UniProtKB - Q7Z4N2 (TRPM1_HUMAN)
Protein
Transient receptor potential cation channel subfamily M member 1
Gene
TRPM1
Organism
Homo sapiens (Human)
Status
Functioni
Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.By similarity3 Publications
GO - Molecular functioni
- calcium channel activity Source: UniProtKB
- cation channel activity Source: GO_Central
GO - Biological processi
- calcium ion transmembrane transport Source: Reactome
- calcium ion transport into cytosol Source: UniProtKB
- cation transmembrane transport Source: GO_Central
- cellular response to light stimulus Source: UniProtKB
- divalent metal ion transport Source: GO_Central
- G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
- protein tetramerization Source: InterPro
- retinal rod cell development Source: Ensembl
- visual perception Source: UniProtKB
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Sensory transduction, Transport, Vision |
Enzyme and pathway databases
PathwayCommonsi | Q7Z4N2 |
Reactomei | R-HSA-3295583, TRP channels |
SIGNORi | Q7Z4N2 |
Protein family/group databases
TCDBi | 1.A.4.5.2, the transient receptor potential ca(2+) channel (trp-cc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transient receptor potential cation channel subfamily M member 1Alternative name(s): Long transient receptor potential channel 1 Short name: LTrpC1 Melastatin-1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000134160.13 |
HGNCi | HGNC:7146, TRPM1 |
MIMi | 603576, gene |
neXtProti | NX_Q7Z4N2 |
Subcellular locationi
Plasma membrane
- Cell membrane Sequence analysis; Multi-pass membrane protein Sequence analysis1 Publication
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- new growing cell tip Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 524 | ExtracellularSequence analysisAdd BLAST | 524 | |
Transmembranei | 525 – 545 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 546 – 745 | CytoplasmicSequence analysisAdd BLAST | 200 | |
Transmembranei | 746 – 766 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 767 – 830 | ExtracellularSequence analysisAdd BLAST | 64 | |
Transmembranei | 831 – 851 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 852 | CytoplasmicSequence analysis | 1 | |
Transmembranei | 853 – 873 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 874 – 897 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 898 – 918 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 919 – 928 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 929 – 949 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 950 – 961 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 962 – 982 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 983 – 1054 | CytoplasmicSequence analysisAdd BLAST | 72 | |
Transmembranei | 1055 – 1075 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1076 – 1105 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 1106 – 1126 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1127 – 1603 | CytoplasmicSequence analysisAdd BLAST | 477 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Night blindness, congenital stationary, 1C (CSNB1C)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063174 | 56 | Y → C in CSNB1C. 1 Publication | 1 | |
