HSD17B13

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	172	SubstrateBy similarity	1
Active siteⁱ	185	Proton acceptorBy similarity	1
Binding siteⁱ	189	NADBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	40 – 67	NADBy similarityAdd BLAST		28

GO - Molecular functionⁱ

oxidoreductase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lipid particle organization Source: Reactome
positive regulation of lipid biosynthetic process
Source: MGI
Inferred from direct assayⁱ
- 25028495

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	NAD

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8964572 Lipid particle organization

Reactomeⁱ

R-HSA-8964572 Lipid particle organization

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 17-beta-hydroxysteroid dehydrogenase 13 (EC:1.1.-.-) Short name: 17-beta-HSD 13 Alternative name(s): Short chain dehydrogenase/reductase family 16C member 3 Short-chain dehydrogenase/reductase 9
Gene namesⁱ	Name:HSD17B13 Synonyms:SCDR9, SDR16C3 ORF Names:HMFN0376, UNQ497/PRO1014
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170509.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18685 HSD17B13
MIMⁱ	612127 gene
neXtProtⁱ	NX_Q7Z5P4

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	345275
Open Targets More...OpenTargetsⁱ	ENSG00000170509
PharmGKBⁱ	PA38634

Polymorphism and mutation databases

BioMutaⁱ	HSD17B13
DMDMⁱ	74750138

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000042583	20 – 300	17-beta-hydroxysteroid dehydrogenase 13Add BLAST		281

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	33	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7Z5P4
PaxDbⁱ	Q7Z5P4
PeptideAtlas More...PeptideAtlasⁱ	Q7Z5P4
PRIDEⁱ	Q7Z5P4
ProteomicsDBⁱ	69338 69339 [Q7Z5P4-2]

PTM databases

iPTMnetⁱ	Q7Z5P4
PhosphoSitePlusⁱ	Q7Z5P4

Expressionⁱ

Tissue specificityⁱ

Highly expressed in the liver. Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000170509 Expressed in 76 organ(s), highest expression level in liver
CleanExⁱ	HS_HSD17B13

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA029125

HPAⁱ

HPA029125

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	131346, 3 interactors
IntActⁱ	Q7Z5P4, 23 interactors
STRINGⁱ	9606.ENSP00000333300

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7Z5P4
SMRⁱ	Q7Z5P4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG1201 Eukaryota COG1028 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148998
HOVERGENⁱ	HBG051352
InParanoidⁱ	Q7Z5P4
OMAⁱ	HFWITKA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0825
PhylomeDBⁱ	Q7Z5P4
TreeFamⁱ	TF312837

Family and domain databases

InterProⁱ	View protein in InterPro IPR036291 NAD(P)-bd_dom_sf IPR002347 SDR_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PRINTSⁱ	PR00081 GDHRDH PR00080 SDRFAMILY
SUPFAMⁱ	SSF51735 SSF51735, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 2 (identifier: Q7Z5P4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNIILEILLL LITIIYSYLE SLVKFFIPQR RKSVAGEIVL ITGAGHGIGR 
        60         70         80         90        100
QTTYEFAKRQ SILVLWDINK RGVEETAAEC RKLGVTAHAY VVDCSNREEI 
       110        120        130        140        150
YRSLNQVKKE VGDVTIVVNN AGTVYPADLL STKDEEITKT FEVNILGHFW 
       160        170        180        190        200
ITKALLPSMM ERNHGHIVTV ASVCGHEGIP YLIPYCSSKF AAVGFHRGLT 
       210        220        230        240        250
SELQALGKTG IKTSCLCPVF VNTGFTKNPS TRLWPVLETD EVVRSLIDGI 
       260        270        280        290        300
LTNKKMIFVP SYINIFLRLQ KFLPERASAI LNRMQNIQFE AVVGHKIKMK

Length:300

Mass (Da):33,655

Last modified:October 1, 2003 - v1

Checksum:ⁱ5B85778554265DFE

GO

Isoform 1 (identifier: Q7Z5P4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
71-106: Missing.

