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UniProtKB - Q7Z5P4 (DHB13_HUMAN)

Entry version 140 (12 Aug 2020)
Sequence version 1 (01 Oct 2003)
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Protein

17-beta-hydroxysteroid dehydrogenase 13

Gene

HSD17B13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei172SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei185Proton acceptorBy similarity1
Binding sitei189NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi40 – 67NADBy similarityAdd BLAST28

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7Z5P4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8964572, Lipid particle organization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase 13 (EC:1.1.-.-)
Short name:
17-beta-HSD 13
Alternative name(s):
Short chain dehydrogenase/reductase family 16C member 3
Short-chain dehydrogenase/reductase 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSD17B13
Synonyms:SCDR9, SDR16C3
ORF Names:HMFN0376, UNQ497/PRO1014
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000170509.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:18685, HSD17B13

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612127, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z5P4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Lipid droplet

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		345275

Open Targets

More...OpenTargetsi		ENSG00000170509

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38634

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7Z5P4, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HSD17B13

Domain mapping of disease mutations (DMDM)

More...DMDMi		74750138

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004258320 – 30017-beta-hydroxysteroid dehydrogenase 13Add BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei33PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z5P4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7Z5P4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7Z5P4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7Z5P4

PeptideAtlas

More...PeptideAtlasi		Q7Z5P4

PRoteomics IDEntifications database

More...PRIDEi		Q7Z5P4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69338 [Q7Z5P4-1]
69339 [Q7Z5P4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z5P4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z5P4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the liver. Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170509, Expressed in liver and 100 other tissues

