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Entry version 132 (07 Apr 2021)
Sequence version 1 (01 Oct 2003)
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Protein
Submitted name:

Glycoprotein receptor gp330/megalin

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImportedARBA annotation
Biological processEndocytosisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Glycoprotein receptor gp330/megalinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei4424 – 4446HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30452

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500429693326 – 4655Sequence analysisAdd BLAST4630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi28 ↔ 40PROSITE-ProRule annotation
Disulfide bondi35 ↔ 53PROSITE-ProRule annotation
Disulfide bondi47 ↔ 62PROSITE-ProRule annotation
Disulfide bondi108 ↔ 120PROSITE-ProRule annotation
Disulfide bondi115 ↔ 133PROSITE-ProRule annotation
Disulfide bondi127 ↔ 142PROSITE-ProRule annotation
Disulfide bondi152 ↔ 170PROSITE-ProRule annotation
Disulfide bondi164 ↔ 179PROSITE-ProRule annotation
Disulfide bondi183 ↔ 195PROSITE-ProRule annotation
Disulfide bondi190 ↔ 208PROSITE-ProRule annotation
Disulfide bondi202 ↔ 217PROSITE-ProRule annotation
Disulfide bondi222 ↔ 234PROSITE-ProRule annotation
Disulfide bondi229 ↔ 247PROSITE-ProRule annotation
Disulfide bondi241 ↔ 256PROSITE-ProRule annotation
Disulfide bondi1026 ↔ 1038PROSITE-ProRule annotation
Disulfide bondi1033 ↔ 1051PROSITE-ProRule annotation
Disulfide bondi1045 ↔ 1060PROSITE-ProRule annotation
Disulfide bondi1067 ↔ 1079PROSITE-ProRule annotation
Disulfide bondi1074 ↔ 1092PROSITE-ProRule annotation
Disulfide bondi1086 ↔ 1101PROSITE-ProRule annotation
Disulfide bondi1109 ↔ 1121PROSITE-ProRule annotation
Disulfide bondi1116 ↔ 1134PROSITE-ProRule annotation
Disulfide bondi1128 ↔ 1143PROSITE-ProRule annotation
Disulfide bondi1149 ↔ 1161PROSITE-ProRule annotation
Disulfide bondi1156 ↔ 1174PROSITE-ProRule annotation
Disulfide bondi1168 ↔ 1183PROSITE-ProRule annotation
Disulfide bondi1207 ↔ 1222PROSITE-ProRule annotation
Disulfide bondi1271 ↔ 1283PROSITE-ProRule annotation
Disulfide bondi1278 ↔ 1296PROSITE-ProRule annotation
Disulfide bondi1290 ↔ 1305PROSITE-ProRule annotation
Disulfide bondi1394 ↔ 1404PROSITE-ProRule annotation
Disulfide bondi2700 ↔ 2712PROSITE-ProRule annotation
Disulfide bondi2707 ↔ 2725PROSITE-ProRule annotation
Disulfide bondi2741 ↔ 2753PROSITE-ProRule annotation
Disulfide bondi2748 ↔ 2766PROSITE-ProRule annotation
Disulfide bondi2760 ↔ 2775PROSITE-ProRule annotation
Disulfide bondi2788 ↔ 2806PROSITE-ProRule annotation
Disulfide bondi2864 ↔ 2876PROSITE-ProRule annotation
Disulfide bondi2871 ↔ 2889PROSITE-ProRule annotation
Disulfide bondi2906 ↔ 2918PROSITE-ProRule annotation
Disulfide bondi2913 ↔ 2931PROSITE-ProRule annotation
Disulfide bondi2993 ↔ 3005PROSITE-ProRule annotation
Disulfide bondi3000 ↔ 3018PROSITE-ProRule annotation
Disulfide bondi3012 ↔ 3027PROSITE-ProRule annotation
Disulfide bondi3032 ↔ 3044PROSITE-ProRule annotation
Disulfide bondi3039 ↔ 3057PROSITE-ProRule annotation
Disulfide bondi3075 ↔ 3087PROSITE-ProRule annotation
Disulfide bondi3082 ↔ 3100PROSITE-ProRule annotation
Disulfide bondi3094 ↔ 3109PROSITE-ProRule annotation
Disulfide bondi3553 ↔ 3565PROSITE-ProRule annotation
Disulfide bondi3560 ↔ 3578PROSITE-ProRule annotation
Disulfide bondi3594 ↔ 3606PROSITE-ProRule annotation
Disulfide bondi3601 ↔ 3619PROSITE-ProRule annotation
Disulfide bondi3635 ↔ 3647PROSITE-ProRule annotation
Disulfide bondi3642 ↔ 3660PROSITE-ProRule annotation
Disulfide bondi3699 ↔ 3714PROSITE-ProRule annotation
Disulfide bondi3727 ↔ 3745PROSITE-ProRule annotation
Disulfide bondi3739 ↔ 3754PROSITE-ProRule annotation
Disulfide bondi3759 ↔ 3771PROSITE-ProRule annotation
Disulfide bondi3766 ↔ 3784PROSITE-ProRule annotation
