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Entry version 135 (16 Oct 2019)
Sequence version 2 (24 Jan 2006)
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Protein

HAUS augmin-like complex subunit 6

Gene

HAUS6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HAUS augmin-like complex subunit 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HAUS6
Synonyms:DGT6, FAM29A, KIAA1574
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25948 HAUS6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613433 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7Z4H7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000147874

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165585815

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7Z4H7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HAUS6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85700957

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000762171 – 955HAUS augmin-like complex subunit 6Add BLAST955

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei406PhosphoserineCombined sources1
Modified residuei507PhosphoserineCombined sources1
Modified residuei524PhosphoserineCombined sources1
Modified residuei530PhosphoserineCombined sources1
Modified residuei550PhosphoserineCombined sources1
Modified residuei552PhosphoserineCombined sources1
Modified residuei584PhosphothreonineCombined sources1
Modified residuei715PhosphoserineCombined sources1
Modified residuei728PhosphoserineCombined sources1
Modified residuei742PhosphoserineCombined sources1
Modified residuei805PhosphoserineCombined sources1
Modified residuei823PhosphothreonineCombined sources1
Modified residuei908PhosphoserineCombined sources1
Modified residuei914PhosphoserineCombined sources1
Modified residuei943PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated during mitosis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7Z4H7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7Z4H7

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q7Z4H7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7Z4H7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7Z4H7

PeptideAtlas

More...
PeptideAtlasi
Q7Z4H7

PRoteomics IDEntifications database

More...
PRIDEi
Q7Z4H7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69184 [Q7Z4H7-1]
69185 [Q7Z4H7-2]
69186 [Q7Z4H7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7Z4H7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7Z4H7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7Z4H7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000147874 Expressed in 183 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7Z4H7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7Z4H7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020960
HPA020965

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly (PubMed:19369198, PubMed:19427217).

Interacts with PLK1, NEDD1 and gamma-tubulin (PubMed:19029337).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120160, 99 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1847 HAUS complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q7Z4H7

Database of interacting proteins

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DIPi
DIP-48830N

Protein interaction database and analysis system

More...
IntActi
Q7Z4H7, 69 interactors

Molecular INTeraction database

More...
MINTi
Q7Z4H7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369871

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7Z4H7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili188 – 219Sequence analysisAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HAUS6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IIH0 Eukaryota
ENOG4111YMT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008250

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7Z4H7

KEGG Orthology (KO)

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KOi
K16589

Identification of Orthologs from Complete Genome Data

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OMAi
IEKQMCQ

Database of Orthologous Groups

More...
OrthoDBi
297770at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7Z4H7

TreeFam database of animal gene trees

More...
TreeFami
TF325931

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026797 HAUS_6
IPR028163 HAUS_6_N

The PANTHER Classification System

More...
PANTHERi
PTHR16151 PTHR16151, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14661 HAUS6_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7Z4H7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSASVTAFE KEHLWMYLQA LGFEPGPATI ACGKIVSHTH LGVNMFDKLN
60 70 80 90 100
RDAFHIISYF LFQVLDQSLT KEVFKFCWPP FDQKSDTEFR KHCCEWIKRI
110 120 130 140 150
SGECGSSFPQ VVGSLFLSPG GPKFIHLMYH FARFVAMKYI KSNSKNSSHH
160 170 180 190 200
FVETFNIKPQ DLHKCIARCH FARSRFLQIL QRQDCVTQKY QENAQLSVKQ
210 220 230 240 250
VRNLRSECIG LENQIKKMEP YDDHSNMEEK IQKVRSLWAS VNETLMFLEK
260 270 280 290 300
EREVVSSVLS LVNQYALDGT NVAINIPRLL LDKIEKQMFQ LHIGNVYEAG
310 320 330 340 350
KLNLLTVIQL LNEVLKVMKY ERCQADQARL TVDLHYLEKE TKFQKERLSD
360 370 380 390 400
LKHMRYRIKD DLTTIRHSVV EKQGEWHKKW KEFLGLSPFS LIKGWTPSVD
410 420 430 440 450
LLPPMSPLSF DPASEEVYAK SILCQYPASL PDAHKQHNQE NGCRGDSDTL
460 470 480 490 500
GALHDLANSP ASFLSQSVSS SDRNSVTVLE KDTKMGTPKE KNEAISKKIP
510 520 530 540 550
EFEVENSPLS DVAKNTESSA FGGSLPAKKS DPFQKEQDHL VEEVARAVLS
560 570 580 590 600
DSPQLSEGKE IKLEELIDSL GSNPFLTRNQ IPRTPENLIT EIRSSWRKAI
610 620 630 640 650
EMEENRTKEP IQMDAEHREV LPESLPVLHN QREFSMADFL LETTVSDFGQ
660 670 680 690 700
SHLTEEKVIS DCECVPQKHV LTSHIDEPPT QNQSDLLNKK VICKQDLECL
710 720 730 740 750
AFTKLSETSR METFSPAVGN RIDVMGGSEE EFMKILDHLE VSCNKPSTNK
760 770 780 790 800
TMLWNSFQIS SGISSKSFKD NDFGILHETL PEEVGHLSFN SSSSSEANFK
810 820 830 840 850
LEPNSPMHGG TLLEDVVGGR QTTPESDFNL QALRSRYEAL KKSLSKKREE
860 870 880 890 900
SYLSNSQTPE RHKPELSPTP QNVQTDDTLN FLDTCDLHTE HIKPSLRTSI
910 920 930 940 950
GERKRSLSPL IKFSPVEQRL RTTIACSLGE LPNLKEEDIL NKSLDAKEPP

