Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 127 (12 Aug 2020)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
Add a publicationFeedback
Protein

Hydroxysteroid 11-beta-dehydrogenase 1-like protein

Gene

HSD11B1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei165SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei178Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi36 – 62NADPBy similarityAdd BLAST27
Nucleotide bindingi87 – 88NADPBy similarity2
Nucleotide bindingi114 – 116NADPBy similarity3
Nucleotide bindingi178 – 182NADPBy similarity5
Nucleotide bindingi211 – 217NADPBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7Z5J1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hydroxysteroid 11-beta-dehydrogenase 1-like protein (EC:1.1.1.-)
Alternative name(s):
11-beta-hydroxysteroid dehydrogenase type 3
Short name:
11-DH3
Short name:
11-beta-HSD3
Short chain dehydrogenase/reductase family 26C member 2
Short-chain dehydrogenase/reductase 10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSD11B1L
Synonyms:HSD3, SCDR10, SDR26C2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167733.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30419, HSD11B1L

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z5J1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
374875

Open Targets

More...
OpenTargetsi
ENSG00000167733

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596423

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z5J1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HSD11B1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750135

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15Sequence analysisAdd BLAST15
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031681616 – 315Hydroxysteroid 11-beta-dehydrogenase 1-like proteinAdd BLAST300

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z5J1

PeptideAtlas

More...
PeptideAtlasi
Q7Z5J1

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z5J1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69295 [Q7Z5J1-1]
69296 [Q7Z5J1-2]
69297 [Q7Z5J1-3]
69298 [Q7Z5J1-4]
69299 [Q7Z5J1-5]
69300 [Q7Z5J1-6]
69301 [Q7Z5J1-7]
69302 [Q7Z5J1-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z5J1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z5J1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167733, Expressed in prefrontal cortex and 156 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z5J1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z5J1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167733, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131927, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q7Z5J1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000480443

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z5J1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z5J1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1205, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162487

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1488559_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z5J1

KEGG Orthology (KO)

More...
KOi
K15680

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z5J1

TreeFam database of animal gene trees

More...
TreeFami
TF329114

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR020904, Sc_DH/Rdtase_CS
IPR002347, SDR_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00106, adh_short, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00081, GDHRDH

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735, SSF51735, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00061, ADH_SHORT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z5J1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVLLLTGLG ALFFAYYWDD NFDPASLQGA RVLLTGANAG VGEELAYHYA
60 70 80 90 100
RLGSHLVLTA HTEALLQKVV GNCRKLGAPK VFYIAADMAS PEAPESVVQF
110 120 130 140 150
ALDKLGGLDY LVLNHIGGAP AGTRARSPQA TRWLMQVNFV SYVQLTSRAL
160 170 180 190 200
PSLTDSKGSL VVVSSLLGRV PTSFSTPYSA AKFALDGFFG SLRRELDVQD
210 220 230 240 250
VNVAITMCVL GLRDRASAAE AVRSSTSRPR QPEHRGVPLQ SQTAMFLPPT
260 270 280 290 300
VPGARTLTET PLRGWPQPKM KSSRQKSKTE KNDGHLEPVT AWEVQVPRVR
310
RLCRGLARPH LFGHD
Length:315
Mass (Da):34,288
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7C3A61476A1E48F
GO
Isoform 2 (identifier: Q7Z5J1-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

Show »
Length:286
Mass (Da):30,848
Checksum:i7311D355E25C630B
GO
Isoform 3 (identifier: Q7Z5J1-3) [UniParc]FASTAAdd to basket
Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     25-105: Missing.

Show »
Length:234
Mass (Da):25,788
Checksum:i7CBF1C61D948593E
GO
Isoform 4 (identifier: Q7Z5J1-4) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Show »
Length:181
Mass (Da):19,965
Checksum:iCA0DD79B7AF1D205
GO
Isoform 5 (identifier: Q7Z5J1-5) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-87: Missing.
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

Show »
Length:199
Mass (Da):21,469
Checksum:iAD34645BA242F217
GO
Isoform 6 (identifier: Q7Z5J1-6) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     25-105: Missing.
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

Show »
Length:205
Mass (Da):22,347
Checksum:i211008CB138A957A
GO
Isoform 7 (identifier: Q7Z5J1-7) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.
     223-234: Missing.
     238-315: PLQSQTAMFL...LARPHLFGHD → TRVKAAPGPK...QELNVTAAAA

Show »
Length:152
Mass (Da):16,524
Checksum:i78DB1E38E7C9E87D
GO
Isoform 8 (identifier: Q7Z5J1-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     69-87: VVGNCRKLGAPKVFYIAAD → ARWLTLVVSTLGGRGKWIT
     88-315: Missing.

