Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 142 (13 Nov 2019)
Sequence version 1 (01 Oct 2003)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Hepatoma-derived growth factor-related protein 2

Gene

HDGFL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cellular growth control, through the regulation of cyclin D1 expression.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 2
Short name:
HDGF-related protein 2
Short name:
HRP-2
Alternative name(s):
Hepatoma-derived growth factor 2
Short name:
HDGF-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HDGFL2Imported
Synonyms:HDGF2, HDGFRP2, HRP2
ORF Names:UNQ785/PRO1604
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14680 HDGFL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617884 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z4V5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84717

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z4V5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HDGFL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74738715

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003176431 – 671Hepatoma-derived growth factor-related protein 2Add BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei114PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei232PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei240PhosphoserineCombined sources1
Modified residuei266PhosphoserineCombined sources1
Modified residuei305PhosphoserineCombined sources1
Modified residuei366PhosphoserineCombined sources1
Modified residuei369PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei396PhosphoserineCombined sources1
Modified residuei397PhosphoserineCombined sources1
Modified residuei399PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Modified residuei458PhosphoserineBy similarity1
Modified residuei490PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki554Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei625PhosphoserineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei640PhosphoserineBy similarity1
Modified residuei652PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z4V5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z4V5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z4V5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z4V5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z4V5

PeptideAtlas

More...
PeptideAtlasi
Q7Z4V5

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z4V5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
46298
69248 [Q7Z4V5-1]
69249 [Q7Z4V5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z4V5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z4V5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7Z4V5

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q7Z4V5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. High expression is found in heart, skeletal muscle, ovary and testis. Overexpression is frequently observed in hepatocellular carcinoma samples.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167674 Expressed in 197 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z4V5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z4V5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042559
HPA044208

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HDGF (By similarity).

Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3).

Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3.

Interacts with IWS1 (PubMed:25689719).

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q155542EBI-1049136,EBI-706637

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124221, 57 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z4V5, 48 interactors

Molecular INTeraction database

More...
MINTi
Q7Z4V5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000483345

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1671
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z4V5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7Z4V5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 64PWWPPROSITE-ProRule annotationAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili521 – 581Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi142 – 269Ser-richAdd BLAST128
Compositional biasi299 – 307Poly-Ser9
Compositional biasi318 – 391Arg-richAdd BLAST74

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HDGF family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1904 Eukaryota
ENOG4111PJT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153942

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230488

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z4V5

Identification of Orthologs from Complete Genome Data

More...
OMAi
RYKASAA

Database of Orthologous Groups

More...
OrthoDBi
530959at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z4V5

TreeFam database of animal gene trees

More...
TreeFami
TF105385

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05834 HDGF_related, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035496 HDGF-rel_PWWP
IPR036218 HIVI-bd_sf
IPR021567 LEDGF_IBD
IPR000313 PWWP_dom
IPR035441 TFIIS/LEDGF_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11467 LEDGF, 1 hit
PF00855 PWWP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00293 PWWP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140576 SSF140576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50812 PWWP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z4V5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET
60 70 80 90 100
AFLGPKDLFP YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS
110 120 130 140 150
SDSEAPEANP ADGSDADEDD EDRGVMAVTA VTATAASDRM ESDSDSDKSS
160 170 180 190 200
DNSGLKRKTP ALKMSVSKRA RKASSDLDQA SVSPSEEENS ESSSESEKTS
210 220 230 240 250
DQDFTPEKKA AVRAPRRGPL GGRKKKKAPS ASDSDSKADS DGAKPEPVAM
260 270 280 290 300
ARSASSSSSS SSSSDSDVSV KKPPRGRKPA EKPLPKPRGR KPKPERPPSS
310 320 330 340 350
SSSDSDSDEV DRISEWKRRD EARRRELEAR RRREQEEELR RLREQEKEEK
360 370 380 390 400
ERRRERADRG EAERGSGGSS GDELREDDEP VKKRGRKGRG RGPPSSSDSE
410 420 430 440 450
PEAELEREAK KSAKKPQSSS TEPARKPGQK EKRVRPEEKQ QAKPVKVERT
460 470 480 490 500
RKRSEGFSMD RKVEKKKEPS VEEKLQKLHS EIKFALKVDS PDVKRCLNAL
510 520 530 540 550
EELGTLQVTS QILQKNTDVV ATLKKIRRYK ANKDVMEKAA EVYTRLKSRV
560 570 580 590 600
LGPKIEAVQK VNKAGMEKEK AEEKLAGEEL AGEEAPQEKA EDKPSTDLSA
610 620 630 640 650
PVNGEATSQK GESAEDKEHE EGRDSEEGPR CGSSEDLHDS VREGPDLDRP
660 670
GSDRQERERA RGDSEALDEE S
Length:671
Mass (Da):74,317
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66CA046E0E802741
GO
Isoform 2 (identifier: Q7Z4V5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     640-640: Missing.

Note: No experimental confirmation available.
Show »
Length:670
Mass (Da):74,230
Checksum:iBAA24291446BDBAD
GO
Isoform 3 (identifier: Q7Z4V5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-574: K → KLAGEE

Note: No experimental confirmation available.
Show »
Length:676
Mass (Da):74,816
Checksum:i78095562E5A10EAC
GO
Isoform 4 (identifier: Q7Z4V5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     574-574: K → KLAGEE
     640-640: Missing.