Natural variantiVAR_063175 | 72 | Y → C in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs200514769Ensembl. | 1 | |
Natural variantiVAR_063176 | 74 | R → C in CSNB1C. 2 PublicationsCorresponds to variant dbSNP:rs774365264Ensembl. | 1 | |
Natural variantiVAR_063177 | 99 | L → P in CSNB1C. 2 PublicationsCorresponds to variant dbSNP:rs191205969Ensembl. | 1 | |
Natural variantiVAR_063178 | 364 | L → R in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs372608320Ensembl. | 1 | |
Natural variantiVAR_063180 | 473 | R → P in CSNB1C. 1 Publication | 1 | |
Natural variantiVAR_063181 | 534 | G → R in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs748043795Ensembl. | 1 | |
Natural variantiVAR_063182 | 541 | M → K in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs1261040173Ensembl. | 1 | |
Natural variantiVAR_063183 | 611 | P → H in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs267607139Ensembl. | 1 | |
Natural variantiVAR_063184 | 721 | R → Q in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs781460164Ensembl. | 1 | |
Natural variantiVAR_063185 | 883 | E → G in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs574652148Ensembl. | 1 | |
Natural variantiVAR_063187 | 1002 | I → F in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs369484186Ensembl. | 1 |
Keywords - Diseasei
Congenital stationary night blindness, Disease mutationOrganism-specific databases
DisGeNETi | 4308 |
MalaCardsi | TRPM1 |
MIMi | 613216, phenotype |
OpenTargetsi | ENSG00000134160 |
Orphaneti | 215, Congenital stationary night blindness |
PharmGKBi | PA35496 |
Miscellaneous databases
Pharosi | Q7Z4N2, Tchem |
Chemistry databases
GuidetoPHARMACOLOGYi | 493 |
Polymorphism and mutation databases
BioMutai | TRPM1 |
DMDMi | 182701419 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000328930 | 1 – 1603 | Transient receptor potential cation channel subfamily M member 1Add BLAST | 1603 |
Proteomic databases
jPOSTi | Q7Z4N2 |
MassIVEi | Q7Z4N2 |
MaxQBi | Q7Z4N2 |
PaxDbi | Q7Z4N2 |
PeptideAtlasi | Q7Z4N2 |
PRIDEi | Q7Z4N2 |
ProteomicsDBi | 15175 30084 40445 69213 [Q7Z4N2-1] 69214 [Q7Z4N2-2] 69215 [Q7Z4N2-3] 69216 [Q7Z4N2-4] |
PTM databases
iPTMneti | Q7Z4N2 |
PhosphoSitePlusi | Q7Z4N2 |
Expressioni
Tissue specificityi
Expressed in the retina where it localizes to the outer plexiform layer. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing.3 Publications
Inductioni
Up-regulated by hexamethylene bisacetamide (HBMA).1 Publication
Gene expression databases
Bgeei | ENSG00000134160, Expressed in pigmented layer of retina and 87 other tissues |
ExpressionAtlasi | Q7Z4N2, baseline and differential |
Genevisiblei | Q7Z4N2, HS |
Organism-specific databases
HPAi | ENSG00000134160, Tissue enriched (retina) |
Interactioni
Binary interactionsi
Protein-protein interaction databases
BioGRIDi | 110453, 5 interactors |
IntActi | Q7Z4N2, 4 interactors |
STRINGi | 9606.ENSP00000437849 |
Miscellaneous databases
RNActi | Q7Z4N2, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1179 – 1240 | Sequence analysisAdd BLAST | 62 |
Sequence similaritiesi