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000170509, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q7Z5P4
With#Exp.IntAct
ABHD16A [O95870]3EBI-18053395,EBI-348517
ADGRE2 [Q9UHX3]3EBI-18053395,EBI-11277970
AGPAT3 [Q9NRZ7]3EBI-18053395,EBI-2803601
AGPAT4 [Q9NRZ5]3EBI-18053395,EBI-1754287
AGTRAP - isoform 2 [Q6RW13-2]3EBI-18053395,EBI-11522760
AIG1 - isoform 2 [Q9NVV5-2]3EBI-18053395,EBI-11957045
ANKRD46 - isoform 1 [Q86W74-2]3EBI-18053395,EBI-12109402
AOC3 [Q16853]3EBI-18053395,EBI-3921628
APOA2 [P02652]3EBI-18053395,EBI-1171525
ARL6IP1 [Q15041]3EBI-18053395,EBI-714543
ATP6V0C [P27449]3EBI-18053395,EBI-721179
BBC3 [Q96PG8]3EBI-18053395,EBI-17289784
BRICD5 - isoform 2 [Q6PL45-2]3EBI-18053395,EBI-12244618
C16orf58 [Q96GQ5]3EBI-18053395,EBI-8636004
CACNG1 [Q06432]3EBI-18053395,EBI-9686780
CALHM6 [Q5R3K3]3EBI-18053395,EBI-19051471
CCDC167 [Q9P0B6]3EBI-18053395,EBI-9083477
CDIPT [O14735]3EBI-18053395,EBI-358858
CLDN10 [P78369]3EBI-18053395,EBI-13372810
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-18053395,EBI-12256978
CLDN4 [O14493]3EBI-18053395,EBI-9316372
CLDND2 [Q8NHS1]3EBI-18053395,EBI-11959453
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-18053395,EBI-11522780
CMTM7 [Q96FZ5]3EBI-18053395,EBI-2807956
CYB5R3 [P00387]3EBI-18053395,EBI-1046040
CYBC1 [Q9BQA9]3EBI-18053395,EBI-2680384
CYP4F2 [P78329]3EBI-18053395,EBI-1752413
DIABLO [Q9NR28]3EBI-18053395,EBI-517508
EBP [Q15125]3EBI-18053395,EBI-3915253
ECPAS [Q5VYK3]3EBI-18053395,EBI-521451
FATE1 [Q969F0]3EBI-18053395,EBI-743099
FAXDC2 [Q96IV6]3EBI-18053395,EBI-12142299
FETUB [Q9UGM5]3EBI-18053395,EBI-13049494
GJB2 [P29033]3EBI-18053395,EBI-3905204
GOLM1 [Q8NBJ4]3EBI-18053395,EBI-712073
GOSR2 [O14653]3EBI-18053395,EBI-4401517
GYPB [P06028]3EBI-18053395,EBI-10194756
HSD3B7 [Q9H2F3]3EBI-18053395,EBI-3918847
IGFBP5 [P24593]3EBI-18053395,EBI-720480
INSIG2 [Q9Y5U4]3EBI-18053395,EBI-8503746
ITGAM [P11215]3EBI-18053395,EBI-2568251
JAGN1 [Q8N5M9]3EBI-18053395,EBI-10266796
LPCAT2 [Q7L5N7]3EBI-18053395,EBI-4280011
LRAT [O95237]3EBI-18053395,EBI-13291307
MARCHF5 [Q9NX47]3EBI-18053395,EBI-2341610
MFSD5 [Q6N075]3EBI-18053395,EBI-3920969
MGLL [A0A0C4DFN3]3EBI-18053395,EBI-12866138
MIEF2 - isoform 3 [Q96C03-3]3EBI-18053395,EBI-11988931
MMP14 [P50281]3EBI-18053395,EBI-992788
MOSPD3 [O75425]3EBI-18053395,EBI-12179105
MS4A1 [P11836]3EBI-18053395,EBI-2808234
NAPB [Q9H115]3EBI-18053395,EBI-3921185
NAT8 [Q9UHE5]3EBI-18053395,EBI-2863634
NRM [Q8IXM6]3EBI-18053395,EBI-10262547
ORMDL3 [Q8N138]3EBI-18053395,EBI-721750
PBX3 [Q96AL5]3EBI-18053395,EBI-741171
PLIN3 [O60664]3EBI-18053395,EBI-725795
PLN [P26678]3EBI-18053395,EBI-692836
PLP2 [Q04941]3EBI-18053395,EBI-608347
PNLIPRP1 [P54315]3EBI-18053395,EBI-8652812
PTPN9 [P43378]3EBI-18053395,EBI-742898
RABAC1 [Q9UI14]3EBI-18053395,EBI-712367
REEP6 - isoform 2 [Q96HR9-2]3EBI-18053395,EBI-14065960
RPRM [Q9NS64]3EBI-18053395,EBI-1052363
SACM1L [Q9NTJ5]3EBI-18053395,EBI-3917235
SCAMP5 [Q8TAC9]3EBI-18053395,EBI-2695784
SCARF1 [Q14162]3EBI-18053395,EBI-12056025
SCD [O00767]3EBI-18053395,EBI-2684237
SEC22B [O75396]3EBI-18053395,EBI-1058865
SERP1 [Q9Y6X1]3EBI-18053395,EBI-10329948
SFT2D2 [O95562]3EBI-18053395,EBI-4402330
SFXN1 [Q9H9B4]3EBI-18053395,EBI-355861
SFXN2 [Q96NB2]3EBI-18053395,EBI-6381136
SFXN3 [A0A1P0AYU5]3EBI-18053395,EBI-14193895
SLC25A46 [Q96AG3]3EBI-18053395,EBI-10281975
SLC30A3 [Q99726]3EBI-18053395,EBI-10294651
SLC35B4 [Q969S0]3EBI-18053395,EBI-10281213
SLC35E4 [Q6ICL7]3EBI-18053395,EBI-12867720
SMIM1 [B2RUZ4]3EBI-18053395,EBI-12188413
SNORC [Q6UX34]3EBI-18053395,EBI-11957067
SPG21 [Q9NZD8]3EBI-18053395,EBI-742688
ST6GAL2 - isoform 2 [Q96JF0-2]3EBI-18053395,EBI-12908338
STRIT1 [P0DN84]3EBI-18053395,EBI-12200293
STX5 [Q13190]3EBI-18053395,EBI-714206
STX7 [O15400]3EBI-18053395,EBI-3221827
TBRG4 [Q969Z0]3EBI-18053395,EBI-702328
TF [P02787]3EBI-18053395,EBI-714319
THSD7A [Q9UPZ6]3EBI-18053395,EBI-310962
TIMM23 [O14925]3EBI-18053395,EBI-1047996
TIMMDC1 [Q9NPL8]3EBI-18053395,EBI-6268651
TMEM100 [Q9NV29]3EBI-18053395,EBI-8644968
TMEM120A [Q9BXJ8]3EBI-18053395,EBI-727322
TMEM140 [Q9NV12]3EBI-18053395,EBI-2844246
TMEM14C [Q9P0S9]3EBI-18053395,EBI-2339195
TMEM167B [Q9NRX6]3EBI-18053395,EBI-17684533
TMEM19 [Q96HH6]3EBI-18053395,EBI-741829
TMEM203 [Q969S6]3EBI-18053395,EBI-12274070
TMEM222 [Q9H0R3]3EBI-18053395,EBI-347385
TMEM229B [Q8NBD8]3EBI-18053395,EBI-12195227
TMEM243 [Q9BU79]3EBI-18053395,EBI-12887458
TMEM255B [Q8WV15]3EBI-18053395,EBI-2870087
TMEM42 [Q69YG0]3EBI-18053395,EBI-12038591
TMEM60 [Q9H2L4]3EBI-18053395,EBI-2852148
TMEM86B [Q8N661]3EBI-18053395,EBI-2548832
TMEM97 [Q5BJF2]3EBI-18053395,EBI-12111910
TMX2 [Q9Y320]3EBI-18053395,EBI-6447886
TPRG1 [Q6ZUI0]3EBI-18053395,EBI-17249488
TREX1 - isoform 1 [Q9NSU2-1]3EBI-18053395,EBI-16746122
TTMP [Q5BVD1]3EBI-18053395,EBI-10243654
UBXN8 [O00124]3EBI-18053395,EBI-1993850
UNC50 [Q53HI1]3EBI-18053395,EBI-7601760
VAMP2 [P63027]3EBI-18053395,EBI-520113
VAPA [Q9P0L0]3EBI-18053395,EBI-1059156
VAPB [O95292]3EBI-18053395,EBI-1188298
YIPF2 [Q9BWQ6]3EBI-18053395,EBI-751204
YIPF4 [Q9BSR8]3EBI-18053395,EBI-751253

