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Entry version 142 (22 Apr 2020)
Sequence version 1 (01 Oct 2003)
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Protein

LIM and senescent cell antigen-like-containing domain protein 2

Gene

LIMS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-446353 Cell-extracellular matrix interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LIM and senescent cell antigen-like-containing domain protein 2
Alternative name(s):
LIM-like protein 2
Particularly interesting new Cys-His protein 2
Short name:
PINCH-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LIMS2
Synonyms:PINCH2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16084 LIMS2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607908 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z4I7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Muscular dystrophy, autosomal recessive, with cardiomyopathy and triangular tongue (MDRCMTT)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive muscular dystrophy characterized by childhood-onset of muscle weakness progressing to a severe quadriparesis. Additionally, patients have biventricular cardiac dysfunction due to dilated cardiomyopathy, and macroglossia with a small tip resulting in a triangular tongue.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07652792N → K in MDRCMTT; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754385302Ensembl.1
Natural variantiVAR_07652897P → L in MDRCMTT; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs768056213Ensembl.1
Natural variantiVAR_076529323L → P in MDRCMTT; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs869025562Ensembl.1

Keywords - Diseasei

Disease mutation, Limb-girdle muscular dystrophy

Organism-specific databases

DisGeNET

More...
DisGeNETi
55679

MalaCards human disease database

More...
MalaCardsi
LIMS2
MIMi616827 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000072163

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
466801 Autosomal recessive limb-girdle muscular dystrophy type 2W

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30390

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z4I7 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LIMS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74750091

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002660111 – 341LIM and senescent cell antigen-like-containing domain protein 2Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei327PhosphothreonineCombined sources1
Modified residuei328PhosphoserineCombined sources1
Isoform 2 (identifier: Q7Z4I7-2)
Modified residuei22PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7Z4I7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q7Z4I7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z4I7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z4I7

PeptideAtlas

More...
PeptideAtlasi
Q7Z4I7

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z4I7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
27166
69191
69192 [Q7Z4I7-1]
69193 [Q7Z4I7-2]
69194 [Q7Z4I7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z4I7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z4I7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000072163 Expressed in fundus of stomach and 189 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z4I7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z4I7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000072163 Tissue enhanced (smooth)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TGFB1I1 (By similarity).

Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS1. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120808, 14 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q7Z4I7

Protein interaction database and analysis system

More...
IntActi
Q7Z4I7, 16 interactors

Molecular INTeraction database

More...
MINTi
Q7Z4I7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000326888

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7Z4I7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7Z4I7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7Z4I7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 74LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST62
Domaini76 – 133LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST58
Domaini138 – 195LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST58
Domaini196 – 255LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST60
Domaini256 – 315LIM zinc-binding 5PROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2272 Eukaryota
ENOG410XP46 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153518

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_001357_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7Z4I7

KEGG Orthology (KO)

More...
KOi
K23354

Identification of Orthologs from Complete Genome Data

More...
OMAi
FAPCCGE

Database of Orthologous Groups

More...
OrthoDBi
1593918at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z4I7

TreeFam database of animal gene trees

More...
TreeFami
TF314113

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017351 PINCH
IPR001781 Znf_LIM

The PANTHER Classification System

More...
PANTHERi
PTHR24210 PTHR24210, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00412 LIM, 5 hits

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF038003 PINCH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00132 LIM, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z4I7-1) [UniParc]FASTAAdd to basket
Also known as: LIM-like protein 2B

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTGSNMSDAL ANAVCQRCQA RFSPAERIVN SNGELYHEHC FVCAQCFRPF
60 70 80 90 100
PEGLFYEFEG RKYCEHDFQM LFAPCCGSCG EFIIGRVIKA MNNNWHPGCF
110 120 130 140 150
RCELCDVELA DLGFVKNAGR HLCRPCHNRE KAKGLGKYIC QRCHLVIDEQ
160 170 180 190 200
PLMFRSDAYH PDHFNCTHCG KELTAEAREL KGELYCLPCH DKMGVPICGA
210 220 230 240 250
CRRPIEGRVV NALGKQWHVE HFVCAKCEKP FLGHRHYEKK GLAYCETHYN
260 270 280 290 300
QLFGDVCYNC SHVIEGDVVS ALNKAWCVSC FSCSTCNSKL TLKNKFVEFD
310 320 330 340
MKPVCKRCYE KFPLELKKRL KKLSELTSRK AQPKATDLNS A
Length:341
Mass (Da):38,916
Last modified:October 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEEA8D74C309D9C8A
GO
Isoform 2 (identifier: Q7Z4I7-2) [UniParc]FASTAAdd to basket
Also known as: LIM-like protein 2A

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MTGS → MAARLGALAASGLYRRRQHRQSPPPATG

Show »
Length:365
Mass (Da):41,512
Checksum:i3B8E1C98AFB2B698
GO
Isoform 3 (identifier: Q7Z4I7-3) [UniParc]FASTAAdd to basket
Also known as: LIM-like protein 2C

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: Missing.