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily. [View classification]Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3614, Eukaryota |
GeneTreei | ENSGT00940000155024 |
HOGENOMi | CLU_046430_1_0_1 |
InParanoidi | Q7Z4N2 |
OMAi | HMYAMEI |
OrthoDBi | 738147at2759 |
PhylomeDBi | Q7Z4N2 |
TreeFami | TF314204 |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029588, TRPM1 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF13, PTHR13800:SF13, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
Isoform 11 Publication (identifier: Q7Z4N2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKDSNRCCCG QFTNQHIPPL PSATPSKNEE ESKQVETQPE KWSVAKHTQS
60 70 80 90 100
YPTDSYGVLE FQGGGYSNKA MYIRVSYDTK PDSLLHLMVK DWQLELPKLL
110 120 130 140 150
ISVHGGLQNF EMQPKLKQVF GKGLIKAAMT TGAWIFTGGV STGVISHVGD
160 170 180 190 200
ALKDHSSKSR GRVCAIGIAP WGIVENKEDL VGKDVTRVYQ TMSNPLSKLS
210 220 230 240 250
VLNNSHTHFI LADNGTLGKY GAEVKLRRLL EKHISLQKIN TRLGQGVPLV
260 270 280 290 300
GLVVEGGPNV VSIVLEYLQE EPPIPVVICD GSGRASDILS FAHKYCEEGG
310 320 330 340 350
IINESLREQL LVTIQKTFNY NKAQSHQLFA IIMECMKKKE LVTVFRMGSE
360 370 380 390 400
GQQDIEMAIL TALLKGTNVS APDQLSLALA WNRVDIARSQ IFVFGPHWPP
410 420 430 440 450
LGSLAPPTDS KATEKEKKPP MATTKGGRGK GKGKKKGKVK EEVEEETDPR
460 470 480 490 500
KIELLNWVNA LEQAMLDALV LDRVDFVKLL IENGVNMQHF LTIPRLEELY
510 520 530 540 550
NTRLGPPNTL HLLVRDVKKS NLPPDYHISL IDIGLVLEYL MGGAYRCNYT
560 570 580 590 600
RKNFRTLYNN LFGPKRPKAL KLLGMEDDEP PAKGKKKKKK KKEEEIDIDV
610 620 630 640 650
DDPAVSRFQY PFHELMVWAV LMKRQKMAVF LWQRGEESMA KALVACKLYK
660 670 680 690 700
AMAHESSESD LVDDISQDLD NNSKDFGQLA LELLDQSYKH DEQIAMKLLT
710 720 730 740 750
YELKNWSNST CLKLAVAAKH RDFIAHTCSQ MLLTDMWMGR LRMRKNPGLK
760 770 780 790 800
VIMGILLPPT ILFLEFRTYD DFSYQTSKEN EDGKEKEEEN TDANADAGSR
810 820 830 840 850
KGDEENEHKK QRSIPIGTKI CEFYNAPIVK FWFYTISYLG YLLLFNYVIL
860 870 880 890 900
VRMDGWPSLQ EWIVISYIVS LALEKIREIL MSEPGKLSQK IKVWLQEYWN
910 920 930 940 950
ITDLVAISTF MIGAILRLQN QPYMGYGRVI YCVDIIFWYI RVLDIFGVNK
960 970 980 990 1000
YLGPYVMMIG KMMIDMLYFV VIMLVVLMSF GVARQAILHP EEKPSWKLAR
1010 1020 1030 1040 1050
NIFYMPYWMI YGEVFADQID LYAMEINPPC GENLYDEEGK RLPPCIPGAW
1060 1070 1080 1090 1100
LTPALMACYL LVANILLVNL LIAVFNNTFF EVKSISNQVW KFQRYQLIMT
1110 1120 1130 1140 1150
FHDRPVLPPP MIILSHIYII IMRLSGRCRK KREGDQEERD RGLKLFLSDE
1160 1170 1180 1190 1200
ELKRLHEFEE QCVQEHFREK EDEQQSSSDE RIRVTSERVE NMSMRLEEIN
1210 1220 1230 1240 1250
ERETFMKTSL QTVDLRLAQL EELSNRMVNA LENLAGIDRS DLIQARSRAS
1260 1270 1280 1290 1300
SECEATYLLR QSSINSADGY SLYRYHFNGE ELLFEDTSLS TSPGTGVRKK
1310 1320 1330 1340 1350
TCSFRIKEEK DVKTHLVPEC QNSLHLSLGT STSATPDGSH LAVDDLKNAE
1360 1370 1380 1390 1400
ESKLGPDIGI SKEDDERQTD SKKEETISPS LNKTDVIHGQ DKSDVQNTQL
1410 1420 1430 1440 1450
TVETTNIEGT ISYPLEETKI TRYFPDETIN ACKTMKSRSF VYSRGRKLVG
1460 1470 1480 1490 1500
GVNQDVEYSS ITDQQLTTEW QCQVQKITRS HSTDIPYIVS EAAVQAEHKE
1510 1520 1530 1540 1550
QFADMQDEHH VAEAIPRIPR LSLTITDRNG MENLLSVKPD QTLGFPSLRS
1560 1570 1580 1590 1600
KSLHGHPRNV KSIQGKLDRS GHASSVSSLV IVSGMTAEEK KVKKEKASTE
TEC
Isoform 41 Publication (identifier: Q7Z4N2-4) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
301-1603: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YM61 | H0YM61_HUMAN | Transient receptor potential cation... | TRPM1 | 505 | Annotation score: | ||
