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UniProtKB - Q7Z5R6 (AB1IP_HUMAN)

Entry version 155 (23 Feb 2022)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
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Protein

Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

Gene

APBB1IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7Z5R6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-354192, Integrin signaling
R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708, p130Cas linkage to MAPK signaling for integrins
R-HSA-5674135, MAP2K and MAPK activation
R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948, Signaling by high-kinase activity BRAF mutants
R-HSA-6802952, Signaling by BRAF and RAF1 fusions
R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-9649948, Signaling downstream of RAS mutants
R-HSA-9656223, Signaling by RAF1 mutants

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q7Z5R6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Alternative name(s):
APBB1-interacting protein 1
Proline-rich EVH1 ligand 1
Short name:
PREL-1
Proline-rich protein 73
Rap1-GTP-interacting adapter molecule
Short name:
RIAM
Retinoic acid-responsive proline-rich protein 1
Short name:
RARP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:APBB1IP
Synonyms:PREL1, RARP1, RIAM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17379, APBB1IP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609036, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z5R6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000077420

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54518

Open Targets

More...OpenTargetsi		ENSG00000077420

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134933955

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z5R6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		APBB1IP

Domain mapping of disease mutations (DMDM)

More...DMDMi		74750143

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001813471 – 666Amyloid beta A4 precursor protein-binding family B member 1-interacting proteinAdd BLAST666

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei55PhosphoserineCombined sources1
Modified residuei526PhosphoserineCombined sources1
Modified residuei528PhosphothreonineBy similarity1
Modified residuei531PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7Z5R6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z5R6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z5R6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7Z5R6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z5R6

PeptideAtlas

More...PeptideAtlasi		Q7Z5R6

PRoteomics IDEntifications database

More...PRIDEi		Q7Z5R6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69350 [Q7Z5R6-1]
71199

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z5R6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z5R6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By all-trans-retinoic acid (ATRA).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000077420, Expressed in tendon and 209 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7Z5R6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000077420, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1.

Interacts with RAP1A, PFN1, TLN1, VASP, VCL and ENAH.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120012, 15 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q7Z5R6

Protein interaction database and analysis system

More...IntActi		Q7Z5R6, 16 interactors

Molecular INTeraction database

More...MINTi		Q7Z5R6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365411

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z5R6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1666
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q7Z5R6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7Z5R6

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini176 – 263Ras-associatingPROSITE-ProRule annotationAdd BLAST88
Domaini310 – 419PHPROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni122 – 155DisorderedSequence analysisAdd BLAST34
Regioni448 – 666DisorderedSequence analysisAdd BLAST219

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi128 – 150Pro residuesSequence analysisAdd BLAST23
Compositional biasi448 – 484Polar residuesSequence analysisAdd BLAST37
Compositional biasi485 – 500Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi510 – 525Pro residuesSequence analysisAdd BLAST16
Compositional biasi549 – 635Pro residuesSequence analysisAdd BLAST87

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The two Pro-rich regions are required for the suppression of AP1 transcription activity.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MRL family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3751, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156105

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023207_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z5R6

Identification of Orthologs from Complete Genome Data

More...OMAi		QENPGHP

Database of Orthologous Groups

More...OrthoDBi		786893at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z5R6

TreeFam database of animal gene trees

More...TreeFami		TF317511

Family and domain databases

Conserved Domains Database

More...CDDi		cd01259, PH_APBB1IP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00572

