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Protein

Rho GTPase-activating protein 22

Gene

ARHGAP22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, GTPase activation
Biological processAngiogenesis, Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 22
Alternative name(s):
Rho-type GTPase-activating protein 22
Gene namesi
Name:ARHGAP22
Synonyms:RHOGAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000128805.14
HGNCiHGNC:30320 ARHGAP22
MIMi610585 gene
neXtProtiNX_Q7Z5H3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi58504
OpenTargetsiENSG00000128805
PharmGKBiPA134979724

Polymorphism and mutation databases

BioMutaiARHGAP22
DMDMi74750129

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804691 – 698Rho GTPase-activating protein 22Add BLAST698

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei359PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7Z5H3
PaxDbiQ7Z5H3
PeptideAtlasiQ7Z5H3
PRIDEiQ7Z5H3
ProteomicsDBi69289
69290 [Q7Z5H3-2]
69291 [Q7Z5H3-3]
69292 [Q7Z5H3-4]

PTM databases

iPTMnetiQ7Z5H3
PhosphoSitePlusiQ7Z5H3

Expressioni

Gene expression databases

BgeeiENSG00000128805 Expressed in 125 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExiHS_ARHGAP22
ExpressionAtlasiQ7Z5H3 baseline and differential
GenevisibleiQ7Z5H3 HS

Organism-specific databases

HPAiCAB020696
HPA040391
HPA064439

Interactioni

Subunit structurei

Interacts with VEZF1.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi121832, 35 interactors
IntActiQ7Z5H3, 3 interactors
STRINGi9606.ENSP00000249601

Structurei

3D structure databases

ProteinModelPortaliQ7Z5H3
SMRiQ7Z5H3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 145PHPROSITE-ProRule annotationAdd BLAST109
Domaini155 – 349Rho-GAPPROSITE-ProRule annotationAdd BLAST195

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili590 – 687Sequence analysisAdd BLAST98

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi427 – 587Ser-richAdd BLAST161

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4270 Eukaryota
ENOG410XRR2 LUCA
GeneTreeiENSGT00760000118863
HOGENOMiHOG000232151
HOVERGENiHBG058875
InParanoidiQ7Z5H3
KOiK20642
OMAiHTEWALE
OrthoDBiEOG091G02DD
PhylomeDBiQ7Z5H3
TreeFamiTF323577

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00169 PH, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q7Z5H3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSPKIRQAR RARSKSLVMG EQSRSPGRMP CPHRLGPVLK AGWLKKQRSI
60 70 80 90 100
MKNWQQRWFV LRGDQLFYYK DKDEIKPQGF ISLQGTQVTE LPPGPEDPGK
110 120 130 140 150
HLFEISPGGA GEREKVPANP EALLLMASSQ RDMEDWVQAI RRVIWAPLGG
160 170 180 190 200
GIFGQRLEET VHHERKYGPR LAPLLVEQCV DFIRERGLTE EGLFRMPGQA
210 220 230 240 250
NLVRDLQDSF DCGEKPLFDS TTDVHTVASL LKLYLRELPE PVVPFARYED
260 270 280 290 300
FLSCAQLLTK DEGEGTLELA KQVSNLPQAN YNLLRYICKF LDEVQAYSNV
310 320 330 340 350
NKMSVQNLAT VFGPNILRPQ VEDPVTIMEG TSLVQHLMTV LIRKHSQLFT
360 370 380 390 400
APVPEGPTSP RGGLQCAVGW GSEEVTRDSQ GEPGGPGLPA HRTSSLDGAA
410 420 430 440 450
VAVLSRTAPT GPGSRCSPGK KVQTLPSWKS SFRQPRSLSG SPKGGGSSLE
460 470 480 490 500
VPIISSGGNW LMNGLSSLRG HRRASSGDRL KDSGSVQRLS TYDNVPAPGL
510 520 530 540 550
VPGIPSVASM AWSGASSSES SVGGSLSSCT ACRASDSSAR SSLHTDWALE
560 570 580 590 600
PSPLPSSSED PKSLDLDHSM DEAGAGASNS EPSEPDSPTR EHARRSEALQ
610 620 630 640 650
GLVTELRAEL CRQRTEYERS VKRIEEGSAD LRKRMSRLEE ELDQEKKKYI
660 670 680 690
MLEIKLRNSE RAREDAERRN QLLQREMEEF FSTLGSLTVG AKGARAPK
Length:698
Mass (Da):76,779
Last modified:October 1, 2003 - v1
Checksum:i3CE8CEB0A9E5D0F8
GO
Isoform 2 (identifier: Q7Z5H3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-150: G → GGTARRSHAHPLEPLPP

