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Entry version 125 (16 Oct 2019)
Sequence version 2 (29 May 2007)
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Protein

Microtubule organization protein AKNA

Gene

AKNA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable).By similarityCurated1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1115 – 1123A.T hook9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processNeurogenesis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule organization protein AKNACurated
Alternative name(s):
AT-hook-containing transcription factor1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKNA1 PublicationImported
Synonyms:KIAA19681 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24108 AKNA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605729 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z591

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80709

Open Targets

More...
OpenTargetsi
ENSG00000106948

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134908332

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z591

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AKNA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
150416853

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002891591 – 1439Microtubule organization protein AKNAAdd BLAST1439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52PhosphoserineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1
Modified residuei767PhosphoserineCombined sources1
Modified residuei770PhosphoserineCombined sources1
Modified residuei848PhosphoserineCombined sources1
Modified residuei886PhosphoserineCombined sources1
Modified residuei997PhosphoserineCombined sources1
Modified residuei1010PhosphoserineCombined sources1
Modified residuei1172PhosphoserineBy similarity1
Modified residuei1173PhosphoserineBy similarity1
Modified residuei1228PhosphoserineCombined sources1
Modified residuei1377PhosphoserineCombined sources1
Modified residuei1387PhosphoserineCombined sources1
Modified residuei1424PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; phosphorylation regulates dissociation from and reassembly at the centrosome.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z591

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z591

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z591

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z591

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z591

PeptideAtlas

More...
PeptideAtlasi
Q7Z591

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z591

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69266 [Q7Z591-1]
69267 [Q7Z591-2]
69268 [Q7Z591-3]
69269 [Q7Z591-4]
69270 [Q7Z591-5]
69271 [Q7Z591-6]
69272 [Q7Z591-7]
69273 [Q7Z591-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z591

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z591

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q7Z591

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by B- and T-lymphocytes, Natural killer cells and CD1a+CD14- but not CD1a-CD14+ dendritic cells. Weakly or not expressed in fetal liver and in adult bone marrow.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106948 Expressed in 167 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z591 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052367
HPA063993

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DCTN1.

Interacts with MAPRE1/EB1.

Interacts with ODF2.

Interacts with CAMSAP3.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123268, 3 interactors

Protein interaction database and analysis system

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IntActi
Q7Z591, 3 interactors

Molecular INTeraction database

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MINTi
Q7Z591

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000303769

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z591

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni771 – 804PESTAdd BLAST34
Regioni911 – 932PESTAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AKNA family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDZE Eukaryota
ENOG4111ICK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154254

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z591

KEGG Orthology (KO)

More...
KOi
K21404

Identification of Orthologs from Complete Genome Data

More...
OMAi
TPGKFDP

Database of Orthologous Groups

More...
OrthoDBi
112521at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z591

