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UniProtKB - Q7Z5H4 (VN1R5_HUMAN)

Entry version 101 (08 May 2019)
Sequence version 2 (05 Jul 2005)
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Protein

Vomeronasal type-1 receptor 5

Gene

VN1R5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative pheromone receptor.

Miscellaneous

The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processPheromone response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vomeronasal type-1 receptor 5
Alternative name(s):
G-protein coupled receptor GPCR26
Short name:
hGPCR26
V1r-like receptor 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VN1R5
Synonyms:V1RL5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19870 VN1R5

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7Z5H4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 3ExtracellularSequence analysis3
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4 – 24Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini25 – 52CytoplasmicSequence analysisAdd BLAST28
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 81ExtracellularSequence analysis8
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 130CytoplasmicSequence analysisAdd BLAST28
Transmembranei131 – 151Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini152 – 163ExtracellularSequence analysisAdd BLAST12
Transmembranei164 – 184Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini185 – 269CytoplasmicSequence analysisAdd BLAST85
Transmembranei270 – 290Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini291 – 300ExtracellularSequence analysis10
Transmembranei301 – 321Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini322 – 357CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		317705

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134993066

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		VN1R5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000702201 – 357Vomeronasal type-1 receptor 5Add BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7Z5H4

PRoteomics IDEntifications database

More...PRIDEi		Q7Z5H4

ProteomicsDB human proteome resource

More...ProteomicsDBi		69293

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q7Z5H4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7Z5H4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7Z5H4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		130446, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q7Z5H4, 2 interactors

Molecular INTeraction database

More...MINTi		Q7Z5H4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7Z5H4

KEGG Orthology (KO)

More...KOi		K04614

Database of Orthologous Groups

More...OrthoDBi		1390012at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7Z5H4

Family and domain databases

Conserved Domains Database

More...CDDi		cd13949 7tm_V1R_pheromone, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004072 Vmron_rcpt_1

The PANTHER Classification System

More...PANTHERi		PTHR24062 PTHR24062, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03402 V1R, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01534 VOMERONASL1R

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7Z5H4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKLVIIENM AEIMLFSLDL LLFSTDILCF NFPSKMIKLP GFITIQIFFY 
        60         70         80         90        100
PQASFGISAN TILLLFHIFT FVFSHRSKSI DMIISHLSLI HILLLFTQAI 
       110        120        130        140        150
LVSLDFFGSQ NTQDDLRYKV IVFLNKVMRG LSICTPCLLS VLQAIISPSI 
       160        170        180        190        200
FSLAKLKHPS ASHILGFFLF SWVLNMFIGV IFCCTLRLPP VKRGQSSVCH 
       210        220        230        240        250
TALFLFAHEL HPQETVFHTN DFEGCHLYRV HGPLKRLHGD YFIQTIRGYL 
       260        270        280        290        300
SAFTQPACPR VSPVKRASQA ILLLVSFVFT YWVDFTFSFS GGVTWINDSL 
       310        320        330        340        350
LVWLQVIVAN SYAAISPLML IYADNQIFKT LQMLWFKYLS PPKLMLKFNR 

QCGSTKK
Length:357
Mass (Da):40,779
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0E01BA2B43D5F2FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti66F → Y in BAB89321 (PubMed:12044878).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

There is an allele VN1R5*2 with a truncating mutation in position 46. It was found with a frequency of about 32%.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022802350R → C in allele VN1R5*3. 1 PublicationCorresponds to variant dbSNP:rs41308154Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY114735 Genomic DNA Translation: AAM66756.1
AY312489 Genomic DNA Translation: AAP85622.1
AY312490 Genomic DNA No translation available.
AY312491 Genomic DNA Translation: AAP85623.1
AB083608 Genomic DNA Translation: BAB89321.1
BC126341 mRNA Translation: AAI26342.1
BC126367 mRNA Translation: AAI26368.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS86062.1

NCBI Reference Sequences

More...RefSeqi		NP_776257.1, NM_173858.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		317705

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:317705

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

No one nose - Issue 61 of August 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY114735 Genomic DNA Translation: AAM66756.1
AY312489 Genomic DNA Translation: AAP85622.1
AY312490 Genomic DNA No translation available.
AY312491 Genomic DNA Translation: AAP85623.1
AB083608 Genomic DNA Translation: BAB89321.1
BC126341 mRNA Translation: AAI26342.1
BC126367 mRNA Translation: AAI26368.1
CCDSiCCDS86062.1
RefSeqiNP_776257.1, NM_173858.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi130446, 1 interactor
IntActiQ7Z5H4, 2 interactors
MINTiQ7Z5H4

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiQ7Z5H4
PhosphoSitePlusiQ7Z5H4

Polymorphism and mutation databases

BioMutaiVN1R5

Proteomic databases

jPOSTiQ7Z5H4
PRIDEiQ7Z5H4
ProteomicsDBi69293
TopDownProteomicsiQ7Z5H4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi317705
KEGGihsa:317705

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		317705
DisGeNETi317705

GeneCards: human genes, protein and diseases

More...GeneCardsi		VN1R5

H-Invitational Database, human transcriptome db

More...H-InvDBi		HIX0093782
HGNCiHGNC:19870 VN1R5
neXtProtiNX_Q7Z5H4
PharmGKBiPA134993066

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

InParanoidiQ7Z5H4
KOiK04614
OrthoDBi1390012at2759
PhylomeDBiQ7Z5H4

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		VN1R5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		317705

Protein Ontology

More...PROi		PR:Q7Z5H4

Family and domain databases

CDDicd13949 7tm_V1R_pheromone, 1 hit
InterProiView protein in InterPro
IPR004072 Vmron_rcpt_1
PANTHERiPTHR24062 PTHR24062, 1 hit
PfamiView protein in Pfam
PF03402 V1R, 2 hits
PRINTSiPR01534 VOMERONASL1R

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVN1R5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z5H4
Secondary accession number(s): A0AVG1, Q8NEU5, Q8TDU3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: May 8, 2019
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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