Show »
Length:336
Mass (Da):38,426
Checksum:i27F7EA97B557804D
GO
Isoform 4 (identifier: Q7Z4I7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.

Show »
Length:189
Mass (Da):21,615
Checksum:i896862131C240B5B
GO
Isoform 5 (identifier: Q7Z4I7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-3: G → GRKRKWGETGTGSGAAPAAALRW

Show »
Length:363
Mass (Da):41,226
Checksum:iD0F6B8B3618F20FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y592H0Y592_HUMAN
LIM and senescent cell antigen-like...
LIMS2
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEF3F8WEF3_HUMAN
LIM and senescent cell antigen-like...
LIMS2
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM77350 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti111D → G in BAG60013 (PubMed:14702039).Curated1
Sequence conflicti294N → D in AAM97589 (PubMed:12167643).Curated1
Sequence conflicti294N → D in BAB14047 (PubMed:15815621).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07652792N → K in MDRCMTT; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs754385302Ensembl.1
Natural variantiVAR_07652897P → L in MDRCMTT; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs768056213Ensembl.1
Natural variantiVAR_076529323L → P in MDRCMTT; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs869025562Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0455391 – 152Missing in isoform 4. 2 PublicationsAdd BLAST152
Alternative sequenceiVSP_0219161 – 5Missing in isoform 3. 2 Publications5
Alternative sequenceiVSP_0219171 – 4MTGS → MAARLGALAASGLYRRRQHR QSPPPATG in isoform 2. 1 Publication4
Alternative sequenceiVSP_0460783G → GRKRKWGETGTGSGAAPAAA LRW in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF484961 mRNA Translation: AAM97589.1
AF520987 mRNA Translation: AAM77350.1 Frameshift.
AF527764 mRNA Translation: AAQ09011.1
AF527765 mRNA Translation: AAQ09012.1
AF527766 mRNA Translation: AAQ09013.1
AF527770 mRNA Translation: AAQ09017.1
AK022470 mRNA Translation: BAB14047.1
AK297645 mRNA Translation: BAG60013.1
BX458594 mRNA No translation available.
AC010976 Genomic DNA No translation available.
AC074114 Genomic DNA No translation available.
BC065816 mRNA Translation: AAH65816.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2147.1 [Q7Z4I7-2]
CCDS54394.1 [Q7Z4I7-3]
CCDS54395.1 [Q7Z4I7-1]
CCDS54396.1 [Q7Z4I7-5]
CCDS58725.1 [Q7Z4I7-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001129509.2, NM_001136037.2 [Q7Z4I7-5]
NP_001154875.1, NM_001161403.1 [Q7Z4I7-1]
NP_001154876.1, NM_001161404.1 [Q7Z4I7-3]
NP_001243471.1, NM_001256542.1 [Q7Z4I7-4]
NP_060450.2, NM_017980.4 [Q7Z4I7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000324938; ENSP00000326888; ENSG00000072163 [Q7Z4I7-2]
ENST00000355119; ENSP00000347240; ENSG00000072163 [Q7Z4I7-1]
ENST00000409254; ENSP00000386907; ENSG00000072163 [Q7Z4I7-4]
ENST00000409286; ENSP00000386252; ENSG00000072163 [Q7Z4I7-4]
ENST00000409455; ENSP00000386383; ENSG00000072163 [Q7Z4I7-3]
ENST00000409754; ENSP00000386345; ENSG00000072163 [Q7Z4I7-4]
ENST00000409808; ENSP00000386637; ENSG00000072163 [Q7Z4I7-3]
ENST00000410011; ENSP00000387002; ENSG00000072163 [Q7Z4I7-3]
ENST00000410038; ENSP00000386570; ENSG00000072163 [Q7Z4I7-4]
ENST00000545738; ENSP00000443794; ENSG00000072163 [Q7Z4I7-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55679