Disulfide bondi3778 ↔ 3793PROSITE-ProRule annotation
Disulfide bondi3798 ↔ 3810PROSITE-ProRule annotation
Disulfide bondi3805 ↔ 3823PROSITE-ProRule annotation
Disulfide bondi3817 ↔ 3832PROSITE-ProRule annotation
Disulfide bondi3842 ↔ 3854PROSITE-ProRule annotation
Disulfide bondi3849 ↔ 3867PROSITE-ProRule annotation
Disulfide bondi3891 ↔ 3909PROSITE-ProRule annotation
Disulfide bondi3928 ↔ 3940PROSITE-ProRule annotation
Disulfide bondi3935 ↔ 3953PROSITE-ProRule annotation
Disulfide bondi3947 ↔ 3962PROSITE-ProRule annotation
Disulfide bondi4011 ↔ 4021PROSITE-ProRule annotation
Disulfide bondi4401 ↔ 4410PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q7Z5C0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z5C0, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati436 – 478LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati479 – 521LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati522 – 568LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati569 – 613LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati753 – 795LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati796 – 837LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati838 – 881LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati882 – 925LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1390 – 1429EGF-likeInterPro annotationAdd BLAST40
Repeati1478 – 1520LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1521 – 1563LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1566 – 1609LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati1610 – 1654LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati1655 – 1695LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Domaini1700 – 1741EGF-likeInterPro annotationAdd BLAST42
Repeati1790 – 1832LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati1833 – 1882LDL-receptor class BPROSITE-ProRule annotationAdd BLAST50
Repeati1883 – 1930LDL-receptor class BPROSITE-ProRule annotationAdd BLAST48
Repeati1931 – 1972LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati1973 – 2013LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati2107 – 2156LDL-receptor class BPROSITE-ProRule annotationAdd BLAST50
Repeati2157 – 2201LDL-receptor class BPROSITE-ProRule annotationAdd BLAST45
Repeati2202 – 2245LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2246 – 2289LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2431 – 2477LDL-receptor class BPROSITE-ProRule annotationAdd BLAST47
Repeati2478 – 2518LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati2519 – 2562LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati2563 – 2604LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati2605 – 2646LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Domaini3110 – 3151EGF-likeInterPro annotationAdd BLAST42
Domaini3152 – 3192EGF-likeInterPro annotationAdd BLAST41
Repeati3239 – 3281LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati3282 – 3324LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati3333 – 3376LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati3377 – 3419LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati3420 – 3460LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Domaini4007 – 4048EGF-likeInterPro annotationAdd BLAST42
Repeati4154 – 4196LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati4197 – 4240LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati4242 – 4283LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Domaini4377 – 4411EGF-likeInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni4550 – 4574DisorderedSequence analysisAdd BLAST25
Regioni4601 – 4655DisorderedSequence analysisAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4613 – 4630Pro-richSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDLR family.ARBA annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
DGHQYNL