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039664, GRB/APBB1IP
IPR011993, PH-like_dom_sf
IPR039665, PH_APBB1IP
IPR001849, PH_domain
IPR000159, RA_dom
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR11243, PTHR11243, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00169, PH, 1 hit
PF00788, RA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233, PH, 1 hit
SM00314, RA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50200, RA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z5R6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGESSEDIDQ MFSTLLGEMD LLTQSLGVDT LPPPDPNPPR AEFNYSVGFK 
        60         70         80         90        100
DLNESLNALE DQDLDALMAD LVADISEAEQ RTIQAQKESL QNQHHSASLQ 
       110        120        130        140        150
ASIFSGAASL GYGTNVAATG ISQYEDDLPP PPADPVLDLP LPPPPPEPLS 
       160        170        180        190        200
QEEEEAQAKA DKIKLALEKL KEAKVKKLVV KVHMNDNSTK SLMVDERQLA 
       210        220        230        240        250
RDVLDNLFEK THCDCNVDWC LYEIYPELQI ERFFEDHENV VEVLSDWTRD 
       260        270        280        290        300
TENKILFLEK EEKYAVFKNP QNFYLDNRGK KESKETNEKM NAKNKESLLE 
       310        320        330        340        350
ESFCGTSIIV PELEGALYLK EDGKKSWKRR YFLLRASGIY YVPKGKTKTS 
       360        370        380        390        400
RDLACFIQFE NVNIYYGTQH KMKYKAPTDY CFVLKHPQIQ KESQYIKYLC 
       410        420        430        440        450
CDDTRTLNQW VMGIRIAKYG KTLYDNYQRA VAKAGLASRW TNLGTVNAAA 
       460        470        480        490        500
PAQPSTGPKT GTTQPNGQIP QATHSVSAVL QEAQRHAETS KDKKPALGNH 
       510        520        530        540        550
HDPAVPRAPH APKSSLPPPP PVRRSSDTSG SPATPLKAKG TGGGGLPAPP 
       560        570        580        590        600
DDFLPPPPPP PPLDDPELPP PPPDFMEPPP DFVPPPPPSY AGIAGSELPP 
       610        620        630        640        650
PPPPPPAPAP APVPDSARPP PAVAKRPPVP PKRQENPGHP GGAGGGEQDF 
       660 
MSDLMKALQK KRGNVS
Length:666
Mass (Da):73,183
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i525C906C490D8D97
GO
Isoform 2 (identifier: Q7Z5R6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-172: EEEEAQAKADKIKLALEKLKE → VSMWDQRWQDHQPLLPITDVP
     173-666: Missing.

Show »
Length:172
Mass (Da):18,686
Checksum:i21314883C4E8C7B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti423L → F in BAC41256 (PubMed:14530287).Curated1
Sequence conflicti599Missing in AAN75525 (PubMed:15469846).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050098404T → A. Corresponds to variant dbSNP:rs34081356Ensembl.1
Natural variantiVAR_059447617A → T. Corresponds to variant dbSNP:rs7903226EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056542152 – 172EEEEA…EKLKE → VSMWDQRWQDHQPLLPITDV P in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_056543173 – 666Missing in isoform 2. 1 PublicationAdd BLAST494

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB085852 mRNA Translation: BAC41256.1
AY152730 mRNA Translation: AAN75525.1
AL160287 Genomic DNA No translation available.
AL355798 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86097.1
BC035636 mRNA Translation: AAH35636.1
BC054516 mRNA Translation: AAH54516.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31167.1 [Q7Z5R6-1]

NCBI Reference Sequences

More...RefSeqi		NP_061916.3, NM_019043.3 [Q7Z5R6-1]
XP_006717514.1, XM_006717451.2 [Q7Z5R6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000356785; ENSP00000349237; ENSG00000077420 [Q7Z5R6-2]
ENST00000376236; ENSP00000365411; ENSG00000077420

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54518

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54518

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000376236.9; ENSP00000365411.4; NM_019043.4; NP_061916.3

