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Entry version 143 (02 Dec 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Rho GTPase-activating protein 22

Gene

ARHGAP22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, GTPase activation
Biological processAngiogenesis, Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7Z5H3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840, Rho GTPase cycle

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q7Z5H3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 22
Alternative name(s):
Rho-type GTPase-activating protein 22
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP22
Synonyms:RHOGAP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000128805.14

Human Gene Nomenclature Database

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HGNCi
HGNC:30320, ARHGAP22

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610585, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z5H3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
58504

Open Targets

More...
OpenTargetsi
ENSG00000128805

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134979724

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z5H3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGAP22

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750129

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002804691 – 698Rho GTPase-activating protein 22Add BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei359PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z5H3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q7Z5H3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z5H3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z5H3

PeptideAtlas

More...
PeptideAtlasi
Q7Z5H3

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z5H3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
3948
69289 [Q7Z5H3-1]
69290 [Q7Z5H3-2]
69291 [Q7Z5H3-3]
69292 [Q7Z5H3-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z5H3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z5H3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000128805, Expressed in C1 segment of cervical spinal cord and 142 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z5H3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z5H3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000128805, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with VEZF1.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121832, 37 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z5H3, 42 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000412461

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z5H3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Small Angle Scattering Biological Data Bank

More...
SASBDBi
Q7Z5H3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z5H3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 145PHPROSITE-ProRule annotationAdd BLAST109
Domaini155 – 349Rho-GAPPROSITE-ProRule annotationAdd BLAST195

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili590 – 687Sequence analysisAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi427 – 587Ser-richAdd BLAST161

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4270, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183015

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020795_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z5H3

Identification of Orthologs from Complete Genome Data

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OMAi
HNRLYSG

Database of Orthologous Groups

More...
OrthoDBi
917149at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z5H3

TreeFam database of animal gene trees

More...
TreeFami
TF323577

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169, PH, 1 hit
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z5H3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSPKIRQAR RARSKSLVMG EQSRSPGRMP CPHRLGPVLK AGWLKKQRSI
60 70 80 90 100
MKNWQQRWFV LRGDQLFYYK DKDEIKPQGF ISLQGTQVTE LPPGPEDPGK
110 120 130 140 150
HLFEISPGGA GEREKVPANP EALLLMASSQ RDMEDWVQAI RRVIWAPLGG
160 170 180 190 200
GIFGQRLEET VHHERKYGPR LAPLLVEQCV DFIRERGLTE EGLFRMPGQA
210 220 230 240 250
NLVRDLQDSF DCGEKPLFDS TTDVHTVASL LKLYLRELPE PVVPFARYED
260 270 280 290 300
FLSCAQLLTK DEGEGTLELA KQVSNLPQAN YNLLRYICKF LDEVQAYSNV
310 320 330 340 350
NKMSVQNLAT VFGPNILRPQ VEDPVTIMEG TSLVQHLMTV LIRKHSQLFT
360 370 380 390 400
APVPEGPTSP RGGLQCAVGW GSEEVTRDSQ GEPGGPGLPA HRTSSLDGAA
410 420 430 440 450
VAVLSRTAPT GPGSRCSPGK KVQTLPSWKS SFRQPRSLSG SPKGGGSSLE
460 470 480 490 500
VPIISSGGNW LMNGLSSLRG HRRASSGDRL KDSGSVQRLS TYDNVPAPGL
510 520 530 540 550
VPGIPSVASM AWSGASSSES SVGGSLSSCT ACRASDSSAR SSLHTDWALE
560 570 580 590 600
PSPLPSSSED PKSLDLDHSM DEAGAGASNS EPSEPDSPTR EHARRSEALQ
610 620 630 640 650
GLVTELRAEL CRQRTEYERS VKRIEEGSAD LRKRMSRLEE ELDQEKKKYI
660 670 680 690
MLEIKLRNSE RAREDAERRN QLLQREMEEF FSTLGSLTVG AKGARAPK
Length:698
Mass (Da):76,779
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CE8CEB0A9E5D0F8
GO
Isoform 2 (identifier: Q7Z5H3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-150: G → GGTARRSHAHPLEPLPP

