Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 157 (11 Dec 2019)
Sequence version 2 (23 Nov 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Tripartite motif-containing protein 46

Gene

TRIM46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri33 – 59RING-type 1; degeneratePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri172 – 231RING-type 2; degeneratePROSITE-ProRule annotationAdd BLAST60
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-877300 Interferon gamma signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tripartite motif-containing protein 46
Alternative name(s):
Gene Y protein
Short name:
GeneY
Tripartite, fibronectin type-III and C-terminal SPRY motif protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRIM46
Synonyms:TRIFIC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163462.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19019 TRIM46

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600986 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z4K8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80128

Open Targets

More...
OpenTargetsi
ENSG00000163462

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134914315

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z4K8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRIM46

Domain mapping of disease mutations (DMDM)

More...
DMDMi
55976496

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000562681 – 759Tripartite motif-containing protein 46Add BLAST759

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei330PhosphoserineBy similarity1
Modified residuei627PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z4K8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7Z4K8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z4K8

PeptideAtlas

More...
PeptideAtlasi
Q7Z4K8

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z4K8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
3355
69201 [Q7Z4K8-1]
69202 [Q7Z4K8-2]
69203 [Q7Z4K8-3]
69204 [Q7Z4K8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z4K8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z4K8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163462 Expressed in 119 organ(s), highest expression level in right hemisphere of cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z4K8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z4K8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055583

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TUBB3 and TUBA4A.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123129, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q7Z4K8, 13 interactors

Molecular INTeraction database

More...
MINTi
Q7Z4K8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000334657

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z4K8 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini370 – 427COSPROSITE-ProRule annotationAdd BLAST58
Domaini429 – 528Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST100
Domaini526 – 747B30.2/SPRYPROSITE-ProRule annotationAdd BLAST222

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 166Required for proximal axon localization, axon formation and migrationBy similarityAdd BLAST166
Regioni411 – 429Required for microtubule association, proximal axon localization and axon formationBy similarityAdd BLAST19

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili322 – 400Sequence analysisAdd BLAST79

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri33 – 59RING-type 1; degeneratePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri172 – 231RING-type 2; degeneratePROSITE-ProRule annotationAdd BLAST60
Zinc fingeri222 – 263B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ITF7 Eukaryota
ENOG411139C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158021

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049213

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z4K8

KEGG Orthology (KO)

More...
KOi
K12022

Identification of Orthologs from Complete Genome Data

More...
OMAi
VAHAYQA

Database of Orthologous Groups

More...
OrthoDBi
180330at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z4K8

TreeFam database of animal gene trees

More...
TreeFami
TF315216

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021 BBOX, 1 hit
cd00063 FN3, 1 hit
cd12895 SPRY_PRY_TRIM46, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR035731 SPRY/PRY_TRIM46
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR017907 Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS51262 COS, 1 hit
PS50853 FN3, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z4K8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEGEDMQTF TSIMDALVRI STSMKNMEKE LLCPVCQEMY KQPLVLPCTH
60 70 80 90 100
NVCQACAREV LGQQGYIGHG GDPSSEPTSP ASTPSTRSPR LSRRTLPKPD
110 120 130 140 150
RLDRLLKSGF GTYPGRKRGA LHPQVIMFPC PACQGDVELG ERGLAGLFRN
160 170 180 190 200
LTLERVVERY RQSVSVGGAI LCQLCKPPPL EATKGCTECR ATFCNECFKL
210 220 230 240 250
FHPWGTQKAQ HEPTLPTLSF RPKGLMCPDH KEEVTHYCKT CQRLVCQLCR
260 270 280 290 300
VRRTHSGHKI TPVLSAYQAL KDKLTKSLTY ILGNQDTVQT QICELEEAVR
310 320 330 340 350
HTEVSGQQAK EEVSQLVRGL GAVLEEKRAS LLQAIEECQQ ERLARLSAQI
360 370 380 390 400
QEHRSLLDGS GLVGYAQEVL KETDQPCFVQ AAKQLHNRIA RATEALQTFR
410 420 430 440 450
PAASSSFRHC QLDVGREMKL LTELNFLRVP EAPVIDTQRT FAYDQIFLCW
460 470 480 490 500
RLPPHSPPAW HYTVEFRRTD VPAQPGPTRW QRREEVRGTS ALLENPDTGS
510 520 530 540 550
VYVLRVRGCN KAGYGEYSED VHLHTPPAPV LHFFLDSRWG ASRERLAISK
560 570 580 590 600
DQRAVRSVPG LPLLLAADRL LTGCHLSVDV VLGDVAVTQG RSYWACAVDP
610 620 630 640 650
ASYLVKVGVG LESKLQESFQ GAPDVISPRY DPDSGHDSGA EDATVEASPP
660 670 680 690 700
FAFLTIGMGK ILLGSGASSN AGLTGRDGPT AGCTVPLPPR LGICLDYERG
710 720 730 740 750
RVSFLDAVSF RGLLECPLDC SGPVCPAFCF IGGGAVQLQE PVGTKPERKV

