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UniProtKB - Q7Z5R6 (AB1IP_HUMAN)
Protein
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Gene
APBB1IP
Organism
Homo sapiens (Human)
Status
Functioni
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
2 PublicationsGO - Biological processi
- positive regulation of cell adhesion Source: Ensembl
- signal transduction Source: InterPro
- T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q7Z5R6 |
Reactomei | R-HSA-354192, Integrin signaling R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708, p130Cas linkage to MAPK signaling for integrins R-HSA-5674135, MAP2K and MAPK activation R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants |
SignaLinki | Q7Z5R6 |
Names & Taxonomyi
Protein namesi | Recommended name: Amyloid beta A4 precursor protein-binding family B member 1-interacting proteinAlternative name(s): APBB1-interacting protein 1 Proline-rich EVH1 ligand 1 Short name: PREL-1 Proline-rich protein 73 Rap1-GTP-interacting adapter molecule Short name: RIAM Retinoic acid-responsive proline-rich protein 1 Short name: RARP-1 |
Gene namesi | Name:APBB1IP Synonyms:PREL1, RARP1, RIAM |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17379, APBB1IP |
MIMi | 609036, gene |
neXtProti | NX_Q7Z5R6 |
VEuPathDBi | HostDB:ENSG00000077420 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Other locations
- lamellipodium By similarity
- focal adhesion By similarity
Note: Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns5P and PtdIns3P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity).By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
- T cell receptor complex Source: Ensembl
Other locations
- focal adhesion Source: UniProtKB-SubCell
- lamellipodium Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 54518 |
OpenTargetsi | ENSG00000077420 |
PharmGKBi | PA134933955 |
Miscellaneous databases
Pharosi | Q7Z5R6, Tbio |
Genetic variation databases
BioMutai | APBB1IP |
DMDMi | 74750143 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000181347 | 1 – 666 | Amyloid beta A4 precursor protein-binding family B member 1-interacting proteinAdd BLAST | 666 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 55 | PhosphoserineCombined sources | 1 | |
Modified residuei | 526 | PhosphoserineCombined sources | 1 | |
Modified residuei | 528 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 531 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q7Z5R6 |
jPOSTi | Q7Z5R6 |
MassIVEi | Q7Z5R6 |
MaxQBi | Q7Z5R6 |
PaxDbi | Q7Z5R6 |
PeptideAtlasi | Q7Z5R6 |
PRIDEi | Q7Z5R6 |
ProteomicsDBi | 69350 [Q7Z5R6-1] 71199 |
PTM databases
iPTMneti | Q7Z5R6 |
PhosphoSitePlusi | Q7Z5R6 |
Expressioni
Tissue specificityi
Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.2 Publications
Inductioni
By all-trans-retinoic acid (ATRA).
Gene expression databases
Bgeei | ENSG00000077420, Expressed in tendon and 209 other tissues |
Genevisiblei | Q7Z5R6, HS |
Organism-specific databases
HPAi | ENSG00000077420, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1.
Interacts with RAP1A, PFN1, TLN1, VASP, VCL and ENAH.
2 PublicationsBinary interactionsi
Q7Z5R6
With | #Exp. | IntAct |
---|---|---|
ZDHHC17 [Q8IUH5] | 2 | EBI-2818084,EBI-524753 |
Isoform 2 [Q7Z5R6-2]
With | #Exp. | IntAct |
---|---|---|
BAG6 - isoform 2 [P46379-2] | 3 | EBI-12059807,EBI-10988864 |
TLX3 [O43711] | 3 | EBI-12059807,EBI-3939165 |
Protein-protein interaction databases
BioGRIDi | 120012, 15 interactors |
CORUMi | Q7Z5R6 |
IntActi | Q7Z5R6, 16 interactors |
MINTi | Q7Z5R6 |
STRINGi | 9606.ENSP00000365411 |
Miscellaneous databases
RNActi | Q7Z5R6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q7Z5R6 |
SMRi | Q7Z5R6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 176 – 263 | Ras-associatingPROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 310 – 419 | PHPROSITE-ProRule annotationAdd BLAST | 110 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 122 – 155 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 448 – 666 | DisorderedSequence analysisAdd BLAST | 219 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 128 – 150 | Pro residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 448 – 484 | Polar residuesSequence analysisAdd BLAST | 37 | |
Compositional biasi | 485 – 500 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 510 – 525 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 549 – 635 | Pro residuesSequence analysisAdd BLAST | 87 |
Domaini
The two Pro-rich regions are required for the suppression of AP1 transcription activity.
Sequence similaritiesi
Belongs to the MRL family.Curated
Phylogenomic databases
eggNOGi | KOG3751, Eukaryota |
GeneTreei | ENSGT00940000156105 |
HOGENOMi | CLU_023207_2_0_1 |
InParanoidi | Q7Z5R6 |
OMAi | QENPGHP |
OrthoDBi | 786893at2759 |
PhylomeDBi | Q7Z5R6 |
TreeFami | TF317511 |
Family and domain databases
CDDi | cd01259, PH_APBB1IP, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
IDEALi | IID00572 |
InterProi | View protein in InterPro IPR039664, GRB/APBB1IP IPR011993, PH-like_dom_sf IPR039665, PH_APBB1IP IPR001849, PH_domain IPR000159, RA_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR11243, PTHR11243, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00788, RA, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00314, RA, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50200, RA, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q7Z5R6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGESSEDIDQ MFSTLLGEMD LLTQSLGVDT LPPPDPNPPR AEFNYSVGFK
60 70 80 90 100
DLNESLNALE DQDLDALMAD LVADISEAEQ RTIQAQKESL QNQHHSASLQ
110 120 130 140 150
ASIFSGAASL GYGTNVAATG ISQYEDDLPP PPADPVLDLP LPPPPPEPLS
160 170 180 190 200
QEEEEAQAKA DKIKLALEKL KEAKVKKLVV KVHMNDNSTK SLMVDERQLA
210 220 230 240 250
RDVLDNLFEK THCDCNVDWC LYEIYPELQI ERFFEDHENV VEVLSDWTRD
260 270 280 290 300
TENKILFLEK EEKYAVFKNP QNFYLDNRGK KESKETNEKM NAKNKESLLE
310 320 330 340 350
ESFCGTSIIV PELEGALYLK EDGKKSWKRR YFLLRASGIY YVPKGKTKTS
360 370 380 390 400
RDLACFIQFE NVNIYYGTQH KMKYKAPTDY CFVLKHPQIQ KESQYIKYLC
410 420 430 440 450
CDDTRTLNQW VMGIRIAKYG KTLYDNYQRA VAKAGLASRW TNLGTVNAAA
460 470 480 490 500
PAQPSTGPKT GTTQPNGQIP QATHSVSAVL QEAQRHAETS KDKKPALGNH
510 520 530 540 550
HDPAVPRAPH APKSSLPPPP PVRRSSDTSG SPATPLKAKG TGGGGLPAPP
560 570 580 590 600
DDFLPPPPPP PPLDDPELPP PPPDFMEPPP DFVPPPPPSY AGIAGSELPP
610 620 630 640 650
PPPPPPAPAP APVPDSARPP PAVAKRPPVP PKRQENPGHP GGAGGGEQDF
660
MSDLMKALQK KRGNVS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 423 | L → F in BAC41256 (PubMed:14530287).Curated | 1 | |
Sequence conflicti | 599 | Missing in AAN75525 (PubMed:15469846).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_050098 | 404 | T → A. Corresponds to variant dbSNP:rs34081356Ensembl. | 1 | |
Natural variantiVAR_059447 | 617 | A → T. Corresponds to variant dbSNP:rs7903226EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056542 | 152 – 172 | EEEEA…EKLKE → VSMWDQRWQDHQPLLPITDV P in isoform 2. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_056543 | 173 – 666 | Missing in isoform 2. 1 PublicationAdd BLAST | 494 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB085852 mRNA Translation: BAC41256.1 AY152730 mRNA Translation: AAN75525.1 AL160287 Genomic DNA No translation available. AL355798 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86097.1 BC035636 mRNA Translation: AAH35636.1 BC054516 mRNA Translation: AAH54516.1 |
CCDSi | CCDS31167.1 [Q7Z5R6-1] |
RefSeqi | NP_061916.3, NM_019043.3 [Q7Z5R6-1] XP_006717514.1, XM_006717451.2 [Q7Z5R6-1] |
Genome annotation databases
Ensembli | ENST00000356785; ENSP00000349237; ENSG00000077420 [Q7Z5R6-2] ENST00000376236; ENSP00000365411; ENSG00000077420 |
GeneIDi | 54518 |
KEGGi | hsa:54518 |
MANE-Selecti | ENST00000376236.9; ENSP00000365411.4; NM_019043.4; NP_061916.3 |
UCSCi | uc001isr.4, human [Q7Z5R6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB085852 mRNA Translation: BAC41256.1 AY152730 mRNA Translation: AAN75525.1 AL160287 Genomic DNA No translation available. AL355798 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86097.1 BC035636 mRNA Translation: AAH35636.1 BC054516 mRNA Translation: AAH54516.1 |