Show »
Length:87
Mass (Da):9,490
Checksum:iD5974BC809897C2A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWR3A0A087WWR3_HUMAN
Hydroxysteroid 11-beta-dehydrogenas...
HSD11B1L
333Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTC8J3KTC8_HUMAN
Hydroxysteroid 11-beta-dehydrogenas...
HSD11B1L
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKQ3J3QKQ3_HUMAN
Hydroxysteroid 11-beta-dehydrogenas...
HSD11B1L
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKX1J3QKX1_HUMAN
Hydroxysteroid 11-beta-dehydrogenas...
HSD11B1L
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSE6J3QSE6_HUMAN
Hydroxysteroid 11-beta-dehydrogenas...
HSD11B1L
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS77J3QS77_HUMAN
Hydroxysteroid 11-beta-dehydrogenas...
HSD11B1L
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRL3J3KRL3_HUMAN
Hydroxysteroid 11-beta-dehydrogenas...
HSD11B1L
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0307911 – 134Missing in isoform 4 and isoform 7. 2 PublicationsAdd BLAST134
Alternative sequenceiVSP_0307921 – 87Missing in isoform 5. 2 PublicationsAdd BLAST87
Alternative sequenceiVSP_03079325 – 105Missing in isoform 3 and isoform 6. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_03079469 – 87VVGNC…YIAAD → ARWLTLVVSTLGGRGKWIT in isoform 8. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_03079588 – 315Missing in isoform 8. 1 PublicationAdd BLAST228
Alternative sequenceiVSP_030796223 – 234Missing in isoform 2, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_030797238 – 315PLQSQ…LFGHD → TRVKAAPGPKAALAVIRGGA TRAAGVFYPWRFRLLCLLRR WLPRPRAWFIRQELNVTAAA A in isoform 2, isoform 5, isoform 6 and isoform 7. 2 PublicationsAdd BLAST78

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY268351 mRNA Translation: AAP42285.1
AY268352 mRNA Translation: AAP42286.1
AY268353 mRNA Translation: AAP42287.1
AY268354 mRNA Translation: AAP42288.1
AY313894 mRNA Translation: AAP83166.1
AY313895 mRNA Translation: AAP83167.1
AY313896 mRNA Translation: AAP83168.1
AC011499 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69156.1
CH471139 Genomic DNA Translation: EAW69157.1
BC053546 mRNA Translation: AAH53546.1
BC072434 mRNA Translation: AAH72434.1
BC093950 mRNA Translation: AAH93950.1
BC112187 mRNA Translation: AAI12188.1
BC018336 mRNA Translation: AAH18336.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12144.1 [Q7Z5J1-6]
CCDS12145.1 [Q7Z5J1-2]
CCDS12146.1 [Q7Z5J1-5]
CCDS45931.1 [Q7Z5J1-1]
CCDS45932.1 [Q7Z5J1-4]
CCDS58641.1 [Q7Z5J1-3]
CCDS58642.1 [Q7Z5J1-7]

NCBI Reference Sequences

More...
RefSeqi
NP_001254798.1, NM_001267869.1 [Q7Z5J1-7]
NP_001254799.1, NM_001267870.1
NP_001254800.1, NM_001267871.1 [Q7Z5J1-3]
NP_940935.1, NM_198533.2 [Q7Z5J1-1]
NP_941993.1, NM_198704.2 [Q7Z5J1-4]
NP_941994.1, NM_198705.2 [Q7Z5J1-6]
NP_941995.1, NM_198706.2 [Q7Z5J1-2]
NP_941996.1, NM_198707.2 [Q7Z5J1-5]
NP_941997.1, NM_198708.2 [Q7Z5J1-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000301382; ENSP00000301382; ENSG00000167733 [Q7Z5J1-6]
ENST00000339423; ENSP00000340436; ENSG00000167733 [Q7Z5J1-2]
ENST00000342970; ENSP00000343451; ENSG00000167733 [Q7Z5J1-5]
ENST00000411793; ENSP00000398955; ENSG00000167733 [Q7Z5J1-4]
ENST00000422535; ENSP00000409592; ENSG00000167733 [Q7Z5J1-8]
ENST00000423665; ENSP00000407154; ENSG00000167733 [Q7Z5J1-1]
ENST00000577917; ENSP00000463073; ENSG00000167733 [Q7Z5J1-3]
ENST00000581521; ENSP00000463794; ENSG00000167733 [Q7Z5J1-2]
ENST00000581773; ENSP00000462975; ENSG00000167733 [Q7Z5J1-2]
ENST00000581893; ENSP00000464454; ENSG00000167733 [Q7Z5J1-7]
ENST00000583928; ENSP00000462586; ENSG00000167733 [Q7Z5J1-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
374875