TIGGFAKLD
Length:759
Mass (Da):83,424
Last modified:November 23, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFEA9DDE1434EB7AA
GO
Isoform 2 (identifier: Q7Z4K8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     530-551: VLHFFLDSRWGASRERLAISKD → GIQNLARRGGACLQFQLLGRLR
     552-759: Missing.

Show »
Length:551
Mass (Da):61,777
Checksum:i798F2654D3251055
GO
Isoform 3 (identifier: Q7Z4K8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MAEGEDMQTFTSIMDALVRIS → MERAGWSANLAWLSGGITLCSGEREARDRGLGRSVNQPKAGALEKLQ
     429-498: VPEAPVIDTQ...TSALLENPDT → GCGHRGLCSG...APPAGSGGRR
     499-759: Missing.

Show »
Length:524
Mass (Da):57,448
Checksum:iCE999C807B0DA817
GO
Isoform 4 (identifier: Q7Z4K8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     429-498: VPEAPVIDTQ...TSALLENPDT → GCGHRGLCSG...APPAGSGGRR
     499-759: Missing.

Show »
Length:498
Mass (Da):54,752
Checksum:i95C02CA96EC0B539
GO
Isoform 5 (identifier: Q7Z4K8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: Missing.

Show »
Length:736
Mass (Da):80,908
Checksum:iB1EC233420ED4E50
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WUH1A0A087WUH1_HUMAN
Tripartite motif-containing protein...
TRIM46
746Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VT61Q5VT61_HUMAN
Tripartite motif-containing 46, iso...
TRIM46 hCG_1997323
644Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYK0F5GYK0_HUMAN
Tripartite motif-containing protein...
TRIM46
633Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MS35A0A0A0MS35_HUMAN
Tripartite motif-containing protein...
TRIM46
717Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18V → A in AAH69568 (PubMed:15489334).Curated1
Sequence conflicti161R → H in AAP51206 (PubMed:16434393).Curated1
Sequence conflicti161R → H in BAB15580 (PubMed:14702039).Curated1
Sequence conflicti254T → A in AAP51206 (PubMed:16434393).Curated1
Sequence conflicti254T → A in BAB15580 (PubMed:14702039).Curated1
Sequence conflicti401P → R in AAH69568 (PubMed:15489334).Curated1
Sequence conflicti406S → P in AK096158 (PubMed:14702039).Curated1
Sequence conflicti414V → A in AK096158 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0459761 – 23Missing in isoform 5. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0119801 – 21MAEGE…LVRIS → MERAGWSANLAWLSGGITLC SGEREARDRGLGRSVNQPKA GALEKLQ in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011981429 – 498VPEAP…ENPDT → GCGHRGLCSGAPQCLRPPSL TPSAPLPMIRSSCAGGCPPI HHLPGTIPLSSGARMCLLSQ APPAGSGGRR in isoform 3 and isoform 4. 2 PublicationsAdd BLAST70
Alternative sequenceiVSP_011982499 – 759Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST261
Alternative sequenceiVSP_011983530 – 551VLHFF…AISKD → GIQNLARRGGACLQFQLLGR LR in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_011984552 – 759Missing in isoform 2. 1 PublicationAdd BLAST208

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY251386 mRNA Translation: AAP51206.1
AK026882 mRNA Translation: BAB15580.1
AK096158 mRNA No translation available.
AK128139 mRNA Translation: BAC87293.1
AL607067 Genomic DNA No translation available.
AL713999 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53120.1
CH471121 Genomic DNA Translation: EAW53123.1
BC069416 mRNA Translation: AAH69416.1
BC069568 mRNA Translation: AAH69568.1
BC126372 mRNA Translation: AAI26373.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1097.1 [Q7Z4K8-1]
CCDS58033.1 [Q7Z4K8-5]
CCDS60285.1 [Q7Z4K8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001243528.1, NM_001256599.1 [Q7Z4K8-5]
NP_001243529.1, NM_001256600.1
NP_001243530.1, NM_001256601.1
NP_001269307.1, NM_001282378.1
NP_001269308.1, NM_001282379.1 [Q7Z4K8-2]
NP_079334.3, NM_025058.4 [Q7Z4K8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334634; ENSP00000334657; ENSG00000163462 [Q7Z4K8-1]
ENST00000368382; ENSP00000357366; ENSG00000163462 [Q7Z4K8-5]
ENST00000368385; ENSP00000357369; ENSG00000163462 [Q7Z4K8-2]
ENST00000543729; ENSP00000442719; ENSG00000163462 [Q7Z4K8-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80128