Note: No experimental confirmation available.
Show »
Length:714
Mass (Da):78,497
Checksum:i74AB4A00D66DE416
GO
Isoform 3 (identifier: Q7Z5H3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: MLSPKIRQAR...PGKHLFEISP → MPFWPIRCLKRSRRMPR

Note: No experimental confirmation available.
Show »
Length:608
Mass (Da):66,611
Checksum:i2D7543609C576A5D
GO
Isoform 4 (identifier: Q7Z5H3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-329: MLSPKIRQAR...QVEDPVTIME → MGQPREFWHL...QGPSPPLFPA

Note: No experimental confirmation available.
Show »
Length:494
Mass (Da):52,697
Checksum:i2E77D20B3241012D
GO
Isoform 5 (identifier: Q7Z5H3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MLSPKIRQARRA → MLPTASSKRRTFAARYFT

Note: No experimental confirmation available.
Show »
Length:704
Mass (Da):77,457
Checksum:iBC4DB2D59C466994
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NJ38A6NJ38_HUMAN
Rho GTPase-activating protein 22
ARHGAP22
539Annotation score:
A6NHM7A6NHM7_HUMAN
Rho GTPase activating protein 22, i...
ARHGAP22 hCG_2042896
589Annotation score:
D6RBJ8D6RBJ8_HUMAN
Rho GTPase-activating protein 22
ARHGAP22
261Annotation score:
D6R9V6D6R9V6_HUMAN
Rho GTPase-activating protein 22
ARHGAP22
531Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031153410T → K. Corresponds to variant dbSNP:rs1867586Ensembl.1
Natural variantiVAR_031154612R → C. Corresponds to variant dbSNP:rs3747853Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0237031 – 329MLSPK…VTIME → MGQPREFWHLRSQVPVPTCH LLTVQPWCLLPHPTPAGGRE RRHSASSLLAALCLRKAVLR PHPAVLPGVGGCVVLSSGRM KAPLRGGLALGTGPAPTKLQ LLHDWQSEPGPSGWQQGPSP PLFPA in isoform 4. 1 PublicationAdd BLAST329
Alternative sequenceiVSP_0237041 – 107MLSPK…FEISP → MPFWPIRCLKRSRRMPR in isoform 3. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_0535021 – 12MLSPK…QARRA → MLPTASSKRRTFAARYFT in isoform 5. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_023705150G → GGTARRSHAHPLEPLPP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY324801 mRNA Translation: AAP85632.1
AK127586 mRNA Translation: BAC87044.1
AK293579 mRNA Translation: BAG57049.1
U90908 mRNA Translation: AAB51057.1
EF560749 mRNA Translation: ABQ59059.1
AC016397 Genomic DNA No translation available.
AC016399 Genomic DNA No translation available.
AC068898 Genomic DNA No translation available.
CH471187 Genomic DNA Translation: EAW93127.1
BC126444 mRNA Translation: AAI26445.1
BC136319 mRNA Translation: AAI36320.1
CCDSiCCDS58079.1 [Q7Z5H3-3]
CCDS58080.1 [Q7Z5H3-2]
CCDS58081.1 [Q7Z5H3-5]
CCDS7227.1 [Q7Z5H3-1]
RefSeqiNP_001242953.1, NM_001256024.1 [Q7Z5H3-2]
NP_001242954.1, NM_001256025.2 [Q7Z5H3-5]
NP_001242955.1, NM_001256026.1 [Q7Z5H3-3]
NP_001334667.1, NM_001347738.1 [Q7Z5H3-5]
NP_067049.2, NM_021226.3 [Q7Z5H3-1]
XP_011538306.1, XM_011540004.1 [Q7Z5H3-5]
UniGeneiHs.655672
Hs.680368
Hs.740750

Genome annotation databases

EnsembliENST00000249601; ENSP00000249601; ENSG00000128805 [Q7Z5H3-1]
ENST00000417247; ENSP00000410054; ENSG00000128805 [Q7Z5H3-3]
ENST00000417912; ENSP00000412461; ENSG00000128805 [Q7Z5H3-2]
ENST00000435790; ENSP00000416701; ENSG00000128805 [Q7Z5H3-5]
GeneIDi58504
KEGGihsa:58504
UCSCiuc001jgs.5 human [Q7Z5H3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRHG22_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5H3
Secondary accession number(s): A0AVP7
, A5YM75, B4DED8, B9EGA0, C9JDM2, O00152, Q6ZSB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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