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Protein

Protein RIC-3

Gene

RIC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • acetylcholine receptor binding Source: GO_Central
  • protein binding involved in protein folding Source: Ensembl

GO - Biological processi

Protein family/group databases

Transport Classification Database

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TCDBi
8.A.71.1.1 the ric3 protein (ric3) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein RIC-3
Alternative name(s):
Resistant to inhibitor of cholinesterase 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RIC3
ORF Names:UNQ720/PRO1385
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000166405.14

Human Gene Nomenclature Database

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HGNCi
HGNC:30338 RIC3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610509 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q7Z5B4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 95LumenalSequence analysisAdd BLAST67
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 369CytoplasmicSequence analysisAdd BLAST253

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
79608

Open Targets

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OpenTargetsi
ENSG00000166405

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA142671066

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
RIC3

Domain mapping of disease mutations (DMDM)

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DMDMi
74713638

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28By similarityAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030273129 – 369Protein RIC-3Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei202N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki202Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7Z5B4

PRoteomics IDEntifications database

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PRIDEi
Q7Z5B4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69281
69282 [Q7Z5B4-2]
69283 [Q7Z5B4-3]
69284 [Q7Z5B4-5]
69285 [Q7Z5B4-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q7Z5B4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z5B4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000166405 Expressed in 111 organ(s), highest expression level in left lobe of thyroid gland

CleanEx database of gene expression profiles

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CleanExi
HS_RIC3

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7Z5B4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7Z5B4 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA065016

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer. Interacts with CHRNA7, CHRNA3, CHRNA4, CHRNB2, CHRNB4 and HTR3A.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122743, 35 interactors

Protein interaction database and analysis system

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IntActi
Q7Z5B4, 16 interactors

Molecular INTeraction database

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MINTi
Q7Z5B4

STRING: functional protein association networks

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STRINGi
9606.ENSP00000308820

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q7Z5B4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7Z5B4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili140 – 169By similarityAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi81 – 94Poly-GlyAdd BLAST14
Compositional biasi269 – 272Poly-Glu4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled-coil domain mediates transient homodimerization with other acetylcholine receptor-bound RIC3 molecules, promoting stepwise ACHR homomeric assembly at the membrane.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ric-3 family.Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IK2V Eukaryota
ENOG410XS3H LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00440000034107

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000034648

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG106009

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z5B4

Identification of Orthologs from Complete Genome Data

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OMAi
DCIKHRQ

Database of Orthologous Groups

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OrthoDBi
1096847at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7Z5B4

TreeFam database of animal gene trees

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TreeFami
TF333291

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR026160 Ric3
IPR032763 RIC3_N

The PANTHER Classification System

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PANTHERi
PTHR21723 PTHR21723, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF15361 RIC3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z5B4-1) [UniParc]FASTAAdd to basket
Also known as: a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAYSTVQRVA LASGLVLALS LLLPKAFLSR GKRQEPPPTP EGKLGRFPPM
60 70 80 90 100
MHHHQAPSDG QTPGARFQRS HLAEAFAKAK GSGGGAGGGG SGRGLMGQII
110 120 130 140 150
PIYGFGIFLY ILYILFKLSK GKTTAEDGKC YTAMPGNTHR KITSFELAQL
160 170 180 190 200
QEKLKETEAA MEKLINRVGP NGESRAQTVT SDQEKRLLHQ LREITRVMKE
210 220 230 240 250
GKFIDRFSPE KEAEEAPYME DWEGYPEETY PIYDLSDCIK RRQETILVDY
260 270 280 290 300
PDPKELSAEE IAERMGMIEE EESDHLGWES LPTDPRAQED NSVTSCDPKP
310 320 330 340 350
ETCSCCFHED EDPAVLAENA GFSADSYPEQ EETTKEEWSQ DFKDEGLGIS
360
TDKAYTGSML RKRNPQGLE
Length:369
Mass (Da):41,092
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15FD70384070345D
GO
Isoform 2 (identifier: Q7Z5B4-2) [UniParc]FASTAAdd to basket
Also known as: d

The sequence of this isoform differs from the canonical sequence as follows:
     118-128: LSKGKTTAEDG → VSRIILIILHQ
     129-369: Missing.