H0YKU7 | H0YKU7_HUMAN | Transient receptor potential cation... | TRPM1 | 1,390 | Annotation score: | ||
A0A0A0MTQ9 | A0A0A0MTQ9_HUMAN | Transient receptor potential cation... | TRPM1 | 1,526 | Annotation score: | ||
A0A0G2JMJ5 | A0A0G2JMJ5_HUMAN | Transient receptor potential cation... | TRPM1 | 1,603 | Annotation score: | ||
A0A0G2JMR4 | A0A0G2JMR4_HUMAN | Transient receptor potential cation... | TRPM1 | 1,625 | Annotation score: | ||
A0A0G2JN34 | A0A0G2JN34_HUMAN | Transient receptor potential cation... | TRPM1 | 1,642 | Annotation score: | ||
A0A0G2JPN6 | A0A0G2JPN6_HUMAN | Transient receptor potential cation... | TRPM1 | 1,603 | Annotation score: | ||
A0A0A0MTR0 | A0A0A0MTR0_HUMAN | Transient receptor potential cation... | TRPM1 | 229 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 | M → T in ADJ52077 (PubMed:19436059).Curated | 1 | |
Sequence conflicti | 369 | V → L in BAC80200 (Ref. 3) Curated | 1 | |
Sequence conflicti | 1195 | R → G in BAC80201 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063173 | 6 | R → W2 Publications | 1 | |
Natural variantiVAR_052370 | 32 | S → N3 PublicationsCorresponds to variant dbSNP:rs2241493Ensembl. | 1 | |
Natural variantiVAR_063174 | 56 | Y → C in CSNB1C. 1 Publication | 1 | |
Natural variantiVAR_063175 | 72 | Y → C in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs200514769Ensembl. | 1 | |
Natural variantiVAR_063176 | 74 | R → C in CSNB1C. 2 PublicationsCorresponds to variant dbSNP:rs774365264Ensembl. | 1 | |
Natural variantiVAR_063177 | 99 | L → P in CSNB1C. 2 PublicationsCorresponds to variant dbSNP:rs191205969Ensembl. | 1 | |
Natural variantiVAR_063178 | 364 | L → R in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs372608320Ensembl. | 1 | |
Natural variantiVAR_063179 | 399 | P → T2 PublicationsCorresponds to variant dbSNP:rs141540242Ensembl. | 1 | |
Natural variantiVAR_063180 | 473 | R → P in CSNB1C. 1 Publication | 1 | |
Natural variantiVAR_063181 | 534 | G → R in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs748043795Ensembl. | 1 | |
Natural variantiVAR_063182 | 541 | M → K in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs1261040173Ensembl. | 1 | |
Natural variantiVAR_052371 | 605 | V → M2 PublicationsCorresponds to variant dbSNP:rs17815774Ensembl. | 1 | |
Natural variantiVAR_063183 | 611 | P → H in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs267607139Ensembl. | 1 | |
Natural variantiVAR_063184 | 721 | R → Q in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs781460164Ensembl. | 1 | |
Natural variantiVAR_063185 | 883 | E → G in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs574652148Ensembl. | 1 | |
Natural variantiVAR_063186 | 962 | M → T in a patient with night blindness started in the third decade; associated in cis with G-1438. 1 Publication | 1 | |
Natural variantiVAR_063187 | 1002 | I → F in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs369484186Ensembl. | 1 | |
Natural variantiVAR_063188 | 1161 | Q → H1 PublicationCorresponds to variant dbSNP:rs182549235Ensembl. | 1 | |
Natural variantiVAR_052372 | 1229 | N → T1 PublicationCorresponds to variant dbSNP:rs17227996Ensembl. | 1 | |
