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Protein

Zinc finger protein 804A

Gene

ZNF804A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 81C2H2-typeAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • positive regulation of dendritic spine maintenance Source: Ensembl
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of neuron projection development Source: UniProtKB
  • regulation of neuron projection development Source: UniProtKB

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 804A
Gene namesi
Name:ZNF804A
Synonyms:C2orf10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000170396.7
HGNCiHGNC:21711 ZNF804A
MIMi612282 gene
neXtProtiNX_Q7Z570

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi91752
OpenTargetsiENSG00000170396
Orphaneti3140 Schizophrenia
PharmGKBiPA162410599

Polymorphism and mutation databases

BioMutaiZNF804A
DMDMi224471869

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002325181 – 1209Zinc finger protein 804AAdd BLAST1209

Proteomic databases

EPDiQ7Z570
PaxDbiQ7Z570
PeptideAtlasiQ7Z570
PRIDEiQ7Z570
ProteomicsDBi69261

PTM databases

iPTMnetiQ7Z570
PhosphoSitePlusiQ7Z570

Expressioni

Gene expression databases

BgeeiENSG00000170396 Expressed in 101 organ(s), highest expression level in frontal cortex
CleanExiHS_ZNF804A
ExpressionAtlasiQ7Z570 baseline and differential
GenevisibleiQ7Z570 HS

Organism-specific databases

HPAiHPA029195

Interactioni

Protein-protein interaction databases

BioGridi124875, 2 interactors
IntActiQ7Z570, 2 interactors
STRINGi9606.ENSP00000303252

Structurei

3D structure databases

ProteinModelPortaliQ7Z570
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 81C2H2-typeAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IGVP Eukaryota
ENOG410ZHVS LUCA
GeneTreeiENSGT00530000063305
HOVERGENiHBG107108
InParanoidiQ7Z570
OMAiPCEVYQH
OrthoDBiEOG091G01DY
PhylomeDBiQ7Z570
TreeFamiTF332138

Family and domain databases

InterProiView protein in InterPro
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF12171 zf-C2H2_jaz, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q7Z570-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MECYYIVISS THLSNGHFRN IKGVFRGPLS KNGNKTLDYA EKENTIAKAL
60 70 80 90 100
EDLKANFYCE LCDKQYYKHQ EFDNHINSYD HAHKQRLKEL KQREFARNVA
110 120 130 140 150
SKSRKDERKQ EKALQRLHKL AELRKETVCA PGSGPMFKST TVTVRENCNE
160 170 180 190 200
ISQRVVVDSV NNQQDFKYTL IHSEENTKDA TTVAEDPESA NNYTAKNNQV
210 220 230 240 250
GDQAQGIHRH KIGFSFAFPK KASVKLESSA AAFSEYSDDA SVGKGFSRKS
260 270 280 290 300
RFVPSACHLQ QSSPTDVLLS SEEKTNSFHP PEAMCRDKET VQTQEIKEVS
310 320 330 340 350
SEKDALLLPS FCKFQLQLSS DADNCQNSVP LADQIPLESV VINEDIPVSG
360 370 380 390 400
NSFELLGNKS TVLDMSNDCI SVQATTEENV KHNEASTTEV ENKNGPETLA
410 420 430 440 450
PSNTEEVNIT IHKKTNFCKR QCEPFVPVLN KHRSTVLQWP SEMLVYTTTK
460 470 480 490 500
PSISYSCNPL CFDFKSTKVN NNLDKNKPDL KDLCSQQKQE DICMGPLSDY
510 520 530 540 550
KDVSTEGLTD YEIGSSKNKC SQVTPLLADD ILSSSCDSGK NENTGQRYKN
560 570 580 590 600
ISCKIRETEK YNFTKSQIKQ DTLDEKYNKI RLKETHEYWF HKSRRKKKRK
610 620 630 640 650
KLCQHHHMEK TKESETRCKM EAENSYTENA GKYLLEPISE KQYLAAEQLL
660 670 680 690 700
DSHQLLDKRP KSESISLSDN EEMCKTWNTE YNTYDTISSK NHCKKNTILL
710 720 730 740 750
NGQSNATMIH SGKHNLTYSR TYCCWKTKMS SCSQDHRSLV LQNDMKHMSQ
760 770 780 790 800
NQAVKRGYNS VMNESERFYR KRRQHSHSYS SDESLNRQNH LPEEFLRPPS
810 820 830 840 850
TSVAPCKPKK KRRRKRGRFH PGFETLELKE NTDYPVKDNS SLNPLDRLIS
860 870 880 890 900
EDKKEKMKPQ EVAKIERNSE QTNQLRNKLS FHPNNLLPSE TNGETEHLEM
910 920 930 940 950
ETTSGELSDV SNDPTTSVCV ASAPTKEAID NTLLEHKERS ENINLNEKQI
960 970 980 990 1000
PFQVPNIERN FRQSQPKSYL CHYELAEALP QGKMNETPTE WLRYNSGILN
1010 1020 1030 1040 1050
TQPPLPFKEA HVSGHTFVTA EQILAPLALP EQALLIPLEN HDKFKNVPCE
1060 1070 1080 1090 1100
VYQHILQPNM LANKVKFTFP PAALPPPSTP LQPLPLQQSL CSTSVTTIHH
1110 1120 1130 1140 1150
TVLQQHAAAA AAAAAAAAAG TFKVLQPHQQ FLSQIPALTR TSLPQLSVGP
1160 1170 1180 1190 1200
VGPRLCPGNQ PTFVAPPQMP IIPASVLHPS HLAFPSLPHA LFPSLLSPHP

