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Entry version 153 (07 Oct 2020)
Sequence version 1 (01 Oct 2003)
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Protein

Prolyl 4-hydroxylase subunit alpha-3

Gene

P4HA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi440IronPROSITE-ProRule annotation1
Metal bindingi442IronPROSITE-ProRule annotation1
Metal bindingi510IronPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei5202-oxoglutaratePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding, Vitamin C

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
1.14.11.2, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q7Z4N8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1650814, Collagen biosynthesis and modifying enzymes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prolyl 4-hydroxylase subunit alpha-3 (EC:1.14.11.2)
Short name:
4-PH alpha-3
Alternative name(s):
Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P4HA3
ORF Names:UNQ711/PRO1374
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000149380.11

Human Gene Nomenclature Database

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HGNCi
HGNC:30135, P4HA3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608987, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z4N8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
283208

Open Targets

More...
OpenTargetsi
ENSG00000149380

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134870931

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z4N8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
P4HA3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74738714

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031776620 – 544Prolyl 4-hydroxylase subunit alpha-3Add BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi482N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylation plays no role in the catalytic activity.

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q7Z4N8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q7Z4N8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z4N8

PeptideAtlas

More...
PeptideAtlasi
Q7Z4N8

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z4N8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
5178
69217 [Q7Z4N8-1]
69218 [Q7Z4N8-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q7Z4N8, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q7Z4N8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z4N8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in placenta, liver and fetal skin. Weakly expressed in fetal epiphyseal cartilage, fetal liver, fibroblast, lung and skeletal muscle. Expressed also in fibrous cap of carotid atherosclerotic lesions.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149380, Expressed in decidua and 146 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z4N8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7Z4N8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000149380, Tissue enhanced (epididymis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two alpha-3 chains and two beta chains (the beta chain is the multi-functional PDI).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q7Z4N8
With#Exp.IntAct
ACOT8 [O14734]3EBI-10181968,EBI-1237371
ADRA2C [P18825]3EBI-10181968,EBI-12015266
ANAPC11 - isoform 2 [Q9NYG5-2]3EBI-10181968,EBI-12224467
ATN1 [Q86V38]3EBI-10181968,EBI-11954292
B9D2 [Q9BPU9]3EBI-10181968,EBI-6958971
BAG4 [O95429]3EBI-10181968,EBI-2949658
BLOC1S2 [Q6QNY1]3EBI-10181968,EBI-465872
C1orf112 [Q9NSG2]3EBI-10181968,EBI-11128910
C1QTNF2 [Q9BXJ5]3EBI-10181968,EBI-2817707
CERCAM [Q5T4B2]3EBI-10181968,EBI-12261896
CKMT2 [P17540]3EBI-10181968,EBI-712973
CLPP [Q16740]3EBI-10181968,EBI-1056029
CT55 [Q8WUE5]3EBI-10181968,EBI-6873363
CTAG1B [P78358]3EBI-10181968,EBI-1188472
CTNNBIP1 [Q9NSA3]3EBI-10181968,EBI-747082
DTNBP1 [Q96EV8]3EBI-10181968,EBI-465804
FAM136A [Q96C01]3EBI-10181968,EBI-373319
GGA3 - isoform Short [Q9NZ52-2]3EBI-10181968,EBI-12075758
GPSM3 [Q9Y4H4]3EBI-10181968,EBI-347538
HGS [O14964]6EBI-10181968,EBI-740220
KRTAP19-5 [Q3LI72]3EBI-10181968,EBI-1048945
KRTAP6-1 [Q3LI64]3EBI-10181968,EBI-12111050
KRTAP8-1 [Q8IUC2]3EBI-10181968,EBI-10261141
LRP2BP [Q9P2M1]3EBI-10181968,EBI-18273118
MAGEA2B [P43356]4EBI-10181968,EBI-5650739
MAGEA2B [Q96E03]3EBI-10181968,EBI-10239285
MAGEC2 [Q9UBF1]4EBI-10181968,EBI-5651487
MCCD1 [P59942]3EBI-10181968,EBI-11987923
MEOX2 [P50222]3EBI-10181968,EBI-748397
MSRA [Q9UJ68]3EBI-10181968,EBI-19157918
NDN [A0A0S2Z3Y6]3EBI-10181968,EBI-16435852
NDN [A0A0S2Z442]3EBI-10181968,EBI-16435864
NICN1 [Q9BSH3]3EBI-10181968,EBI-13324229
NUTM1 [Q86Y26]4EBI-10181968,EBI-10178410
OIP5 [O43482]3EBI-10181968,EBI-536879
PROP1 [O75360]3EBI-10181968,EBI-9027467
PSMB4 [P28070]3EBI-10181968,EBI-603350
RBFOX1 - isoform 5 [Q9NWB1-5]3EBI-10181968,EBI-12123390
RUSC1 [Q9BVN2]3EBI-10181968,EBI-6257312
SCARA5 - isoform 2 [Q6ZMJ2-2]3EBI-10181968,EBI-12823227
SERTAD1 [Q53GC0]3EBI-10181968,EBI-2826300
SERTAD3 [Q9UJW9]3EBI-10181968,EBI-748621
STMN3 [Q9NZ72]3EBI-10181968,EBI-725557
TLE5 - isoform 2 [Q08117-2]3EBI-10181968,EBI-11741437
TOX2 - isoform 3 [Q96NM4-3]3EBI-10181968,EBI-12815137
VPS37C [A5D8V6]3EBI-10181968,EBI-2559305
WDR62 [O43379]3EBI-10181968,EBI-714790
ZBTB7B - isoform 2 [O15156-2]3EBI-10181968,EBI-11522250
ZC3H12A [Q5D1E8]6EBI-10181968,EBI-747793