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80128

UCSC genome browser

More...
UCSCi
uc001fhr.6 human [Q7Z4K8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY251386 mRNA Translation: AAP51206.1
AK026882 mRNA Translation: BAB15580.1
AK096158 mRNA No translation available.
AK128139 mRNA Translation: BAC87293.1
AL607067 Genomic DNA No translation available.
AL713999 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53120.1
CH471121 Genomic DNA Translation: EAW53123.1
BC069416 mRNA Translation: AAH69416.1
BC069568 mRNA Translation: AAH69568.1
BC126372 mRNA Translation: AAI26373.1
CCDSiCCDS1097.1 [Q7Z4K8-1]
CCDS58033.1 [Q7Z4K8-5]
CCDS60285.1 [Q7Z4K8-2]
RefSeqiNP_001243528.1, NM_001256599.1 [Q7Z4K8-5]
NP_001243529.1, NM_001256600.1
NP_001243530.1, NM_001256601.1
NP_001269307.1, NM_001282378.1
NP_001269308.1, NM_001282379.1 [Q7Z4K8-2]
NP_079334.3, NM_025058.4 [Q7Z4K8-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi123129, 22 interactors
IntActiQ7Z4K8, 13 interactors
MINTiQ7Z4K8
STRINGi9606.ENSP00000334657

PTM databases

iPTMnetiQ7Z4K8
PhosphoSitePlusiQ7Z4K8

Polymorphism and mutation databases

BioMutaiTRIM46
DMDMi55976496

Proteomic databases

jPOSTiQ7Z4K8
MassIVEiQ7Z4K8
PaxDbiQ7Z4K8
PeptideAtlasiQ7Z4K8
PRIDEiQ7Z4K8
ProteomicsDBi3355
69201 [Q7Z4K8-1]
69202 [Q7Z4K8-2]
69203 [Q7Z4K8-3]
69204 [Q7Z4K8-4]

Genome annotation databases

EnsembliENST00000334634; ENSP00000334657; ENSG00000163462 [Q7Z4K8-1]
ENST00000368382; ENSP00000357366; ENSG00000163462 [Q7Z4K8-5]
ENST00000368385; ENSP00000357369; ENSG00000163462 [Q7Z4K8-2]
ENST00000543729; ENSP00000442719; ENSG00000163462 [Q7Z4K8-4]
GeneIDi80128
KEGGihsa:80128
UCSCiuc001fhr.6 human [Q7Z4K8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80128
DisGeNETi80128
EuPathDBiHostDB:ENSG00000163462.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRIM46
HGNCiHGNC:19019 TRIM46
HPAiHPA055583
MIMi600986 gene
neXtProtiNX_Q7Z4K8
OpenTargetsiENSG00000163462
PharmGKBiPA134914315

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ITF7 Eukaryota
ENOG411139C LUCA
GeneTreeiENSGT00940000158021
HOGENOMiHOG000049213
InParanoidiQ7Z4K8
KOiK12022
OMAiVAHAYQA
OrthoDBi180330at2759
PhylomeDBiQ7Z4K8
TreeFamiTF315216

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRIM46 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80128
PharosiQ7Z4K8 Tbio

Protein Ontology

More...
PROi
PR:Q7Z4K8
RNActiQ7Z4K8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163462 Expressed in 119 organ(s), highest expression level in right hemisphere of cerebellum
ExpressionAtlasiQ7Z4K8 baseline and differential
GenevisibleiQ7Z4K8 HS

Family and domain databases

CDDicd00021 BBOX, 1 hit
cd00063 FN3, 1 hit
cd12895 SPRY_PRY_TRIM46, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR017903 COS_domain
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR035731 SPRY/PRY_TRIM46
IPR027370 Znf-RING_LisH
IPR000315 Znf_B-box
IPR001841 Znf_RING
IPR017907 Znf_RING_CS
PfamiView protein in Pfam
PF00643 zf-B_box, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF49265 SSF49265, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS51262 COS, 1 hit
PS50853 FN3, 1 hit
PS50119 ZF_BBOX, 1 hit
PS00518 ZF_RING_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRI46_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z4K8
Secondary accession number(s): A0AVI6
, B1AVQ4, Q5VT60, Q5VT62, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: December 11, 2019
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again