Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HEAT repeat-containing protein 3

Gene

HEATR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • unfolded protein binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
HEAT repeat-containing protein 3
Gene namesi
Name:HEATR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000155393.12
HGNCiHGNC:26087 HEATR3
MIMi614951 gene
neXtProtiNX_Q7Z4Q2

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi55027
OpenTargetsiENSG00000155393
PharmGKBiPA144596426

Polymorphism and mutation databases

BioMutaiHEATR3
DMDMi45477280

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508211 – 680HEAT repeat-containing protein 3Add BLAST680

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Modified residuei144PhosphoserineBy similarity1
Modified residuei340PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7Z4Q2
MaxQBiQ7Z4Q2
PaxDbiQ7Z4Q2
PeptideAtlasiQ7Z4Q2
PRIDEiQ7Z4Q2
ProteomicsDBi69221
69222 [Q7Z4Q2-2]
69223 [Q7Z4Q2-3]

PTM databases

iPTMnetiQ7Z4Q2
PhosphoSitePlusiQ7Z4Q2

Expressioni

Gene expression databases

BgeeiENSG00000155393 Expressed in 199 organ(s), highest expression level in corpus callosum
CleanExiHS_HEATR3
GenevisibleiQ7Z4Q2 HS

Organism-specific databases

HPAiHPA041990
HPA058579

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120357, 87 interactors
IntActiQ7Z4Q2, 20 interactors
MINTiQ7Z4Q2
STRINGi9606.ENSP00000299192

Structurei

3D structure databases

ProteinModelPortaliQ7Z4Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati38 – 69HEAT 1Add BLAST32
Repeati74 – 110HEAT 2Add BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 28Poly-Ala7

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IGCR Eukaryota
ENOG410Y5P1 LUCA
GeneTreeiENSGT00390000012529
HOGENOMiHOG000008167
HOVERGENiHBG047958
InParanoidiQ7Z4Q2
OMAiGDCQAEA
OrthoDBiEOG091G04LB
PhylomeDBiQ7Z4Q2
TreeFamiTF324159

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7Z4Q2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKSRTKRFK RPQFSPTGDC QAEAAAAANG TGGEEDDGPA AELLEKLQHP
60 70 80 90 100
SAEVRECACA GLARLVQQRP ALPGLARRDA VRRLGPLLLD PSLAVRETAA
110 120 130 140 150
GALRNLSACG GFEVCDDMVT KDIMTPLVAL LKECSAGLDS NEMSLQEKKD
160 170 180 190 200
QNRNSIENIA NETVNVLWNI CECSSRAVSI FNKEGCLEIV LKYLSRFPTN
210 220 230 240 250
VDLAISVAYC LQTVTEDNPE LLKSFSATAL NMLESALLSP VSSMESLLLK
260 270 280 290 300
TLVAGTIWNL KDIIPCKSQA EIINALLKIL SEVLGMDAGE MVIQMKEAET
310 320 330 340 350
QRLKTAAEAE EILENTNGDD LIEDDEMEGI SHKRRVRRKT FVSDLLPPTD
360 370 380 390 400
KELRETIALL TAQQTALEII VNMCCNEDPS DDEWEELSSS DESDAFMENS
410 420 430 440 450
FSECGGQLFS PLCLSHEVHT ALTNYLIPKK IFEKTAFPNS IAVDLCSRNP
460 470 480 490 500
TWKPLIRKMN TIQCRALFCL QSLVSLLDVE HLGGAAALQT LAQHLSQLLF
510 520 530 540 550
SQPDFAKHVD FLEAISSALR ALLQTMASKN ISQCMTPDQL MTLCKAGIHS
560 570 580 590 600
SNVGVRVNVV SILGITGSVL AKEDGTLETL KNIGCFLLEV TTKDPSLVVA
610 620 630 640 650
GEALDALFDV FADGKEAERA SIQIKLLSAL KEFQPVFKMK IRKEGRGNYS
660 670 680
TDQLCVLDNV KMNLRRFIAY QETVEKRLTS
Length:680
Mass (Da):74,583
Last modified:March 15, 2004 - v2
Checksum:iF7892F94AC5103B5
GO
Isoform 2 (identifier: Q7Z4Q2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: MGKSRTKRFK...ETAAGALRNL → MGPEARRTTGRRRSCWKRNP

Show »
Length:594
Mass (Da):65,813
Checksum:i4B68D5E367072F4D
GO
Isoform 3 (identifier: Q7Z4Q2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: MGKSRTKRFK...ETAAGALRNL → MGPEARRTTGRRRSCWKRNP
     378-400: DPSDDEWEELSSSDESDAFMENS → GLLTFTFRHFPPEPRGKLPWRFS
     401-680: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:314
Mass (Da):35,134
Checksum:iF762BC9F4F7B61A4
GO

