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Protein

Interferon regulatory factor 2-binding protein 2

Gene

IRF2BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798).4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri506 – 553RING-type; degenerateAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • immature B cell differentiation Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

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SIGNORi
Q7Z5L9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon regulatory factor 2-binding protein 2
Short name:
IRF-2-binding protein 2
Short name:
IRF-2BP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IRF2BP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000168264.10

Human Gene Nomenclature Database

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HGNCi
HGNC:21729 IRF2BP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615332 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q7Z5L9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency, common variable, 14 (CVID14)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency resulting in recurrent sinopulmonary infections since early childhood, and characterized by hypogammaglobulinemia with undetectable IgG and IgA, poor response to vaccination, and decreased levels of switched memory B cells. CVID14 inheritance is autosomal dominant.
See also OMIM:617765
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080578551S → N in CVID14; increased protein abundance in patient-derived B lymphocytes; impairs immature B cell differentiation. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

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DisGeNETi
359948

MalaCards human disease database

More...
MalaCardsi
IRF2BP2
MIMi617765 phenotype

Open Targets

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OpenTargetsi
ENSG00000168264

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134947294

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
IRF2BP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229462882

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003287342 – 587Interferon regulatory factor 2-binding protein 2Add BLAST586

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei240PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki289Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki303Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei318PhosphoserineCombined sources1
Cross-linki324Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki326Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki348Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei360PhosphoserineCombined sources1 Publication1
Modified residuei406PhosphoserineBy similarity1
Modified residuei423PhosphoserineBy similarity1
Modified residuei455PhosphoserineCombined sources1
Modified residuei457PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1
Isoform 2 (identifier: Q7Z5L9-2)
Cross-linki326Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-360 is required for nuclear targeting.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q7Z5L9

MaxQB - The MaxQuant DataBase

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MaxQBi
Q7Z5L9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7Z5L9

PeptideAtlas

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PeptideAtlasi
Q7Z5L9

PRoteomics IDEntifications database

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PRIDEi
Q7Z5L9

ProteomicsDB human proteome resource

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ProteomicsDBi
69325
69326 [Q7Z5L9-2]
69327 [Q7Z5L9-3]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q7Z5L9-2 [Q7Z5L9-2]
Q7Z5L9-3 [Q7Z5L9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q7Z5L9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q7Z5L9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000168264 Expressed in 214 organ(s), highest expression level in adult mammalian kidney

CleanEx database of gene expression profiles

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CleanExi
HS_IRF2BP2

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7Z5L9 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA027815
HPA062269

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP1. Interacts with VGLL4.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
131797, 31 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q7Z5L9

Protein interaction database and analysis system

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IntActi
Q7Z5L9, 3 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000355568

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q7Z5L9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7Z5L9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni506 – 550Cys-richAdd BLAST45

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi354 – 361Nuclear localization signal1 Publication8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi104 – 200Pro-richAdd BLAST97

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal RING-type zinc finger domain is sufficient for interaction with IRF2.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IRF2BP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri506 – 553RING-type; degenerateAdd BLAST48

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IPPD Eukaryota
ENOG4110EVD LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160591

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108364

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z5L9

KEGG Orthology (KO)

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KOi
K22383

Identification of Orthologs from Complete Genome Data

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OMAi
ESHKNRA

Database of Orthologous Groups

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OrthoDBi
EOG091G040R

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7Z5L9

TreeFam database of animal gene trees

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TreeFami
TF317075

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR022750 Interferon_reg_fac2-bd1_2_Znf

Pfam protein domain database

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Pfami
View protein in Pfam
PF11261 IRF-2BP1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z5L9-1) [UniParc]FASTAAdd to basket
Also known as: IRF-2BP2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAVAVAAA SRRQSCYLCD LPRMPWAMIW DFTEPVCRGC VNYEGADRVE
60 70 80 90 100
FVIETARQLK RAHGCFPEGR SPPGAAASAA AKPPPLSAKD ILLQQQQQLG
110 120 130 140 150
HGGPEAAPRA PQALERYPLA AAAERPPRLG SDFGSSRPAA SLAQPPTPQP
160 170 180 190 200
PPVNGILVPN GFSKLEEPPE LNRQSPNPRR GHAVPPTLVP LMNGSATPLP
210 220 230 240 250
TALGLGGRAA ASLAAVSGTA AASLGSAQPT DLGAHKRPAS VSSSAAVEHE
260 270 280 290 300
QREAAAKEKQ PPPPAHRGPA DSLSTAAGAA ELSAEGAGKS RGSGEQDWVN
310 320 330 340 350
RPKTVRDTLL ALHQHGHSGP FESKFKKEPA LTAGRLLGFE ANGANGSKAV
360 370 380 390 400
ARTARKRKPS PEPEGEVGPP KINGEAQPWL STSTEGLKIP MTPTSSFVSP
410 420 430 440 450
PPPTASPHSN RTTPPEAAQN GQSPMAALIL VADNAGGSHA SKDANQVHST
460 470 480 490 500
TRRNSNSPPS PSSMNQRRLG PREVGGQGAG NTGGLEPVHP ASLPDSSLAT
510 520 530 540 550
SAPLCCTLCH ERLEDTHFVQ CPSVPSHKFC FPCSRQSIKQ QGASGEVYCP
560 570 580
SGEKCPLVGS NVPWAFMQGE IATILAGDVK VKKERDS
Length:587
Mass (Da):61,025
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B36B7EE2C3B96A6
GO
Isoform 2 (identifier: Q7Z5L9-2) [UniParc]FASTAAdd to basket
Also known as: IRF-2BP2B

The sequence of this isoform differs from the canonical sequence as follows:
     333-348: Missing.