TVIPLQPLF
Length:1,209
Mass (Da):136,888
Last modified:March 3, 2009 - v3
Checksum:i467982636EF1DFC0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X014A0A087X014_HUMAN
Zinc finger protein 804A
ZNF804A
1,124Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti492I → V in AAI50199 (PubMed:15489334).Curated1
Sequence conflicti545G → S in AAI50199 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025943261Q → L1 PublicationCorresponds to variant dbSNP:rs12476147Ensembl.1
Natural variantiVAR_035599324N → S in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_054133479D → G1 PublicationCorresponds to variant dbSNP:rs35676856Ensembl.1
Natural variantiVAR_025944542E → K1 PublicationCorresponds to variant dbSNP:rs4667001Ensembl.1
Natural variantiVAR_054134600K → R. Corresponds to variant dbSNP:rs35925696Ensembl.1
Natural variantiVAR_025945707T → K. Corresponds to variant dbSNP:rs1366842Ensembl.1
Natural variantiVAR_025946747H → R1 PublicationCorresponds to variant dbSNP:rs12477430Ensembl.1
Natural variantiVAR_0259471081L → V. Corresponds to variant dbSNP:rs3731834Ensembl.1
Natural variantiVAR_0541351152G → R. Corresponds to variant dbSNP:rs12105159Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327407 mRNA Translation: AAP92799.1
AC010747 Genomic DNA No translation available.
AC112720 Genomic DNA No translation available.
AC096667 Genomic DNA No translation available.
BC150198 mRNA Translation: AAI50199.1
AK131402 mRNA Translation: BAD18549.1
CCDSiCCDS2291.1
RefSeqiNP_919226.1, NM_194250.1
UniGeneiHs.159528

Genome annotation databases

EnsembliENST00000302277; ENSP00000303252; ENSG00000170396
GeneIDi91752
KEGGihsa:91752
UCSCiuc002uph.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY327407 mRNA Translation: AAP92799.1
AC010747 Genomic DNA No translation available.
AC112720 Genomic DNA No translation available.
AC096667 Genomic DNA No translation available.
BC150198 mRNA Translation: AAI50199.1
AK131402 mRNA Translation: BAD18549.1
CCDSiCCDS2291.1
RefSeqiNP_919226.1, NM_194250.1
UniGeneiHs.159528

3D structure databases

ProteinModelPortaliQ7Z570
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124875, 2 interactors
IntActiQ7Z570, 2 interactors
STRINGi9606.ENSP00000303252

PTM databases

iPTMnetiQ7Z570
PhosphoSitePlusiQ7Z570

Polymorphism and mutation databases

BioMutaiZNF804A
DMDMi224471869

Proteomic databases

EPDiQ7Z570
PaxDbiQ7Z570
PeptideAtlasiQ7Z570
PRIDEiQ7Z570
ProteomicsDBi69261

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302277; ENSP00000303252; ENSG00000170396
GeneIDi91752
KEGGihsa:91752
UCSCiuc002uph.4 human

Organism-specific databases

CTDi91752
DisGeNETi91752
EuPathDBiHostDB:ENSG00000170396.7
GeneCardsiZNF804A
HGNCiHGNC:21711 ZNF804A
HPAiHPA029195
MIMi612282 gene
neXtProtiNX_Q7Z570
OpenTargetsiENSG00000170396
Orphaneti3140 Schizophrenia
PharmGKBiPA162410599
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGVP Eukaryota
ENOG410ZHVS LUCA
GeneTreeiENSGT00530000063305
HOVERGENiHBG107108
InParanoidiQ7Z570
OMAiPCEVYQH
OrthoDBiEOG091G01DY
PhylomeDBiQ7Z570
TreeFamiTF332138

Miscellaneous databases

ChiTaRSiZNF804A human
GeneWikiiZinc_finger_protein_804A
GenomeRNAii91752
PROiPR:Q7Z570
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170396 Expressed in 101 organ(s), highest expression level in frontal cortex
CleanExiHS_ZNF804A
ExpressionAtlasiQ7Z570 baseline and differential
GenevisibleiQ7Z570 HS

Family and domain databases

InterProiView protein in InterPro
IPR022755 Znf_C2H2_jaz
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF12171 zf-C2H2_jaz, 1 hit
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZ804A_HUMAN
AccessioniPrimary (citable) accession number: Q7Z570
Secondary accession number(s): A7E253, Q6ZN26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 3, 2009
Last modified: September 12, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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