TreeFam database of animal gene trees

More...
TreeFami
TF336885

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022150 AKNA

The PANTHER Classification System

More...
PANTHERi
PTHR21510 PTHR21510, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12443 AKNA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z591-1) [UniParc]FASTAAdd to basket
Also known as: B21 Publication, D1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSETEIRW AEPGLGKGPQ RRRWAWAEDK RDVDRSSSQS WEEERLFPNA
60 70 80 90 100
TSPELLEDFR LAQQHLPPLE WDPHPQPDGH QDSESGETSG EEAEAEDVDS
110 120 130 140 150
PASSHEPLAW LPQQGRQLDM TEEEPDGTLG SLEVEEAGES SSRLGYEAGL
160 170 180 190 200
SLEGHGNTSP MALGHGQARG WVASGEQASG DKLSEHSEVN PSVELSPARS
210 220 230 240 250
WSSGTVSLDH PSDSLDSTWE GETDGPQPTA LAETLPEGPS HHLLSPDGRT
260 270 280 290 300
GGSVARATPM EFQDSSAPPA QSPQHATDRW RRETTRFFCP QPKEHIWKQT
310 320 330 340 350
KTSPKPLPSR FIGSISPLNP QPRPTRQGRP LPRQGATLAG RSSSNAPKYG
360 370 380 390 400
RGQLNYPLPD FSKVGPRVRF PKDESYRPPK SRSHNRKPQA PARPLIFKSP
410 420 430 440 450
AEIVQEVLLS SGEAALAKDT PPAHPITRVP QEFQTPEQAT ELVHQLQEDY
460 470 480 490 500
HRLLTKYAEA ENTIDQLRLG AKVNLFSDPP QPNHSIHTGM VPQGTKVLSF
510 520 530 540 550
TIPQPRSAEW WPGPAEDPQA SAASGWPSAR GDLSPSSLTS MPTLGWLPEN
560 570 580 590 600
RDISEDQSSA EQTQALASQA SQFLAKVESF ERLIQAGRLM PQDQVKGFQR
610 620 630 640 650
LKAAHAALEE EYLKACREQH PAQPLAGSKG TPGRFDPRRE LEAEIYRLGS
660 670 680 690 700
CLEELKEHID QTQQEPEPPG SDSALDSTPA LPCLHQPTHL PAPSGQAPMP
710 720 730 740 750
AIKTSCPEPA TTTAAASTGP CPLHVNVEVS SGNSEVEDRP QDPLARLRHK
760 770 780 790 800
ELQMEQVYHG LMERYLSVKS LPEAMRMEEE EEGEEEEEEE GGGDSLEVDG
810 820 830 840 850
VAATPGKAEA TRVLPRQCPV QAEKSHGAPL EEATEKMVSM KPPGFQASLA
860 870 880 890 900
RDGHMSGLGK AEAAPPGPGV PPHPPGTKSA ASHQSSMTSL EGSGISERLP
910 920 930 940 950
QKPLHRGGGP HLEETWMASP ETDSGFVGSE TSRVSPLTQT PEHRLSHIST
960 970 980 990 1000
AGTLAQPFAA SVPRDGASYP KARGSLIPRR ATEPSTPRSQ AQRYLSSPSG
1010 1020 1030 1040 1050
PLRQRAPNFS LERTLAAEMA VPGSEFEGHK RISEQPLPNK TISPPPAPAP
1060 1070 1080 1090 1100
AAAPLPCGPT ETIPSFLLTR AGRDQAICEL QEEVSRLRLR LEDSLHQPLQ
1110 1120 1130 1140 1150
GSPTRPASAF DRPARTRGRP ADSPATWGSH YGSKSTERLP GEPRGEEQIV
1160 1170 1180 1190 1200
PPGRQRARSS SVPREVLRLS LSSESELPSL PLFSEKSKTT KDSPQAARDG
1210 1220 1230 1240 1250
KRGVGSAGWP DRVTFRGQYT GHEYHVLSPK AVPKGNGTVS CPHCRPIRTQ
1260 1270 1280 1290 1300
DAGGAVTGDP LGPPPADTLQ CPLCGQVGSP PEADGPGSAT SGAEKATTRR
1310 1320 1330 1340 1350
KASSTPSPKQ RSKQAGSSPR PPPGLWYLAT APPAPAPPAF AYISSVPIMP
1360 1370 1380 1390 1400
YPPAAVYYAP AGPTSAQPAA KWPPTASPPP ARRHRHSIQL DLGDLEELNK
1410 1420 1430
ALSRAVQAAE SVRSTTRQMR SSLSADLRQA HSLRGSCLF
Length:1,439
Mass (Da):155,139
Last modified:May 29, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51688A0C5C55A7BE
GO
Isoform 2 (identifier: Q7Z591-2) [UniParc]FASTAAdd to basket
Also known as: E1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MASSETEIRW...DSESGETSGE → MLRSEWPVFP

Show »
Length:1,358
Mass (Da):145,921
Checksum:iA96C7EBC4EF10401
GO
Isoform 3 (identifier: Q7Z591-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     832-1439: Missing.

Show »
Length:831
Mass (Da):90,917
Checksum:i60F24D16072CF37D
GO
Isoform 4 (identifier: Q7Z591-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1055: Missing.
     1056-1074: PCGPTETIPSFLLTRAGRD → MSAGGGTRGYSPRSPGATS

Note: No experimental confirmation available.
Show »
Length:384
Mass (Da):40,606
Checksum:iD195D6878CCF4F5C
GO
Isoform 5 (identifier: Q7Z591-5) [UniParc]FASTAAdd to basket
Also known as: F11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-753: Missing.

Show »
Length:686
Mass (Da):72,810
Checksum:i77843A242C71E4E2
GO
Isoform 6 (identifier: Q7Z591-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     448-572: EDYHRLLTKY...TQALASQASQ → VSGTHGCGCV...GGWLGQEALG
     573-1439: Missing.

Show »
Length:572
Mass (Da):61,839
Checksum:iC5AA7024B767C695
GO
Isoform 7 (identifier: Q7Z591-7) [UniParc]FASTAAdd to basket
Also known as: A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-119: Missing.

Show »
Length:1,320
Mass (Da):141,619
Checksum:iBB6B6B38C6C0AFB0
GO
Isoform 8 (identifier: Q7Z591-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-540: Missing.

