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Protein

17-beta-hydroxysteroid dehydrogenase 13

Gene

HSD17B13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei172SubstrateBy similarity1
Active sitei185Proton acceptorBy similarity1
Binding sitei189NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 67NADBy similarityAdd BLAST28

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-HSA-8964572 Lipid particle organization

Names & Taxonomyi

Protein namesi
Recommended name:
17-beta-hydroxysteroid dehydrogenase 13 (EC:1.1.-.-)
Short name:
17-beta-HSD 13
Alternative name(s):
Short chain dehydrogenase/reductase family 16C member 3
Short-chain dehydrogenase/reductase 9
Gene namesi
Name:HSD17B13
Synonyms:SCDR9, SDR16C3
ORF Names:HMFN0376, UNQ497/PRO1014
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000170509.11
HGNCiHGNC:18685 HSD17B13
MIMi612127 gene
neXtProtiNX_Q7Z5P4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi345275
OpenTargetsiENSG00000170509
PharmGKBiPA38634

Polymorphism and mutation databases

BioMutaiHSD17B13
DMDMi74750138

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000004258320 – 30017-beta-hydroxysteroid dehydrogenase 13Add BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z5P4
PaxDbiQ7Z5P4
PeptideAtlasiQ7Z5P4
PRIDEiQ7Z5P4
ProteomicsDBi69338
69339 [Q7Z5P4-2]

PTM databases

iPTMnetiQ7Z5P4
PhosphoSitePlusiQ7Z5P4

Expressioni

Tissue specificityi

Highly expressed in the liver. Also detected in ovary, bone marrow, kidney, brain, lung, skeletal muscle, bladder and testis.1 Publication

Gene expression databases

BgeeiENSG00000170509 Expressed in 76 organ(s), highest expression level in liver
CleanExiHS_HSD17B13

Organism-specific databases

HPAiHPA029125

Interactioni

Protein-protein interaction databases

BioGridi131346, 3 interactors
IntActiQ7Z5P4, 23 interactors
STRINGi9606.ENSP00000333300

Structurei

3D structure databases

ProteinModelPortaliQ7Z5P4
SMRiQ7Z5P4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1201 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00920000148998
HOVERGENiHBG051352
InParanoidiQ7Z5P4
OMAiHFWITKA
OrthoDBiEOG091G0825
PhylomeDBiQ7Z5P4
TreeFamiTF312837

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 2 (identifier: Q7Z5P4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNIILEILLL LITIIYSYLE SLVKFFIPQR RKSVAGEIVL ITGAGHGIGR
60 70 80 90 100
QTTYEFAKRQ SILVLWDINK RGVEETAAEC RKLGVTAHAY VVDCSNREEI
110 120 130 140 150
YRSLNQVKKE VGDVTIVVNN AGTVYPADLL STKDEEITKT FEVNILGHFW
160 170 180 190 200
ITKALLPSMM ERNHGHIVTV ASVCGHEGIP YLIPYCSSKF AAVGFHRGLT
210 220 230 240 250
SELQALGKTG IKTSCLCPVF VNTGFTKNPS TRLWPVLETD EVVRSLIDGI
260 270 280 290 300
LTNKKMIFVP SYINIFLRLQ KFLPERASAI LNRMQNIQFE AVVGHKIKMK
Length:300
Mass (Da):33,655
Last modified:October 1, 2003 - v1
Checksum:i5B85778554265DFE
GO
Isoform 1 (identifier: Q7Z5P4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-106: Missing.

