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Protein

Hepatoma-derived growth factor-related protein 2

Gene

HDGFL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cellular growth control, through the regulation of cyclin D1 expression.1 Publication

GO - Biological processi

  • positive regulation of cell growth Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 2
Short name:
HDGF-related protein 2
Short name:
HRP-2
Alternative name(s):
Hepatoma-derived growth factor 2
Short name:
HDGF-2
Gene namesi
Name:HDGFL2Imported
Synonyms:HDGF2, HDGFRP2, HRP2
ORF Names:UNQ785/PRO1604
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167674.14
HGNCiHGNC:14680 HDGFL2
MIMi617884 gene
neXtProtiNX_Q7Z4V5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi84717

Polymorphism and mutation databases

BioMutaiHDGFRP2
DMDMi74738715

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176431 – 671Hepatoma-derived growth factor-related protein 2Add BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei266PhosphoserineCombined sources1
Modified residuei305PhosphoserineCombined sources1
Modified residuei366PhosphoserineCombined sources1
Modified residuei369PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei396PhosphoserineCombined sources1
Modified residuei397PhosphoserineCombined sources1
Modified residuei399PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Modified residuei458PhosphoserineBy similarity1
Modified residuei490PhosphoserineCombined sources1
Cross-linki554Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei625PhosphoserineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei640PhosphoserineBy similarity1
Modified residuei652PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7Z4V5
MaxQBiQ7Z4V5
PaxDbiQ7Z4V5
PeptideAtlasiQ7Z4V5
PRIDEiQ7Z4V5
ProteomicsDBi69248
69249 [Q7Z4V5-2]

PTM databases

iPTMnetiQ7Z4V5
PhosphoSitePlusiQ7Z4V5
SwissPalmiQ7Z4V5

Miscellaneous databases

PMAP-CutDBiQ7Z4V5

Expressioni

Tissue specificityi

Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples.1 Publication

Gene expression databases

BgeeiENSG00000167674 Expressed in 197 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ7Z4V5 baseline and differential
GenevisibleiQ7Z4V5 HS

Organism-specific databases

HPAiHPA042559
HPA044208

Interactioni

Subunit structurei

Interacts with HDGF (By similarity). Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3. Interacts with IWS1 (PubMed:25689719).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2Q155542EBI-1049136,EBI-706637

Protein-protein interaction databases

BioGridi124221, 46 interactors
IntActiQ7Z4V5, 26 interactors
MINTiQ7Z4V5
STRINGi9606.ENSP00000301284

Structurei

Secondary structure

1671
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ7Z4V5
SMRiQ7Z4V5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7Z4V5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 64PWWPPROSITE-ProRule annotationAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili521 – 581Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi142 – 269Ser-richAdd BLAST128
Compositional biasi299 – 307Poly-Ser9
Compositional biasi318 – 391Arg-richAdd BLAST74

Sequence similaritiesi

Belongs to the HDGF family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1904 Eukaryota
ENOG4111PJT LUCA
GeneTreeiENSGT00530000063013
HOGENOMiHOG000230488
HOVERGENiHBG099722
InParanoidiQ7Z4V5
OMAiLFAYEKY
OrthoDBiEOG091G045X
PhylomeDBiQ7Z4V5
TreeFamiTF105385

Family and domain databases

CDDicd05834 HDGF_related, 1 hit
Gene3Di1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR035496 HDGF-rel_PWWP
IPR036218 HIVI-bd_sf
IPR021567 LEDGF_IBD
IPR000313 PWWP_dom
IPR035441 TFIIS/LEDGF_dom_sf
PfamiView protein in Pfam
PF11467 LEDGF, 1 hit
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
SUPFAMiSSF140576 SSF140576, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z4V5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET
60 70 80 90 100
AFLGPKDLFP YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS
110 120 130 140 150
SDSEAPEANP ADGSDADEDD EDRGVMAVTA VTATAASDRM ESDSDSDKSS
160 170 180 190 200
DNSGLKRKTP ALKMSVSKRA RKASSDLDQA SVSPSEEENS ESSSESEKTS
210 220 230 240 250
DQDFTPEKKA AVRAPRRGPL GGRKKKKAPS ASDSDSKADS DGAKPEPVAM
260 270 280 290 300
ARSASSSSSS SSSSDSDVSV KKPPRGRKPA EKPLPKPRGR KPKPERPPSS
310 320 330 340 350
SSSDSDSDEV DRISEWKRRD EARRRELEAR RRREQEEELR RLREQEKEEK
360 370 380 390 400
ERRRERADRG EAERGSGGSS GDELREDDEP VKKRGRKGRG RGPPSSSDSE
410 420 430 440 450
PEAELEREAK KSAKKPQSSS TEPARKPGQK EKRVRPEEKQ QAKPVKVERT
460 470 480 490 500
RKRSEGFSMD RKVEKKKEPS VEEKLQKLHS EIKFALKVDS PDVKRCLNAL
510 520 530 540 550
EELGTLQVTS QILQKNTDVV ATLKKIRRYK ANKDVMEKAA EVYTRLKSRV
560 570 580 590 600
LGPKIEAVQK VNKAGMEKEK AEEKLAGEEL AGEEAPQEKA EDKPSTDLSA
610 620 630 640 650
PVNGEATSQK GESAEDKEHE EGRDSEEGPR CGSSEDLHDS VREGPDLDRP
660 670
GSDRQERERA RGDSEALDEE S
Length:671
Mass (Da):74,317
Last modified:October 1, 2003 - v1
Checksum:i66CA046E0E802741
GO
Isoform 2 (identifier: Q7Z4V5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     640-640: Missing.