Show »
Length:899
Mass (Da):96,014
Checksum:iCB0341DD1715B61F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK83024 differs from that shown. Reason: Frameshift.Curated
The sequence AAU34192 differs from that shown. Reason: Frameshift.Curated
The sequence BAB84866 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB85554 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC85132 differs from that shown. Reason: Frameshift.Curated
The sequence BAD18725 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti799D → V in BAD18725 (PubMed:14702039).Curated1
Sequence conflicti799D → V in BAC85132 (PubMed:14702039).Curated1
Sequence conflicti816R → S in BAD18725 (PubMed:14702039).Curated1
Sequence conflicti1037L → F in AAK83024 (PubMed:11268217).Curated1
Sequence conflicti1103P → Q in BAD18725 (PubMed:14702039).Curated1
Sequence conflicti1114A → P in BAD18725 (PubMed:14702039).Curated1
Sequence conflicti1429Q → P in BAD18725 (PubMed:14702039).Curated1
Sequence conflicti1435 – 1436GS → AP in BAD18725 (PubMed:14702039).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032586624P → L2 PublicationsCorresponds to variant dbSNP:rs3748176Ensembl.1
Natural variantiVAR_0325871097Q → R. Corresponds to variant dbSNP:rs1265891Ensembl.1
Natural variantiVAR_0325881119R → Q1 PublicationCorresponds to variant dbSNP:rs3748178Ensembl.1
Natural variantiVAR_0325891303S → P2 PublicationsCorresponds to variant dbSNP:rs2250242Ensembl.1
Natural variantiVAR_0325901327Y → C. Corresponds to variant dbSNP:rs2787344Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0259321 – 1055Missing in isoform 4. 1 PublicationAdd BLAST1055
Alternative sequenceiVSP_0259331 – 753Missing in isoform 5. 1 PublicationAdd BLAST753
Alternative sequenceiVSP_0259341 – 540Missing in isoform 8. 1 PublicationAdd BLAST540
Alternative sequenceiVSP_0259351 – 119Missing in isoform 7. 1 PublicationAdd BLAST119
Alternative sequenceiVSP_0259361 – 91MASSE…ETSGE → MLRSEWPVFP in isoform 2. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_025937448 – 572EDYHR…SQASQ → VSGTHGCGCVTKAPVGLGWR LIGVGRPGVEAGWGGEAWDR AWLGWEALGRRLVGWGGLGW RLARVGSPGMEASGVGRPGV GSPGVEPGGVGRPGVEAGWG RKPWDRGWWGGEAWGGGWLG QEALG in isoform 6. 1 PublicationAdd BLAST125
Alternative sequenceiVSP_025938573 – 1439Missing in isoform 6. 1 PublicationAdd BLAST867
Alternative sequenceiVSP_025939832 – 1439Missing in isoform 3. 1 PublicationAdd BLAST608
Alternative sequenceiVSP_0259401056 – 1074PCGPT…RAGRD → MSAGGGTRGYSPRSPGATS in isoform 4. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY703039 mRNA Translation: AAU34186.1
AY703043 mRNA Translation: AAU34190.1
AY703044 mRNA Translation: AAU34191.1
AY703045 mRNA Translation: AAU34192.1 Frameshift.
AB075848 mRNA Translation: BAB85554.1 Different initiation.
AK024431 mRNA Translation: BAB15721.1
AK074040 mRNA Translation: BAB84866.1 Different initiation.
AK131082 mRNA Translation: BAC85132.1 Sequence problems.
AK160382 mRNA Translation: BAD18725.1 Sequence problems.
AL356796 Genomic DNA No translation available.
BC042202 mRNA Translation: AAH42202.1
BC055285 mRNA Translation: AAH55285.1
AF286341 mRNA Translation: AAK83024.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6805.1 [Q7Z591-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001304879.1, NM_001317950.1 [Q7Z591-1]
NP_001304881.1, NM_001317952.1 [Q7Z591-7]
NP_110394.3, NM_030767.5 [Q7Z591-1]
XP_005252301.1, XM_005252244.2 [Q7Z591-1]
XP_005252302.1, XM_005252245.1 [Q7Z591-1]
XP_005252304.1, XM_005252247.4 [Q7Z591-1]
XP_006717357.1, XM_006717294.1 [Q7Z591-1]
XP_006717358.1, XM_006717295.2
XP_011517365.1, XM_011519063.2 [Q7Z591-7]
XP_011517367.2, XM_011519065.2 [Q7Z591-7]
XP_016870661.1, XM_017015172.1 [Q7Z591-7]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000223791; ENSP00000223791; ENSG00000106948 [Q7Z591-8]
ENST00000307564; ENSP00000303769; ENSG00000106948 [Q7Z591-1]
ENST00000312033; ENSP00000309222; ENSG00000106948 [Q7Z591-3]
ENST00000374075; ENSP00000363188; ENSG00000106948 [Q7Z591-2]
ENST00000374079; ENSP00000363192; ENSG00000106948 [Q7Z591-4]
ENST00000374088; ENSP00000363201; ENSG00000106948 [Q7Z591-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80709

