UniProtKB - Q7Z5H3 (RHG22_HUMAN)
Protein
Rho GTPase-activating protein 22
Gene
ARHGAP22
Organism
Homo sapiens (Human)
Status
Functioni
Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).By similarity
GO - Molecular functioni
- GTPase activator activity Source: GO_Central
GO - Biological processi
- activation of GTPase activity Source: GO_Central
- angiogenesis Source: UniProtKB-KW
- cell differentiation Source: UniProtKB-KW
- regulation of postsynapse organization Source: GO_Central
- regulation of small GTPase mediated signal transduction Source: Reactome
- signal transduction Source: InterPro
Keywordsi
Molecular function | Developmental protein, GTPase activation |
Biological process | Angiogenesis, Differentiation, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q7Z5H3 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
SIGNORi | Q7Z5H3 |
Names & Taxonomyi
Protein namesi | Recommended name: Rho GTPase-activating protein 22Alternative name(s): Rho-type GTPase-activating protein 22 |
Gene namesi | Name:ARHGAP22 Synonyms:RHOGAP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000128805.14 |
HGNCi | HGNC:30320, ARHGAP22 |
MIMi | 610585, gene |
neXtProti | NX_Q7Z5H3 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- focal adhesion Source: UniProtKB
- glutamatergic synapse Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 58504 |
OpenTargetsi | ENSG00000128805 |
PharmGKBi | PA134979724 |
Miscellaneous databases
Pharosi | Q7Z5H3, Tbio |
Polymorphism and mutation databases
BioMutai | ARHGAP22 |
DMDMi | 74750129 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280469 | 1 – 698 | Rho GTPase-activating protein 22Add BLAST | 698 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 359 | PhosphoserineCombined sources | 1 | |
Modified residuei | 395 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q7Z5H3 |
MassIVEi | Q7Z5H3 |
MaxQBi | Q7Z5H3 |
PaxDbi | Q7Z5H3 |
PeptideAtlasi | Q7Z5H3 |
PRIDEi | Q7Z5H3 |
ProteomicsDBi | 3948 69289 [Q7Z5H3-1] 69290 [Q7Z5H3-2] 69291 [Q7Z5H3-3] 69292 [Q7Z5H3-4] |
PTM databases
iPTMneti | Q7Z5H3 |
PhosphoSitePlusi | Q7Z5H3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000128805, Expressed in C1 segment of cervical spinal cord and 142 other tissues |
ExpressionAtlasi | Q7Z5H3, baseline and differential |
Genevisiblei | Q7Z5H3, HS |
Organism-specific databases
HPAi | ENSG00000128805, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with VEZF1.
By similarityBinary interactionsi
Hide detailsQ7Z5H3
With | #Exp. | IntAct |
---|---|---|
CACNA1A [O00555] | 2 | EBI-3866859,EBI-766279 |
CCNDBP1 [O95273] | 3 | EBI-3866859,EBI-748961 |
Isoform 2 [Q7Z5H3-2]
With | #Exp. | IntAct |
---|---|---|
DEF6 [Q9H4E7] | 3 | EBI-12084490,EBI-745369 |
Protein-protein interaction databases
BioGRIDi | 121832, 37 interactors |
IntActi | Q7Z5H3, 42 interactors |
STRINGi | 9606.ENSP00000412461 |
Miscellaneous databases
RNActi | Q7Z5H3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 37 – 145 | PHPROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 155 – 349 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 195 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 590 – 687 | Sequence analysisAdd BLAST | 98 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 427 – 587 | Ser-richAdd BLAST | 161 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4270, Eukaryota |
GeneTreei | ENSGT00950000183015 |
HOGENOMi | CLU_020795_0_0_1 |
InParanoidi | Q7Z5H3 |
OMAi | HNRLYSG |
OrthoDBi | 917149at2759 |