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131346, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q7Z5P4, 117 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000333300

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7Z5P4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7Z5P4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1201, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161743

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010194_2_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z5P4

Identification of Orthologs from Complete Genome Data

More...OMAi		CLMEGIL

Database of Orthologous Groups

More...OrthoDBi		1373099at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z5P4

TreeFam database of animal gene trees

More...TreeFami		TF312837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR002347, SDR_fam

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00106, adh_short, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00081, GDHRDH
PR00080, SDRFAMILY

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735, SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 2 (identifier: Q7Z5P4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNIILEILLL LITIIYSYLE SLVKFFIPQR RKSVAGEIVL ITGAGHGIGR 
        60         70         80         90        100
QTTYEFAKRQ SILVLWDINK RGVEETAAEC RKLGVTAHAY VVDCSNREEI 
       110        120        130        140        150
YRSLNQVKKE VGDVTIVVNN AGTVYPADLL STKDEEITKT FEVNILGHFW 
       160        170        180        190        200
ITKALLPSMM ERNHGHIVTV ASVCGHEGIP YLIPYCSSKF AAVGFHRGLT 
       210        220        230        240        250
SELQALGKTG IKTSCLCPVF VNTGFTKNPS TRLWPVLETD EVVRSLIDGI 
       260        270        280        290        300
LTNKKMIFVP SYINIFLRLQ KFLPERASAI LNRMQNIQFE AVVGHKIKMK
Length:300
Mass (Da):33,655
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B85778554265DFE
GO
Isoform 1 (identifier: Q7Z5P4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-106: Missing.

