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UniProtKB - Q7Z4N2 (TRPM1_HUMAN)

Protein

Transient receptor potential cation channel subfamily M member 1

Gene

TRPM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.By similarity3 Publications

GO - Molecular functioni

  • calcium channel activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Sensory transduction, Transport, Vision

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels
SIGNORiQ7Z4N2

Protein family/group databases

TCDBi1.A.4.5.2 the transient receptor potential ca(2+) channel (trp-cc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 1
Alternative name(s):
Long transient receptor potential channel 1
Short name:
LTrpC1
Melastatin-1
Gene namesi
Name:TRPM1Imported
Synonyms:LTRPC1, MLSN1 Publication, MLSN1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000134160.13
HGNCiHGNC:7146 TRPM1
MIMi603576 gene
neXtProtiNX_Q7Z4N2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 524ExtracellularSequence analysisAdd BLAST524
Transmembranei525 – 545HelicalSequence analysisAdd BLAST21
Topological domaini546 – 745CytoplasmicSequence analysisAdd BLAST200
Transmembranei746 – 766HelicalSequence analysisAdd BLAST21
Topological domaini767 – 830ExtracellularSequence analysisAdd BLAST64
Transmembranei831 – 851HelicalSequence analysisAdd BLAST21
Topological domaini852CytoplasmicSequence analysis1
Transmembranei853 – 873HelicalSequence analysisAdd BLAST21
Topological domaini874 – 897ExtracellularSequence analysisAdd BLAST24
Transmembranei898 – 918HelicalSequence analysisAdd BLAST21
Topological domaini919 – 928CytoplasmicSequence analysis10
Transmembranei929 – 949HelicalSequence analysisAdd BLAST21
Topological domaini950 – 961ExtracellularSequence analysisAdd BLAST12
Transmembranei962 – 982HelicalSequence analysisAdd BLAST21
Topological domaini983 – 1054CytoplasmicSequence analysisAdd BLAST72
Transmembranei1055 – 1075HelicalSequence analysisAdd BLAST21
Topological domaini1076 – 1105ExtracellularSequence analysisAdd BLAST30
Transmembranei1106 – 1126HelicalSequence analysisAdd BLAST21
Topological domaini1127 – 1603CytoplasmicSequence analysisAdd BLAST477

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Night blindness, congenital stationary, 1C (CSNB1C)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia.
See also OMIM:613216
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06317456Y → C in CSNB1C. 1 Publication1
Natural variantiVAR_06317572Y → C in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs200514769Ensembl.1
Natural variantiVAR_06317674R → C in CSNB1C. 2 PublicationsCorresponds to variant dbSNP:rs774365264Ensembl.1
Natural variantiVAR_06317799L → P in CSNB1C. 2 PublicationsCorresponds to variant dbSNP:rs191205969EnsemblClinVar.1
Natural variantiVAR_063178364L → R in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs372608320Ensembl.1
Natural variantiVAR_063180473R → P in CSNB1C. 1 Publication1
Natural variantiVAR_063181534G → R in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs748043795Ensembl.1
Natural variantiVAR_063182541M → K in CSNB1C. 1 Publication1
Natural variantiVAR_063183611P → H in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs267607139EnsemblClinVar.1
Natural variantiVAR_063184721R → Q in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs781460164EnsemblClinVar.1
Natural variantiVAR_063185883E → G in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs574652148Ensembl.1
Natural variantiVAR_0631871002I → F in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs369484186EnsemblClinVar.1

Keywords - Diseasei

Congenital stationary night blindness, Disease mutation

Organism-specific databases

DisGeNETi4308
MalaCardsiTRPM1
MIMi613216 phenotype
OpenTargetsiENSG00000134160
Orphaneti215 Congenital stationary night blindness
PharmGKBiPA35496

Chemistry databases

GuidetoPHARMACOLOGYi493

Polymorphism and mutation databases

BioMutaiTRPM1
DMDMi182701419

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003289301 – 1603Transient receptor potential cation channel subfamily M member 1Add BLAST1603