Natural variantiVAR_052373 | 1305 | R → H. Corresponds to variant dbSNP:rs13380059Ensembl. | 1 | |
Natural variantiVAR_063189 | 1379 | P → T1 PublicationCorresponds to variant dbSNP:rs61734298Ensembl. | 1 | |
Natural variantiVAR_052374 | 1395 | V → I2 PublicationsCorresponds to variant dbSNP:rs3784588Ensembl. | 1 | |
Natural variantiVAR_052375 | 1422 | R → G. Corresponds to variant dbSNP:rs3784587Ensembl. | 1 | |
Natural variantiVAR_063190 | 1422 | R → W1 Publication | 1 | |
Natural variantiVAR_063191 | 1438 | R → G in a patient with night blindness started in the third decade; associated in cis with T-962. 1 Publication | 1 | |
Natural variantiVAR_052376 | 1498 | H → Q2 PublicationsCorresponds to variant dbSNP:rs12898290Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052748 | 1 – 70 | Missing in isoform 2. 2 PublicationsAdd BLAST | 70 | |
Alternative sequenceiVSP_046786 | 1 | M → MSSFKRGSLKSSTSGSQKGQ KSWIEKTFCKRECIFVIPSM in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_046787 | 1 | M → MGQKSWIEKTFCKRECIFVI PSM in isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_046788 | 72 – 136 | YIRVS…GAWIF → VRKAFRHGATRITAFIGGQS PSPKLQIPGLLHGCGSIFLD ISLKNQEIYLCTWLLAMRLG NWTPL in isoform 7. 1 PublicationAdd BLAST | 65 | |
Alternative sequenceiVSP_046789 | 137 – 1603 | Missing in isoform 7. 1 PublicationAdd BLAST | 1467 | |
Alternative sequenceiVSP_052749 | 295 – 300 | Missing in isoform 3. 1 Publication | 6 | |
Alternative sequenceiVSP_052750 | 301 – 1603 | Missing in isoform 4. 1 PublicationAdd BLAST | 1303 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF071787 mRNA Translation: AAC80000.1 HM135790 mRNA Translation: ADJ52077.1 HM135791 mRNA Translation: ADJ52078.1 AB115498 mRNA Translation: BAC80200.1 AB115499 mRNA Translation: BAC80201.1 AB115500 mRNA Translation: BAC80202.1 AB115501 mRNA Translation: BAC80203.1 AB115502 mRNA Translation: BAC80204.1 AC009562 Genomic DNA No translation available. AC090829 Genomic DNA No translation available. CH471216 Genomic DNA Translation: EAW61261.1 BC058286 mRNA Translation: AAH58286.1 |
CCDSi | CCDS10024.2 [Q7Z4N2-1] CCDS58345.1 [Q7Z4N2-7] CCDS58346.1 [Q7Z4N2-6] CCDS58347.1 [Q7Z4N2-5] |
RefSeqi | NP_001238949.1, NM_001252020.1 [Q7Z4N2-5] NP_001238953.1, NM_001252024.1 [Q7Z4N2-6] NP_001238959.1, NM_001252030.1 [Q7Z4N2-7] NP_002411.3, NM_002420.5 [Q7Z4N2-1] |
Genome annotation databases
Ensembli | ENST00000256552; ENSP00000256552; ENSG00000134160 [Q7Z4N2-6] ENST00000397795; ENSP00000380897; ENSG00000134160 [Q7Z4N2-1] ENST00000542188; ENSP00000437849; ENSG00000134160 [Q7Z4N2-5] ENST00000559179; ENSP00000453851; ENSG00000134160 [Q7Z4N2-7] ENST00000560658; ENSP00000454077; ENSG00000134160 [Q7Z4N2-4] |
GeneIDi | 4308 |
KEGGi | hsa:4308 |
UCSCi | uc001zfm.4, human [Q7Z4N2-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF071787 mRNA Translation: AAC80000.1 HM135790 mRNA Translation: ADJ52077.1 HM135791 mRNA Translation: ADJ52078.1 AB115498 mRNA Translation: BAC80200.1 AB115499 mRNA Translation: BAC80201.1 AB115500 mRNA Translation: BAC80202.1 AB115501 mRNA Translation: BAC80203.1 AB115502 mRNA Translation: BAC80204.1 AC009562 Genomic DNA No translation available. AC090829 Genomic DNA No translation available. CH471216 Genomic DNA Translation: EAW61261.1 BC058286 mRNA Translation: AAH58286.1 |