Note: No experimental confirmation available.
Show »
Length:670
Mass (Da):74,230
Checksum:iBAA24291446BDBAD
GO
Isoform 3 (identifier: Q7Z4V5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-574: K → KLAGEE

Note: No experimental confirmation available.
Show »
Length:676
Mass (Da):74,816
Checksum:i78095562E5A10EAC
GO
Isoform 4 (identifier: Q7Z4V5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-574: K → KLAGEE
     640-640: Missing.

Show »
Length:675
Mass (Da):74,729
Checksum:iD9F34E7A654236BB
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPS6K7EPS6_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
153Annotation score:
A0A087WT54A0A087WT54_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
473Annotation score:
M0R0J3M0R0J3_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
97Annotation score:
K7ERA4K7ERA4_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
175Annotation score:
K7EJP7K7EJP7_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
121Annotation score:
A0A087WX58A0A087WX58_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
68Annotation score:
K7EQ06K7EQ06_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
24Annotation score:
A0A087WZ99A0A087WZ99_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
71Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047329574K → KLAGEE in isoform 3 and isoform 4. Curated1
Alternative sequenceiVSP_031116640Missing in isoform 2 and isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294267 mRNA Translation: AAP97281.1
AY358600 mRNA Translation: AAQ88963.1
AC011498 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69215.1
CH471139 Genomic DNA Translation: EAW69216.1
BC000755 mRNA Translation: AAH00755.1
BC009449 mRNA Translation: AAH09449.1
CCDSiCCDS42472.1 [Q7Z4V5-1]
CCDS59336.1 [Q7Z4V5-2]
RefSeqiNP_001001520.1, NM_001001520.2 [Q7Z4V5-1]
NP_116020.1, NM_032631.3 [Q7Z4V5-2]
UniGeneiHs.43071

Genome annotation databases

EnsembliENST00000616600; ENSP00000483345; ENSG00000167674 [Q7Z4V5-1]
ENST00000621835; ENSP00000483702; ENSG00000167674 [Q7Z4V5-2]
GeneIDi84717
KEGGihsa:84717
UCSCiuc032hkd.2 human [Q7Z4V5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294267 mRNA Translation: AAP97281.1
AY358600 mRNA Translation: AAQ88963.1
AC011498 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69215.1
CH471139 Genomic DNA Translation: EAW69216.1
BC000755 mRNA Translation: AAH00755.1
BC009449 mRNA Translation: AAH09449.1
CCDSiCCDS42472.1 [Q7Z4V5-1]
CCDS59336.1 [Q7Z4V5-2]
RefSeqiNP_001001520.1, NM_001001520.2 [Q7Z4V5-1]
NP_116020.1, NM_032631.3 [Q7Z4V5-2]
UniGeneiHs.43071

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EAEX-ray2.24A/B1-93[»]
3QBYX-ray1.95A/B/C1-93[»]
3QJ6X-ray2.30A1-93[»]
ProteinModelPortaliQ7Z4V5
SMRiQ7Z4V5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124221, 46 interactors
IntActiQ7Z4V5, 26 interactors
MINTiQ7Z4V5
STRINGi9606.ENSP00000301284

PTM databases

iPTMnetiQ7Z4V5
PhosphoSitePlusiQ7Z4V5
SwissPalmiQ7Z4V5

Polymorphism and mutation databases

BioMutaiHDGFRP2
DMDMi74738715

Proteomic databases

EPDiQ7Z4V5
MaxQBiQ7Z4V5
PaxDbiQ7Z4V5
PeptideAtlasiQ7Z4V5
PRIDEiQ7Z4V5
ProteomicsDBi69248
69249 [Q7Z4V5-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000616600; ENSP00000483345; ENSG00000167674 [Q7Z4V5-1]
ENST00000621835; ENSP00000483702; ENSG00000167674 [Q7Z4V5-2]
GeneIDi84717
KEGGihsa:84717
UCSCiuc032hkd.2 human [Q7Z4V5-1]

Organism-specific databases

CTDi84717
DisGeNETi84717
EuPathDBiHostDB:ENSG00000167674.14
GeneCardsiHDGFL2
HGNCiHGNC:14680 HDGFL2
HPAiHPA042559
HPA044208
MIMi617884 gene
neXtProtiNX_Q7Z4V5
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1904 Eukaryota
ENOG4111PJT LUCA
GeneTreeiENSGT00530000063013
HOGENOMiHOG000230488
HOVERGENiHBG099722
InParanoidiQ7Z4V5
OMAiLFAYEKY
OrthoDBiEOG091G045X
PhylomeDBiQ7Z4V5
TreeFamiTF105385

Miscellaneous databases

ChiTaRSiHDGFRP2 human
EvolutionaryTraceiQ7Z4V5
GenomeRNAii84717
PMAP-CutDBiQ7Z4V5
PROiPR:Q7Z4V5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167674 Expressed in 197 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ7Z4V5 baseline and differential
GenevisibleiQ7Z4V5 HS

Family and domain databases

CDDicd05834 HDGF_related, 1 hit
Gene3Di1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR035496 HDGF-rel_PWWP
IPR036218 HIVI-bd_sf
IPR021567 LEDGF_IBD
IPR000313 PWWP_dom
IPR035441 TFIIS/LEDGF_dom_sf
PfamiView protein in Pfam
PF11467 LEDGF, 1 hit
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
SUPFAMiSSF140576 SSF140576, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHDGR2_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4V5
Secondary accession number(s): I3L080
, K7EQZ6, Q96GI5, Q9BW08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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