Show »
Length:264
Mass (Da):29,605
Checksum:iE18D65C68306E3B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti260P → S in AAO72313 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01586071 – 106Missing in isoform 1. 2 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186249 mRNA Translation: AAO72313.1
AY186250 mRNA Translation: AAO72314.1
AY268355 mRNA Translation: AAP42289.1
AY358575 mRNA Translation: AAQ88938.1
AB073347 mRNA Translation: BAD38632.1
AK292784 mRNA Translation: BAF85473.1
CH471057 Genomic DNA Translation: EAX05986.1
BC112303 mRNA Translation: AAI12304.1
BC112305 mRNA Translation: AAI12306.1
CCDSiCCDS3618.1 [Q7Z5P4-1]
CCDS47097.1 [Q7Z5P4-2]
RefSeqiNP_001129702.1, NM_001136230.2 [Q7Z5P4-2]
NP_835236.2, NM_178135.4 [Q7Z5P4-1]
UniGeneiHs.284414

Genome annotation databases

EnsembliENST00000302219; ENSP00000305438; ENSG00000170509 [Q7Z5P4-2]
ENST00000328546; ENSP00000333300; ENSG00000170509 [Q7Z5P4-1]
GeneIDi345275
KEGGihsa:345275
UCSCiuc003hqo.3 human [Q7Z5P4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY186249 mRNA Translation: AAO72313.1
AY186250 mRNA Translation: AAO72314.1
AY268355 mRNA Translation: AAP42289.1
AY358575 mRNA Translation: AAQ88938.1
AB073347 mRNA Translation: BAD38632.1
AK292784 mRNA Translation: BAF85473.1
CH471057 Genomic DNA Translation: EAX05986.1
BC112303 mRNA Translation: AAI12304.1
BC112305 mRNA Translation: AAI12306.1
CCDSiCCDS3618.1 [Q7Z5P4-1]
CCDS47097.1 [Q7Z5P4-2]
RefSeqiNP_001129702.1, NM_001136230.2 [Q7Z5P4-2]
NP_835236.2, NM_178135.4 [Q7Z5P4-1]
UniGeneiHs.284414

3D structure databases

ProteinModelPortaliQ7Z5P4
SMRiQ7Z5P4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131346, 3 interactors
IntActiQ7Z5P4, 23 interactors
STRINGi9606.ENSP00000333300

PTM databases

iPTMnetiQ7Z5P4
PhosphoSitePlusiQ7Z5P4

Polymorphism and mutation databases

BioMutaiHSD17B13
DMDMi74750138

Proteomic databases

MaxQBiQ7Z5P4
PaxDbiQ7Z5P4
PeptideAtlasiQ7Z5P4
PRIDEiQ7Z5P4
ProteomicsDBi69338
69339 [Q7Z5P4-2]

Protocols and materials databases

DNASUi345275
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302219; ENSP00000305438; ENSG00000170509 [Q7Z5P4-2]
ENST00000328546; ENSP00000333300; ENSG00000170509 [Q7Z5P4-1]
GeneIDi345275
KEGGihsa:345275
UCSCiuc003hqo.3 human [Q7Z5P4-1]

Organism-specific databases

CTDi345275
DisGeNETi345275
EuPathDBiHostDB:ENSG00000170509.11
GeneCardsiHSD17B13
HGNCiHGNC:18685 HSD17B13
HPAiHPA029125
MIMi612127 gene
neXtProtiNX_Q7Z5P4
OpenTargetsiENSG00000170509
PharmGKBiPA38634
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1201 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00920000148998
HOVERGENiHBG051352
InParanoidiQ7Z5P4
OMAiHFWITKA
OrthoDBiEOG091G0825
PhylomeDBiQ7Z5P4
TreeFamiTF312837

Enzyme and pathway databases

ReactomeiR-HSA-8964572 Lipid particle organization

Miscellaneous databases

ChiTaRSiHSD17B13 human
GenomeRNAii345275
PROiPR:Q7Z5P4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170509 Expressed in 76 organ(s), highest expression level in liver
CleanExiHS_HSD17B13

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHB13_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5P4
Secondary accession number(s): A8K9R9
, Q2M1L5, Q86W22, Q86W23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2005
Last sequence update: October 1, 2003
Last modified: October 10, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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