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80709

UCSC genome browser

More...
UCSCi
uc004bio.5 human [Q7Z591-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY703039 mRNA Translation: AAU34186.1
AY703043 mRNA Translation: AAU34190.1
AY703044 mRNA Translation: AAU34191.1
AY703045 mRNA Translation: AAU34192.1 Frameshift.
AB075848 mRNA Translation: BAB85554.1 Different initiation.
AK024431 mRNA Translation: BAB15721.1
AK074040 mRNA Translation: BAB84866.1 Different initiation.
AK131082 mRNA Translation: BAC85132.1 Sequence problems.
AK160382 mRNA Translation: BAD18725.1 Sequence problems.
AL356796 Genomic DNA No translation available.
BC042202 mRNA Translation: AAH42202.1
BC055285 mRNA Translation: AAH55285.1
AF286341 mRNA Translation: AAK83024.1 Frameshift.
CCDSiCCDS6805.1 [Q7Z591-1]
RefSeqiNP_001304879.1, NM_001317950.1 [Q7Z591-1]
NP_001304881.1, NM_001317952.1 [Q7Z591-7]
NP_110394.3, NM_030767.5 [Q7Z591-1]
XP_005252301.1, XM_005252244.2 [Q7Z591-1]
XP_005252302.1, XM_005252245.1 [Q7Z591-1]
XP_005252304.1, XM_005252247.4 [Q7Z591-1]
XP_006717357.1, XM_006717294.1 [Q7Z591-1]
XP_006717358.1, XM_006717295.2
XP_011517365.1, XM_011519063.2 [Q7Z591-7]
XP_011517367.2, XM_011519065.2 [Q7Z591-7]
XP_016870661.1, XM_017015172.1 [Q7Z591-7]

3D structure databases

SMRiQ7Z591
ModBaseiSearch...

Protein-protein interaction databases

BioGridi123268, 3 interactors
IntActiQ7Z591, 3 interactors
MINTiQ7Z591
STRINGi9606.ENSP00000303769

PTM databases

iPTMnetiQ7Z591
PhosphoSitePlusiQ7Z591

Polymorphism and mutation databases

BioMutaiAKNA
DMDMi150416853

Proteomic databases

EPDiQ7Z591
jPOSTiQ7Z591
MassIVEiQ7Z591
MaxQBiQ7Z591
PaxDbiQ7Z591
PeptideAtlasiQ7Z591
PRIDEiQ7Z591
ProteomicsDBi69266 [Q7Z591-1]
69267 [Q7Z591-2]
69268 [Q7Z591-3]
69269 [Q7Z591-4]
69270 [Q7Z591-5]
69271 [Q7Z591-6]
69272 [Q7Z591-7]
69273 [Q7Z591-8]

Genome annotation databases

EnsembliENST00000223791; ENSP00000223791; ENSG00000106948 [Q7Z591-8]
ENST00000307564; ENSP00000303769; ENSG00000106948 [Q7Z591-1]
ENST00000312033; ENSP00000309222; ENSG00000106948 [Q7Z591-3]
ENST00000374075; ENSP00000363188; ENSG00000106948 [Q7Z591-2]
ENST00000374079; ENSP00000363192; ENSG00000106948 [Q7Z591-4]
ENST00000374088; ENSP00000363201; ENSG00000106948 [Q7Z591-1]
GeneIDi80709
KEGGihsa:80709
UCSCiuc004bio.5 human [Q7Z591-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80709
DisGeNETi80709

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AKNA
HGNCiHGNC:24108 AKNA
HPAiHPA052367
HPA063993
MIMi605729 gene
neXtProtiNX_Q7Z591
OpenTargetsiENSG00000106948
PharmGKBiPA134908332

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IDZE Eukaryota
ENOG4111ICK LUCA
GeneTreeiENSGT00940000154254
InParanoidiQ7Z591
KOiK21404
OMAiTPGKFDP
OrthoDBi112521at2759
PhylomeDBiQ7Z591
TreeFamiTF336885

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AKNA human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80709
PharosiQ7Z591
PMAP-CutDBiQ7Z591

Protein Ontology

More...
PROi
PR:Q7Z591

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106948 Expressed in 167 organ(s), highest expression level in blood
GenevisibleiQ7Z591 HS

Family and domain databases

InterProiView protein in InterPro
IPR022150 AKNA
PANTHERiPTHR21510 PTHR21510, 1 hit
PfamiView protein in Pfam
PF12443 AKNA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKNA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z591
Secondary accession number(s): Q05BK5
, Q5T535, Q5T536, Q5T537, Q64FX6, Q64FX7, Q64FX8, Q64FY2, Q6ZMK0, Q6ZNL2, Q6ZTX0, Q8TET1, Q8TF33, Q96RR9, Q9H7P7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: October 16, 2019
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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