Database of Orthologous Groups

More...
OrthoDBi
1606at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 34 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 8 hits
4.10.400.10, 36 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
IPR019825, Lectin_legB_Mn/Ca_BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 2 hits
PF00057, Ldl_recept_a, 34 hits
PF00058, Ldl_recept_b, 14 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 26 hits
SM00179, EGF_CA, 10 hits
SM00192, LDLa, 36 hits
SM00135, LY, 38 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 2 hits
SSF57424, SSF57424, 36 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 4 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 6 hits
PS01187, EGF_CA, 3 hits
PS01209, LDLRA_1, 17 hits
PS50068, LDLRA_2, 36 hits
PS51120, LDLRB, 35 hits
PS00307, LECTIN_LEGUME_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7Z5C0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRGPAAVAC TLLLALVACL APASGQECDS AHFRCGSGHC IPADWRCDGT
60 70 80 90 100
KDCSDDADEI GCAVVTCQQG YFKCQSEGQC IPSSWVCDQD QDCDDGSDER
110 120 130 140 150
QDCSQSTCSS HQITCSNGQC IPSEYRCDHV RDCPDGADEN DCQYPTCEQL
160 170 180 190 200
TCDNGACYNT SQKCDWKVDC RDSSDEINCT EICLHNEFSC GNGECIPRAY
210 220 230 240 250
VCDHDNDCQD GSDEHACNYP TCGGYQFTCP SGRCIYQNWV CDGEDDCKDN
260 270 280 290 300
GDEDGCESGP HDVHKCSPRE WSCPESGRCI SIYKVCDGIL DCPGREDENN
310 320 330 340 350
TSTGKYCSMT LCSALNCQYQ CHETPYGGAC FCPPGYIINH NDSRTCVEFD
360 370 380 390 400
DCQIWGICDQ KCESRPGRHL CHCEEGYILE RGQYCKANDS FGEASIIFSN
410 420 430 440 450
GRDLLIGDIH GRSFRILVES QNRGVAVGVA FHYHLQRVFW TDTVQNKVFS
460 470 480 490 500
VDINGLNIQE VLNVSVETPE NLAVDWVNNK IYLVETKVNR IDMVNLDGSY
510 520 530 540 550
RVTLITENLG HPRGIAVDPT VGYLFFSDWE SLSGEPKLER AFMDGSNRKD
560 570 580 590 600
LVKTKLGWPA GVTLDMISKR VYWVDSRFDY IETVTYDGIQ RKTVVHGGSL
610 620 630 640 650
IPHPFGVSLF EGQVFFTDWT KMAVLKANKF TETNPQVYYQ ASLRPYGVTV
660 670 680 690 700
YHSLRQPYAT NPCKDNNGGC EQVCVLSHRT DNDGLGFRCK CTFGFQLDTD
710 720 730 740 750
ERHCIAVQNF LIFSSQVAIR GIPFTLSTQE DVMVPVSGNP SFFVGIDFDA
760 770 780 790 800
QDSTIFFSDM SKHMIFKQKI DGTGREILAA NRVENVESLA FDWISKNLYW
810 820 830 840 850
TDSHYKSISV MRLADKTRRT VVQYLNNPRS VVVHPFAGYL FFTDWFRPAK
860 870 880 890 900
IMRAWSDGSH LLPVINTTLG WPNGLAIDWA ASRLYWVDAY FDKIEHSTFD
910 920 930 940 950
GLDRRRLGHI EQMTHPFGLA IFGEHLFFTD WRLGAIIRVR KADGGEMTVI
960 970 980 990 1000
RSGIAYILHL KSYDVNIQTG SNACNQPTHP NGDCSHFCFP VPNFQRVCGC
1010 1020 1030 1040 1050
PYGMRLASNH LTCEGDPTNE PPTEQCGLFS FPCKNGRCVP NYYLCDGVDD
1060 1070 1080 1090 1100
CHDNSDEQLC GTLNNTCSSS AFTCGHGECI PAHWRCDKRN DCVDGSDEHN
1110 1120 1130 1140 1150
CPTHAPASCL DTQYTCDNHQ CISKNWVCDT DNDCGDGSDE KNCNSTETCQ
1160 1170 1180 1190 1200
PSQFNCPNHR CIDLSFVCDG DKDCVDGSDE VGCVLNCTAS QFKCASGDKC