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
129495, 108 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q7Z4N8

Protein interaction database and analysis system

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IntActi
Q7Z4N8, 103 interactors

Molecular INTeraction database

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MINTi
Q7Z4N8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000401749

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z4N8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z4N8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati227 – 260TPRAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini422 – 529Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST108

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili107 – 131Sequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the P4HA family.Curated

Keywords - Domaini

Coiled coil, Signal, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1591, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000158967

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024155_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z4N8

KEGG Orthology (KO)

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KOi
K00472

Identification of Orthologs from Complete Genome Data

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OMAi
EQEDYYH

Database of Orthologous Groups

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OrthoDBi
1438683at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7Z4N8

TreeFam database of animal gene trees

More...
TreeFami
TF313393

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005123, Oxoglu/Fe-dep_dioxygenase
IPR006620, Pro_4_hyd_alph
IPR013547, Pro_4_hyd_alph_N
IPR011990, TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13640, 2OG-FeII_Oxy_3, 1 hit
PF08336, P4Ha_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00702, P4Hc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51471, FE2OG_OXY, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z4N8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPGARLAAL LAVLALGTGD PERAAARGDT FSALTSVARA LAPERRLLGL
60 70 80 90 100
LRRYLRGEEA RLRDLTRFYD KVLSLHEDST TPVANPLLAF TLIKRLQSDW
110 120 130 140 150
RNVVHSLEAS ENIRALKDGY EKVEQDLPAF EDLEGAARAL MRLQDVYMLN
160 170 180 190 200
VKGLARGVFQ RVTGSAITDL YSPKRLFSLT GDDCFQVGKV AYDMGDYYHA
210 220 230 240 250
IPWLEEAVSL FRGSYGEWKT EDEASLEDAL DHLAFAYFRA GNVSCALSLS
260 270 280 290 300
REFLLYSPDN KRMARNVLKY ERLLAESPNH VVAEAVIQRP NIPHLQTRDT
310 320 330 340 350
YEGLCQTLGS QPTLYQIPSL YCSYETNSNA YLLLQPIRKE VIHLEPYIAL
360 370 380 390 400
YHDFVSDSEA QKIRELAEPW LQRSVVASGE KQLQVEYRIS KSAWLKDTVD
410 420 430 440 450
PKLVTLNHRI AALTGLDVRP PYAEYLQVVN YGIGGHYEPH FDHATSPSSP
460 470 480 490 500
LYRMKSGNRV ATFMIYLSSV EAGGATAFIY ANLSVPVVRN AALFWWNLHR
510 520 530 540
SGEGDSDTLH AGCPVLVGDK WVANKWIHEY GQEFRRPCSS SPED
Length:544
Mass (Da):61,126
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C88C168A268572F
GO
Isoform 2 (identifier: Q7Z4N8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     257-257: S → R
     258-544: Missing.

Show »
Length:257
Mass (Da):28,701
Checksum:iA610B9B8CF4E4238
GO
Isoform 3 (identifier: Q7Z4N8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     490-544: NAALFWWNLH...RRPCSSSPED → HCFGGTCTGV...CYQGTLRMYI

Show »
Length:604
Mass (Da):67,591
Checksum:iE2A37A126C60A2A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PM97E9PM97_HUMAN
Prolyl 4-hydroxylase subunit alpha-...
P4HA3
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCC3H0YCC3_HUMAN
Prolyl 4-hydroxylase subunit alpha-...
P4HA3
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti222D → Y in AAH89446 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038675400D → N1 PublicationCorresponds to variant dbSNP:rs2282488Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_031146257S → R in isoform 2. 1 Publication1
Alternative sequenceiVSP_031147258 – 544Missing in isoform 2. 1 PublicationAdd BLAST287
Alternative sequenceiVSP_054131490 – 544NAALF…SSPED → HCFGGTCTGVVKGTVTHFML AVLSWWEISGWPTSGYMSMD RNSADPAAPALKTELLAERS WWSPVAFQRSQEPKAGVGEE KAEQPPGRRPCQLCLCLANQ RQGRGCYQGTLRMYI in isoform 3. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY313448 mRNA Translation: AAQ87603.1
AY327887 mRNA Translation: AAP97874.1
AY358521 mRNA Translation: AAQ88885.1
AK300598 mRNA Translation: BAG62295.1
AP000577 Genomic DNA No translation available.
AP001085 Genomic DNA No translation available.
AL833965 mRNA Translation: CAI46215.1
CH471076 Genomic DNA Translation: EAW74935.1
BC089446 mRNA Translation: AAH89446.1
BC117333 mRNA Translation: AAI17334.1
BC126170 mRNA Translation: AAI26171.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS73347.1 [Q7Z4N8-3]
CCDS8230.1 [Q7Z4N8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001275677.1, NM_001288748.1 [Q7Z4N8-3]
NP_878907.1, NM_182904.4 [Q7Z4N8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331597; ENSP00000332170; ENSG00000149380 [Q7Z4N8-1]
ENST00000427714; ENSP00000401749; ENSG00000149380 [Q7Z4N8-3]
ENST00000524388; ENSP00000433860; ENSG00000149380 [Q7Z4N8-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
283208