Proteomic databases

MaxQBiQ7Z4N2
PaxDbiQ7Z4N2
PeptideAtlasiQ7Z4N2
PRIDEiQ7Z4N2
ProteomicsDBi69213
69214 [Q7Z4N2-2]
69215 [Q7Z4N2-3]
69216 [Q7Z4N2-4]

PTM databases

iPTMnetiQ7Z4N2
PhosphoSitePlusiQ7Z4N2

Expressioni

Tissue specificityi

Expressed in the retina where it localizes to the outer plexiform layer. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing.3 Publications

Inductioni

Up-regulated by hexamethylene bisacetamide (HBMA).1 Publication

Gene expression databases

BgeeiENSG00000134160 Expressed in 75 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_TRPM1
ExpressionAtlasiQ7Z4N2 baseline and differential
GenevisibleiQ7Z4N2 HS

Organism-specific databases

HPAiHPA014779
HPA014785

Interactioni

Protein-protein interaction databases

BioGridi110453, 4 interactors
IntActiQ7Z4N2, 2 interactors
STRINGi9606.ENSP00000380897

Structurei

3D structure databases

ProteinModelPortaliQ7Z4N2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1179 – 1240Sequence analysisAdd BLAST62

Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily. [View classification]Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3614 Eukaryota
ENOG410XR5B LUCA
GeneTreeiENSGT00760000119127
HOGENOMiHOG000230920
HOVERGENiHBG055663
InParanoidiQ7Z4N2
KOiK04976
OMAiLYKSMAH
OrthoDBiEOG091G0DHL
PhylomeDBiQ7Z4N2
TreeFamiTF314204

