UniProtKB - Q7Z5L7 (PODN_HUMAN)
Protein
Podocan
Gene
PODN
Organism
Homo sapiens (Human)
Status
Functioni
Negatively regulates cell proliferation and cell migration.1 Publication
GO - Molecular functioni
- collagen binding Source: UniProtKB
GO - Biological processi
- negative regulation of cell migration Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q7Z5L7 |
Names & Taxonomyi
Protein namesi | Recommended name: Podocan |
Gene namesi | Name:PODN Synonyms:SLRR5A ORF Names:UNQ293/PRO332 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23174, PODN |
MIMi | 608661, gene |
neXtProti | NX_Q7Z5L7 |
VEuPathDBi | HostDB:ENSG00000174348.13 |
Subcellular locationi
Extracellular region or secreted
Other locations
- Cytoplasm Curated
Other locations
- Cytoplasm Curated
Other locations
- Cytoplasm Curated
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular space Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Extracellular matrix, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 127435 |
OpenTargetsi | ENSG00000174348 |
PharmGKBi | PA134980106 |
Miscellaneous databases
Pharosi | Q7Z5L7, Tbio |
Genetic variation databases
BioMutai | PODN |
DMDMi | 118573110 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000262524 | 20 – 613 | PodocanAdd BLAST | 594 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 214 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 281 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 299 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 410 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.2 Publications
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q7Z5L7 |
jPOSTi | Q7Z5L7 |
MassIVEi | Q7Z5L7 |
PaxDbi | Q7Z5L7 |
PeptideAtlasi | Q7Z5L7 |
PRIDEi | Q7Z5L7 |
ProteomicsDBi | 69321 [Q7Z5L7-1] 69322 [Q7Z5L7-2] 69323 [Q7Z5L7-3] 69324 [Q7Z5L7-4] |
PTM databases
GlyConnecti | 1618, 7 N-Linked glycans (2 sites) |
GlyGeni | Q7Z5L7, 4 sites |
iPTMneti | Q7Z5L7 |
PhosphoSitePlusi | Q7Z5L7 |
Expressioni
Tissue specificityi
Kidney, heart, liver, pancreas and vascular smooth muscle cells. Also detected in aortic intima (at protein level).3 Publications
Gene expression databases
Bgeei | ENSG00000174348, Expressed in esophagus and 175 other tissues |
Genevisiblei | Q7Z5L7, HS |
Organism-specific databases
HPAi | ENSG00000174348, Low tissue specificity |
Interactioni
Subunit structurei
Binds to type I collagen.
Binary interactionsi
Isoform 3 [Q7Z5L7-3]
With | #Exp. | IntAct |
---|---|---|
LRRC6 [Q86X45] | 3 | EBI-23806733,EBI-9379658 |
Protein-protein interaction databases
BioGRIDi | 126059, 9 interactors |
IntActi | Q7Z5L7, 8 interactors |
STRINGi | 9606.ENSP00000308315 |
Miscellaneous databases
RNActi | Q7Z5L7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 59 – 96 | LRRNTAdd BLAST | 38 | |
Repeati | 97 – 118 | LRR 1Add BLAST | 22 | |
Repeati | 121 – 141 | LRR 2Add BLAST | 21 | |
Repeati | 147 – 168 | LRR 3Add BLAST | 22 | |
Repeati | 169 – 189 | LRR 4Add BLAST | 21 | |
Repeati | 192 – 212 | LRR 5Add BLAST | 21 | |
Repeati | 218 – 238 | LRR 6Add BLAST | 21 | |
Repeati | 239 – 260 | LRR 7Add BLAST | 22 | |
Repeati | 263 – 283 | LRR 8Add BLAST | 21 | |
Repeati | 289 – 310 | LRR 9Add BLAST | 22 | |
Repeati | 311 – 331 | LRR 10Add BLAST | 21 | |
Repeati | 334 – 357 | LRR 11Add BLAST | 24 | |
Repeati | 360 – 380 | LRR 12Add BLAST | 21 | |
Repeati | 381 – 402 | LRR 13Add BLAST | 22 | |
Repeati | 405 – 426 | LRR 14Add BLAST | 22 | |
Repeati | 431 – 452 | LRR 15Add BLAST | 22 | |
Repeati | 476 – 489 | LRR 16Add BLAST | 14 | |