SDLTR
Length:955
Mass (Da):108,621
Last modified:January 24, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8EA52C24BA818C00
GO
Isoform 2 (identifier: Q7Z4H7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     589-606: ITEIRSSWRKAIEMEENR → SKLIMLSVTFFFHRHNHC
     607-955: Missing.

Show »
Length:606
Mass (Da):69,328
Checksum:i6BA4D3414DC9072C
GO
Isoform 3 (identifier: Q7Z4H7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     355-389: Missing.

Note: No experimental confirmation available.
Show »
Length:920
Mass (Da):104,310
Checksum:i01F0DAA9DC32D0CB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VY60Q5VY60_HUMAN
HAUS augmin-like complex subunit 6
HAUS6
802Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SYF9Q5SYF9_HUMAN
HAUS augmin-like complex subunit 6
HAUS6
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH26178 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI11042 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA90922 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14334 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB14388 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAG63294 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82D → E in AAQ09022 (Ref. 1) Curated1
Sequence conflicti183Missing in AAI11042 (PubMed:15164053).Curated1
Sequence conflicti297Y → H in BAG63294 (PubMed:14702039).Curated1
Sequence conflicti347R → G in BAB14334 (PubMed:14702039).Curated1
Sequence conflicti409S → L in BAB14388 (PubMed:14702039).Curated1
Sequence conflicti615A → V in AAH10632 (PubMed:15489334).Curated1
Sequence conflicti615A → V in AAI14493 (PubMed:15489334).Curated1
Sequence conflicti686L → M in BAB14388 (PubMed:14702039).Curated1
Sequence conflicti936 – 938EED → GKV in BAB14334 (PubMed:14702039).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_062243552S → T. Corresponds to variant dbSNP:rs41269003Ensembl.1
Natural variantiVAR_024926674H → Q1 PublicationCorresponds to variant dbSNP:rs10511670Ensembl.1
Natural variantiVAR_024927761S → I1 PublicationCorresponds to variant dbSNP:rs4977493Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040919355 – 389Missing in isoform 3. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_017017589 – 606ITEIR…MEENR → SKLIMLSVTFFFHRHNHC in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_017018607 – 955Missing in isoform 2. 1 PublicationAdd BLAST349

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF533709 mRNA Translation: AAQ09022.1
AF537091 mRNA Translation: AAN05700.1
AK000067 mRNA Translation: BAA90922.1 Different initiation.
AK022964 mRNA Translation: BAB14334.1 Different initiation.
AK023068 mRNA Translation: BAB14388.1 Different initiation.
AK301852 mRNA Translation: BAG63294.1 Different initiation.
AK056458 mRNA Translation: BAG51716.1
AL356000 Genomic DNA No translation available.
AL591206 Genomic DNA No translation available.
BC010632 mRNA Translation: AAH10632.1
BC026178 mRNA Translation: AAH26178.1 Sequence problems.
BC065935 mRNA Translation: AAH65935.1
BC071625 mRNA Translation: AAH71625.1
BC111041 mRNA Translation: AAI11042.1 Different initiation.
BC113981 mRNA Translation: AAI13982.1
BC114492 mRNA Translation: AAI14493.1
AB046794 mRNA Translation: BAB13400.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6489.1 [Q7Z4H7-1]