Show »
Length:128
Mass (Da):13,663
Checksum:i01D76A36CC9F0C2F
GO
Isoform 3 (identifier: Q7Z5B4-3) [UniParc]FASTAAdd to basket
Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     41-222: Missing.

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):20,954
Checksum:iC51C0B8B8F21B4B2
GO
Isoform 4 (identifier: Q7Z5B4-5) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     174-174: Missing.

Show »
Length:368
Mass (Da):41,005
Checksum:iC66CFFD8641778DA
GO
Isoform 5 (identifier: Q7Z5B4-6) [UniParc]FASTAAdd to basket
Also known as: e

The sequence of this isoform differs from the canonical sequence as follows:
     143-224: TSFELAQLQE...EAPYMEDWEG → S

Show »
Length:288
Mass (Da):31,643
Checksum:i2D0010517F3E6E20
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PK46E9PK46_HUMAN
Protein RIC-3
RIC3
328Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKX8E9PKX8_HUMAN
Protein RIC-3
RIC3
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNI0E9PNI0_HUMAN
Protein RIC-3
RIC3
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13871 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti23Missing in AAP92163 (PubMed:12821669).Curated1
Sequence conflicti165I → F in AAH22455 (PubMed:15489334).Curated1
Isoform 2 (identifier: Q7Z5B4-2)
Sequence conflicti124I → T in AAP92163 (PubMed:12821669).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03494357P → H1 PublicationCorresponds to variant dbSNP:rs17855498Ensembl.1
Natural variantiVAR_062208130C → Y. Corresponds to variant dbSNP:rs55990541Ensembl.1
Natural variantiVAR_036391346G → V in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02793941 – 222Missing in isoform 3. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_027940118 – 128LSKGKTTAEDG → VSRIILIILHQ in isoform 2. 2 PublicationsAdd BLAST11
Alternative sequenceiVSP_027941129 – 369Missing in isoform 2. 2 PublicationsAdd BLAST241
Alternative sequenceiVSP_043786143 – 224TSFEL…EDWEG → S in isoform 5. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_027943174Missing in isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY326435 mRNA Translation: AAP92162.1
AY326436 mRNA Translation: AAP92163.1
AM422214 mRNA Translation: CAM12309.1
AY358475 mRNA Translation: AAQ88839.1
AK021670 mRNA Translation: BAB13871.1 Sequence problems.
AK315379 mRNA Translation: BAG37772.1
AL832601 mRNA Translation: CAD89943.1
AC091013 Genomic DNA No translation available.
AC116456 Genomic DNA No translation available.
AC129895 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68628.1
CH471064 Genomic DNA Translation: EAW68630.1
BC022455 mRNA Translation: AAH22455.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44533.1 [Q7Z5B4-3]
CCDS55741.1 [Q7Z5B4-6]
CCDS55742.1 [Q7Z5B4-1]
CCDS7788.1 [Q7Z5B4-5]

NCBI Reference Sequences

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RefSeqi
NP_001128581.1, NM_001135109.3 [Q7Z5B4-3]
NP_001193600.1, NM_001206671.3 [Q7Z5B4-1]
NP_001193601.1, NM_001206672.3 [Q7Z5B4-6]
NP_001333619.1, NM_001346690.1
NP_078833.3, NM_024557.5 [Q7Z5B4-5]
XP_006718381.1, XM_006718318.3 [Q7Z5B4-5]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.231850
Hs.568986
Hs.720186
Hs.733193

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000309737; ENSP00000308820; ENSG00000166405 [Q7Z5B4-1]
ENST00000335425; ENSP00000333988; ENSG00000166405 [Q7Z5B4-3]
ENST00000343202; ENSP00000344904; ENSG00000166405 [Q7Z5B4-5]
ENST00000419822; ENSP00000404415; ENSG00000166405 [Q7Z5B4-2]
ENST00000425599; ENSP00000395320; ENSG00000166405 [Q7Z5B4-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
79608