Show »
Length:675
Mass (Da):74,729
Checksum:iD9F34E7A654236BB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EPS6K7EPS6_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJP7K7EJP7_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WT54A0A087WT54_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WX58A0A087WX58_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ99A0A087WZ99_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERA4K7ERA4_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EQ06K7EQ06_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0J3M0R0J3_HUMAN
Hepatoma-derived growth factor-rela...
HDGFL2
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_047329574K → KLAGEE in isoform 3 and isoform 4. Curated1
Alternative sequenceiVSP_031116640Missing in isoform 2 and isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF294267 mRNA Translation: AAP97281.1
AY358600 mRNA Translation: AAQ88963.1
AC011498 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69215.1
CH471139 Genomic DNA Translation: EAW69216.1
BC000755 mRNA Translation: AAH00755.1
BC009449 mRNA Translation: AAH09449.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS42472.1 [Q7Z4V5-1]
CCDS59336.1 [Q7Z4V5-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001001520.1, NM_001001520.2 [Q7Z4V5-1]
NP_116020.1, NM_032631.3 [Q7Z4V5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000616600; ENSP00000483345; ENSG00000167674 [Q7Z4V5-1]
ENST00000621835; ENSP00000483702; ENSG00000167674 [Q7Z4V5-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84717

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84717

UCSC genome browser

More...
UCSCi
uc032hkd.2 human [Q7Z4V5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF294267 mRNA Translation: AAP97281.1
AY358600 mRNA Translation: AAQ88963.1
AC011498 Genomic DNA No translation available.
CH471139 Genomic DNA Translation: EAW69215.1
CH471139 Genomic DNA Translation: EAW69216.1
BC000755 mRNA Translation: AAH00755.1
BC009449 mRNA Translation: AAH09449.1
CCDSiCCDS42472.1 [Q7Z4V5-1]
CCDS59336.1 [Q7Z4V5-2]
RefSeqiNP_001001520.1, NM_001001520.2 [Q7Z4V5-1]
NP_116020.1, NM_032631.3 [Q7Z4V5-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EAEX-ray2.24A/B1-93[»]
3QBYX-ray1.95A/B/C1-93[»]
3QJ6X-ray2.30A1-93[»]
SMRiQ7Z4V5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi124221, 57 interactors
IntActiQ7Z4V5, 48 interactors
MINTiQ7Z4V5
STRINGi9606.ENSP00000483345

PTM databases

iPTMnetiQ7Z4V5
PhosphoSitePlusiQ7Z4V5
SwissPalmiQ7Z4V5

Polymorphism and mutation databases

BioMutaiHDGFL2
DMDMi74738715

Proteomic databases

EPDiQ7Z4V5
jPOSTiQ7Z4V5
MassIVEiQ7Z4V5
MaxQBiQ7Z4V5
PaxDbiQ7Z4V5
PeptideAtlasiQ7Z4V5
PRIDEiQ7Z4V5
ProteomicsDBi46298
69248 [Q7Z4V5-1]
69249 [Q7Z4V5-2]

Genome annotation databases

EnsembliENST00000616600; ENSP00000483345; ENSG00000167674 [Q7Z4V5-1]
ENST00000621835; ENSP00000483702; ENSG00000167674 [Q7Z4V5-2]
GeneIDi84717
KEGGihsa:84717
UCSCiuc032hkd.2 human [Q7Z4V5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84717
DisGeNETi84717

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HDGFL2
HGNCiHGNC:14680 HDGFL2
HPAiHPA042559
HPA044208
MIMi617884 gene
neXtProtiNX_Q7Z4V5

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1904 Eukaryota
ENOG4111PJT LUCA
GeneTreeiENSGT00940000153942
HOGENOMiHOG000230488
InParanoidiQ7Z4V5
OMAiRYKASAA
OrthoDBi530959at2759
PhylomeDBiQ7Z4V5
TreeFamiTF105385

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HDGFRP2 human
EvolutionaryTraceiQ7Z4V5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84717
PharosiQ7Z4V5
PMAP-CutDBiQ7Z4V5

Protein Ontology

More...
PROi
PR:Q7Z4V5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167674 Expressed in 197 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ7Z4V5 baseline and differential
GenevisibleiQ7Z4V5 HS

Family and domain databases

CDDicd05834 HDGF_related, 1 hit
Gene3Di1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR035496 HDGF-rel_PWWP
IPR036218 HIVI-bd_sf
IPR021567 LEDGF_IBD
IPR000313 PWWP_dom
IPR035441 TFIIS/LEDGF_dom_sf
PfamiView protein in Pfam
PF11467 LEDGF, 1 hit
PF00855 PWWP, 1 hit
SMARTiView protein in SMART
SM00293 PWWP, 1 hit
SUPFAMiSSF140576 SSF140576, 1 hit
PROSITEiView protein in PROSITE
PS50812 PWWP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHDGR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z4V5
Secondary accession number(s): I3L080
, K7EQZ6, Q96GI5, Q9BW08
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: November 13, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again