PhylomeDBi | Q7Z5H3 |
TreeFami | TF323577 |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50238, RHOGAP, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7Z5H3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLSPKIRQAR RARSKSLVMG EQSRSPGRMP CPHRLGPVLK AGWLKKQRSI
60 70 80 90 100
MKNWQQRWFV LRGDQLFYYK DKDEIKPQGF ISLQGTQVTE LPPGPEDPGK
110 120 130 140 150
HLFEISPGGA GEREKVPANP EALLLMASSQ RDMEDWVQAI RRVIWAPLGG
160 170 180 190 200
GIFGQRLEET VHHERKYGPR LAPLLVEQCV DFIRERGLTE EGLFRMPGQA
210 220 230 240 250
NLVRDLQDSF DCGEKPLFDS TTDVHTVASL LKLYLRELPE PVVPFARYED
260 270 280 290 300
FLSCAQLLTK DEGEGTLELA KQVSNLPQAN YNLLRYICKF LDEVQAYSNV
310 320 330 340 350
NKMSVQNLAT VFGPNILRPQ VEDPVTIMEG TSLVQHLMTV LIRKHSQLFT
360 370 380 390 400
APVPEGPTSP RGGLQCAVGW GSEEVTRDSQ GEPGGPGLPA HRTSSLDGAA
410 420 430 440 450
VAVLSRTAPT GPGSRCSPGK KVQTLPSWKS SFRQPRSLSG SPKGGGSSLE
460 470 480 490 500
VPIISSGGNW LMNGLSSLRG HRRASSGDRL KDSGSVQRLS TYDNVPAPGL
510 520 530 540 550
VPGIPSVASM AWSGASSSES SVGGSLSSCT ACRASDSSAR SSLHTDWALE
560 570 580 590 600
PSPLPSSSED PKSLDLDHSM DEAGAGASNS EPSEPDSPTR EHARRSEALQ
610 620 630 640 650
GLVTELRAEL CRQRTEYERS VKRIEEGSAD LRKRMSRLEE ELDQEKKKYI
660 670 680 690
MLEIKLRNSE RAREDAERRN QLLQREMEEF FSTLGSLTVG AKGARAPK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA6NJ38 | A6NJ38_HUMAN | Rho GTPase-activating protein 22 | ARHGAP22 | 539 | Annotation score: | ||
A6NHM7 | A6NHM7_HUMAN | Rho GTPase activating protein 22, i... | ARHGAP22 hCG_2042896 | 589 | Annotation score: | ||
D6R9V6 | D6R9V6_HUMAN | Rho GTPase-activating protein 22 | ARHGAP22 | 531 | Annotation score: | ||
D6RBJ8 | D6RBJ8_HUMAN | Rho GTPase-activating protein 22 | ARHGAP22 | 261 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031153 | 410 | T → K. Corresponds to variant dbSNP:rs1867586Ensembl. | 1 | |
Natural variantiVAR_031154 | 612 | R → C. Corresponds to variant dbSNP:rs3747853EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023703 | 1 – 329 | MLSPK…VTIME → MGQPREFWHLRSQVPVPTCH LLTVQPWCLLPHPTPAGGRE RRHSASSLLAALCLRKAVLR PHPAVLPGVGGCVVLSSGRM KAPLRGGLALGTGPAPTKLQ LLHDWQSEPGPSGWQQGPSP PLFPA in isoform 4. 1 PublicationAdd BLAST | 329 | |
Alternative sequenceiVSP_023704 | 1 – 107 | MLSPK…FEISP → MPFWPIRCLKRSRRMPR in isoform 3. 1 PublicationAdd BLAST | 107 | |
Alternative sequenceiVSP_053502 | 1 – 12 | MLSPK…QARRA → MLPTASSKRRTFAARYFT in isoform 5. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_023705 | 150 | G → GGTARRSHAHPLEPLPP in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY324801 mRNA Translation: AAP85632.1 AK127586 mRNA Translation: BAC87044.1 AK293579 mRNA Translation: BAG57049.1 U90908 mRNA Translation: AAB51057.1 EF560749 mRNA Translation: ABQ59059.1 AC016397 Genomic DNA No translation available. AC016399 Genomic DNA No translation available. AC068898 Genomic DNA No translation available. CH471187 Genomic DNA Translation: EAW93127.1 BC126444 mRNA Translation: AAI26445.1 BC136319 mRNA Translation: AAI36320.1 |
CCDSi | CCDS58079.1 [Q7Z5H3-3] CCDS58080.1 [Q7Z5H3-2] CCDS58081.1 [Q7Z5H3-5] CCDS7227.1 [Q7Z5H3-1] |
RefSeqi | NP_001242953.1, NM_001256024.1 [Q7Z5H3-2] NP_001242954.1, NM_001256025.2 [Q7Z5H3-5] NP_001242955.1, NM_001256026.1 [Q7Z5H3-3] NP_001334667.1, NM_001347738.1 [Q7Z5H3-5] NP_067049.2, NM_021226.3 [Q7Z5H3-1] XP_011538306.1, XM_011540004.1 |
Genome annotation databases
Ensembli | ENST00000249601; ENSP00000249601; ENSG00000128805 [Q7Z5H3-1] ENST00000417247; ENSP00000410054; ENSG00000128805 [Q7Z5H3-3] ENST00000417912; ENSP00000412461; ENSG00000128805 [Q7Z5H3-2] ENST00000435790; ENSP00000416701; ENSG00000128805 [Q7Z5H3-5] |
