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Entry version 136 (31 Jul 2019)
Sequence version 2 (15 Mar 2004)
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Protein

HEAT repeat-containing protein 3

Gene

HEATR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HEAT repeat-containing protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HEATR3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26087 HEATR3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614951 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z4Q2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55027

Open Targets

More...
OpenTargetsi
ENSG00000155393

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596426

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HEATR3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
45477280

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000508211 – 680HEAT repeat-containing protein 3Add BLAST680

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineCombined sources1
Modified residuei144PhosphoserineBy similarity1
Modified residuei340PhosphothreonineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z4Q2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z4Q2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z4Q2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z4Q2

PeptideAtlas

More...
PeptideAtlasi
Q7Z4Q2

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z4Q2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69221 [Q7Z4Q2-1]
69222 [Q7Z4Q2-2]
69223 [Q7Z4Q2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z4Q2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z4Q2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000155393 Expressed in 199 organ(s), highest expression level in corpus callosum

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z4Q2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041990
HPA058579

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120357, 90 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z4Q2, 25 interactors

Molecular INTeraction database

More...
MINTi
Q7Z4Q2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299192

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati38 – 69HEAT 1Add BLAST32
Repeati74 – 110HEAT 2Add BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 28Poly-Ala7

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGCR Eukaryota
ENOG410Y5P1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012529

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008167

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z4Q2

Identification of Orthologs from Complete Genome Data

More...
OMAi
GDCQAEA

Database of Orthologous Groups

More...
OrthoDBi
475746at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z4Q2

TreeFam database of animal gene trees

More...
TreeFami
TF324159

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z4Q2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKSRTKRFK RPQFSPTGDC QAEAAAAANG TGGEEDDGPA AELLEKLQHP
60 70 80 90 100
SAEVRECACA GLARLVQQRP ALPGLARRDA VRRLGPLLLD PSLAVRETAA
110 120 130 140 150
GALRNLSACG GFEVCDDMVT KDIMTPLVAL LKECSAGLDS NEMSLQEKKD
160 170 180 190 200
QNRNSIENIA NETVNVLWNI CECSSRAVSI FNKEGCLEIV LKYLSRFPTN
210 220 230 240 250
VDLAISVAYC LQTVTEDNPE LLKSFSATAL NMLESALLSP VSSMESLLLK
260 270 280 290 300
TLVAGTIWNL KDIIPCKSQA EIINALLKIL SEVLGMDAGE MVIQMKEAET
310 320 330 340 350
QRLKTAAEAE EILENTNGDD LIEDDEMEGI SHKRRVRRKT FVSDLLPPTD
360 370 380 390 400
KELRETIALL TAQQTALEII VNMCCNEDPS DDEWEELSSS DESDAFMENS
410 420 430 440 450
FSECGGQLFS PLCLSHEVHT ALTNYLIPKK IFEKTAFPNS IAVDLCSRNP
460 470 480 490 500
TWKPLIRKMN TIQCRALFCL QSLVSLLDVE HLGGAAALQT LAQHLSQLLF
510 520 530 540 550
SQPDFAKHVD FLEAISSALR ALLQTMASKN ISQCMTPDQL MTLCKAGIHS
560 570 580 590 600
SNVGVRVNVV SILGITGSVL AKEDGTLETL KNIGCFLLEV TTKDPSLVVA
610 620 630 640 650
GEALDALFDV FADGKEAERA SIQIKLLSAL KEFQPVFKMK IRKEGRGNYS
660 670 680
TDQLCVLDNV KMNLRRFIAY QETVEKRLTS
Length:680
Mass (Da):74,583
Last modified:March 15, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7892F94AC5103B5
GO
Isoform 2 (identifier: Q7Z4Q2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: MGKSRTKRFK...ETAAGALRNL → MGPEARRTTGRRRSCWKRNP