1210 1220 1230 1240 1250
IGVTNRCDGV FDCSDNSDEA GCPTRPPGMC HSDEFQCQED GICIPNFWEC
1260 1270 1280 1290 1300
DGHPDCLYGS DEHNACVPKT CPSSYFHCDN GNCIHRAWLC DRDNDCGDMS
1310 1320 1330 1340 1350
DEKDCPTQPF RCPSWQWQCL GHNICVNLSV VCDGIFDCPN GTDESPLCNG
1360 1370 1380 1390 1400
NSCSDFNGGC THECVQEPFG AKCLCPLGFL LANDSKTCED IDECDILGSC
1410 1420 1430 1440 1450
SQHCYNMRGS FRCSCDTGYM LESDGRTCKV TASESLLLLV ASQNKIIADS
1460 1470 1480 1490 1500
VTSQVHNIYS LVENGSYIVA VDFDSISGRI FWSDATQGKT WSAFQNGTDR
1510 1520 1530 1540 1550
RVVFDSSIIL TETIAIDWVG RNLYWTDYAL ETIEVSKIDG SHRTVLISKN
1560 1570 1580 1590 1600
LTNPRGLALD PRMNEHLLFW SDWGHHPRIE RASMDGSMRT VIVQDKIFWP
1610 1620 1630 1640 1650
CGLTIDYPNR LLYFMDSYLD YMDFCDYNGH HRRQVIASDL IIRHPYALTL
1660 1670 1680 1690 1700
FEDSVYWTDR ATRRVMRANK WHGGNQSVVM YNIQWPLGIV AVHPSKQPNS
1710 1720 1730 1740 1750
VNPCAFSRCS HLCLLSSQGP HFYSCVCPSG WSLSPDLLNC LRDDQPFLIT
1760 1770 1780 1790 1800
VRQHIIFGIS LNPEVKSNDA MVPIAGIQNG LDVEFDDAEQ YIYWVENPGE
1810 1820 1830 1840 1850
IHRVKTDGTN RTVFASISMV GPSMNLALDW ISRNLYSTNP RTQSIEVLTL
1860 1870 1880 1890 1900
HGDIRYRKTL IANDGTALGV GFPIGITVDP ARGKLYWSDQ GTDSGVPAKI
1910 1920 1930 1940 1950
ASANMDGTSV KTLFTGNLEH LECVTLDIEE QKLYWAVTGR GVIERGNVDG
1960 1970 1980 1990 2000
TDRMILVHQL SHPWGIAVHD SFLYYTDEQY EVIERVDKAT GANKIVLRDN
2010 2020 2030 2040 2050
VPNLRGLQVY HRRNAAESSN GCSNNMNACQ QICLPVPGGL FSCACATGFK
2060 2070 2080 2090 2100
LNPDNRSCSP YNSFIVVSML SAIRGFSLEL SDHSETMVPV AGQGRNALHV
2110 2120 2130 2140 2150
DVDVSSGFIY WCDFSSSVAS DNAIRRIKPD GSSLMNIVTH GIGENGVRGI
2160 2170 2180 2190 2200
AVDWVAGNLY FTNAFVSETL IEVLRINTTY RRVLLKVTVD MPRHIVVDPK
2210 2220 2230 2240 2250
NRYLFWADYG QRPKIERSFL DCTNRTVLVS EGIVTPRGLA VDRSDGYVYW
2260 2270 2280 2290 2300
VDDSLDIIAR IRINGENSEV IRYGSRYPTP YGITVFENSI IWVDRNLKKI
2310 2320 2330 2340 2350
FQASKEPENT EPPTVIRDNI NWLRDVTIFD KQVQPRSPAE VNNNPCLENN
2360 2370 2380 2390 2400
GGCSHLCFAL PGLHTPKCDC AFGTLQSDGK NCAISTENFL IFALSNSLRS
2410 2420 2430 2440 2450
LHLDPENHSP PFQTINVERT VMSLDYDSVS DRIYFTQNLA SGVGQISYAT
2460 2470 2480 2490 2500
LSSGIHTPTV IASGIGTADG IAFDWITRRI YYSDYLNQMI NSMAEDGSNR
2510 2520 2530 2540 2550
TVIARVPKPR AIVLDPCQGY LYWADWDTHA KIERATLGGN FRVPIVNSSL
2560 2570 2580 2590 2600
VMPSGLTLDY EEDLLYWVDA SLQRIERSTL TGVDREVIVN AAVHAFGLTL
2610 2620 2630 2640 2650
YGQYIYWTDL YTQRIYRANK YDGSGQIAMT TNLLSQPRGI NTVVKNQKQQ
2660 2670 2680 2690 2700
CNNPCEQFNG GCSHICAPGP NGAECQCPHE GNWYLANNRK HCIVDNGERC
2710 2720 2730 2740 2750
GASSFTCSNG RCISEEWKCD NDNDCGDGSD EMESVCALHT CSPTAFTCAN
2760 2770 2780 2790 2800
GRCVQYSYRC DYYNDCGDGS DEAGCLFRDC NATTEFMCNN RRCIPREFIC
2810 2820 2830 2840 2850
NGVDNCHDNN TSDEKNCPDR TCQSGYTKCH NSNICIPRVY LCDGDNDCGD
2860 2870 2880 2890 2900
NSDENPTYCT THTCSSSEFQ CASGRCIPQH WYCDQETDCF DASDEPASCG
2910 2920 2930 2940 2950