Repeati | 502 – 522 | LRR 17Add BLAST | 21 | |
Repeati | 523 – 544 | LRR 18Add BLAST | 22 | |
Repeati | 547 – 568 | LRR 19Add BLAST | 22 | |
Repeati | 573 – 595 | LRR 20Add BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 598 – 611 | Glu-richAdd BLAST | 14 |
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, Repeat, SignalPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000160740 |
HOGENOMi | CLU_000288_186_3_1 |
InParanoidi | Q7Z5L7 |
OMAi | TINCPRD |
OrthoDBi | 826997at2759 |
PhylomeDBi | Q7Z5L7 |
TreeFami | TF336377 |
Family and domain databases
Gene3Di | 3.80.10.10, 5 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR026906, LRR_5 IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF13306, LRR_5, 1 hit PF13855, LRR_8, 4 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 13 hits SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 17 hits |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7Z5L7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQSRVLLLL LLLPPQLHLG PVLAVRAPGF GRSGGHSLSP EENEFAEEEP
60 70 80 90 100
VLVLSPEEPG PGPAAVSCPR DCACSQEGVV DCGGIDLREF PGDLPEHTNH
110 120 130 140 150
LSLQNNQLEK IYPEELSRLH RLETLNLQNN RLTSRGLPEK AFEHLTNLNY
160 170 180 190 200
LYLANNKLTL APRFLPNALI SVDFAANYLT KIYGLTFGQK PNLRSVYLHN
210 220 230 240 250
NKLADAGLPD NMFNGSSNVE VLILSSNFLR HVPKHLPPAL YKLHLKNNKL
260 270 280 290 300
EKIPPGAFSE LSSLRELYLQ NNYLTDEGLD NETFWKLSSL EYLDLSSNNL
310 320 330 340 350
SRVPAGLPRS LVLLHLEKNA IRSVDANVLT PIRSLEYLLL HSNQLREQGI
360 370 380 390 400
HPLAFQGLKR LHTVHLYNNA LERVPSGLPR RVRTLMILHN QITGIGREDF
410 420 430 440 450
ATTYFLEELN LSYNRITSPQ VHRDAFRKLR LLRSLDLSGN RLHTLPPGLP
460 470 480 490 500
RNVHVLKVKR NELAALARGA LVGMAQLREL YLTSNRLRSR ALGPRAWVDL
510 520 530 540 550
AHLQLLDIAG NQLTEIPEGL PESLEYLYLQ NNKISAVPAN AFDSTPNLKG
560 570 580 590 600
IFLRFNKLAV GSVVDSAFRR LKHLQVLDIE GNLEFGDISK DRGRLGKEKE
610
EEEEEEEEEE ETR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A669KB13 | A0A669KB13_HUMAN | Podocan | PODN | 471 | Annotation score: | ||
A0A669KBI2 | A0A669KBI2_HUMAN | Podocan | PODN | 89 | Annotation score: |
Sequence cautioni
The sequence AAH28292 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 3 (identifier: Q7Z5L7-3) | |||||
Sequence conflicti | 32 | R → H in AAH30608 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029497 | 444 | T → M1 PublicationCorresponds to variant dbSNP:rs12567021Ensembl. | 1 | |
Natural variantiVAR_029498 | 472 | V → A4 PublicationsCorresponds to variant dbSNP:rs1288389Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037827 | 1 | M → MEGEEAEQPAWFRQPWRPGA SDSAPPAGTM in isoform 2. 2 Publications | 1 | |
Alternative sequenceiVSP_021784 | 1 | M → MEGARARGAQLRLGERVRPV GRRSAPGRSRFRQPWRPGAS DSAPPAGTM in isoform 3 and isoform 4. 2 Publications | 1 | |
Alternative sequenceiVSP_039064 | 105 – 246 | Missing in isoform 4. 1 PublicationAdd BLAST | 142 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY313607 mRNA Translation: AAP79898.1 AY358294 mRNA Translation: AAQ88661.1 AK296649 mRNA Translation: BAG59247.1 AK299375 mRNA Translation: BAG61365.1 AK304599 mRNA Translation: BAG65385.1 AL445183 Genomic DNA No translation available. BC028292 mRNA Translation: AAH28292.1 Different initiation. BC030608 mRNA Translation: AAH30608.1 |
CCDSi | CCDS55602.1 [Q7Z5L7-1] CCDS573.1 [Q7Z5L7-1] |
RefSeqi | NP_001186009.1, NM_001199080.2 [Q7Z5L7-1] NP_001186010.1, NM_001199081.2 [Q7Z5L7-1] NP_714914.2, NM_153703.4 [Q7Z5L7-1] XP_005270514.1, XM_005270457.3 [Q7Z5L7-1] |
Genome annotation databases