Show »
Length:714
Mass (Da):78,497
Checksum:i74AB4A00D66DE416
GO
Isoform 3 (identifier: Q7Z5H3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: MLSPKIRQAR...PGKHLFEISP → MPFWPIRCLKRSRRMPR

Show »
Length:608
Mass (Da):66,611
Checksum:i2D7543609C576A5D
GO
Isoform 4 (identifier: Q7Z5H3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: MLSPKIRQAR...QVEDPVTIME → MGQPREFWHL...QGPSPPLFPA

Show »
Length:494
Mass (Da):52,697
Checksum:i2E77D20B3241012D
GO
Isoform 5 (identifier: Q7Z5H3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLSPKIRQARRA → MLPTASSKRRTFAARYFT

Show »
Length:704
Mass (Da):77,457
Checksum:iBC4DB2D59C466994
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NJ38A6NJ38_HUMAN
Rho GTPase-activating protein 22
ARHGAP22
539Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6NHM7A6NHM7_HUMAN
Rho GTPase activating protein 22, i...
ARHGAP22 hCG_2042896
589Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9V6D6R9V6_HUMAN
Rho GTPase-activating protein 22
ARHGAP22
531Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBJ8D6RBJ8_HUMAN
Rho GTPase-activating protein 22
ARHGAP22
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031153410T → K. Corresponds to variant dbSNP:rs1867586Ensembl.1
Natural variantiVAR_031154612R → C. Corresponds to variant dbSNP:rs3747853EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0237031 – 329MLSPK…VTIME → MGQPREFWHLRSQVPVPTCH LLTVQPWCLLPHPTPAGGRE RRHSASSLLAALCLRKAVLR PHPAVLPGVGGCVVLSSGRM KAPLRGGLALGTGPAPTKLQ LLHDWQSEPGPSGWQQGPSP PLFPA in isoform 4. 1 PublicationAdd BLAST329
Alternative sequenceiVSP_0237041 – 107MLSPK…FEISP → MPFWPIRCLKRSRRMPR in isoform 3. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_0535021 – 12MLSPK…QARRA → MLPTASSKRRTFAARYFT in isoform 5. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_023705150G → GGTARRSHAHPLEPLPP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY324801 mRNA Translation: AAP85632.1
AK127586 mRNA Translation: BAC87044.1
AK293579 mRNA Translation: BAG57049.1
U90908 mRNA Translation: AAB51057.1
EF560749 mRNA Translation: ABQ59059.1
AC016397 Genomic DNA No translation available.
AC016399 Genomic DNA No translation available.
AC068898 Genomic DNA No translation available.
CH471187 Genomic DNA Translation: EAW93127.1
BC126444 mRNA Translation: AAI26445.1
BC136319 mRNA Translation: AAI36320.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58079.1 [Q7Z5H3-3]
CCDS58080.1 [Q7Z5H3-2]
CCDS58081.1 [Q7Z5H3-5]
CCDS7227.1 [Q7Z5H3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001242953.1, NM_001256024.1 [Q7Z5H3-2]
NP_001242954.1, NM_001256025.2 [Q7Z5H3-5]
NP_001242955.1, NM_001256026.1 [Q7Z5H3-3]
NP_001334667.1, NM_001347738.1 [Q7Z5H3-5]
NP_067049.2, NM_021226.3 [Q7Z5H3-1]
XP_011538306.1, XM_011540004.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000249601; ENSP00000249601; ENSG00000128805 [Q7Z5H3-1]
ENST00000417247; ENSP00000410054; ENSG00000128805 [Q7Z5H3-3]
ENST00000417912; ENSP00000412461; ENSG00000128805 [Q7Z5H3-2]
ENST00000435790; ENSP00000416701; ENSG00000128805 [Q7Z5H3-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
58504