Show »
Length:571
Mass (Da):59,481
Checksum:iCE45834F631B6E86
GO
Isoform 3 (identifier: Q7Z5L9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-424: Missing.

Show »
Length:163
Mass (Da):17,139
Checksum:i9929F96A8CD66921
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti177N → K in AAP78944 (PubMed:12799427).Curated1
Sequence conflicti177N → K in AAP78945 (PubMed:12799427).Curated1
Sequence conflicti183A → T in AAP78944 (PubMed:12799427).Curated1
Sequence conflicti183A → T in AAP78945 (PubMed:12799427).Curated1
Sequence conflicti246A → T in AAP78944 (PubMed:12799427).Curated1
Sequence conflicti246A → T in AAP78945 (PubMed:12799427).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042503254A → V. Corresponds to variant dbSNP:rs11502Ensembl.1
Natural variantiVAR_080578551S → N in CVID14; increased protein abundance in patient-derived B lymphocytes; impairs immature B cell differentiation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0327691 – 424Missing in isoform 3. 1 PublicationAdd BLAST424
Alternative sequenceiVSP_032770333 – 348Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY278023 mRNA Translation: AAP78944.1
AY278024 mRNA Translation: AAP78945.1
AL160408 Genomic DNA No translation available.
BC020516 mRNA Translation: AAH20516.1
BC065759 mRNA Translation: AAH65759.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1602.1 [Q7Z5L9-1]
CCDS41475.1 [Q7Z5L9-2]

NCBI Reference Sequences

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RefSeqi
NP_001070865.1, NM_001077397.1 [Q7Z5L9-2]
NP_892017.2, NM_182972.2 [Q7Z5L9-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.350268

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000366609; ENSP00000355568; ENSG00000168264 [Q7Z5L9-1]
ENST00000366610; ENSP00000355569; ENSG00000168264 [Q7Z5L9-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
359948

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:359948

UCSC genome browser

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UCSCi
uc001hwf.3 human [Q7Z5L9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278023 mRNA Translation: AAP78944.1
AY278024 mRNA Translation: AAP78945.1
AL160408 Genomic DNA No translation available.
BC020516 mRNA Translation: AAH20516.1
BC065759 mRNA Translation: AAH65759.1
CCDSiCCDS1602.1 [Q7Z5L9-1]
CCDS41475.1 [Q7Z5L9-2]
RefSeqiNP_001070865.1, NM_001077397.1 [Q7Z5L9-2]
NP_892017.2, NM_182972.2 [Q7Z5L9-1]
UniGeneiHs.350268

3D structure databases

ProteinModelPortaliQ7Z5L9
SMRiQ7Z5L9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131797, 31 interactors
CORUMiQ7Z5L9
IntActiQ7Z5L9, 3 interactors
STRINGi9606.ENSP00000355568

PTM databases

iPTMnetiQ7Z5L9
PhosphoSitePlusiQ7Z5L9

Polymorphism and mutation databases

BioMutaiIRF2BP2
DMDMi229462882

Proteomic databases

EPDiQ7Z5L9
MaxQBiQ7Z5L9
PaxDbiQ7Z5L9
PeptideAtlasiQ7Z5L9
PRIDEiQ7Z5L9
ProteomicsDBi69325
69326 [Q7Z5L9-2]
69327 [Q7Z5L9-3]
TopDownProteomicsiQ7Z5L9-2 [Q7Z5L9-2]
Q7Z5L9-3 [Q7Z5L9-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
359948
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366609; ENSP00000355568; ENSG00000168264 [Q7Z5L9-1]
ENST00000366610; ENSP00000355569; ENSG00000168264 [Q7Z5L9-2]
GeneIDi359948
KEGGihsa:359948
UCSCiuc001hwf.3 human [Q7Z5L9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
359948
DisGeNETi359948
EuPathDBiHostDB:ENSG00000168264.10

GeneCards: human genes, protein and diseases

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GeneCardsi
IRF2BP2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0023152
HGNCiHGNC:21729 IRF2BP2
HPAiHPA027815
HPA062269
MalaCardsiIRF2BP2
MIMi615332 gene
617765 phenotype
neXtProtiNX_Q7Z5L9
OpenTargetsiENSG00000168264
PharmGKBiPA134947294

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IPPD Eukaryota
ENOG4110EVD LUCA
GeneTreeiENSGT00940000160591
HOVERGENiHBG108364
InParanoidiQ7Z5L9
KOiK22383
OMAiESHKNRA
OrthoDBiEOG091G040R
PhylomeDBiQ7Z5L9
TreeFamiTF317075

Enzyme and pathway databases

SIGNORiQ7Z5L9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IRF2BP2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
359948

Protein Ontology

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PROi
PR:Q7Z5L9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168264 Expressed in 214 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_IRF2BP2
GenevisibleiQ7Z5L9 HS

Family and domain databases

InterProiView protein in InterPro
IPR022750 Interferon_reg_fac2-bd1_2_Znf
PfamiView protein in Pfam
PF11261 IRF-2BP1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiI2BP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z5L9
Secondary accession number(s): B1AM35
, B1AM36, Q6P083, Q7Z5L8, Q8N351, Q8WUH8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 5, 2009
Last modified: December 5, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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