Ensembli | ENST00000312553; ENSP00000308315; ENSG00000174348 [Q7Z5L7-1] ENST00000371500; ENSP00000360555; ENSG00000174348 [Q7Z5L7-2] ENST00000395871; ENSP00000379212; ENSG00000174348 [Q7Z5L7-3] ENST00000618387; ENSP00000479233; ENSG00000174348 [Q7Z5L7-2] |
GeneIDi | 127435 |
KEGGi | hsa:127435 |
UCSCi | uc001cuv.4, human [Q7Z5L7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY313607 mRNA Translation: AAP79898.1 AY358294 mRNA Translation: AAQ88661.1 AK296649 mRNA Translation: BAG59247.1 AK299375 mRNA Translation: BAG61365.1 AK304599 mRNA Translation: BAG65385.1 AL445183 Genomic DNA No translation available. BC028292 mRNA Translation: AAH28292.1 Different initiation. BC030608 mRNA Translation: AAH30608.1 |
CCDSi | CCDS55602.1 [Q7Z5L7-1] CCDS573.1 [Q7Z5L7-1] |
RefSeqi | NP_001186009.1, NM_001199080.2 [Q7Z5L7-1] NP_001186010.1, NM_001199081.2 [Q7Z5L7-1] NP_714914.2, NM_153703.4 [Q7Z5L7-1] XP_005270514.1, XM_005270457.3 [Q7Z5L7-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126059, 9 interactors |
IntActi | Q7Z5L7, 8 interactors |
STRINGi | 9606.ENSP00000308315 |
PTM databases
GlyConnecti | 1618, 7 N-Linked glycans (2 sites) |
GlyGeni | Q7Z5L7, 4 sites |
iPTMneti | Q7Z5L7 |
PhosphoSitePlusi | Q7Z5L7 |
Genetic variation databases
BioMutai | PODN |
DMDMi | 118573110 |
Proteomic databases
EPDi | Q7Z5L7 |
jPOSTi | Q7Z5L7 |
MassIVEi | Q7Z5L7 |
PaxDbi | Q7Z5L7 |
PeptideAtlasi | Q7Z5L7 |
PRIDEi | Q7Z5L7 |
ProteomicsDBi | 69321 [Q7Z5L7-1] 69322 [Q7Z5L7-2] 69323 [Q7Z5L7-3] 69324 [Q7Z5L7-4] |
Protocols and materials databases
Antibodypediai | 2151, 114 antibodies |
DNASUi | 127435 |
Genome annotation databases
Ensembli | ENST00000312553; ENSP00000308315; ENSG00000174348 [Q7Z5L7-1] ENST00000371500; ENSP00000360555; ENSG00000174348 [Q7Z5L7-2] ENST00000395871; ENSP00000379212; ENSG00000174348 [Q7Z5L7-3] ENST00000618387; ENSP00000479233; ENSG00000174348 [Q7Z5L7-2] |
GeneIDi | 127435 |
KEGGi | hsa:127435 |
UCSCi | uc001cuv.4, human [Q7Z5L7-1] |
Organism-specific databases
CTDi | 127435 |
DisGeNETi | 127435 |
GeneCardsi | PODN |
HGNCi | HGNC:23174, PODN |
HPAi | ENSG00000174348, Low tissue specificity |
MIMi | 608661, gene |
neXtProti | NX_Q7Z5L7 |
OpenTargetsi | ENSG00000174348 |
PharmGKBi | PA134980106 |
VEuPathDBi | HostDB:ENSG00000174348.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
GeneTreei | ENSGT00940000160740 |
HOGENOMi | CLU_000288_186_3_1 |
InParanoidi | Q7Z5L7 |
OMAi | TINCPRD |
OrthoDBi | 826997at2759 |
PhylomeDBi | Q7Z5L7 |
TreeFami | TF336377 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z5L7 |
Miscellaneous databases
BioGRID-ORCSi | 127435, 4 hits in 875 CRISPR screens |
ChiTaRSi | PODN, human |
GenomeRNAii | 127435 |
Pharosi | Q7Z5L7, Tbio |
PROi | PR:Q7Z5L7 |
RNActi | Q7Z5L7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000174348, Expressed in esophagus and 175 other tissues |
Genevisiblei | Q7Z5L7, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 5 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR026906, LRR_5 IPR032675, LRR_dom_sf IPR000372, LRRNT |
Pfami | View protein in Pfam PF13306, LRR_5, 1 hit PF13855, LRR_8, 4 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 13 hits SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 17 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PODN_HUMAN | |
Accessioni | Q7Z5L7Primary (citable) accession number: Q7Z5L7 Secondary accession number(s): B4DKN5 Q8N641 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | November 28, 2006 | |
Last modified: | February 10, 2021 | |
This is version 160 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants