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Protein

Ankyrin and armadillo repeat-containing protein

Gene

ANKAR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ7Z5J8

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin and armadillo repeat-containing protein
Gene namesi
Name:ANKAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000151687.14
HGNCiHGNC:26350 ANKAR
MIMi609803 gene
neXtProtiNX_Q7Z5J8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151687
PharmGKBiPA145149868

Polymorphism and mutation databases

BioMutaiANKAR
DMDMi308153635

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868061 – 1434Ankyrin and armadillo repeat-containing proteinAdd BLAST1434

Proteomic databases

PaxDbiQ7Z5J8
PeptideAtlasiQ7Z5J8
PRIDEiQ7Z5J8
ProteomicsDBi69307
69308 [Q7Z5J8-2]
69309 [Q7Z5J8-3]
69310 [Q7Z5J8-4]

PTM databases

iPTMnetiQ7Z5J8
PhosphoSitePlusiQ7Z5J8

Expressioni

Tissue specificityi

Ubiquitously expressed with highest level in pancreas and lowest in skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000151687
CleanExiHS_ANKAR
ExpressionAtlasiQ7Z5J8 baseline and differential
GenevisibleiQ7Z5J8 HS

Organism-specific databases

HPAiHPA036168

Interactioni

Protein-protein interaction databases

BioGridi127319, 1 interactor
IntActiQ7Z5J8, 1 interactor
STRINGi9606.ENSP00000313513

Structurei

3D structure databases

ProteinModelPortaliQ7Z5J8
SMRiQ7Z5J8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati532 – 561ANK 1Add BLAST30
Repeati569 – 598ANK 2Add BLAST30
Repeati602 – 631ANK 3Add BLAST30
Repeati638 – 667ANK 4Add BLAST30
Repeati671 – 701ANK 5Add BLAST31
Repeati732 – 771ARM 1Add BLAST40
Repeati773 – 812ARM 2Add BLAST40
Repeati814 – 852ARM 3Add BLAST39
Repeati855 – 894ARM 4Add BLAST40
Repeati897 – 936ARM 5Add BLAST40
Repeati1072 – 1112ARM 6Add BLAST41

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II69 Eukaryota
ENOG410XSRG LUCA
GeneTreeiENSGT00680000100065
HOGENOMiHOG000007170
HOVERGENiHBG106658
InParanoidiQ7Z5J8
OMAiICEGNGI
OrthoDBiEOG091G0281
PhylomeDBiQ7Z5J8
TreeFamiTF324155

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.10.10, 3 hits
1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00514 Arm, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 5 hits
SM00185 ARM, 9 hits
SUPFAMiSSF48371 SSF48371, 4 hits
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits
PS50176 ARM_REPEAT, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7Z5J8-1) [UniParc]FASTAAdd to basket
Also known as: FLJ25415-2P

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRLPKKGLP RFEQVQDEDT YLENLAIQRN ASAFFEKYDR SEIQELLTTA
60 70 80 90 100
LVSWLSAKED VRSQVDLPCG IMSQMNNVGF STAILLTPVD PTALLDYREV
110 120 130 140 150
HQMIRELAIG IYCLNQIPSI SLEANYDQSS SCQLPPAYYD TRIGQILINI
160 170 180 190 200
DYMLKALWHG IYMPKEKRAR FSELWRAIMD IDPDGKPQTN KDIFSEFSSA
210 220 230 240 250
GLTDITKDPD FNEIYDEDVN EDPTYDPNSP EETAVFMKYA ENIMLKLTFS
260 270 280 290 300
TTQIQQYENV FIFETGYWLT NAIKYNQDYL DICTYQRLQQ RLYLQKKIIQ
310 320 330 340 350
KHFEKKKDIR RGIGYLKLIC FLIPFLLSLK KKMKVPYLSS LLQPFSDDKV
360 370 380 390 400
KTERELPPFI YGRDFKCQNF HYKENQYFHV HGGIEFDIST PSIENALEDF
410 420 430 440 450
QKNLEKIRDC AANTFIEDSG YKEYYSIPVM EFHGKSYYVI YFELETFYQQ
460 470 480 490 500
LYKTQWWGAI NEIVNNLRLK RLPLTDAQLH EQFKKKLGFK RAMKCKSIPF
510 520 530 540 550
GMKSAVERGL SAVFHTFSRK TSSSTINVSD EAGYTIFHHA ALHNRVSIIC
560 570 580 590 600
QLCNANFKVN QRRFVTFSQG PTPLHLAAQA CSLETTVCLL CSKADYTLSE
610 620 630 640 650
KRGWMPIHFA AFYDNVCIII ALCRKDPSLL EAEATAENQC TPLLLAATSG
660 670 680 690 700
ALDTIQYLFS IGANWRKTDI KGNNIIHLSV LTFHTEVLKY IIKLNIPELP
710 720 730 740 750
VWKTLVEMLQ CESYKRRMMA VMSLEVICLA NDQYWRCILD AGTIPALINL
760 770 780 790 800
LKSSKIKLQC KTVGLLSNIS THKSAVHALV EAGGIPSLIN LLVCDEPEVH
810 820 830 840 850
SRCAVILYDI AQCENKDVIA KYNGIPSLIN LLNLNIENVL VNVMNCIRVL
860 870 880 890 900
CIGNENNQRA VREHKGLPYL IRFLSSDSDV LKAVSSAAIA EVGRDNKEIQ
910 920 930 940 950
DAIAMEGAIP PLVALFKGKQ ISVQMKGAMA VESLASHNAL IQKAFLEKSL
960 970 980 990 1000
TKYLLKLLKA FQIDVKEQGA VALWALAGQT LKQQKYMAEQ IGYSFIINML
1010 1020 1030 1040 1050
LSPSAKMQYV GGEAVIALSK DSRMHQNQIC EGNGIAPLVR LLRISTIAEG
1060 1070 1080 1090 1100
TLLSVIRAVG SICIGVAHTS NPVSQQLVVD ENAFPVLIQL LRNHPSPNIK
1110 1120 1130 1140 1150
VEVAFSLACI VLGNDVLQKD LHENEGFEYA DVLYLLHSTE KDICLRAGYA
1160 1170 1180 1190 1200
LTLFAFNNRF QQYLILESGI MTISIFERFL ESTVETEKAM AAFQIVVLAK
1210 1220 1230 1240 1250
VIRDMDHITL SARGVTILVD SLYSVQTSTI VLTGNLIASL AHSRAGIPEA
1260 1270 1280 1290 1300
FTTLGTIQRL CYHLYSGIEE VRAACSSALG YLTYNANAFR ILLKECRNKP
1310 1320 1330 1340 1350
NQFIRIKNNI SRDASINPAF LKEFQMQQTL VGLPSLSLEK NGGPSIIPIF
1360 1370 1380 1390 1400
KRGKEHRRKL KPKIQPKDSL TLLPPVTNFM GLFKATKKTK DSHNIFSFSS
1410 1420 1430
TITSDITNVS RPRIVCLNQL GKHVQKANPE PAEG
Length:1,434
Mass (Da):162,026
Last modified:October 5, 2010 - v3
Checksum:iE8011736C96C1EC5
GO
Isoform 2 (identifier: Q7Z5J8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1066-1080: VAHTSNPVSQQLVVD → YLLKSRLCINTFCLQ
     1081-1434: Missing.

Note: No experimental confirmation available.
Show »
Length:1,080
Mass (Da):122,726
Checksum:iC29679373ECAAA45
GO
Isoform 3 (identifier: Q7Z5J8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-236: Missing.
     878-878: S → SGLFNLFLNSFE
     1012-1026: GEAVIALSKDSRMHQ → YLLKSRLCINTFCLQ
     1027-1434: Missing.

Note: No experimental confirmation available.
Show »
Length:801
Mass (Da):91,350
Checksum:i75F1D126E1CB0EFC
GO
Isoform 4 (identifier: Q7Z5J8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-332: Missing.
     706-716: VEMLQCESYKR → KCYSVKAINEG
     717-1434: Missing.

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):44,059
Checksum:i3E16C2EDAAEEA5F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8G → R in BAC86425 (PubMed:14702039).Curated1
Sequence conflicti207K → R in BAC86425 (PubMed:14702039).Curated1
Sequence conflicti436S → G in AAH47413 (PubMed:15489334).Curated1
Sequence conflicti623C → Y in AAH47413 (PubMed:15489334).Curated1
Sequence conflicti679S → L in AAH47413 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032164675I → V. Corresponds to variant dbSNP:rs16831887Ensembl.1
Natural variantiVAR_0321651077L → F1 PublicationCorresponds to variant dbSNP:rs1225090Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0251661 – 332Missing in isoform 4. 1 PublicationAdd BLAST332
Alternative sequenceiVSP_0251671 – 236Missing in isoform 3. 1 PublicationAdd BLAST236
Alternative sequenceiVSP_025168706 – 716VEMLQCESYKR → KCYSVKAINEG in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_025169717 – 1434Missing in isoform 4. 1 PublicationAdd BLAST718
Alternative sequenceiVSP_025170878S → SGLFNLFLNSFE in isoform 3. 1 Publication1
Alternative sequenceiVSP_0251711012 – 1026GEAVI…SRMHQ → YLLKSRLCINTFCLQ in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0251721027 – 1434Missing in isoform 3. 1 PublicationAdd BLAST408
Alternative sequenceiVSP_0251731066 – 1080VAHTS…QLVVD → YLLKSRLCINTFCLQ in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0251741081 – 1434Missing in isoform 2. 1 PublicationAdd BLAST354

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126073 mRNA Translation: BAC86425.1
AC012488 Genomic DNA No translation available.
AC013468 Genomic DNA No translation available.
BC044907 mRNA Translation: AAH44907.1
BC047413 mRNA Translation: AAH47413.1
AJ549812 mRNA Translation: CAD71147.1
CCDSiCCDS33351.2 [Q7Z5J8-1]
RefSeqiNP_653309.3, NM_144708.3 [Q7Z5J8-1]
XP_011508976.1, XM_011510674.1 [Q7Z5J8-1]
UniGeneiHs.60772
Hs.655700

Genome annotation databases

EnsembliENST00000313581; ENSP00000313513; ENSG00000151687 [Q7Z5J8-1]
ENST00000441800; ENSP00000407459; ENSG00000151687 [Q7Z5J8-3]
ENST00000520309; ENSP00000427882; ENSG00000151687 [Q7Z5J8-1]
GeneIDi150709
KEGGihsa:150709
UCSCiuc002uqw.3 human [Q7Z5J8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiANKAR_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5J8
Secondary accession number(s): Q3ZCS6, Q4G0M2, Q6ZU02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 5, 2010
Last modified: June 20, 2018
This is version 117 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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