Show »
Length:264
Mass (Da):29,605
Checksum:iE18D65C68306E3B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti260P → S in AAO72313 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01586071 – 106Missing in isoform 1. 2 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY186249 mRNA Translation: AAO72313.1
AY186250 mRNA Translation: AAO72314.1
AY268355 mRNA Translation: AAP42289.1
AY358575 mRNA Translation: AAQ88938.1
AB073347 mRNA Translation: BAD38632.1
AK292784 mRNA Translation: BAF85473.1
CH471057 Genomic DNA Translation: EAX05986.1
BC112303 mRNA Translation: AAI12304.1
BC112305 mRNA Translation: AAI12306.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3618.1 [Q7Z5P4-1]
CCDS47097.1 [Q7Z5P4-2]

NCBI Reference Sequences

More...RefSeqi		NP_001129702.1, NM_001136230.2 [Q7Z5P4-2]
NP_835236.2, NM_178135.4 [Q7Z5P4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000302219; ENSP00000305438; ENSG00000170509 [Q7Z5P4-2]
ENST00000328546; ENSP00000333300; ENSG00000170509 [Q7Z5P4-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		345275

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:345275

UCSC genome browser

More...UCSCi		uc003hqo.3, human [Q7Z5P4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186249 mRNA Translation: AAO72313.1
AY186250 mRNA Translation: AAO72314.1
AY268355 mRNA Translation: AAP42289.1
AY358575 mRNA Translation: AAQ88938.1
AB073347 mRNA Translation: BAD38632.1
AK292784 mRNA Translation: BAF85473.1
CH471057 Genomic DNA Translation: EAX05986.1
BC112303 mRNA Translation: AAI12304.1
BC112305 mRNA Translation: AAI12306.1
CCDSiCCDS3618.1 [Q7Z5P4-1]
CCDS47097.1 [Q7Z5P4-2]
RefSeqiNP_001129702.1, NM_001136230.2 [Q7Z5P4-2]
NP_835236.2, NM_178135.4 [Q7Z5P4-1]

3D structure databases

SMRiQ7Z5P4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131346, 3 interactors
IntActiQ7Z5P4, 117 interactors
STRINGi9606.ENSP00000333300

PTM databases

iPTMnetiQ7Z5P4
PhosphoSitePlusiQ7Z5P4

Polymorphism and mutation databases

BioMutaiHSD17B13
DMDMi74750138

Proteomic databases

jPOSTiQ7Z5P4
MassIVEiQ7Z5P4
MaxQBiQ7Z5P4
PaxDbiQ7Z5P4
PeptideAtlasiQ7Z5P4
PRIDEiQ7Z5P4
ProteomicsDBi69338 [Q7Z5P4-1]
69339 [Q7Z5P4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		25413, 152 antibodies

The DNASU plasmid repository

More...DNASUi		345275

Genome annotation databases

EnsembliENST00000302219; ENSP00000305438; ENSG00000170509 [Q7Z5P4-2]
ENST00000328546; ENSP00000333300; ENSG00000170509 [Q7Z5P4-1]
GeneIDi345275
KEGGihsa:345275
UCSCiuc003hqo.3, human [Q7Z5P4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		345275
DisGeNETi345275
EuPathDBiHostDB:ENSG00000170509.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		HSD17B13
HGNCiHGNC:18685, HSD17B13
HPAiENSG00000170509, Tissue enriched (liver)
MIMi612127, gene
neXtProtiNX_Q7Z5P4
OpenTargetsiENSG00000170509
PharmGKBiPA38634

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1201, Eukaryota
GeneTreeiENSGT00940000161743
HOGENOMiCLU_010194_2_5_1
InParanoidiQ7Z5P4
OMAiCLMEGIL
OrthoDBi1373099at2759
PhylomeDBiQ7Z5P4
TreeFamiTF312837

Enzyme and pathway databases

PathwayCommonsiQ7Z5P4
ReactomeiR-HSA-8964572, Lipid particle organization

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		345275, 3 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HSD17B13, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		345275
PharosiQ7Z5P4, Tdark

Protein Ontology

More...PROi		PR:Q7Z5P4
RNActiQ7Z5P4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170509, Expressed in liver and 100 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR002347, SDR_fam
PfamiView protein in Pfam
PF00106, adh_short, 1 hit
PRINTSiPR00081, GDHRDH
PR00080, SDRFAMILY
SUPFAMiSSF51735, SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHB13_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z5P4
Secondary accession number(s): A8K9R9
, Q2M1L5, Q86W22, Q86W23
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2003
Last modified: August 12, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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