Sequence cautioni

The sequence AAH14415 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti197F → L in AAP97710 (Ref. 1) Curated1
Isoform 3 (identifier: Q7Z4Q2-3)
Sequence conflicti20P → L in AAP97710 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033989302R → S. Corresponds to variant dbSNP:rs34703459Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0096401 – 106MGKSR…ALRNL → MGPEARRTTGRRRSCWKRNP in isoform 2 and isoform 3. 2 PublicationsAdd BLAST106
Alternative sequenceiVSP_009641378 – 400DPSDD…FMENS → GLLTFTFRHFPPEPRGKLPW RFS in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_009642401 – 680Missing in isoform 3. 1 PublicationAdd BLAST280

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462442 mRNA Translation: AAP97710.1
AK000725 mRNA Translation: BAA91342.1
AK289949 mRNA Translation: BAF82638.1
CH471092 Genomic DNA Translation: EAW82743.1
BC014415 mRNA Translation: AAH14415.1 Different initiation.
BC018730 mRNA Translation: AAH18730.2
BC033077 mRNA Translation: AAH33077.1
CCDSiCCDS10739.1 [Q7Z4Q2-1]
RefSeqiNP_891552.1, NM_182922.3 [Q7Z4Q2-1]
UniGeneiHs.733027

Genome annotation databases

EnsembliENST00000299192; ENSP00000299192; ENSG00000155393 [Q7Z4Q2-1]
GeneIDi55027
KEGGihsa:55027
UCSCiuc002efw.4 human [Q7Z4Q2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF462442 mRNA Translation: AAP97710.1
AK000725 mRNA Translation: BAA91342.1
AK289949 mRNA Translation: BAF82638.1
CH471092 Genomic DNA Translation: EAW82743.1
BC014415 mRNA Translation: AAH14415.1 Different initiation.
BC018730 mRNA Translation: AAH18730.2
BC033077 mRNA Translation: AAH33077.1
CCDSiCCDS10739.1 [Q7Z4Q2-1]
RefSeqiNP_891552.1, NM_182922.3 [Q7Z4Q2-1]
UniGeneiHs.733027

3D structure databases

ProteinModelPortaliQ7Z4Q2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120357, 87 interactors
IntActiQ7Z4Q2, 20 interactors
MINTiQ7Z4Q2
STRINGi9606.ENSP00000299192

PTM databases

iPTMnetiQ7Z4Q2
PhosphoSitePlusiQ7Z4Q2

Polymorphism and mutation databases

BioMutaiHEATR3
DMDMi45477280

Proteomic databases

EPDiQ7Z4Q2
MaxQBiQ7Z4Q2
PaxDbiQ7Z4Q2
PeptideAtlasiQ7Z4Q2
PRIDEiQ7Z4Q2
ProteomicsDBi69221
69222 [Q7Z4Q2-2]
69223 [Q7Z4Q2-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299192; ENSP00000299192; ENSG00000155393 [Q7Z4Q2-1]
GeneIDi55027
KEGGihsa:55027
UCSCiuc002efw.4 human [Q7Z4Q2-1]

Organism-specific databases

CTDi55027
DisGeNETi55027
EuPathDBiHostDB:ENSG00000155393.12
GeneCardsiHEATR3
H-InvDBiHIX0013021
HGNCiHGNC:26087 HEATR3
HPAiHPA041990
HPA058579
MIMi614951 gene
neXtProtiNX_Q7Z4Q2
OpenTargetsiENSG00000155393
PharmGKBiPA144596426
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGCR Eukaryota
ENOG410Y5P1 LUCA
GeneTreeiENSGT00390000012529
HOGENOMiHOG000008167
HOVERGENiHBG047958
InParanoidiQ7Z4Q2
OMAiGDCQAEA
OrthoDBiEOG091G04LB
PhylomeDBiQ7Z4Q2
TreeFamiTF324159

Miscellaneous databases

ChiTaRSiHEATR3 human
GenomeRNAii55027
PROiPR:Q7Z4Q2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155393 Expressed in 199 organ(s), highest expression level in corpus callosum
CleanExiHS_HEATR3
GenevisibleiQ7Z4Q2 HS

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEAT3_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4Q2
Secondary accession number(s): A8K1N4
, Q8N525, Q8WV56, Q96CC9, Q9NWN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: November 7, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again