Show »
Length:594
Mass (Da):65,813
Checksum:i4B68D5E367072F4D
GO
Isoform 3 (identifier: Q7Z4Q2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: MGKSRTKRFK...ETAAGALRNL → MGPEARRTTGRRRSCWKRNP
     378-400: DPSDDEWEELSSSDESDAFMENS → GLLTFTFRHFPPEPRGKLPWRFS
     401-680: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:314
Mass (Da):35,134
Checksum:iF762BC9F4F7B61A4
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH14415 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti197F → L in AAP97710 (Ref. 1) Curated1
Isoform 3 (identifier: Q7Z4Q2-3)
Sequence conflicti20P → L in AAP97710 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033989302R → S. Corresponds to variant dbSNP:rs34703459Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0096401 – 106MGKSR…ALRNL → MGPEARRTTGRRRSCWKRNP in isoform 2 and isoform 3. 2 PublicationsAdd BLAST106
Alternative sequenceiVSP_009641378 – 400DPSDD…FMENS → GLLTFTFRHFPPEPRGKLPW RFS in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_009642401 – 680Missing in isoform 3. 1 PublicationAdd BLAST280

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF462442 mRNA Translation: AAP97710.1
AK000725 mRNA Translation: BAA91342.1
AK289949 mRNA Translation: BAF82638.1
CH471092 Genomic DNA Translation: EAW82743.1
BC014415 mRNA Translation: AAH14415.1 Different initiation.
BC018730 mRNA Translation: AAH18730.2
BC033077 mRNA Translation: AAH33077.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10739.1 [Q7Z4Q2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_891552.1, NM_182922.3 [Q7Z4Q2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299192; ENSP00000299192; ENSG00000155393 [Q7Z4Q2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55027

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55027

UCSC genome browser

More...
UCSCi
uc002efw.4 human [Q7Z4Q2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462442 mRNA Translation: AAP97710.1
AK000725 mRNA Translation: BAA91342.1
AK289949 mRNA Translation: BAF82638.1
CH471092 Genomic DNA Translation: EAW82743.1
BC014415 mRNA Translation: AAH14415.1 Different initiation.
BC018730 mRNA Translation: AAH18730.2
BC033077 mRNA Translation: AAH33077.1
CCDSiCCDS10739.1 [Q7Z4Q2-1]
RefSeqiNP_891552.1, NM_182922.3 [Q7Z4Q2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120357, 90 interactors
IntActiQ7Z4Q2, 25 interactors
MINTiQ7Z4Q2
STRINGi9606.ENSP00000299192

PTM databases

iPTMnetiQ7Z4Q2
PhosphoSitePlusiQ7Z4Q2

Polymorphism and mutation databases

BioMutaiHEATR3
DMDMi45477280

Proteomic databases

EPDiQ7Z4Q2
jPOSTiQ7Z4Q2
MaxQBiQ7Z4Q2
PaxDbiQ7Z4Q2
PeptideAtlasiQ7Z4Q2
PRIDEiQ7Z4Q2
ProteomicsDBi69221 [Q7Z4Q2-1]
69222 [Q7Z4Q2-2]
69223 [Q7Z4Q2-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299192; ENSP00000299192; ENSG00000155393 [Q7Z4Q2-1]
GeneIDi55027
KEGGihsa:55027
UCSCiuc002efw.4 human [Q7Z4Q2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55027
DisGeNETi55027

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HEATR3
HGNCiHGNC:26087 HEATR3
HPAiHPA041990
HPA058579
MIMi614951 gene
neXtProtiNX_Q7Z4Q2
OpenTargetsiENSG00000155393
PharmGKBiPA144596426

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGCR Eukaryota
ENOG410Y5P1 LUCA
GeneTreeiENSGT00390000012529
HOGENOMiHOG000008167
InParanoidiQ7Z4Q2
OMAiGDCQAEA
OrthoDBi475746at2759
PhylomeDBiQ7Z4Q2
TreeFamiTF324159

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HEATR3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55027

Protein Ontology

More...
PROi
PR:Q7Z4Q2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000155393 Expressed in 199 organ(s), highest expression level in corpus callosum
GenevisibleiQ7Z4Q2 HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEAT3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z4Q2
Secondary accession number(s): A8K1N4
, Q8N525, Q8WV56, Q96CC9, Q9NWN7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: July 31, 2019
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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