HSERTCLADE FKCDGGRCIP SEWICDGDND CGDMSDEDKR HQCQNQNCSD
2960 2970 2980 2990 3000
SEFLCVNDRP PDRRCIPQSW VCDGDVDCTD GYDENQNCTR RTCSENEFTC
3010 3020 3030 3040 3050
GYGLCIPKIF RCDRHNDCGD YSDERGCLYQ TCQQNQFTCQ NGRCISKTFV
3060 3070 3080 3090 3100
CDEDNDCGDG SDELMHLCHT PEPTCPPHEF KCDNGRCIEM MKLCNHLDDC
3110 3120 3130 3140 3150
LDNSDEKGCG INECHDPSIS GCDHNCTDTL TSFYCSCRPG YKLMSDKRTC
3160 3170 3180 3190 3200
VDIDECTEMP FVCSQKCENV IGSYICKCAP GYLREPDGKT CRQNSNIEPY
3210 3220 3230 3240 3250
LIFSNRYYLR NLTIDGYFYS LILEGLDNVV ALDFDRVEKR LYWIDTQRQV
3260 3270 3280 3290 3300
IERMFLNKTN KETIINHRLP AAESLAVDWV SRKLYWLDAR LDGLFVSDLN
3310 3320 3330 3340 3350
GGHRRMLAQH CVDANNTFCF DNPRGLALHP QYGYLYWADW GHRAYIGRVG
3360 3370 3380 3390 3400
MDGTNKSVII STKLEWPNGI TIDYTNDLLY WADAHLGYIE YSDLEGHHRH
3410 3420 3430 3440 3450
TVYDGALPHP FAITIFEDTI YWTDWNTRTV EKGNKYDGSN RQTLVNTTHR
3460 3470 3480 3490 3500
PFDIHVYHPY RQPIVSNPCG TNNGGCSHLC LIKPGGKGFT CECPDDFRTL
3510 3520 3530 3540 3550
QLSGSTYCMP MCSSTQFLCA NNEKCIPIWW KCDGQKDCSD GSDELALCPQ
3560 3570 3580 3590 3600
RFCRLGQFQC SDGNCTSPQT LCNAHQNCPD GSDEDRLLCE NHHCDSNEWQ
3610 3620 3630 3640 3650
CANKRCIPES WQCDTFNDCE DNSDEDSSHC ASRTCRPGQF RCANGRCIPQ
3660 3670 3680 3690 3700
AWKCDVDNDC GDHSDEPIEE CMSSAHLCDN FTEFSCKTNY RCIPKWAVCN
3710 3720 3730 3740 3750
GVDDCRDNSD EQGCEERTCH PVGDFRCKNH HCIPLRWQCD GQNDCGDNSD
3760 3770 3780 3790 3800
EENCAPRECT ESEFRCVNQQ CIPSRWICDH YNDCGDNSDE RDCEMRTCHP
3810 3820 3830 3840 3850
EYFQCTSGHC VHSELKCDGS ADCLDASDEA DCPTRFPDGA YCQATMFECK
3860 3870 3880 3890 3900
NHVCIPPYWK CDGDDDCGDG SDEELHLCLD VPCNSPNRFR CDNNRCIYSH
3910 3920 3930 3940 3950
EVCNGVDDCG DGTDETEEHC RKPTPKPCTE YEYKCGNGHC IPHDNVCDDA
3960 3970 3980 3990 4000
DDCGDWSDEL GCNKGKERTC AENICEQNCT QLNEGGFICS CTAGFETNVF
4010 4020 4030 4040 4050
DRTSCLDINE CEQFGTCPQH CRNTKGSYEC VCADGFTSMS DRPGKRCAAE
4060 4070 4080 4090 4100
GSSPLLLLPD NVRIRKYNLS SERFSEYLQD EEYIQAVDYD WDPEDIGLSV
4110 4120 4130 4140 4150
VYYTVRGEGS RFGAIKRAYI PNFESGRNNL VQEVDLKLKY VMQPDGIAVD
4160 4170 4180 4190 4200
WVGRHIYWSD VKNKRIEVAK LDGRYRKWLI STDLDQPAAI AVNPKLGLMF
4210 4220 4230 4240 4250
WTDWGKEPKL ESAWMNGEDR NILVFEDLGW PTGLSIDYLN NDRIYWSDFK
4260 4270 4280 4290 4300
EDVIETIKYD GTDRRVIAKE AMNPYSLDIF EDQLYWISKE KGEVWKQNKF
4310 4320 4330 4340 4350
GQGKKEKTLV VNPWLTQVRI FHQLRYNKSV PNLCKQICSH LCLLRPGGYS
4360 4370 4380 4390 4400
CACPQGSSFI EGSTTECDAA IELPINLPPP CRCMHGGNCY FDETDLPKCK
4410 4420 4430 4440 4450
CPSGYTGKYC EMAFSKGISP GTTAVAVLLT ILLIVVIGAL AIAGFFHYRR
4460 4470 4480 4490 4500
TGSLLPALPK LPSLSSLVKP SENGNGVTFR SGADLNMDIG VSGFGPETAI
4510 4520 4530 4540 4550
DRSMAMSEDF VMEMGKQPII FENPMYSARD SAVKVVQPIQ VTVSENVDNK
4560 4570 4580 4590 4600
NYGSPINPSE IVPETNPTSP AADGTQVTKW NLFKRKSKQT TNFENPIYAQ
4610 4620 4630 4640 4650
MENEQKESVA ATPPPSPSLP AKPKPPSRRD PTPTYSATED TFKDTANLVK