CCDSi | CCDS10024.2 [Q7Z4N2-1] CCDS58345.1 [Q7Z4N2-7] CCDS58346.1 [Q7Z4N2-6] CCDS58347.1 [Q7Z4N2-5] |
RefSeqi | NP_001238949.1, NM_001252020.1 [Q7Z4N2-5] NP_001238953.1, NM_001252024.1 [Q7Z4N2-6] NP_001238959.1, NM_001252030.1 [Q7Z4N2-7] NP_002411.3, NM_002420.5 [Q7Z4N2-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 110453, 5 interactors |
IntActi | Q7Z4N2, 4 interactors |
STRINGi | 9606.ENSP00000437849 |
Chemistry databases
GuidetoPHARMACOLOGYi | 493 |
Protein family/group databases
TCDBi | 1.A.4.5.2, the transient receptor potential ca(2+) channel (trp-cc) family |
PTM databases
iPTMneti | Q7Z4N2 |
PhosphoSitePlusi | Q7Z4N2 |
Polymorphism and mutation databases
BioMutai | TRPM1 |
DMDMi | 182701419 |
Proteomic databases
jPOSTi | Q7Z4N2 |
MassIVEi | Q7Z4N2 |
MaxQBi | Q7Z4N2 |
PaxDbi | Q7Z4N2 |
PeptideAtlasi | Q7Z4N2 |
PRIDEi | Q7Z4N2 |
ProteomicsDBi | 15175 30084 40445 69213 [Q7Z4N2-1] 69214 [Q7Z4N2-2] 69215 [Q7Z4N2-3] 69216 [Q7Z4N2-4] |
Protocols and materials databases
Antibodypediai | 9410, 70 antibodies |
Genome annotation databases
Ensembli | ENST00000256552; ENSP00000256552; ENSG00000134160 [Q7Z4N2-6] ENST00000397795; ENSP00000380897; ENSG00000134160 [Q7Z4N2-1] ENST00000542188; ENSP00000437849; ENSG00000134160 [Q7Z4N2-5] ENST00000559179; ENSP00000453851; ENSG00000134160 [Q7Z4N2-7] ENST00000560658; ENSP00000454077; ENSG00000134160 [Q7Z4N2-4] |
GeneIDi | 4308 |
KEGGi | hsa:4308 |
UCSCi | uc001zfm.4, human [Q7Z4N2-1] |
Organism-specific databases
CTDi | 4308 |
DisGeNETi | 4308 |
EuPathDBi | HostDB:ENSG00000134160.13 |
GeneCardsi | TRPM1 |
HGNCi | HGNC:7146, TRPM1 |
HPAi | ENSG00000134160, Tissue enriched (retina) |
MalaCardsi | TRPM1 |
MIMi | 603576, gene 613216, phenotype |
neXtProti | NX_Q7Z4N2 |
OpenTargetsi | ENSG00000134160 |
Orphaneti | 215, Congenital stationary night blindness |
PharmGKBi | PA35496 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3614, Eukaryota |
GeneTreei | ENSGT00940000155024 |
HOGENOMi | CLU_046430_1_0_1 |
InParanoidi | Q7Z4N2 |
OMAi | HMYAMEI |
OrthoDBi | 738147at2759 |
PhylomeDBi | Q7Z4N2 |
TreeFami | TF314204 |
Enzyme and pathway databases
PathwayCommonsi | Q7Z4N2 |
Reactomei | R-HSA-3295583, TRP channels |
SIGNORi | Q7Z4N2 |
Miscellaneous databases
BioGRID-ORCSi | 4308, 2 hits in 838 CRISPR screens |
ChiTaRSi | TRPM1, human |
GeneWikii | TRPM1 |
GenomeRNAii | 4308 |
Pharosi | Q7Z4N2, Tchem |
PROi | PR:Q7Z4N2 |
RNActi | Q7Z4N2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134160, Expressed in pigmented layer of retina and 87 other tissues |
ExpressionAtlasi | Q7Z4N2, baseline and differential |
Genevisiblei | Q7Z4N2, HS |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029588, TRPM1 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF13, PTHR13800:SF13, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRPM1_HUMAN | |
Accessioni | Q7Z4N2Primary (citable) accession number: Q7Z4N2 Secondary accession number(s): D9IDV2 Q7Z4N5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | December 2, 2020 | |
This is version 140 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations