UniProtKB - Q7Z5P4 (DHB13_HUMAN)
Protein
17-beta-hydroxysteroid dehydrogenase 13
Gene
HSD17B13
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 172 | SubstrateBy similarity | 1 | |
Active sitei | 185 | Proton acceptorBy similarity | 1 | |
Binding sitei | 189 | NADBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 40 – 67 | NADBy similarityAdd BLAST | 28 |
GO - Molecular functioni
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: GO_Central
- steroid dehydrogenase activity Source: GO_Central
GO - Biological processi
- lipid droplet organization Source: Reactome
- positive regulation of lipid biosynthetic process Source: MGI
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
PathwayCommonsi | Q7Z5P4 |
Reactomei | R-HSA-8964572, Lipid particle organization |
Names & Taxonomyi
Protein namesi | Recommended name: 17-beta-hydroxysteroid dehydrogenase 13 (EC:1.1.-.-)Short name: 17-beta-HSD 13 Alternative name(s): Short chain dehydrogenase/reductase family 16C member 3 Short-chain dehydrogenase/reductase 9 |
Gene namesi | Name:HSD17B13 Synonyms:SCDR9, SDR16C3 ORF Names:HMFN0376, UNQ497/PRO1014 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170509.11 |
HGNCi | HGNC:18685, HSD17B13 |
MIMi | 612127, gene |
neXtProti | NX_Q7Z5P4 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Other locations
- Lipid droplet By similarity
Note: Redistributed from the endoplasmic reticulum to lipids droplets in the cell upon induction of lipids droplet formation.By similarity
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Other locations
- lipid droplet Source: MGI
Keywords - Cellular componenti
Endoplasmic reticulum, Lipid dropletPathology & Biotechi
Organism-specific databases
DisGeNETi | 345275 |
OpenTargetsi | ENSG00000170509 |
PharmGKBi | PA38634 |
Miscellaneous databases
Pharosi | Q7Z5P4, Tdark |
Polymorphism and mutation databases
BioMutai | HSD17B13 |
DMDMi | 74750138 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000042583 | 20 – 300 | 17-beta-hydroxysteroid dehydrogenase 13Add BLAST | 281 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 33 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q7Z5P4 |
MassIVEi | Q7Z5P4 |
MaxQBi | Q7Z5P4 |
PaxDbi | Q7Z5P4 |
PeptideAtlasi | Q7Z5P4 |
PRIDEi | Q7Z5P4 |
ProteomicsDBi | 69338 [Q7Z5P4-1] 69339 [Q7Z5P4-2] |
PTM databases
iPTMneti | Q7Z5P4 |
PhosphoSitePlusi | Q7Z5P4 |
Expressioni
Tissue specificityi
Highly expressed in the liver. Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.1 Publication
Gene expression databases
Bgeei | ENSG00000170509, Expressed in liver and 100 other tissues |
Organism-specific databases
HPAi | ENSG00000170509, Tissue enriched (liver) |
Interactioni
Binary interactionsi
Q7Z5P4
Protein-protein interaction databases
BioGRIDi | 131346, 120 interactors |
IntActi | Q7Z5P4, 117 interactors |
STRINGi | 9606.ENSP00000333300 |
Miscellaneous databases
RNActi | Q7Z5P4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1201, Eukaryota |
GeneTreei | ENSGT00940000161743 |
HOGENOMi | CLU_010194_2_5_1 |
InParanoidi | Q7Z5P4 |
OMAi | CLMEGIL |
OrthoDBi | 1373099at2759 |
PhylomeDBi | Q7Z5P4 |
TreeFami | TF312837 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 2 (identifier: Q7Z5P4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNIILEILLL LITIIYSYLE SLVKFFIPQR RKSVAGEIVL ITGAGHGIGR
60 70 80 90 100
QTTYEFAKRQ SILVLWDINK RGVEETAAEC RKLGVTAHAY VVDCSNREEI
110 120 130 140 150
YRSLNQVKKE VGDVTIVVNN AGTVYPADLL STKDEEITKT FEVNILGHFW
160 170 180 190 200
ITKALLPSMM ERNHGHIVTV ASVCGHEGIP YLIPYCSSKF AAVGFHRGLT
210 220 230 240 250
SELQALGKTG IKTSCLCPVF VNTGFTKNPS TRLWPVLETD EVVRSLIDGI
260 270 280 290 300