EDSEV
Length:4,655
Mass (Da):521,932
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBDFF6846CC129B69
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY265358 mRNA Translation: AAP88586.1

NCBI Reference Sequences

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RefSeqi
NP_004516.2, NM_004525.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
4036

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4036

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY265358 mRNA Translation: AAP88586.1
RefSeqiNP_004516.2, NM_004525.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ7Z5C0

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4036

Genome annotation databases

GeneIDi4036
KEGGihsa:4036

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4036
PharmGKBiPA30452

Phylogenomic databases

OMAiDGHQYNL
OrthoDBi1606at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
4036, 4 hits in 988 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4036

Gene expression databases

GenevisibleiQ7Z5C0, HS

Family and domain databases

CDDicd00112, LDLa, 34 hits
Gene3Di2.120.10.30, 8 hits
4.10.400.10, 36 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
IPR019825, Lectin_legB_Mn/Ca_BS
PfamiView protein in Pfam
PF12662, cEGF, 1 hit
PF07645, EGF_CA, 2 hits
PF00057, Ldl_recept_a, 34 hits
PF00058, Ldl_recept_b, 14 hits
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00181, EGF, 26 hits
SM00179, EGF_CA, 10 hits
SM00192, LDLa, 36 hits
SM00135, LY, 38 hits
SUPFAMiSSF57184, SSF57184, 2 hits
SSF57424, SSF57424, 36 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 4 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 6 hits
PS01187, EGF_CA, 3 hits
PS01209, LDLRA_1, 17 hits
PS50068, LDLRA_2, 36 hits
PS51120, LDLRB, 35 hits
PS00307, LECTIN_LEGUME_BETA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7Z5C0_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z5C0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: April 7, 2021
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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