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Entry version 127 (16 Oct 2019)
Sequence version 1 (01 Oct 2003)
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Protein

Protein ABHD12B

Gene

ABHD12B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-ABHD12B ABHD12-PHARC

MEROPS protease database

More...
MEROPSi
S09.061

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ABHD12BCurated (EC:3.-.-.-)
Alternative name(s):
Abhydrolase domain-containing protein 12BImported
Alpha/beta hydrolase domain-containing protein 12BCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABHD12BImported
Synonyms:C14orf29
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19837 ABHD12B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z5M8

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
145447

Open Targets

More...
OpenTargetsi
ENSG00000131969

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162375213

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z5M8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABHD12B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50401854

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000898871 – 362Protein ABHD12BAdd BLAST362

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z5M8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z5M8

PeptideAtlas

More...
PeptideAtlasi
Q7Z5M8

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z5M8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69331 [Q7Z5M8-1]
69332 [Q7Z5M8-2]
69333 [Q7Z5M8-4]
69334 [Q7Z5M8-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z5M8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z5M8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131969 Expressed in 121 organ(s), highest expression level in caudate nucleus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z5M8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA002873

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126913, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q7Z5M8, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000336693

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the serine esterase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1552 Eukaryota
COG1073 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161597

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230822

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z5M8

KEGG Orthology (KO)

More...
KOi
K13705

Identification of Orthologs from Complete Genome Data

More...
OMAi
FYIRVEP

Database of Orthologous Groups

More...
OrthoDBi
691954at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z5M8

TreeFam database of animal gene trees

More...
TreeFami
TF315122

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR022742 Hydrolase_4

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12146 Hydrolase_4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z5M8-1) [UniParc]FASTAAdd to basket
Also known as: Variant 1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAQDCQAAA SPEPPGPPAR SCVAAWWDMV DRNLRYFPHS CSMLGRKIAA
60 70 80 90 100
LYDSFTSKSL KEHVFLPLID MLIYFNFFKA PFLVDLKKPE LKIPHTVNFY
110 120 130 140 150
LRVEPGVMLG IWHTVPSCRG EDAKGKDCCW YEAALRDGNP IIVYLHGSAE
160 170 180 190 200
HRAASHRLKL VKVLSDGGFH VLSVDYRGFG DSTGKPTEEG LTTDAICVYE
210 220 230 240 250
WTKARSGITP VCLWGHSLGT GVATNAAKVL EEKGCPVDAI VLEAPFTNMW
260 270 280 290 300
VASINYPLLK IYRNIPGFLR TLMDALRKDK IIFPNDENVK FLSSPLLILH
310 320 330 340 350
GEDDRTVPLE YGKKLYEIAR NAYRNKERVK MVIFPPGFQH NLLCKSPTLL
360
ITVRDFLSKQ WS
Length:362
Mass (Da):40,776
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6BD2858CE7C04AA
GO
Isoform 2 (identifier: Q7Z5M8-2) [UniParc]FASTAAdd to basket
Also known as: Variant 3

The sequence of this isoform differs from the canonical sequence as follows:
     36-112: Missing.

Show »
Length:285
Mass (Da):31,771
Checksum:i0E38F605D66D3A04
GO
Isoform 4 (identifier: Q7Z5M8-4) [UniParc]FASTAAdd to basket
Also known as: Variant 4

The sequence of this isoform differs from the canonical sequence as follows:
     36-60: YFPHSCSMLGRKIAALYDSFTSKSL → QSPISCGFKETRVKDSSHSELLPES
     61-362: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:60
Mass (Da):6,557
Checksum:i630A1E99452393C1
GO
Isoform 5 (identifier: Q7Z5M8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-112: Missing.
     261-312: IYRNIPGFLR...DDRTVPLEYG → SLALSSRLEC...HHAWLIFLCF
     313-362: Missing.

Note: No experimental confirmation available.
Show »
Length:235
Mass (Da):25,316
Checksum:iA73508AF6155B38A
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH34603 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAP78477 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAP78479 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035676282I → V in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs28564871Ensembl.1
Natural variantiVAR_019100334F → L1 PublicationCorresponds to variant dbSNP:rs7154732Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01068736 – 112Missing in isoform 2 and isoform 5. 3 PublicationsAdd BLAST77
Alternative sequenceiVSP_04114936 – 60YFPHS…TSKSL → QSPISCGFKETRVKDSSHSE LLPES in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_04115061 – 362Missing in isoform 4. 1 PublicationAdd BLAST302
Alternative sequenceiVSP_010688261 – 312IYRNI…PLEYG → SLALSSRLECSGVISAHCKL RFPGSRHSPASASRVAGTTG ARHHAWLIFLCF in isoform 5. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_010689313 – 362Missing in isoform 5. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY311396 mRNA Translation: AAP78476.1
AY311397 mRNA Translation: AAP78477.1 Sequence problems.
AY311398 mRNA Translation: AAP78478.1
AY311399 mRNA Translation: AAP78479.1 Sequence problems.
AK128464 mRNA Translation: BAC87452.1
AL358334 Genomic DNA No translation available.
BC034603 mRNA Translation: AAH34603.3 Different initiation.
BC107141 mRNA Translation: AAI07142.1
BC107142 mRNA Translation: AAI07143.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55916.1 [Q7Z5M8-1]
CCDS9702.1 [Q7Z5M8-2]