LTNKKMIFVP SYINIFLRLQ KFLPERASAI LNRMQNIQFE AVVGHKIKMK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 260 | P → S in AAO72313 (Ref. 1) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015860 | 71 – 106 | Missing in isoform 1. 2 PublicationsAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY186249 mRNA Translation: AAO72313.1 AY186250 mRNA Translation: AAO72314.1 AY268355 mRNA Translation: AAP42289.1 AY358575 mRNA Translation: AAQ88938.1 AB073347 mRNA Translation: BAD38632.1 AK292784 mRNA Translation: BAF85473.1 CH471057 Genomic DNA Translation: EAX05986.1 BC112303 mRNA Translation: AAI12304.1 BC112305 mRNA Translation: AAI12306.1 |
CCDSi | CCDS3618.1 [Q7Z5P4-1] CCDS47097.1 [Q7Z5P4-2] |
RefSeqi | NP_001129702.1, NM_001136230.2 [Q7Z5P4-2] NP_835236.2, NM_178135.4 [Q7Z5P4-1] |
Genome annotation databases
Ensembli | ENST00000302219; ENSP00000305438; ENSG00000170509 [Q7Z5P4-2] ENST00000328546; ENSP00000333300; ENSG00000170509 [Q7Z5P4-1] |
GeneIDi | 345275 |
KEGGi | hsa:345275 |
UCSCi | uc003hqo.3, human [Q7Z5P4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY186249 mRNA Translation: AAO72313.1 AY186250 mRNA Translation: AAO72314.1 AY268355 mRNA Translation: AAP42289.1 AY358575 mRNA Translation: AAQ88938.1 AB073347 mRNA Translation: BAD38632.1 AK292784 mRNA Translation: BAF85473.1 CH471057 Genomic DNA Translation: EAX05986.1 BC112303 mRNA Translation: AAI12304.1 BC112305 mRNA Translation: AAI12306.1 |
CCDSi | CCDS3618.1 [Q7Z5P4-1] CCDS47097.1 [Q7Z5P4-2] |
RefSeqi | NP_001129702.1, NM_001136230.2 [Q7Z5P4-2] NP_835236.2, NM_178135.4 [Q7Z5P4-1] |
3D structure databases
SMRi | Q7Z5P4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131346, 120 interactors |
IntActi | Q7Z5P4, 117 interactors |
STRINGi | 9606.ENSP00000333300 |
PTM databases
iPTMneti | Q7Z5P4 |
PhosphoSitePlusi | Q7Z5P4 |
Polymorphism and mutation databases
BioMutai | HSD17B13 |
DMDMi | 74750138 |
Proteomic databases
jPOSTi | Q7Z5P4 |
MassIVEi | Q7Z5P4 |
MaxQBi | Q7Z5P4 |
PaxDbi | Q7Z5P4 |
PeptideAtlasi | Q7Z5P4 |
PRIDEi | Q7Z5P4 |
ProteomicsDBi | 69338 [Q7Z5P4-1] 69339 [Q7Z5P4-2] |
Protocols and materials databases
Antibodypediai | 25413, 152 antibodies |
DNASUi | 345275 |
Genome annotation databases
Ensembli | ENST00000302219; ENSP00000305438; ENSG00000170509 [Q7Z5P4-2] ENST00000328546; ENSP00000333300; ENSG00000170509 [Q7Z5P4-1] |
GeneIDi | 345275 |
KEGGi | hsa:345275 |
UCSCi | uc003hqo.3, human [Q7Z5P4-1] |
Organism-specific databases
CTDi | 345275 |
DisGeNETi | 345275 |
EuPathDBi | HostDB:ENSG00000170509.11 |
GeneCardsi | HSD17B13 |
HGNCi | HGNC:18685, HSD17B13 |
HPAi | ENSG00000170509, Tissue enriched (liver) |
MIMi | 612127, gene |
neXtProti | NX_Q7Z5P4 |
OpenTargetsi | ENSG00000170509 |
PharmGKBi | PA38634 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1201, Eukaryota |
GeneTreei | ENSGT00940000161743 |
HOGENOMi | CLU_010194_2_5_1 |
InParanoidi | Q7Z5P4 |
OMAi | CLMEGIL |
OrthoDBi | 1373099at2759 |
PhylomeDBi | Q7Z5P4 |
TreeFami | TF312837 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z5P4 |
Reactomei | R-HSA-8964572, Lipid particle organization |
Miscellaneous databases
BioGRID-ORCSi | 345275, 3 hits in 845 CRISPR screens |
ChiTaRSi | HSD17B13, human |
GenomeRNAii | 345275 |
Pharosi | Q7Z5P4, Tdark |
PROi | PR:Q7Z5P4 |
RNActi | Q7Z5P4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170509, Expressed in liver and 100 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DHB13_HUMAN | |
Accessioni | Q7Z5P4Primary (citable) accession number: Q7Z5P4 Secondary accession number(s): A8K9R9 Q86W23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 11, 2005 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families