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Protein

Growth/differentiation factor 7

Gene

GDF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play an active role in the motor area of the primate neocortex.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 7
Short name:
GDF-7
Gene namesi
Name:GDF7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000143869.6
HGNCiHGNC:4222 GDF7
MIMi604651 gene
neXtProtiNX_Q7Z4P5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi151449
OpenTargetsiENSG00000143869
PharmGKBiPA28637

Polymorphism and mutation databases

BioMutaiGDF7
DMDMi296434517

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003392220 – 321Sequence analysisAdd BLAST302
ChainiPRO_0000033923322 – 450Growth/differentiation factor 7Add BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi349 ↔ 415By similarity
Disulfide bondi378 ↔ 447By similarity
Disulfide bondi382 ↔ 449By similarity
Disulfide bondi414InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7Z4P5
PeptideAtlasiQ7Z4P5
PRIDEiQ7Z4P5
ProteomicsDBi69219

PTM databases

iPTMnetiQ7Z4P5
PhosphoSitePlusiQ7Z4P5

Expressioni

Gene expression databases

BgeeiENSG00000143869 Expressed in 126 organ(s), highest expression level in endometrium
CleanExiHS_GDF7
GenevisibleiQ7Z4P5 HS

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000272224

Structurei

3D structure databases

ProteinModelPortaliQ7Z4P5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOVERGENiHBG107938
InParanoidiQ7Z4P5
KOiK20013
OMAiLVGQRWE
OrthoDBiEOG091G09KP
PhylomeDBiQ7Z4P5
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7Z4P5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPVRSP GGGGGGGGGG
60 70 80 90 100
RTLAQAAGAA AVPAAAVPRA RAARRAAGSG FRNGSVVPHH FMMSLYRSLA
110 120 130 140 150
GRAPAGAAAV SASGHGRADT ITGFTDQATQ DESAAETGQS FLFDVSSLND
160 170 180 190 200
ADEVVGAELR VLRRGSPESG PGSWTSPPLL LLSTCPGAAR APRLLYSRAA
210 220 230 240 250
EPLVGQRWEA FDVADAMRRH RREPRPPRAF CLLLRAVAGP VPSPLALRRL
260 270 280 290 300
GFGWPGGGGS AAEERAVLVV SSRTQRKESL FREIRAQARA LGAALASEPL
310 320 330 340 350
PDPGTGTASP RAVIGGRRRR RTALAGTRTA QGSGGGAGRG HGRRGRSRCS
360 370 380 390 400
RKPLHVDFKE LGWDDWIIAP LDYEAYHCEG LCDFPLRSHL EPTNHAIIQT
410 420 430 440 450
LLNSMAPDAA PASCCVPARL SPISILYIDA ANNVVYKQYE DMVVEACGCR
Length:450
Mass (Da):46,950
Last modified:May 18, 2010 - v2
Checksum:iC7D4D417685D25BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti330A → S in AAP97720 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522369 mRNA Translation: AAP97720.1
AC012065 Genomic DNA No translation available.
CCDSiCCDS1701.1
RefSeqiNP_878248.2, NM_182828.3
UniGeneiHs.447688
Hs.596282

Genome annotation databases

EnsembliENST00000272224; ENSP00000272224; ENSG00000143869
GeneIDi151449
KEGGihsa:151449
UCSCiuc002rdz.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF522369 mRNA Translation: AAP97720.1
AC012065 Genomic DNA No translation available.
CCDSiCCDS1701.1
RefSeqiNP_878248.2, NM_182828.3
UniGeneiHs.447688
Hs.596282

3D structure databases

ProteinModelPortaliQ7Z4P5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000272224

PTM databases

iPTMnetiQ7Z4P5
PhosphoSitePlusiQ7Z4P5

Polymorphism and mutation databases

BioMutaiGDF7
DMDMi296434517

Proteomic databases

PaxDbiQ7Z4P5
PeptideAtlasiQ7Z4P5
PRIDEiQ7Z4P5
ProteomicsDBi69219

Protocols and materials databases

DNASUi151449
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272224; ENSP00000272224; ENSG00000143869
GeneIDi151449
KEGGihsa:151449
UCSCiuc002rdz.2 human

Organism-specific databases

CTDi151449
DisGeNETi151449
EuPathDBiHostDB:ENSG00000143869.6
GeneCardsiGDF7
HGNCiHGNC:4222 GDF7
MIMi604651 gene
neXtProtiNX_Q7Z4P5
OpenTargetsiENSG00000143869
PharmGKBiPA28637
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOVERGENiHBG107938
InParanoidiQ7Z4P5
KOiK20013
OMAiLVGQRWE
OrthoDBiEOG091G09KP
PhylomeDBiQ7Z4P5
TreeFamiTF316134

Miscellaneous databases

GeneWikiiGDF7
GenomeRNAii151449
PROiPR:Q7Z4P5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143869 Expressed in 126 organ(s), highest expression level in endometrium
CleanExiHS_GDF7
GenevisibleiQ7Z4P5 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGDF7_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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