NCBI Reference Sequences

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RefSeqi
NP_001193602.1, NM_001206673.1 [Q7Z5M8-1]
NP_853511.2, NM_181533.3
NP_861535.1, NM_181814.1 [Q7Z5M8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337334; ENSP00000336693; ENSG00000131969 [Q7Z5M8-1]
ENST00000353130; ENSP00000343951; ENSG00000131969 [Q7Z5M8-2]
ENST00000382029; ENSP00000371460; ENSG00000131969 [Q7Z5M8-4]
ENST00000557345; ENSP00000450643; ENSG00000131969 [Q7Z5M8-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
145447

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:145447

UCSC genome browser

More...
UCSCi
uc001wyq.4 human [Q7Z5M8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY311396 mRNA Translation: AAP78476.1
AY311397 mRNA Translation: AAP78477.1 Sequence problems.
AY311398 mRNA Translation: AAP78478.1
AY311399 mRNA Translation: AAP78479.1 Sequence problems.
AK128464 mRNA Translation: BAC87452.1
AL358334 Genomic DNA No translation available.
BC034603 mRNA Translation: AAH34603.3 Different initiation.
BC107141 mRNA Translation: AAI07142.1
BC107142 mRNA Translation: AAI07143.1
CCDSiCCDS55916.1 [Q7Z5M8-1]
CCDS9702.1 [Q7Z5M8-2]
RefSeqiNP_001193602.1, NM_001206673.1 [Q7Z5M8-1]
NP_853511.2, NM_181533.3
NP_861535.1, NM_181814.1 [Q7Z5M8-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi126913, 1 interactor
IntActiQ7Z5M8, 2 interactors
STRINGi9606.ENSP00000336693

Protein family/group databases

ESTHERihuman-ABHD12B ABHD12-PHARC
MEROPSiS09.061

PTM databases

iPTMnetiQ7Z5M8
PhosphoSitePlusiQ7Z5M8

Polymorphism and mutation databases

BioMutaiABHD12B
DMDMi50401854

Proteomic databases

jPOSTiQ7Z5M8
PaxDbiQ7Z5M8
PeptideAtlasiQ7Z5M8
PRIDEiQ7Z5M8
ProteomicsDBi69331 [Q7Z5M8-1]
69332 [Q7Z5M8-2]
69333 [Q7Z5M8-4]
69334 [Q7Z5M8-5]

Genome annotation databases

EnsembliENST00000337334; ENSP00000336693; ENSG00000131969 [Q7Z5M8-1]
ENST00000353130; ENSP00000343951; ENSG00000131969 [Q7Z5M8-2]
ENST00000382029; ENSP00000371460; ENSG00000131969 [Q7Z5M8-4]
ENST00000557345; ENSP00000450643; ENSG00000131969 [Q7Z5M8-4]
GeneIDi145447
KEGGihsa:145447
UCSCiuc001wyq.4 human [Q7Z5M8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
145447
DisGeNETi145447

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABHD12B
HGNCiHGNC:19837 ABHD12B
HPAiHPA002873
neXtProtiNX_Q7Z5M8
OpenTargetsiENSG00000131969
PharmGKBiPA162375213

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1552 Eukaryota
COG1073 LUCA
GeneTreeiENSGT00940000161597
HOGENOMiHOG000230822
InParanoidiQ7Z5M8
KOiK13705
OMAiFYIRVEP
OrthoDBi691954at2759
PhylomeDBiQ7Z5M8
TreeFamiTF315122

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ABHD12B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
145447
PharosiQ7Z5M8

Protein Ontology

More...
PROi
PR:Q7Z5M8

Gene expression databases

BgeeiENSG00000131969 Expressed in 121 organ(s), highest expression level in caudate nucleus
GenevisibleiQ7Z5M8 HS

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR022742 Hydrolase_4
PfamiView protein in Pfam
PF12146 Hydrolase_4, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAB12B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z5M8
Secondary accession number(s): Q3KNR9
, Q3KNS0, Q7Z5M6, Q7Z5M7, Q8N4D2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: October 1, 2003
Last modified: October 16, 2019
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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