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:58504

UCSC genome browser

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UCSCi
uc001jgs.5, human [Q7Z5H3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324801 mRNA Translation: AAP85632.1
AK127586 mRNA Translation: BAC87044.1
AK293579 mRNA Translation: BAG57049.1
U90908 mRNA Translation: AAB51057.1
EF560749 mRNA Translation: ABQ59059.1
AC016397 Genomic DNA No translation available.
AC016399 Genomic DNA No translation available.
AC068898 Genomic DNA No translation available.
CH471187 Genomic DNA Translation: EAW93127.1
BC126444 mRNA Translation: AAI26445.1
BC136319 mRNA Translation: AAI36320.1
CCDSiCCDS58079.1 [Q7Z5H3-3]
CCDS58080.1 [Q7Z5H3-2]
CCDS58081.1 [Q7Z5H3-5]
CCDS7227.1 [Q7Z5H3-1]
RefSeqiNP_001242953.1, NM_001256024.1 [Q7Z5H3-2]
NP_001242954.1, NM_001256025.2 [Q7Z5H3-5]
NP_001242955.1, NM_001256026.1 [Q7Z5H3-3]
NP_001334667.1, NM_001347738.1 [Q7Z5H3-5]
NP_067049.2, NM_021226.3 [Q7Z5H3-1]
XP_011538306.1, XM_011540004.1

3D structure databases

SASBDBiQ7Z5H3
SMRiQ7Z5H3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121832, 37 interactors
IntActiQ7Z5H3, 42 interactors
STRINGi9606.ENSP00000412461

PTM databases

iPTMnetiQ7Z5H3
PhosphoSitePlusiQ7Z5H3

Polymorphism and mutation databases

BioMutaiARHGAP22
DMDMi74750129

Proteomic databases

jPOSTiQ7Z5H3
MassIVEiQ7Z5H3
MaxQBiQ7Z5H3
PaxDbiQ7Z5H3
PeptideAtlasiQ7Z5H3
PRIDEiQ7Z5H3
ProteomicsDBi3948
69289 [Q7Z5H3-1]
69290 [Q7Z5H3-2]
69291 [Q7Z5H3-3]
69292 [Q7Z5H3-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
58456, 148 antibodies

Genome annotation databases

EnsembliENST00000249601; ENSP00000249601; ENSG00000128805 [Q7Z5H3-1]
ENST00000417247; ENSP00000410054; ENSG00000128805 [Q7Z5H3-3]
ENST00000417912; ENSP00000412461; ENSG00000128805 [Q7Z5H3-2]
ENST00000435790; ENSP00000416701; ENSG00000128805 [Q7Z5H3-5]
GeneIDi58504
KEGGihsa:58504
UCSCiuc001jgs.5, human [Q7Z5H3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
58504
DisGeNETi58504
EuPathDBiHostDB:ENSG00000128805.14

GeneCards: human genes, protein and diseases

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GeneCardsi
ARHGAP22
HGNCiHGNC:30320, ARHGAP22
HPAiENSG00000128805, Tissue enriched (brain)
MIMi610585, gene
neXtProtiNX_Q7Z5H3
OpenTargetsiENSG00000128805
PharmGKBiPA134979724

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4270, Eukaryota
GeneTreeiENSGT00950000183015
HOGENOMiCLU_020795_0_0_1
InParanoidiQ7Z5H3
OMAiHNRLYSG
OrthoDBi917149at2759
PhylomeDBiQ7Z5H3
TreeFamiTF323577

Enzyme and pathway databases

PathwayCommonsiQ7Z5H3
ReactomeiR-HSA-194840, Rho GTPase cycle
SIGNORiQ7Z5H3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
58504, 4 hits in 846 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARHGAP22, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
58504
PharosiQ7Z5H3, Tbio

Protein Ontology

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PROi
PR:Q7Z5H3
RNActiQ7Z5H3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128805, Expressed in C1 segment of cervical spinal cord and 142 other tissues
ExpressionAtlasiQ7Z5H3, baseline and differential
GenevisibleiQ7Z5H3, HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG22_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z5H3
Secondary accession number(s): A0AVP7
, A5YM75, B4DED8, B9EGA0, C9JDM2, O00152, Q6ZSB0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2003
Last modified: December 2, 2020
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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