« Hide

        10         20         30         40         50
MNIILEILLL LITIIYSYLE SLVKFFIPQR RKSVAGEIVL ITGAGHGIGR 
        60         70         80         90        100
QTTYEFAKRQ SILVLWDINK VKKEVGDVTI VVNNAGTVYP ADLLSTKDEE 
       110        120        130        140        150
ITKTFEVNIL GHFWITKALL PSMMERNHGH IVTVASVCGH EGIPYLIPYC 
       160        170        180        190        200
SSKFAAVGFH RGLTSELQAL GKTGIKTSCL CPVFVNTGFT KNPSTRLWPV 
       210        220        230        240        250
LETDEVVRSL IDGILTNKKM IFVPSYINIF LRLQKFLPER ASAILNRMQN 
       260 
IQFEAVVGHK IKMK

Show »

Length:264

Mass (Da):29,605

Checksum:ⁱE18D65C68306E3B2

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	260	P → S in AAO72313 (Ref. 1) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_015860	71 – 106	Missing in isoform 1. 2 PublicationsAdd BLAST		36

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY186249 mRNA Translation: AAO72313.1 AY186250 mRNA Translation: AAO72314.1 AY268355 mRNA Translation: AAP42289.1 AY358575 mRNA Translation: AAQ88938.1 AB073347 mRNA Translation: BAD38632.1 AK292784 mRNA Translation: BAF85473.1 CH471057 Genomic DNA Translation: EAX05986.1 BC112303 mRNA Translation: AAI12304.1 BC112305 mRNA Translation: AAI12306.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3618.1 [Q7Z5P4-1] CCDS47097.1 [Q7Z5P4-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001129702.1, NM_001136230.2 [Q7Z5P4-2] NP_835236.2, NM_178135.4 [Q7Z5P4-1]
UniGeneⁱ	Hs.284414

Genome annotation databases

Ensemblⁱ	ENST00000302219; ENSP00000305438; ENSG00000170509 [Q7Z5P4-2] ENST00000328546; ENSP00000333300; ENSG00000170509 [Q7Z5P4-1]
GeneIDⁱ	345275
KEGGⁱ	hsa:345275
UCSC genome browser More...UCSCⁱ	uc003hqo.3 human [Q7Z5P4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7Z5P4	Hydroxysteroid 17-beta dehydrogenase 13		SAIBB		303	UniRef90_Q7Z5P4
HSD17B13 isoform 1		PANTR		300
HSD17B13 isoform 1		PONAB		300
Hydroxysteroid 17-beta dehydrogenase 13		GORGO		300
Hydroxysteroid 17-beta dehydrogenase 13		CALJA		300
+9
Q7Z5P4-2	HSD17B13 isoform 2		PANTR		264	UniRef90_Q7Z5P4-2
Hydroxysteroid 17-beta dehydrogenase 13		SAIBB		264
Hydroxysteroid 17-beta dehydrogenase 13		CALJA		264
Hydroxysteroid 17-beta dehydrogenase 13		MACMU		264
Hydroxysteroid 17-beta dehydrogenase 13		MACFA		264
+13

Protein	Similar proteins		Species	Score	Length	Source
Q7Z5P4	Estradiol 17-beta-dehydrogenase 11	)	HUMAN		300	UniRef50_Q8NBQ5
Estradiol 17-beta-dehydrogenase 11		PONAB		300
Estradiol 17-beta-dehydrogenase 11		MACFA		300
Estradiol 17-beta-dehydrogenase 11		MOUSE		298
Estradiol 17-beta-dehydrogenase 11		RAT		298
+128
Q7Z5P4-2	Hydroxysteroid 17-beta dehydrogenase 13		PAPAN		264	UniRef50_Q7Z5P4-2
Hydroxysteroid 17-beta dehydrogenase 13		MANLE		264
Hydroxysteroid 17-beta dehydrogenase 13		AOTNA		264
HSD17B13 isoform 2		PONAB		264
Hydroxysteroid 17-beta dehydrogenase 13		SAIBB		264
+52

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY186249 mRNA Translation: AAO72313.1 AY186250 mRNA Translation: AAO72314.1 AY268355 mRNA Translation: AAP42289.1 AY358575 mRNA Translation: AAQ88938.1 AB073347 mRNA Translation: BAD38632.1 AK292784 mRNA Translation: BAF85473.1 CH471057 Genomic DNA Translation: EAX05986.1 BC112303 mRNA Translation: AAI12304.1 BC112305 mRNA Translation: AAI12306.1
CCDSⁱ	CCDS3618.1 [Q7Z5P4-1] CCDS47097.1 [Q7Z5P4-2]
RefSeqⁱ	NP_001129702.1, NM_001136230.2 [Q7Z5P4-2] NP_835236.2, NM_178135.4 [Q7Z5P4-1]
UniGeneⁱ	Hs.284414

3D structure databases

ProteinModelPortalⁱ	Q7Z5P4
SMRⁱ	Q7Z5P4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	131346, 3 interactors
IntActⁱ	Q7Z5P4, 23 interactors
STRINGⁱ	9606.ENSP00000333300

PTM databases

iPTMnetⁱ	Q7Z5P4
PhosphoSitePlusⁱ	Q7Z5P4

Polymorphism and mutation databases

BioMutaⁱ	HSD17B13
DMDMⁱ	74750138

Proteomic databases

MaxQBⁱ	Q7Z5P4
PaxDbⁱ	Q7Z5P4
PeptideAtlasⁱ	Q7Z5P4
PRIDEⁱ	Q7Z5P4
ProteomicsDBⁱ	69338 69339 [Q7Z5P4-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	345275
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000302219; ENSP00000305438; ENSG00000170509 [Q7Z5P4-2] ENST00000328546; ENSP00000333300; ENSG00000170509 [Q7Z5P4-1]
GeneIDⁱ	345275
KEGGⁱ	hsa:345275
UCSCⁱ	uc003hqo.3 human [Q7Z5P4-1]

Organism-specific databases

CTDⁱ	345275
DisGeNETⁱ	345275
EuPathDBⁱ	HostDB:ENSG00000170509.11
GeneCardsⁱ	HSD17B13
HGNCⁱ	HGNC:18685 HSD17B13
HPAⁱ	HPA029125
MIMⁱ	612127 gene
neXtProtⁱ	NX_Q7Z5P4
OpenTargetsⁱ	ENSG00000170509
PharmGKBⁱ	PA38634
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1201 Eukaryota COG1028 LUCA
GeneTreeⁱ	ENSGT00920000148998
HOVERGENⁱ	HBG051352
InParanoidⁱ	Q7Z5P4
OMAⁱ	HFWITKA
OrthoDBⁱ	EOG091G0825
PhylomeDBⁱ	Q7Z5P4
TreeFamⁱ	TF312837

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8964572 Lipid particle organization

Reactomeⁱ

R-HSA-8964572 Lipid particle organization

Miscellaneous databases

ChiTaRSⁱ	HSD17B13 human
GenomeRNAiⁱ	345275
Protein Ontology More...PROⁱ	PR:Q7Z5P4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170509 Expressed in 76 organ(s), highest expression level in liver
CleanExⁱ	HS_HSD17B13

Family and domain databases

InterProⁱ	View protein in InterPro IPR036291 NAD(P)-bd_dom_sf IPR002347 SDR_fam
Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PRINTSⁱ	PR00081 GDHRDH PR00080 SDRFAMILY
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DHB13_HUMAN
Accessionⁱ	Q7Z5P4Primary (citable) accession number: Q7Z5P4 Secondary accession number(s): A8K9R9 , Q2M1L5, Q86W22, Q86W23
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 11, 2005
	Last sequence update:	October 1, 2003
	Last modified:	September 12, 2018
	This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7Z5P4 (DHB13_HUMAN)

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17-beta-hydroxysteroid dehydrogenase 13

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Cytosol

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