UCSC genome browser

More...UCSCi		uc001isr.4, human [Q7Z5R6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085852 mRNA Translation: BAC41256.1
AY152730 mRNA Translation: AAN75525.1
AL160287 Genomic DNA No translation available.
AL355798 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86097.1
BC035636 mRNA Translation: AAH35636.1
BC054516 mRNA Translation: AAH54516.1
CCDSiCCDS31167.1 [Q7Z5R6-1]
RefSeqiNP_061916.3, NM_019043.3 [Q7Z5R6-1]
XP_006717514.1, XM_006717451.2 [Q7Z5R6-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MWNNMR-A7-30[»]
3ZDLX-ray2.30B1-31[»]
BMRBiQ7Z5R6
SMRiQ7Z5R6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120012, 15 interactors
CORUMiQ7Z5R6
IntActiQ7Z5R6, 16 interactors
MINTiQ7Z5R6
STRINGi9606.ENSP00000365411

PTM databases

iPTMnetiQ7Z5R6
PhosphoSitePlusiQ7Z5R6

Genetic variation databases

BioMutaiAPBB1IP
DMDMi74750143

Proteomic databases

EPDiQ7Z5R6
jPOSTiQ7Z5R6
MassIVEiQ7Z5R6
MaxQBiQ7Z5R6
PaxDbiQ7Z5R6
PeptideAtlasiQ7Z5R6
PRIDEiQ7Z5R6
ProteomicsDBi69350 [Q7Z5R6-1]
71199

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		38122, 235 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		54518

Genome annotation databases

EnsembliENST00000356785; ENSP00000349237; ENSG00000077420 [Q7Z5R6-2]
ENST00000376236; ENSP00000365411; ENSG00000077420
GeneIDi54518
KEGGihsa:54518
MANE-SelectiENST00000376236.9; ENSP00000365411.4; NM_019043.4; NP_061916.3
UCSCiuc001isr.4, human [Q7Z5R6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54518
DisGeNETi54518

GeneCards: human genes, protein and diseases

More...GeneCardsi		APBB1IP
HGNCiHGNC:17379, APBB1IP
HPAiENSG00000077420, Tissue enhanced (lymphoid)
MIMi609036, gene
neXtProtiNX_Q7Z5R6
OpenTargetsiENSG00000077420
PharmGKBiPA134933955
VEuPathDBiHostDB:ENSG00000077420

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3751, Eukaryota
GeneTreeiENSGT00940000156105
HOGENOMiCLU_023207_2_0_1
InParanoidiQ7Z5R6
OMAiQENPGHP
OrthoDBi786893at2759
PhylomeDBiQ7Z5R6
TreeFamiTF317511

Enzyme and pathway databases

PathwayCommonsiQ7Z5R6
ReactomeiR-HSA-354192, Integrin signaling
R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-372708, p130Cas linkage to MAPK signaling for integrins
R-HSA-5674135, MAP2K and MAPK activation
R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants
R-HSA-6802948, Signaling by high-kinase activity BRAF mutants
R-HSA-6802952, Signaling by BRAF and RAF1 fusions
R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-9649948, Signaling downstream of RAS mutants
R-HSA-9656223, Signaling by RAF1 mutants
SignaLinkiQ7Z5R6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54518, 10 hits in 1035 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		APBB1IP, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		APBB1IP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54518
PharosiQ7Z5R6, Tbio

Protein Ontology

More...PROi		PR:Q7Z5R6
RNActiQ7Z5R6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000077420, Expressed in tendon and 209 other tissues
GenevisibleiQ7Z5R6, HS

Family and domain databases

CDDicd01259, PH_APBB1IP, 1 hit
Gene3Di2.30.29.30, 1 hit
IDEALiIID00572
InterProiView protein in InterPro
IPR039664, GRB/APBB1IP
IPR011993, PH-like_dom_sf
IPR039665, PH_APBB1IP
IPR001849, PH_domain
IPR000159, RA_dom
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR11243, PTHR11243, 1 hit
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF00788, RA, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00314, RA, 1 hit
SUPFAMiSSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50200, RA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAB1IP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z5R6
Secondary accession number(s): Q8IWS8, Q8IYL7, Q8IZZ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2003
Last modified: February 23, 2022
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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