CCDSi | CCDS31167.1 [Q7Z5R6-1] |
RefSeqi | NP_061916.3, NM_019043.3 [Q7Z5R6-1] XP_006717514.1, XM_006717451.2 [Q7Z5R6-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2MWN | NMR | - | A | 7-30 | [»] | |
3ZDL | X-ray | 2.30 | B | 1-31 | [»] | |
BMRBi | Q7Z5R6 | |||||
SMRi | Q7Z5R6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120012, 15 interactors |
CORUMi | Q7Z5R6 |
IntActi | Q7Z5R6, 16 interactors |
MINTi | Q7Z5R6 |
STRINGi | 9606.ENSP00000365411 |
PTM databases
iPTMneti | Q7Z5R6 |
PhosphoSitePlusi | Q7Z5R6 |
Genetic variation databases
BioMutai | APBB1IP |
DMDMi | 74750143 |
Proteomic databases
EPDi | Q7Z5R6 |
jPOSTi | Q7Z5R6 |
MassIVEi | Q7Z5R6 |
MaxQBi | Q7Z5R6 |
PaxDbi | Q7Z5R6 |
PeptideAtlasi | Q7Z5R6 |
PRIDEi | Q7Z5R6 |
ProteomicsDBi | 69350 [Q7Z5R6-1] 71199 |
Protocols and materials databases
Antibodypediai | 38122, 235 antibodies from 30 providers |
DNASUi | 54518 |
Genome annotation databases
Ensembli | ENST00000356785; ENSP00000349237; ENSG00000077420 [Q7Z5R6-2] ENST00000376236; ENSP00000365411; ENSG00000077420 |
GeneIDi | 54518 |
KEGGi | hsa:54518 |
MANE-Selecti | ENST00000376236.9; ENSP00000365411.4; NM_019043.4; NP_061916.3 |
UCSCi | uc001isr.4, human [Q7Z5R6-1] |
Organism-specific databases
CTDi | 54518 |
DisGeNETi | 54518 |
GeneCardsi | APBB1IP |
HGNCi | HGNC:17379, APBB1IP |
HPAi | ENSG00000077420, Tissue enhanced (lymphoid) |
MIMi | 609036, gene |
neXtProti | NX_Q7Z5R6 |
OpenTargetsi | ENSG00000077420 |
PharmGKBi | PA134933955 |
VEuPathDBi | HostDB:ENSG00000077420 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3751, Eukaryota |
GeneTreei | ENSGT00940000156105 |
HOGENOMi | CLU_023207_2_0_1 |
InParanoidi | Q7Z5R6 |
OMAi | QENPGHP |
OrthoDBi | 786893at2759 |
PhylomeDBi | Q7Z5R6 |
TreeFami | TF317511 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z5R6 |
Reactomei | R-HSA-354192, Integrin signaling R-HSA-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-372708, p130Cas linkage to MAPK signaling for integrins R-HSA-5674135, MAP2K and MAPK activation R-HSA-6802946, Signaling by moderate kinase activity BRAF mutants R-HSA-6802948, Signaling by high-kinase activity BRAF mutants R-HSA-6802952, Signaling by BRAF and RAF1 fusions R-HSA-6802955, Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-9649948, Signaling downstream of RAS mutants R-HSA-9656223, Signaling by RAF1 mutants |
SignaLinki | Q7Z5R6 |
Miscellaneous databases
BioGRID-ORCSi | 54518, 10 hits in 1035 CRISPR screens |
ChiTaRSi | APBB1IP, human |
GeneWikii | APBB1IP |
GenomeRNAii | 54518 |
Pharosi | Q7Z5R6, Tbio |
PROi | PR:Q7Z5R6 |
RNActi | Q7Z5R6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000077420, Expressed in tendon and 209 other tissues |
Genevisiblei | Q7Z5R6, HS |
Family and domain databases
CDDi | cd01259, PH_APBB1IP, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
IDEALi | IID00572 |
InterProi | View protein in InterPro IPR039664, GRB/APBB1IP IPR011993, PH-like_dom_sf IPR039665, PH_APBB1IP IPR001849, PH_domain IPR000159, RA_dom IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR11243, PTHR11243, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00788, RA, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00314, RA, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50200, RA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AB1IP_HUMAN | |
Accessioni | Q7Z5R6Primary (citable) accession number: Q7Z5R6 Secondary accession number(s): Q8IWS8, Q8IYL7, Q8IZZ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | October 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families