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:283208

UCSC genome browser

More...
UCSCi
uc001ouz.5, human [Q7Z4N8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313448 mRNA Translation: AAQ87603.1
AY327887 mRNA Translation: AAP97874.1
AY358521 mRNA Translation: AAQ88885.1
AK300598 mRNA Translation: BAG62295.1
AP000577 Genomic DNA No translation available.
AP001085 Genomic DNA No translation available.
AL833965 mRNA Translation: CAI46215.1
CH471076 Genomic DNA Translation: EAW74935.1
BC089446 mRNA Translation: AAH89446.1
BC117333 mRNA Translation: AAI17334.1
BC126170 mRNA Translation: AAI26171.1
CCDSiCCDS73347.1 [Q7Z4N8-3]
CCDS8230.1 [Q7Z4N8-1]
RefSeqiNP_001275677.1, NM_001288748.1 [Q7Z4N8-3]
NP_878907.1, NM_182904.4 [Q7Z4N8-1]

3D structure databases

SMRiQ7Z4N8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129495, 108 interactors
CORUMiQ7Z4N8
IntActiQ7Z4N8, 103 interactors
MINTiQ7Z4N8
STRINGi9606.ENSP00000401749

PTM databases

GlyGeniQ7Z4N8, 2 sites
iPTMnetiQ7Z4N8
PhosphoSitePlusiQ7Z4N8

Polymorphism and mutation databases

BioMutaiP4HA3
DMDMi74738714

Proteomic databases

MassIVEiQ7Z4N8
MaxQBiQ7Z4N8
PaxDbiQ7Z4N8
PeptideAtlasiQ7Z4N8
PRIDEiQ7Z4N8
ProteomicsDBi5178
69217 [Q7Z4N8-1]
69218 [Q7Z4N8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2002, 139 antibodies

Genome annotation databases

EnsembliENST00000331597; ENSP00000332170; ENSG00000149380 [Q7Z4N8-1]
ENST00000427714; ENSP00000401749; ENSG00000149380 [Q7Z4N8-3]
ENST00000524388; ENSP00000433860; ENSG00000149380 [Q7Z4N8-2]
GeneIDi283208
KEGGihsa:283208
UCSCiuc001ouz.5, human [Q7Z4N8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
283208
DisGeNETi283208
EuPathDBiHostDB:ENSG00000149380.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
P4HA3
HGNCiHGNC:30135, P4HA3
HPAiENSG00000149380, Tissue enhanced (epididymis)
MIMi608987, gene
neXtProtiNX_Q7Z4N8
OpenTargetsiENSG00000149380
PharmGKBiPA134870931

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1591, Eukaryota
GeneTreeiENSGT00940000158967
HOGENOMiCLU_024155_0_0_1
InParanoidiQ7Z4N8
KOiK00472
OMAiEQEDYYH
OrthoDBi1438683at2759
PhylomeDBiQ7Z4N8
TreeFamiTF313393

Enzyme and pathway databases

BRENDAi1.14.11.2, 2681
PathwayCommonsiQ7Z4N8
ReactomeiR-HSA-1650814, Collagen biosynthesis and modifying enzymes

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
283208, 5 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
P4HA3, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
283208
PharosiQ7Z4N8, Tdark

Protein Ontology

More...
PROi
PR:Q7Z4N8
RNActiQ7Z4N8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149380, Expressed in decidua and 146 other tissues
ExpressionAtlasiQ7Z4N8, baseline and differential
GenevisibleiQ7Z4N8, HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR005123, Oxoglu/Fe-dep_dioxygenase
IPR006620, Pro_4_hyd_alph
IPR013547, Pro_4_hyd_alph_N
IPR011990, TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF13640, 2OG-FeII_Oxy_3, 1 hit
PF08336, P4Ha_N, 1 hit
SMARTiView protein in SMART
SM00702, P4Hc, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS51471, FE2OG_OXY, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP4HA3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z4N8
Secondary accession number(s): A0AV13
, B4DUD3, Q5EBL3, Q5JPA9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: October 7, 2020
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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