UniProtKB - Q7Z5H4 (VN1R5_HUMAN)
Protein
Vomeronasal type-1 receptor 5
Gene
VN1R5
Organism
Homo sapiens (Human)
Status
Functioni
Putative pheromone receptor.
Miscellaneous
The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.
GO - Molecular functioni
- pheromone receptor activity Source: InterPro
GO - Biological processi
- response to pheromone Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Pheromone response |
Enzyme and pathway databases
PathwayCommonsi | Q7Z5H4 |
Names & Taxonomyi
Protein namesi | Recommended name: Vomeronasal type-1 receptor 5Alternative name(s): G-protein coupled receptor GPCR26 Short name: hGPCR26 V1r-like receptor 5 |
Gene namesi | Name:VN1R5 Synonyms:V1RL5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19870, VN1R5 |
neXtProti | NX_Q7Z5H4 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 3 | ExtracellularSequence analysis | 3 | |
Transmembranei | 4 – 24 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 25 – 52 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 53 – 73 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 74 – 81 | ExtracellularSequence analysis | 8 | |
Transmembranei | 82 – 102 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 103 – 130 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 131 – 151 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 152 – 163 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 164 – 184 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 185 – 269 | CytoplasmicSequence analysisAdd BLAST | 85 | |
Transmembranei | 270 – 290 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 291 – 300 | ExtracellularSequence analysis | 10 | |
Transmembranei | 301 – 321 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 322 – 357 | CytoplasmicSequence analysisAdd BLAST | 36 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 317705 |
PharmGKBi | PA134993066 |
Miscellaneous databases
Pharosi | Q7Z5H4, Tdark |
Genetic variation databases
BioMutai | VN1R5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070220 | 1 – 357 | Vomeronasal type-1 receptor 5Add BLAST | 357 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 297 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q7Z5H4 |
PRIDEi | Q7Z5H4 |
ProteomicsDBi | 69293 |
TopDownProteomicsi | Q7Z5H4 |
PTM databases
GlyGeni | Q7Z5H4, 1 site |
iPTMneti | Q7Z5H4 |
PhosphoSitePlusi | Q7Z5H4 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 130446, 1 interactor |
IntActi | Q7Z5H4, 2 interactors |
MINTi | Q7Z5H4 |
Miscellaneous databases
RNActi | Q7Z5H4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
InParanoidi | Q7Z5H4 |
OrthoDBi | 1390012at2759 |
PhylomeDBi | Q7Z5H4 |
Family and domain databases
InterProi | View protein in InterPro IPR004072, Vmron_rcpt_1 |
PANTHERi | PTHR24062, PTHR24062, 1 hit |
Pfami | View protein in Pfam PF03402, V1R, 2 hits |
PRINTSi | PR01534, VOMERONASL1R |
i Sequence
Sequence statusi: Complete.
Q7Z5H4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKLVIIENM AEIMLFSLDL LLFSTDILCF NFPSKMIKLP GFITIQIFFY
60 70 80 90 100
PQASFGISAN TILLLFHIFT FVFSHRSKSI DMIISHLSLI HILLLFTQAI
110 120 130 140 150
LVSLDFFGSQ NTQDDLRYKV IVFLNKVMRG LSICTPCLLS VLQAIISPSI
160 170 180 190 200
FSLAKLKHPS ASHILGFFLF SWVLNMFIGV IFCCTLRLPP VKRGQSSVCH
210 220 230 240 250
TALFLFAHEL HPQETVFHTN DFEGCHLYRV HGPLKRLHGD YFIQTIRGYL
260 270 280 290 300
SAFTQPACPR VSPVKRASQA ILLLVSFVFT YWVDFTFSFS GGVTWINDSL
310 320 330 340 350
LVWLQVIVAN SYAAISPLML IYADNQIFKT LQMLWFKYLS PPKLMLKFNR
QCGSTKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 66 | F → Y in BAB89321 (PubMed:12044878).Curated | 1 |
Polymorphismi
There is an allele VN1R5*2 with a truncating mutation in position 46. It was found with a frequency of about 32%.1 Publication
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022802 | 350 | R → C in allele VN1R5*3. 1 PublicationCorresponds to variant dbSNP:rs41308154Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY114735 Genomic DNA Translation: AAM66756.1 AY312489 Genomic DNA Translation: AAP85622.1 AY312490 Genomic DNA No translation available. AY312491 Genomic DNA Translation: AAP85623.1 AB083608 Genomic DNA Translation: BAB89321.1 BC126341 mRNA Translation: AAI26342.1 BC126367 mRNA Translation: AAI26368.1 |
CCDSi | CCDS86062.1 |
RefSeqi | NP_776257.1, NM_173858.1 |
Genome annotation databases
GeneIDi | 317705 |
KEGGi | hsa:317705 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Protein Spotlight No one nose - Issue 61 of August 2005 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY114735 Genomic DNA Translation: AAM66756.1 AY312489 Genomic DNA Translation: AAP85622.1 AY312490 Genomic DNA No translation available. AY312491 Genomic DNA Translation: AAP85623.1 AB083608 Genomic DNA Translation: BAB89321.1 BC126341 mRNA Translation: AAI26342.1 BC126367 mRNA Translation: AAI26368.1 |
CCDSi | CCDS86062.1 |
RefSeqi | NP_776257.1, NM_173858.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 130446, 1 interactor |
IntActi | Q7Z5H4, 2 interactors |
MINTi | Q7Z5H4 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q7Z5H4, 1 site |
iPTMneti | Q7Z5H4 |
PhosphoSitePlusi | Q7Z5H4 |
Genetic variation databases
BioMutai | VN1R5 |
Proteomic databases
MassIVEi | Q7Z5H4 |
PRIDEi | Q7Z5H4 |
ProteomicsDBi | 69293 |
TopDownProteomicsi | Q7Z5H4 |
Genome annotation databases
GeneIDi | 317705 |
KEGGi | hsa:317705 |
Organism-specific databases
CTDi | 317705 |
DisGeNETi | 317705 |
GeneCardsi | VN1R5 |
HGNCi | HGNC:19870, VN1R5 |
neXtProti | NX_Q7Z5H4 |
PharmGKBi | PA134993066 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | Q7Z5H4 |
OrthoDBi | 1390012at2759 |
PhylomeDBi | Q7Z5H4 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z5H4 |
Miscellaneous databases
BioGRID-ORCSi | 317705, 2 hits in 121 CRISPR screens |
GeneWikii | VN1R5 |
GenomeRNAii | 317705 |
Pharosi | Q7Z5H4, Tdark |
PROi | PR:Q7Z5H4 |
RNActi | Q7Z5H4, protein |
Family and domain databases
InterProi | View protein in InterPro IPR004072, Vmron_rcpt_1 |
PANTHERi | PTHR24062, PTHR24062, 1 hit |
Pfami | View protein in Pfam PF03402, V1R, 2 hits |
PRINTSi | PR01534, VOMERONASL1R |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VN1R5_HUMAN | |
Accessioni | Q7Z5H4Primary (citable) accession number: Q7Z5H4 Secondary accession number(s): A0AVG1, Q8NEU5, Q8TDU3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | July 5, 2005 | |
Last modified: | April 7, 2021 | |
This is version 112 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families - Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries