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Protein

Protein FAM220A

Gene

FAM220A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May negatively regulate STAT3.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM220A
Alternative name(s):
STAT3-interacting protein as a repressor
Gene namesi
Name:FAM220A
Synonyms:C7orf70, SIPAR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000178397.12
HGNCiHGNC:22422 FAM220A
MIMi616628 gene
neXtProtiNX_Q7Z4H9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178397
PharmGKBiPA165617654

Polymorphism and mutation databases

BioMutaiFAM220A
DMDMi74713515

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003219231 – 259Protein FAM220AAdd BLAST259

Proteomic databases

PaxDbiQ7Z4H9
PeptideAtlasiQ7Z4H9
PRIDEiQ7Z4H9
ProteomicsDBi69190

PTM databases

iPTMnetiQ7Z4H9
PhosphoSitePlusiQ7Z4H9

Expressioni

Gene expression databases

BgeeiENSG00000178397 Expressed in 205 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ7Z4H9 baseline and differential
GenevisibleiQ7Z4H9 HS

Organism-specific databases

HPAiHPA055050

Interactioni

Subunit structurei

Interacts with STAT3.By similarity

Protein-protein interaction databases

IntActiQ7Z4H9, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ7Z4H9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IZT7 Eukaryota
ENOG4111MFX LUCA
GeneTreeiENSGT00390000014156
HOGENOMiHOG000111641
HOVERGENiHBG106751
InParanoidiQ7Z4H9
OrthoDBiEOG091G0LYI
PhylomeDBiQ7Z4H9
TreeFamiTF336869

Family and domain databases

InterProiView protein in InterPro
IPR029155 SIPAR
PfamiView protein in Pfam
PF15487 FAM220, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q7Z4H9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDRRGPLGT CLAQVQQAGG GDSDKLSCSL KKRMPEGPWP ADAPSWMNKP
60 70 80 90 100
VVDGNSQSEA LSLEMRKDPS GAGLWLHSGG PVLPYVRESV RRNPASAATP
110 120 130 140 150
STAVGLFPAP TECFARVSCS GVEALGRRDW LGGGPRATDG HRGQCPKGEP
160 170 180 190 200
RVSRLPRHQK VPEMGSFQDD PPSAFPKGLG SELEPACLHS ILSATLHVYP
210 220 230 240 250
EVLLSEETKR IFLDRLKPMF SKQTIEFKKM LKSTSDGLQI TLGLLALQPF

ELANTLCHS
Length:259
Mass (Da):28,021
Last modified:October 1, 2003 - v1
Checksum:iF649BE355ADBF5E9
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGP1A0A0C4DGP1_HUMAN
Protein FAM220A
FAM220A
68Annotation score:
E9PQC6E9PQC6_HUMAN
Protein FAM220A
FAM220A
109Annotation score:
E9PQY0E9PQY0_HUMAN
Protein FAM220A
FAM220A
120Annotation score:

Sequence cautioni

The sequence AAS07509 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAG34819 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03937571G → R. Corresponds to variant dbSNP:rs3750041Ensembl.1
Natural variantiVAR_039376127R → Q2 PublicationsCorresponds to variant dbSNP:rs3750040Ensembl.1
Natural variantiVAR_039377161V → L2 PublicationsCorresponds to variant dbSNP:rs3750039Ensembl.1
Natural variantiVAR_039378198V → M2 PublicationsCorresponds to variant dbSNP:rs6952125Ensembl.1
Natural variantiVAR_039379237G → S. Corresponds to variant dbSNP:rs2241445Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533707 mRNA Translation: AAQ09020.1
AK093156 mRNA Translation: BAC04076.1
AK311878 mRNA Translation: BAG34819.1 Sequence problems.
AC009412 Genomic DNA Translation: AAS07509.1 Sequence problems.
CH878731 Genomic DNA Translation: EAW55045.1
BC006110 mRNA Translation: AAH06110.2
BC142977 mRNA Translation: AAI42978.1
CCDSiCCDS34599.1
RefSeqiNP_001032240.1, NM_001037163.1
UniGeneiHs.696146

Genome annotation databases

EnsembliENST00000313324; ENSP00000317289; ENSG00000178397
ENST00000616824; ENSP00000483140; ENSG00000178397
GeneIDi84792
KEGGihsa:84792
UCSCiuc003spu.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF220A_HUMAN
AccessioniPrimary (citable) accession number: Q7Z4H9
Secondary accession number(s): Q75ML2, Q8NA52, Q9BRR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: September 12, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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