Family and domain databases

Gene3Di1.20.5.1010, 1 hit
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR029588 TRPM1
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf
PANTHERiPTHR13800:SF13 PTHR13800:SF13, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF16519 TRPM_tetra, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q7Z4N2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKDSNRCCCG QFTNQHIPPL PSATPSKNEE ESKQVETQPE KWSVAKHTQS 
        60         70         80         90        100
YPTDSYGVLE FQGGGYSNKA MYIRVSYDTK PDSLLHLMVK DWQLELPKLL 
       110        120        130        140        150
ISVHGGLQNF EMQPKLKQVF GKGLIKAAMT TGAWIFTGGV STGVISHVGD 
       160        170        180        190        200
ALKDHSSKSR GRVCAIGIAP WGIVENKEDL VGKDVTRVYQ TMSNPLSKLS 
       210        220        230        240        250
VLNNSHTHFI LADNGTLGKY GAEVKLRRLL EKHISLQKIN TRLGQGVPLV 
       260        270        280        290        300
GLVVEGGPNV VSIVLEYLQE EPPIPVVICD GSGRASDILS FAHKYCEEGG 
       310        320        330        340        350
IINESLREQL LVTIQKTFNY NKAQSHQLFA IIMECMKKKE LVTVFRMGSE 
       360        370        380        390        400
GQQDIEMAIL TALLKGTNVS APDQLSLALA WNRVDIARSQ IFVFGPHWPP 
       410        420        430        440        450
LGSLAPPTDS KATEKEKKPP MATTKGGRGK GKGKKKGKVK EEVEEETDPR 
       460        470        480        490        500
KIELLNWVNA LEQAMLDALV LDRVDFVKLL IENGVNMQHF LTIPRLEELY 
       510        520        530        540        550
NTRLGPPNTL HLLVRDVKKS NLPPDYHISL IDIGLVLEYL MGGAYRCNYT 
       560        570        580        590        600
RKNFRTLYNN LFGPKRPKAL KLLGMEDDEP PAKGKKKKKK KKEEEIDIDV 
       610        620        630        640        650
DDPAVSRFQY PFHELMVWAV LMKRQKMAVF LWQRGEESMA KALVACKLYK 
       660        670        680        690        700
AMAHESSESD LVDDISQDLD NNSKDFGQLA LELLDQSYKH DEQIAMKLLT 
       710        720        730        740        750
YELKNWSNST CLKLAVAAKH RDFIAHTCSQ MLLTDMWMGR LRMRKNPGLK 
       760        770        780        790        800
VIMGILLPPT ILFLEFRTYD DFSYQTSKEN EDGKEKEEEN TDANADAGSR 
       810        820        830        840        850
KGDEENEHKK QRSIPIGTKI CEFYNAPIVK FWFYTISYLG YLLLFNYVIL 
       860        870        880        890        900
VRMDGWPSLQ EWIVISYIVS LALEKIREIL MSEPGKLSQK IKVWLQEYWN 
       910        920        930        940        950
ITDLVAISTF MIGAILRLQN QPYMGYGRVI YCVDIIFWYI RVLDIFGVNK 
       960        970        980        990       1000
YLGPYVMMIG KMMIDMLYFV VIMLVVLMSF GVARQAILHP EEKPSWKLAR 
      1010       1020       1030       1040       1050
NIFYMPYWMI YGEVFADQID LYAMEINPPC GENLYDEEGK RLPPCIPGAW 
      1060       1070       1080       1090       1100
LTPALMACYL LVANILLVNL LIAVFNNTFF EVKSISNQVW KFQRYQLIMT 
      1110       1120       1130       1140       1150
FHDRPVLPPP MIILSHIYII IMRLSGRCRK KREGDQEERD RGLKLFLSDE 
      1160       1170       1180       1190       1200
ELKRLHEFEE QCVQEHFREK EDEQQSSSDE RIRVTSERVE NMSMRLEEIN 
      1210       1220       1230       1240       1250
ERETFMKTSL QTVDLRLAQL EELSNRMVNA LENLAGIDRS DLIQARSRAS 
      1260       1270       1280       1290       1300
SECEATYLLR QSSINSADGY SLYRYHFNGE ELLFEDTSLS TSPGTGVRKK 
      1310       1320       1330       1340       1350
TCSFRIKEEK DVKTHLVPEC QNSLHLSLGT STSATPDGSH LAVDDLKNAE 
      1360       1370       1380       1390       1400
ESKLGPDIGI SKEDDERQTD SKKEETISPS LNKTDVIHGQ DKSDVQNTQL 
      1410       1420       1430       1440       1450
TVETTNIEGT ISYPLEETKI TRYFPDETIN ACKTMKSRSF VYSRGRKLVG 
      1460       1470       1480       1490       1500
GVNQDVEYSS ITDQQLTTEW QCQVQKITRS HSTDIPYIVS EAAVQAEHKE 
      1510       1520       1530       1540       1550
QFADMQDEHH VAEAIPRIPR LSLTITDRNG MENLLSVKPD QTLGFPSLRS 
      1560       1570       1580       1590       1600
KSLHGHPRNV KSIQGKLDRS GHASSVSSLV IVSGMTAEEK KVKKEKASTE 

TEC
Note: No experimental confirmation available.Curated
Length:1,603
Mass (Da):182,178
Last modified:April 8, 2008 - v2
Checksum:i8B9658FAE3F7B32F
GO
Isoform 22 Publications (identifier: Q7Z4N2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Show »
Length:1,533
Mass (Da):174,418
Checksum:iD824DC467BC1A70F
GO
Isoform 31 Publication (identifier: Q7Z4N2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-300: Missing.

Show »
Length:1,597
Mass (Da):181,540
Checksum:i44A93B1C9CF533C7
GO
Isoform 41 Publication (identifier: Q7Z4N2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-1603: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:300
Mass (Da):32,814
Checksum:iEA1EE23D05248823
GO
Isoform 5 (identifier: Q7Z4N2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSSFKRGSLKSSTSGSQKGQKSWIEKTFCKRECIFVIPSM

Show »
Length:1,642
Mass (Da):186,545
Checksum:i8FCF58496AF8504D
GO
Isoform 6 (identifier: Q7Z4N2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGQKSWIEKTFCKRECIFVIPSM

Show »
Length:1,625
Mass (Da):184,792
Checksum:i242329CE4A78C0F6
GO
Isoform 7 (identifier: Q7Z4N2-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     72-136: YIRVSYDTKP...AAMTTGAWIF → VRKAFRHGAT...AMRLGNWTPL
     137-1603: Missing.

