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Protein

Serine protease 42

Gene

PRSS42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei120Charge relay systemBy similarity1
Active sitei166Charge relay systemBy similarity1
Active sitei267Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.362

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease 42 (EC:3.4.21.-)
Alternative name(s):
Testis serine protease 2
Gene namesi
Name:PRSS42
Synonyms:TESSP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000178055.11
HGNCiHGNC:30716 PRSS42
neXtProtiNX_Q7Z5A4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178055
PharmGKBiPA165698214

Polymorphism and mutation databases

BioMutaiPRSS42
DMDMi74759189

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500007058427 – 293Serine protease 42Add BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi105 ↔ 121PROSITE-ProRule annotation
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi200 ↔ 273PROSITE-ProRule annotation
Disulfide bondi232 ↔ 253PROSITE-ProRule annotation
Disulfide bondi263 ↔ 291PROSITE-ProRule annotation
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7Z5A4
PeptideAtlasiQ7Z5A4
PRIDEiQ7Z5A4
ProteomicsDBi69274

PTM databases

iPTMnetiQ7Z5A4
PhosphoSitePlusiQ7Z5A4

Expressioni

Gene expression databases

BgeeiENSG00000178055
ExpressionAtlasiQ7Z5A4 baseline and differential

Organism-specific databases

HPAiHPA046925

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DMBX1Q8NFW54EBI-13040866,EBI-12823415

Protein-protein interaction databases

BioGridi130963, 1 interactor
IntActiQ7Z5A4, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ7Z5A4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 293Peptidase S1PROSITE-ProRule annotationAdd BLAST214

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00900000140825
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ7Z5A4
OMAiCEYNDTW
OrthoDBiEOG091G0AH5
PhylomeDBiQ7Z5A4
TreeFamiTF351676

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z5A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSGGGSRGL LAWLLLLQPW PGQNWAGMAA PRLPSPLLSE EGGENPEASP
60 70 80 90 100
APGPEAGPPL NLFTSFPGDS LLCGRTPLRI VGGVDAEEGR WPWQVSVRTK
110 120 130 140 150
GRHICGGTLV TATWVLTAGH CISSRFHYSV KMGDRSVYNE NTSVVVSVQR
160 170 180 190 200
AFVHPKFSTV TTIRNDLALL QLQHPVNFTS NIQPICIPQE NFQVEGRTRC
210 220 230 240 250
WVTGWGKTPE REKLASEILQ DVDQYIMCYE ECNKIIQKAL SSTKDVIIKG
260 270 280 290
MVCGYKEQGK DSCQGDSGGR LACEYNDTWV QVGIVSWGIG CGR
Length:293
Mass (Da):32,006
Last modified:October 1, 2003 - v1
Checksum:iE49251407381B489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ544583 mRNA Translation: CAD67566.1
CH471055 Genomic DNA Translation: EAW64788.1
CCDSiCCDS46816.1
RefSeqiNP_874361.1, NM_182702.1
UniGeneiHs.585127

Genome annotation databases

EnsembliENST00000429665; ENSP00000401701; ENSG00000178055
GeneIDi339906
KEGGihsa:339906
UCSCiuc011bap.2 human

Similar proteinsi

Entry informationi

Entry nameiPRS42_HUMAN
AccessioniPrimary (citable) accession number: Q7Z5A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2003
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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