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:79608

UCSC genome browser

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UCSCi
uc001mgc.3 human [Q7Z5B4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY326435 mRNA Translation: AAP92162.1
AY326436 mRNA Translation: AAP92163.1
AM422214 mRNA Translation: CAM12309.1
AY358475 mRNA Translation: AAQ88839.1
AK021670 mRNA Translation: BAB13871.1 Sequence problems.
AK315379 mRNA Translation: BAG37772.1
AL832601 mRNA Translation: CAD89943.1
AC091013 Genomic DNA No translation available.
AC116456 Genomic DNA No translation available.
AC129895 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68628.1
CH471064 Genomic DNA Translation: EAW68630.1
BC022455 mRNA Translation: AAH22455.1
CCDSiCCDS44533.1 [Q7Z5B4-3]
CCDS55741.1 [Q7Z5B4-6]
CCDS55742.1 [Q7Z5B4-1]
CCDS7788.1 [Q7Z5B4-5]
RefSeqiNP_001128581.1, NM_001135109.3 [Q7Z5B4-3]
NP_001193600.1, NM_001206671.3 [Q7Z5B4-1]
NP_001193601.1, NM_001206672.3 [Q7Z5B4-6]
NP_001333619.1, NM_001346690.1
NP_078833.3, NM_024557.5 [Q7Z5B4-5]
XP_006718381.1, XM_006718318.3 [Q7Z5B4-5]
UniGeneiHs.231850
Hs.568986
Hs.720186
Hs.733193

3D structure databases

ProteinModelPortaliQ7Z5B4
SMRiQ7Z5B4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122743, 35 interactors
IntActiQ7Z5B4, 16 interactors
MINTiQ7Z5B4
STRINGi9606.ENSP00000308820

Protein family/group databases

TCDBi8.A.71.1.1 the ric3 protein (ric3) family

PTM databases

iPTMnetiQ7Z5B4
PhosphoSitePlusiQ7Z5B4

Polymorphism and mutation databases

BioMutaiRIC3
DMDMi74713638

Proteomic databases

PaxDbiQ7Z5B4
PRIDEiQ7Z5B4
ProteomicsDBi69281
69282 [Q7Z5B4-2]
69283 [Q7Z5B4-3]
69284 [Q7Z5B4-5]
69285 [Q7Z5B4-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309737; ENSP00000308820; ENSG00000166405 [Q7Z5B4-1]
ENST00000335425; ENSP00000333988; ENSG00000166405 [Q7Z5B4-3]
ENST00000343202; ENSP00000344904; ENSG00000166405 [Q7Z5B4-5]
ENST00000419822; ENSP00000404415; ENSG00000166405 [Q7Z5B4-2]
ENST00000425599; ENSP00000395320; ENSG00000166405 [Q7Z5B4-6]
GeneIDi79608
KEGGihsa:79608
UCSCiuc001mgc.3 human [Q7Z5B4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79608
DisGeNETi79608
EuPathDBiHostDB:ENSG00000166405.14

GeneCards: human genes, protein and diseases

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GeneCardsi
RIC3

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0009421
HGNCiHGNC:30338 RIC3
HPAiHPA065016
MIMi610509 gene
neXtProtiNX_Q7Z5B4
OpenTargetsiENSG00000166405
PharmGKBiPA142671066

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IK2V Eukaryota
ENOG410XS3H LUCA
GeneTreeiENSGT00440000034107
HOGENOMiHOG000034648
HOVERGENiHBG106009
InParanoidiQ7Z5B4
OMAiDCIKHRQ
OrthoDBi1096847at2759
PhylomeDBiQ7Z5B4
TreeFamiTF333291

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RIC3 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RIC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79608

Protein Ontology

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PROi
PR:Q7Z5B4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166405 Expressed in 111 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_RIC3
ExpressionAtlasiQ7Z5B4 baseline and differential
GenevisibleiQ7Z5B4 HS

Family and domain databases

InterProiView protein in InterPro
IPR026160 Ric3
IPR032763 RIC3_N
PANTHERiPTHR21723 PTHR21723, 1 hit
PfamiView protein in Pfam
PF15361 RIC3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRIC3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z5B4
Secondary accession number(s): B0B1U0
, B2RD25, D3DQU5, Q6UX78, Q7Z5B3, Q86T94, Q8TBJ9, Q9HAH8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2003
Last modified: January 16, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
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