Podocan

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• collagen binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15063725
• extracellular matrix structural constituent conferring compression resistance Source: BHF-UCLInferred from high throughput direct assayⁱ
  • 27068509
• protein kinase inhibitor activity Source: GO_Central

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• cytokine-mediated signaling pathway Source: GO_Central
• negative regulation of cell migration Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15063725
• negative regulation of cell proliferation Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15063725
• negative regulation of JAK-STAT cascade Source: GO_Central
• negative regulation of protein kinase activity Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MAQSRVLLLL LLLPPQLHLG PVLAVRAPGF GRSGGHSLSP EENEFAEEEP 
        60         70         80         90        100
VLVLSPEEPG PGPAAVSCPR DCACSQEGVV DCGGIDLREF PGDLPEHTNH 
       110        120        130        140        150
LSLQNNQLEK IYPEELSRLH RLETLNLQNN RLTSRGLPEK AFEHLTNLNY 
       160        170        180        190        200
LYLANNKLTL APRFLPNALI SVDFAANYLT KIYGLTFGQK PNLRSVYLHN 
       210        220        230        240        250
NKLADAGLPD NMFNGSSNVE VLILSSNFLR HVPKHLPPAL YKLHLKNNKL 
       260        270        280        290        300
EKIPPGAFSE LSSLRELYLQ NNYLTDEGLD NETFWKLSSL EYLDLSSNNL 
       310        320        330        340        350
SRVPAGLPRS LVLLHLEKNA IRSVDANVLT PIRSLEYLLL HSNQLREQGI 
       360        370        380        390        400
HPLAFQGLKR LHTVHLYNNA LERVPSGLPR RVRTLMILHN QITGIGREDF 
       410        420        430        440        450
ATTYFLEELN LSYNRITSPQ VHRDAFRKLR LLRSLDLSGN RLHTLPPGLP 
       460        470        480        490        500
RNVHVLKVKR NELAALARGA LVGMAQLREL YLTSNRLRSR ALGPRAWVDL 
       510        520        530        540        550
AHLQLLDIAG NQLTEIPEGL PESLEYLYLQ NNKISAVPAN AFDSTPNLKG 
       560        570        580        590        600
IFLRFNKLAV GSVVDSAFRR LKHLQVLDIE GNLEFGDISK DRGRLGKEKE 
       610 
EEEEEEEEEE ETR                                         

        10         20         30         40         50
MEGEEAEQPA WFRQPWRPGA SDSAPPAGTM AQSRVLLLLL LLPPQLHLGP 
        60         70         80         90        100
VLAVRAPGFG RSGGHSLSPE ENEFAEEEPV LVLSPEEPGP GPAAVSCPRD 
       110        120        130        140        150
CACSQEGVVD CGGIDLREFP GDLPEHTNHL SLQNNQLEKI YPEELSRLHR 
       160        170        180        190        200
LETLNLQNNR LTSRGLPEKA FEHLTNLNYL YLANNKLTLA PRFLPNALIS 
       210        220        230        240        250
VDFAANYLTK IYGLTFGQKP NLRSVYLHNN KLADAGLPDN MFNGSSNVEV 
       260        270        280        290        300
LILSSNFLRH VPKHLPPALY KLHLKNNKLE KIPPGAFSEL SSLRELYLQN 
       310        320        330        340        350
NYLTDEGLDN ETFWKLSSLE YLDLSSNNLS RVPAGLPRSL VLLHLEKNAI 
       360        370        380        390        400
RSVDANVLTP IRSLEYLLLH SNQLREQGIH PLAFQGLKRL HTVHLYNNAL 
       410        420        430        440        450
ERVPSGLPRR VRTLMILHNQ ITGIGREDFA TTYFLEELNL SYNRITSPQV 
       460        470        480        490        500
HRDAFRKLRL LRSLDLSGNR LHTLPPGLPR NVHVLKVKRN ELAALARGAL 
       510        520        530        540        550
VGMAQLRELY LTSNRLRSRA LGPRAWVDLA HLQLLDIAGN QLTEIPEGLP 
       560        570        580        590        600
ESLEYLYLQN NKISAVPANA FDSTPNLKGI FLRFNKLAVG SVVDSAFRRL 
       610        620        630        640 
KHLQVLDIEG NLEFGDISKD RGRLGKEKEE EEEEEEEEEE TR         