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55679

UCSC genome browser

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UCSCi
uc002tov.4 human [Q7Z4I7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF484961 mRNA Translation: AAM97589.1
AF520987 mRNA Translation: AAM77350.1 Frameshift.
AF527764 mRNA Translation: AAQ09011.1
AF527765 mRNA Translation: AAQ09012.1
AF527766 mRNA Translation: AAQ09013.1
AF527770 mRNA Translation: AAQ09017.1
AK022470 mRNA Translation: BAB14047.1
AK297645 mRNA Translation: BAG60013.1
BX458594 mRNA No translation available.
AC010976 Genomic DNA No translation available.
AC074114 Genomic DNA No translation available.
BC065816 mRNA Translation: AAH65816.1
CCDSiCCDS2147.1 [Q7Z4I7-2]
CCDS54394.1 [Q7Z4I7-3]
CCDS54395.1 [Q7Z4I7-1]
CCDS54396.1 [Q7Z4I7-5]
CCDS58725.1 [Q7Z4I7-4]
RefSeqiNP_001129509.2, NM_001136037.2 [Q7Z4I7-5]
NP_001154875.1, NM_001161403.1 [Q7Z4I7-1]
NP_001154876.1, NM_001161404.1 [Q7Z4I7-3]
NP_001243471.1, NM_001256542.1 [Q7Z4I7-4]
NP_060450.2, NM_017980.4 [Q7Z4I7-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IXEX-ray1.90B11-73[»]
SMRiQ7Z4I7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120808, 14 interactors
CORUMiQ7Z4I7
IntActiQ7Z4I7, 16 interactors
MINTiQ7Z4I7
STRINGi9606.ENSP00000326888

PTM databases

iPTMnetiQ7Z4I7
PhosphoSitePlusiQ7Z4I7

Polymorphism and mutation databases

BioMutaiLIMS2
DMDMi74750091

Proteomic databases

jPOSTiQ7Z4I7
MassIVEiQ7Z4I7
MaxQBiQ7Z4I7
PaxDbiQ7Z4I7
PeptideAtlasiQ7Z4I7
PRIDEiQ7Z4I7
ProteomicsDBi27166
69191
69192 [Q7Z4I7-1]
69193 [Q7Z4I7-2]
69194 [Q7Z4I7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
55985 145 antibodies

Genome annotation databases

EnsembliENST00000324938; ENSP00000326888; ENSG00000072163 [Q7Z4I7-2]
ENST00000355119; ENSP00000347240; ENSG00000072163 [Q7Z4I7-1]
ENST00000409254; ENSP00000386907; ENSG00000072163 [Q7Z4I7-4]
ENST00000409286; ENSP00000386252; ENSG00000072163 [Q7Z4I7-4]
ENST00000409455; ENSP00000386383; ENSG00000072163 [Q7Z4I7-3]
ENST00000409754; ENSP00000386345; ENSG00000072163 [Q7Z4I7-4]
ENST00000409808; ENSP00000386637; ENSG00000072163 [Q7Z4I7-3]
ENST00000410011; ENSP00000387002; ENSG00000072163 [Q7Z4I7-3]
ENST00000410038; ENSP00000386570; ENSG00000072163 [Q7Z4I7-4]
ENST00000545738; ENSP00000443794; ENSG00000072163 [Q7Z4I7-5]
GeneIDi55679
KEGGihsa:55679
UCSCiuc002tov.4 human [Q7Z4I7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55679
DisGeNETi55679

GeneCards: human genes, protein and diseases

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GeneCardsi
LIMS2
HGNCiHGNC:16084 LIMS2
HPAiENSG00000072163 Tissue enhanced (smooth)
MalaCardsiLIMS2
MIMi607908 gene
616827 phenotype
neXtProtiNX_Q7Z4I7
OpenTargetsiENSG00000072163
Orphaneti466801 Autosomal recessive limb-girdle muscular dystrophy type 2W
PharmGKBiPA30390

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2272 Eukaryota
ENOG410XP46 LUCA
GeneTreeiENSGT00940000153518
HOGENOMiCLU_001357_0_0_1
InParanoidiQ7Z4I7
KOiK23354
OMAiFAPCCGE
OrthoDBi1593918at2759
PhylomeDBiQ7Z4I7
TreeFamiTF314113

Enzyme and pathway databases

ReactomeiR-HSA-446353 Cell-extracellular matrix interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
LIMS2 human
EvolutionaryTraceiQ7Z4I7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55679
PharosiQ7Z4I7 Tbio

Protein Ontology

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PROi
PR:Q7Z4I7
RNActiQ7Z4I7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000072163 Expressed in fundus of stomach and 189 other tissues
ExpressionAtlasiQ7Z4I7 baseline and differential
GenevisibleiQ7Z4I7 HS

Family and domain databases

InterProiView protein in InterPro
IPR017351 PINCH
IPR001781 Znf_LIM
PANTHERiPTHR24210 PTHR24210, 1 hit
PfamiView protein in Pfam
PF00412 LIM, 5 hits
PIRSFiPIRSF038003 PINCH, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 5 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 4 hits
PS50023 LIM_DOMAIN_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLIMS2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z4I7
Secondary accession number(s): A6NLH0
, B4DMV1, F5H6E6, Q7Z4I2, Q7Z4I6, Q7Z4I8, Q8NFE7, Q9HA13
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2003
Last modified: April 22, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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