Show »
Length:136
Mass (Da):15,099
Checksum:iEAA6CA0DA32B87D7
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YM61H0YM61_HUMAN
Transient receptor potential cation...
TRPM1
505Annotation score:
H0YKU7H0YKU7_HUMAN
Transient receptor potential cation...
TRPM1
1,390Annotation score:
A0A0A0MTQ9A0A0A0MTQ9_HUMAN
Transient receptor potential cation...
TRPM1
1,526Annotation score:
A0A0G2JMJ5A0A0G2JMJ5_HUMAN
Transient receptor potential cation...
TRPM1
1,603Annotation score:
A0A0G2JPN6A0A0G2JPN6_HUMAN
Transient receptor potential cation...
TRPM1
1,603Annotation score:
A0A0G2JN34A0A0G2JN34_HUMAN
Transient receptor potential cation...
TRPM1
1,642Annotation score:
A0A0G2JMR4A0A0G2JMR4_HUMAN
Transient receptor potential cation...
TRPM1
1,625Annotation score:
A0A0A0MTR0A0A0A0MTR0_HUMAN
Transient receptor potential cation...
TRPM1
229Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → T in ADJ52077 (PubMed:19436059).Curated1
Sequence conflicti369V → L in BAC80200 (Ref. 3) Curated1
Sequence conflicti1195R → G in BAC80201 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0631736R → W2 Publications1
Natural variantiVAR_05237032S → N3 PublicationsCorresponds to variant dbSNP:rs2241493EnsemblClinVar.1
Natural variantiVAR_06317456Y → C in CSNB1C. 1 Publication1
Natural variantiVAR_06317572Y → C in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs200514769Ensembl.1
Natural variantiVAR_06317674R → C in CSNB1C. 2 PublicationsCorresponds to variant dbSNP:rs774365264Ensembl.1
Natural variantiVAR_06317799L → P in CSNB1C. 2 PublicationsCorresponds to variant dbSNP:rs191205969EnsemblClinVar.1
Natural variantiVAR_063178364L → R in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs372608320Ensembl.1
Natural variantiVAR_063179399P → T2 PublicationsCorresponds to variant dbSNP:rs141540242Ensembl.1
Natural variantiVAR_063180473R → P in CSNB1C. 1 Publication1
Natural variantiVAR_063181534G → R in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs748043795Ensembl.1
Natural variantiVAR_063182541M → K in CSNB1C. 1 Publication1
Natural variantiVAR_052371605V → M2 PublicationsCorresponds to variant dbSNP:rs17815774EnsemblClinVar.1
Natural variantiVAR_063183611P → H in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs267607139EnsemblClinVar.1
Natural variantiVAR_063184721R → Q in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs781460164EnsemblClinVar.1
Natural variantiVAR_063185883E → G in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs574652148Ensembl.1
Natural variantiVAR_063186962M → T in a patient with night blindness started in the third decade; associated in cis with G-1438. 1 Publication1
Natural variantiVAR_0631871002I → F in CSNB1C. 1 PublicationCorresponds to variant dbSNP:rs369484186EnsemblClinVar.1
Natural variantiVAR_0631881161Q → H1 PublicationCorresponds to variant dbSNP:rs182549235EnsemblClinVar.1
Natural variantiVAR_0523721229N → T1 PublicationCorresponds to variant dbSNP:rs17227996EnsemblClinVar.1
Natural variantiVAR_0523731305R → H. Corresponds to variant dbSNP:rs13380059Ensembl.1
Natural variantiVAR_0631891379P → T1 PublicationCorresponds to variant dbSNP:rs61734298EnsemblClinVar.1
Natural variantiVAR_0523741395V → I2 PublicationsCorresponds to variant dbSNP:rs3784588EnsemblClinVar.1
Natural variantiVAR_0523751422R → G. Corresponds to variant dbSNP:rs3784587Ensembl.1
Natural variantiVAR_0631901422R → W1 Publication1
Natural variantiVAR_0631911438R → G in a patient with night blindness started in the third decade; associated in cis with T-962. 1 Publication1
Natural variantiVAR_0523761498H → Q2 PublicationsCorresponds to variant dbSNP:rs12898290EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0527481 – 70Missing in isoform 2. 2 PublicationsAdd BLAST70
Alternative sequenceiVSP_0467861M → MSSFKRGSLKSSTSGSQKGQ KSWIEKTFCKRECIFVIPSM in isoform 5. 1 Publication1
Alternative sequenceiVSP_0467871M → MGQKSWIEKTFCKRECIFVI PSM in isoform 6. 1 Publication1
Alternative sequenceiVSP_04678872 – 136YIRVS…GAWIF → VRKAFRHGATRITAFIGGQS PSPKLQIPGLLHGCGSIFLD ISLKNQEIYLCTWLLAMRLG NWTPL in isoform 7. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_046789137 – 1603Missing in isoform 7. 1 PublicationAdd BLAST1467
Alternative sequenceiVSP_052749295 – 300Missing in isoform 3. 1 Publication6
Alternative sequenceiVSP_052750301 – 1603Missing in isoform 4. 1 PublicationAdd BLAST1303