        10         20         30         40         50
MEGARARGAQ LRLGERVRPV GRRSAPGRSR FRQPWRPGAS DSAPPAGTMA 
        60         70         80         90        100
QSRVLLLLLL LPPQLHLGPV LAVRAPGFGR SGGHSLSPEE NEFAEEEPVL 
       110        120        130        140        150
VLSPEEPGPG PAAVSCPRDC ACSQEGVVDC GGIDLREFPG DLPEHTNHLS 
       160        170        180        190        200
LQNNQLEKIY PEELSRLHRL ETLNLQNNRL TSRGLPEKAF EHLTNLNYLY 
       210        220        230        240        250
LANNKLTLAP RFLPNALISV DFAANYLTKI YGLTFGQKPN LRSVYLHNNK 
       260        270        280        290        300
LADAGLPDNM FNGSSNVEVL ILSSNFLRHV PKHLPPALYK LHLKNNKLEK 
       310        320        330        340        350
IPPGAFSELS SLRELYLQNN YLTDEGLDNE TFWKLSSLEY LDLSSNNLSR 
       360        370        380        390        400
VPAGLPRSLV LLHLEKNAIR SVDANVLTPI RSLEYLLLHS NQLREQGIHP 
       410        420        430        440        450
LAFQGLKRLH TVHLYNNALE RVPSGLPRRV RTLMILHNQI TGIGREDFAT 
       460        470        480        490        500
TYFLEELNLS YNRITSPQVH RDAFRKLRLL RSLDLSGNRL HTLPPGLPRN 
       510        520        530        540        550
VHVLKVKRNE LAALARGALV GMAQLRELYL TSNRLRSRAL GPRAWVDLAH 
       560        570        580        590        600
LQLLDIAGNQ LTEIPEGLPE SLEYLYLQNN KISAVPANAF DSTPNLKGIF 
       610        620        630        640        650
LRFNKLAVGS VVDSAFRRLK HLQVLDIEGN LEFGDISKDR GRLGKEKEEE 
       660 
EEEEEEEEET R                                           

        10         20         30         40         50
MEGARARGAQ LRLGERVRPV GRRSAPGRSR FRQPWRPGAS DSAPPAGTMA 
        60         70         80         90        100
QSRVLLLLLL LPPQLHLGPV LAVRAPGFGR SGGHSLSPEE NEFAEEEPVL 
       110        120        130        140        150
VLSPEEPGPG PAAVSCPRDC ACSQEGVVDC GGIDLREFPG DLPEHTNHLS 
       160        170        180        190        200
LQNNKLEKIP PGAFSELSSL RELYLQNNYL TDEGLDNETF WKLSSLEYLD 
       210        220        230        240        250
LSSNNLSRVP AGLPRSLVLL HLEKNAIRSV DANVLTPIRS LEYLLLHSNQ 
       260        270        280        290        300
LREQGIHPLA FQGLKRLHTV HLYNNALERV PSGLPRRVRT LMILHNQITG 
       310        320        330        340        350
IGREDFATTY FLEELNLSYN RITSPQVHRD AFRKLRLLRS LDLSGNRLHT 
       360        370        380        390        400
LPPGLPRNVH VLKVKRNELA ALARGALVGM AQLRELYLTS NRLRSRALGP 
       410        420        430        440        450
RAWVDLAHLQ LLDIAGNQLT EIPEGLPESL EYLYLQNNKI SAVPANAFDS 
       460        470        480        490        500
TPNLKGIFLR FNKLAVGSVV DSAFRRLKHL QVLDIEGNLE FGDISKDRGR 
       510 
LGKEKEEEEE EEEEEEETR                                   

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. SIMILARITY comments
   Index of protein domains and families