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:374875

UCSC genome browser

More...
UCSCi
uc002mcj.6, human [Q7Z5J1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY268351 mRNA Translation: AAP42285.1
AY268352 mRNA Translation: AAP42286.1
AY268353 mRNA Translation: AAP42287.1
AY268354 mRNA Translation: AAP42288.1
AY313894 mRNA Translation: AAP83166.1
AY313895 mRNA Translation: AAP83167.1
AY313896 mRNA Translation: AAP83168.1
AC011499 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69156.1
CH471139 Genomic DNA Translation: EAW69157.1
BC053546 mRNA Translation: AAH53546.1
BC072434 mRNA Translation: AAH72434.1
BC093950 mRNA Translation: AAH93950.1
BC112187 mRNA Translation: AAI12188.1
BC018336 mRNA Translation: AAH18336.1
CCDSiCCDS12144.1 [Q7Z5J1-6]
CCDS12145.1 [Q7Z5J1-2]
CCDS12146.1 [Q7Z5J1-5]
CCDS45931.1 [Q7Z5J1-1]
CCDS45932.1 [Q7Z5J1-4]
CCDS58641.1 [Q7Z5J1-3]
CCDS58642.1 [Q7Z5J1-7]
RefSeqiNP_001254798.1, NM_001267869.1 [Q7Z5J1-7]
NP_001254799.1, NM_001267870.1
NP_001254800.1, NM_001267871.1 [Q7Z5J1-3]
NP_940935.1, NM_198533.2 [Q7Z5J1-1]
NP_941993.1, NM_198704.2 [Q7Z5J1-4]
NP_941994.1, NM_198705.2 [Q7Z5J1-6]
NP_941995.1, NM_198706.2 [Q7Z5J1-2]
NP_941996.1, NM_198707.2 [Q7Z5J1-5]
NP_941997.1, NM_198708.2 [Q7Z5J1-7]

3D structure databases

SMRiQ7Z5J1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131927, 1 interactor
IntActiQ7Z5J1, 1 interactor
STRINGi9606.ENSP00000480443

PTM databases

iPTMnetiQ7Z5J1
PhosphoSitePlusiQ7Z5J1

Polymorphism and mutation databases

BioMutaiHSD11B1L
DMDMi74750135

Proteomic databases

PaxDbiQ7Z5J1
PeptideAtlasiQ7Z5J1
PRIDEiQ7Z5J1
ProteomicsDBi69295 [Q7Z5J1-1]
69296 [Q7Z5J1-2]
69297 [Q7Z5J1-3]
69298 [Q7Z5J1-4]
69299 [Q7Z5J1-5]
69300 [Q7Z5J1-6]
69301 [Q7Z5J1-7]
69302 [Q7Z5J1-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
64961, 116 antibodies

The DNASU plasmid repository

More...
DNASUi
374875

Genome annotation databases

EnsembliENST00000301382; ENSP00000301382; ENSG00000167733 [Q7Z5J1-6]
ENST00000339423; ENSP00000340436; ENSG00000167733 [Q7Z5J1-2]
ENST00000342970; ENSP00000343451; ENSG00000167733 [Q7Z5J1-5]
ENST00000411793; ENSP00000398955; ENSG00000167733 [Q7Z5J1-4]
ENST00000422535; ENSP00000409592; ENSG00000167733 [Q7Z5J1-8]
ENST00000423665; ENSP00000407154; ENSG00000167733 [Q7Z5J1-1]
ENST00000577917; ENSP00000463073; ENSG00000167733 [Q7Z5J1-3]
ENST00000581521; ENSP00000463794; ENSG00000167733 [Q7Z5J1-2]
ENST00000581773; ENSP00000462975; ENSG00000167733 [Q7Z5J1-2]
ENST00000581893; ENSP00000464454; ENSG00000167733 [Q7Z5J1-7]
ENST00000583928; ENSP00000462586; ENSG00000167733 [Q7Z5J1-7]
GeneIDi374875
KEGGihsa:374875
UCSCiuc002mcj.6, human [Q7Z5J1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
374875
DisGeNETi374875
EuPathDBiHostDB:ENSG00000167733.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HSD11B1L
HGNCiHGNC:30419, HSD11B1L
HPAiENSG00000167733, Tissue enhanced (brain)
neXtProtiNX_Q7Z5J1
OpenTargetsiENSG00000167733
PharmGKBiPA144596423

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1205, Eukaryota
GeneTreeiENSGT00940000162487
HOGENOMiCLU_1488559_0_0_1
InParanoidiQ7Z5J1
KOiK15680
PhylomeDBiQ7Z5J1
TreeFamiTF329114

Enzyme and pathway databases

PathwayCommonsiQ7Z5J1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
374875, 62 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HSD11B1L, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
374875
PharosiQ7Z5J1, Tdark

Protein Ontology

More...
PROi
PR:Q7Z5J1
RNActiQ7Z5J1, protein

Gene expression databases

BgeeiENSG00000167733, Expressed in prefrontal cortex and 156 other tissues
ExpressionAtlasiQ7Z5J1, baseline and differential
GenevisibleiQ7Z5J1, HS

Family and domain databases

InterProiView protein in InterPro
IPR036291, NAD(P)-bd_dom_sf
IPR020904, Sc_DH/Rdtase_CS
IPR002347, SDR_fam
PfamiView protein in Pfam
PF00106, adh_short, 1 hit
PRINTSiPR00081, GDHRDH
SUPFAMiSSF51735, SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061, ADH_SHORT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHI1L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z5J1
Secondary accession number(s): Q05D45
, Q52LF4, Q7Z5I9, Q7Z5J0, Q7Z5P5, Q7Z5P6, Q7Z5P7, Q7Z5P8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: August 12, 2020
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again