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071787 mRNA Translation: AAC80000.1
HM135790 mRNA Translation: ADJ52077.1
HM135791 mRNA Translation: ADJ52078.1
AB115498 mRNA Translation: BAC80200.1
AB115499 mRNA Translation: BAC80201.1
AB115500 mRNA Translation: BAC80202.1
AB115501 mRNA Translation: BAC80203.1
AB115502 mRNA Translation: BAC80204.1
AC009562 Genomic DNA No translation available.
AC090829 Genomic DNA No translation available.
CH471216 Genomic DNA Translation: EAW61261.1
BC058286 mRNA Translation: AAH58286.1
CCDSiCCDS10024.2 [Q7Z4N2-1]
CCDS58345.1 [Q7Z4N2-7]
CCDS58346.1 [Q7Z4N2-6]
CCDS58347.1 [Q7Z4N2-5]
RefSeqiNP_001238949.1, NM_001252020.1 [Q7Z4N2-5]
NP_001238953.1, NM_001252024.1 [Q7Z4N2-6]
NP_001238959.1, NM_001252030.1 [Q7Z4N2-7]
NP_002411.3, NM_002420.5 [Q7Z4N2-1]
UniGeneiHs.155942
Hs.732541

Genome annotation databases

EnsembliENST00000256552; ENSP00000256552; ENSG00000134160 [Q7Z4N2-6]
ENST00000397795; ENSP00000380897; ENSG00000134160 [Q7Z4N2-1]
ENST00000542188; ENSP00000437849; ENSG00000134160 [Q7Z4N2-5]
ENST00000559179; ENSP00000453851; ENSG00000134160 [Q7Z4N2-7]
ENST00000560658; ENSP00000454077; ENSG00000134160 [Q7Z4N2-4]
GeneIDi4308
KEGGihsa:4308
UCSCiuc001zfm.4 human [Q7Z4N2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071787 mRNA Translation: AAC80000.1
HM135790 mRNA Translation: ADJ52077.1
HM135791 mRNA Translation: ADJ52078.1
AB115498 mRNA Translation: BAC80200.1
AB115499 mRNA Translation: BAC80201.1
AB115500 mRNA Translation: BAC80202.1
AB115501 mRNA Translation: BAC80203.1
AB115502 mRNA Translation: BAC80204.1
AC009562 Genomic DNA No translation available.
AC090829 Genomic DNA No translation available.
CH471216 Genomic DNA Translation: EAW61261.1
BC058286 mRNA Translation: AAH58286.1
CCDSiCCDS10024.2 [Q7Z4N2-1]
CCDS58345.1 [Q7Z4N2-7]
CCDS58346.1 [Q7Z4N2-6]
CCDS58347.1 [Q7Z4N2-5]
RefSeqiNP_001238949.1, NM_001252020.1 [Q7Z4N2-5]
NP_001238953.1, NM_001252024.1 [Q7Z4N2-6]
NP_001238959.1, NM_001252030.1 [Q7Z4N2-7]
NP_002411.3, NM_002420.5 [Q7Z4N2-1]
UniGeneiHs.155942
Hs.732541