GeneIDi | 58504 |
KEGGi | hsa:58504 |
UCSCi | uc001jgs.5, human [Q7Z5H3-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY324801 mRNA Translation: AAP85632.1 AK127586 mRNA Translation: BAC87044.1 AK293579 mRNA Translation: BAG57049.1 U90908 mRNA Translation: AAB51057.1 EF560749 mRNA Translation: ABQ59059.1 AC016397 Genomic DNA No translation available. AC016399 Genomic DNA No translation available. AC068898 Genomic DNA No translation available. CH471187 Genomic DNA Translation: EAW93127.1 BC126444 mRNA Translation: AAI26445.1 BC136319 mRNA Translation: AAI36320.1 |
CCDSi | CCDS58079.1 [Q7Z5H3-3] CCDS58080.1 [Q7Z5H3-2] CCDS58081.1 [Q7Z5H3-5] CCDS7227.1 [Q7Z5H3-1] |
RefSeqi | NP_001242953.1, NM_001256024.1 [Q7Z5H3-2] NP_001242954.1, NM_001256025.2 [Q7Z5H3-5] NP_001242955.1, NM_001256026.1 [Q7Z5H3-3] NP_001334667.1, NM_001347738.1 [Q7Z5H3-5] NP_067049.2, NM_021226.3 [Q7Z5H3-1] XP_011538306.1, XM_011540004.1 |
3D structure databases
SASBDBi | Q7Z5H3 |
SMRi | Q7Z5H3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121832, 37 interactors |
IntActi | Q7Z5H3, 42 interactors |
STRINGi | 9606.ENSP00000412461 |
PTM databases
iPTMneti | Q7Z5H3 |
PhosphoSitePlusi | Q7Z5H3 |
Polymorphism and mutation databases
BioMutai | ARHGAP22 |
DMDMi | 74750129 |
Proteomic databases
jPOSTi | Q7Z5H3 |
MassIVEi | Q7Z5H3 |
MaxQBi | Q7Z5H3 |
PaxDbi | Q7Z5H3 |
PeptideAtlasi | Q7Z5H3 |
PRIDEi | Q7Z5H3 |
ProteomicsDBi | 3948 69289 [Q7Z5H3-1] 69290 [Q7Z5H3-2] 69291 [Q7Z5H3-3] 69292 [Q7Z5H3-4] |
Protocols and materials databases
Antibodypediai | 58456, 148 antibodies |
Genome annotation databases
Ensembli | ENST00000249601; ENSP00000249601; ENSG00000128805 [Q7Z5H3-1] ENST00000417247; ENSP00000410054; ENSG00000128805 [Q7Z5H3-3] ENST00000417912; ENSP00000412461; ENSG00000128805 [Q7Z5H3-2] ENST00000435790; ENSP00000416701; ENSG00000128805 [Q7Z5H3-5] |
GeneIDi | 58504 |
KEGGi | hsa:58504 |
UCSCi | uc001jgs.5, human [Q7Z5H3-1] |
Organism-specific databases
CTDi | 58504 |
DisGeNETi | 58504 |
EuPathDBi | HostDB:ENSG00000128805.14 |
GeneCardsi | ARHGAP22 |
HGNCi | HGNC:30320, ARHGAP22 |
HPAi | ENSG00000128805, Tissue enriched (brain) |
MIMi | 610585, gene |
neXtProti | NX_Q7Z5H3 |
OpenTargetsi | ENSG00000128805 |
PharmGKBi | PA134979724 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4270, Eukaryota |
GeneTreei | ENSGT00950000183015 |
HOGENOMi | CLU_020795_0_0_1 |
InParanoidi | Q7Z5H3 |
OMAi | HNRLYSG |
OrthoDBi | 917149at2759 |
PhylomeDBi | Q7Z5H3 |
TreeFami | TF323577 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z5H3 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
SIGNORi | Q7Z5H3 |
Miscellaneous databases
BioGRID-ORCSi | 58504, 4 hits in 846 CRISPR screens |
ChiTaRSi | ARHGAP22, human |
GenomeRNAii | 58504 |
Pharosi | Q7Z5H3, Tbio |
PROi | PR:Q7Z5H3 |
RNActi | Q7Z5H3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000128805, Expressed in C1 segment of cervical spinal cord and 142 other tissues |
ExpressionAtlasi | Q7Z5H3, baseline and differential |
Genevisiblei | Q7Z5H3, HS |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50003, PH_DOMAIN, 1 hit PS50238, RHOGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RHG22_HUMAN | |
Accessioni | Q7Z5H3Primary (citable) accession number: Q7Z5H3 Secondary accession number(s): A0AVP7 Q6ZSB0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | October 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations