CleanExiHS_APBB1IP
GenevisibleiQ7Z5R6 HS

Organism-specific databases

HPAiHPA017009
HPA063903

Interactioni

Subunit structurei

Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, TLN1, VASP, VCL and ENAH.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ZDHHC17Q8IUH52EBI-2818084,EBI-524753

Protein-protein interaction databases

BioGridi120012, 10 interactors
CORUMiQ7Z5R6
IntActiQ7Z5R6, 12 interactors
MINTiQ7Z5R6
STRINGi9606.ENSP00000365411

Structurei

Secondary structure

1666
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 25Combined sources18
Turni26 – 31Combined sources6

3D structure databases

ProteinModelPortaliQ7Z5R6
SMRiQ7Z5R6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 263Ras-associatingPROSITE-ProRule annotationAdd BLAST88
Domaini310 – 419PHPROSITE-ProRule annotationAdd BLAST110

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 148Pro-richAdd BLAST20
Compositional biasi152 – 155Poly-Glu4
Compositional biasi503 – 640Pro-richAdd BLAST138

Domaini

The two Pro-rich regions are required for the suppression of AP1 transcription activity.

Sequence similaritiesi

Belongs to the MRL family.Curated

Phylogenomic databases

eggNOGiKOG3751 Eukaryota
ENOG410XXC8 LUCA
GeneTreeiENSGT00550000074537
HOGENOMiHOG000033749
HOVERGENiHBG080806
InParanoidiQ7Z5R6
KOiK17704
OMAiQWVMGIR
OrthoDBiEOG091G05PM
PhylomeDBiQ7Z5R6
TreeFamiTF317511

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR000159 RA_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00788 RA, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50200 RA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5R6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGESSEDIDQ MFSTLLGEMD LLTQSLGVDT LPPPDPNPPR AEFNYSVGFK
60 70 80 90 100
DLNESLNALE DQDLDALMAD LVADISEAEQ RTIQAQKESL QNQHHSASLQ
110 120 130 140 150
ASIFSGAASL GYGTNVAATG ISQYEDDLPP PPADPVLDLP LPPPPPEPLS
160 170 180 190 200
QEEEEAQAKA DKIKLALEKL KEAKVKKLVV KVHMNDNSTK SLMVDERQLA
210 220 230 240 250
RDVLDNLFEK THCDCNVDWC LYEIYPELQI ERFFEDHENV VEVLSDWTRD
260 270 280 290 300
TENKILFLEK EEKYAVFKNP QNFYLDNRGK KESKETNEKM NAKNKESLLE
310 320 330 340 350
ESFCGTSIIV PELEGALYLK EDGKKSWKRR YFLLRASGIY YVPKGKTKTS
360 370 380 390 400
RDLACFIQFE NVNIYYGTQH KMKYKAPTDY CFVLKHPQIQ KESQYIKYLC
410 420 430 440 450
CDDTRTLNQW VMGIRIAKYG KTLYDNYQRA VAKAGLASRW TNLGTVNAAA
460 470 480 490 500
PAQPSTGPKT GTTQPNGQIP QATHSVSAVL QEAQRHAETS KDKKPALGNH
510 520 530 540 550
HDPAVPRAPH APKSSLPPPP PVRRSSDTSG SPATPLKAKG TGGGGLPAPP
560 570 580 590 600
DDFLPPPPPP PPLDDPELPP PPPDFMEPPP DFVPPPPPSY AGIAGSELPP
610 620 630 640 650
PPPPPPAPAP APVPDSARPP PAVAKRPPVP PKRQENPGHP GGAGGGEQDF
660
MSDLMKALQK KRGNVS
Length:666
Mass (Da):73,183
Last modified:October 1, 2003 - v1
Checksum:i525C906C490D8D97
GO
Isoform 2 (identifier: Q7Z5R6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-172: EEEEAQAKADKIKLALEKLKE → VSMWDQRWQDHQPLLPITDVP
     173-666: Missing.

Note: No experimental confirmation available.
Show »
Length:172
Mass (Da):18,686
Checksum:i21314883C4E8C7B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti423L → F in BAC41256 (PubMed:14530287).Curated1
Sequence conflicti599Missing in AAN75525 (PubMed:15469846).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050098404T → A. Corresponds to variant dbSNP:rs34081356Ensembl.1
Natural variantiVAR_059447617A → T. Corresponds to variant dbSNP:rs7903226Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056542152 – 172EEEEA…EKLKE → VSMWDQRWQDHQPLLPITDV P in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_056543173 – 666Missing in isoform 2. 1 PublicationAdd BLAST494

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085852 mRNA Translation: BAC41256.1
AY152730 mRNA Translation: AAN75525.1
AL160287 Genomic DNA No translation available.
AL355798 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86097.1
BC035636 mRNA Translation: AAH35636.1
BC054516 mRNA Translation: AAH54516.1
CCDSiCCDS31167.1 [Q7Z5R6-1]
RefSeqiNP_061916.3, NM_019043.3 [Q7Z5R6-1]
XP_006717514.1, XM_006717451.2 [Q7Z5R6-1]
UniGeneiHs.310421

Genome annotation databases

EnsembliENST00000356785; ENSP00000349237; ENSG00000077420 [Q7Z5R6-2]
ENST00000376236; ENSP00000365411; ENSG00000077420 [Q7Z5R6-1]
GeneIDi54518
KEGGihsa:54518
UCSCiuc001isr.4 human [Q7Z5R6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAB1IP_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5R6
Secondary accession number(s): Q8IWS8, Q8IYL7, Q8IZZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2003
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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