3D structure databases

ProteinModelPortaliQ7Z4N2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110453, 4 interactors
IntActiQ7Z4N2, 2 interactors
STRINGi9606.ENSP00000380897

Chemistry databases

GuidetoPHARMACOLOGYi493

Protein family/group databases

TCDBi1.A.4.5.2 the transient receptor potential ca(2+) channel (trp-cc) family

PTM databases

iPTMnetiQ7Z4N2
PhosphoSitePlusiQ7Z4N2

Polymorphism and mutation databases

BioMutaiTRPM1
DMDMi182701419

Proteomic databases

MaxQBiQ7Z4N2
PaxDbiQ7Z4N2
PeptideAtlasiQ7Z4N2
PRIDEiQ7Z4N2
ProteomicsDBi69213
69214 [Q7Z4N2-2]
69215 [Q7Z4N2-3]
69216 [Q7Z4N2-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256552; ENSP00000256552; ENSG00000134160 [Q7Z4N2-6]
ENST00000397795; ENSP00000380897; ENSG00000134160 [Q7Z4N2-1]
ENST00000542188; ENSP00000437849; ENSG00000134160 [Q7Z4N2-5]
ENST00000559179; ENSP00000453851; ENSG00000134160 [Q7Z4N2-7]
ENST00000560658; ENSP00000454077; ENSG00000134160 [Q7Z4N2-4]
GeneIDi4308
KEGGihsa:4308
UCSCiuc001zfm.4 human [Q7Z4N2-1]

Organism-specific databases

CTDi4308
DisGeNETi4308
EuPathDBiHostDB:ENSG00000134160.13
GeneCardsiTRPM1
H-InvDBiHIX0038069
HGNCiHGNC:7146 TRPM1
HPAiHPA014779
HPA014785
MalaCardsiTRPM1
MIMi603576 gene
613216 phenotype
neXtProtiNX_Q7Z4N2
OpenTargetsiENSG00000134160
Orphaneti215 Congenital stationary night blindness
PharmGKBiPA35496
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3614 Eukaryota
ENOG410XR5B LUCA
GeneTreeiENSGT00760000119127
HOGENOMiHOG000230920
HOVERGENiHBG055663
InParanoidiQ7Z4N2
KOiK04976
OMAiLYKSMAH
OrthoDBiEOG091G0DHL
PhylomeDBiQ7Z4N2
TreeFamiTF314204

Enzyme and pathway databases

ReactomeiR-HSA-3295583 TRP channels
SIGNORiQ7Z4N2

Miscellaneous databases

ChiTaRSiTRPM1 human
GeneWikiiTRPM1
GenomeRNAii4308
PROiPR:Q7Z4N2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134160 Expressed in 75 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_TRPM1
ExpressionAtlasiQ7Z4N2 baseline and differential
GenevisibleiQ7Z4N2 HS

Family and domain databases

Gene3Di1.20.5.1010, 1 hit
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR029588 TRPM1
IPR032415 TRPM_tetra
IPR037162 TRPM_tetra_sf
PANTHERiPTHR13800:SF13 PTHR13800:SF13, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 1 hit
PF16519 TRPM_tetra, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRPM1_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4N2
Secondary accession number(s): D9IDV2
, D9IDV3, F8W865, H0YN37, O75560, Q6PE48, Q7Z4N1, Q7Z4N3, Q7Z4N4, Q7Z4N5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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