NCBI Reference Sequences

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RefSeqi
NP_001257819.1, NM_001270890.1 [Q7Z4H7-3]
NP_060115.3, NM_017645.4 [Q7Z4H7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000380502; ENSP00000369871; ENSG00000147874 [Q7Z4H7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54801

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54801

UCSC genome browser

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UCSCi
uc003znk.5 human [Q7Z4H7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF533709 mRNA Translation: AAQ09022.1
AF537091 mRNA Translation: AAN05700.1
AK000067 mRNA Translation: BAA90922.1 Different initiation.
AK022964 mRNA Translation: BAB14334.1 Different initiation.
AK023068 mRNA Translation: BAB14388.1 Different initiation.
AK301852 mRNA Translation: BAG63294.1 Different initiation.
AK056458 mRNA Translation: BAG51716.1
AL356000 Genomic DNA No translation available.
AL591206 Genomic DNA No translation available.
BC010632 mRNA Translation: AAH10632.1
BC026178 mRNA Translation: AAH26178.1 Sequence problems.
BC065935 mRNA Translation: AAH65935.1
BC071625 mRNA Translation: AAH71625.1
BC111041 mRNA Translation: AAI11042.1 Different initiation.
BC113981 mRNA Translation: AAI13982.1
BC114492 mRNA Translation: AAI14493.1
AB046794 mRNA Translation: BAB13400.1
CCDSiCCDS6489.1 [Q7Z4H7-1]
RefSeqiNP_001257819.1, NM_001270890.1 [Q7Z4H7-3]
NP_060115.3, NM_017645.4 [Q7Z4H7-1]

3D structure databases

SMRiQ7Z4H7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120160, 99 interactors
ComplexPortaliCPX-1847 HAUS complex
CORUMiQ7Z4H7
DIPiDIP-48830N
IntActiQ7Z4H7, 69 interactors
MINTiQ7Z4H7
STRINGi9606.ENSP00000369871

PTM databases

iPTMnetiQ7Z4H7
PhosphoSitePlusiQ7Z4H7
SwissPalmiQ7Z4H7

Polymorphism and mutation databases

BioMutaiHAUS6
DMDMi85700957

Proteomic databases

EPDiQ7Z4H7
jPOSTiQ7Z4H7
MassIVEiQ7Z4H7
MaxQBiQ7Z4H7
PaxDbiQ7Z4H7
PeptideAtlasiQ7Z4H7
PRIDEiQ7Z4H7
ProteomicsDBi69184 [Q7Z4H7-1]
69185 [Q7Z4H7-2]
69186 [Q7Z4H7-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
54801

Genome annotation databases

EnsembliENST00000380502; ENSP00000369871; ENSG00000147874 [Q7Z4H7-1]
GeneIDi54801
KEGGihsa:54801
UCSCiuc003znk.5 human [Q7Z4H7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54801

GeneCards: human genes, protein and diseases

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GeneCardsi
HAUS6
HGNCiHGNC:25948 HAUS6
HPAiHPA020960
HPA020965
MIMi613433 gene
neXtProtiNX_Q7Z4H7
OpenTargetsiENSG00000147874
PharmGKBiPA165585815

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIH0 Eukaryota
ENOG4111YMT LUCA
GeneTreeiENSGT00390000008250
InParanoidiQ7Z4H7
KOiK16589
OMAiIEKQMCQ
OrthoDBi297770at2759
PhylomeDBiQ7Z4H7
TreeFamiTF325931

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-8854518 AURKA Activation by TPX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HAUS6 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FAM29A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54801
PharosiQ7Z4H7

Protein Ontology

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PROi
PR:Q7Z4H7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000147874 Expressed in 183 organ(s), highest expression level in testis
ExpressionAtlasiQ7Z4H7 baseline and differential
GenevisibleiQ7Z4H7 HS

Family and domain databases

InterProiView protein in InterPro
IPR026797 HAUS_6
IPR028163 HAUS_6_N
PANTHERiPTHR16151 PTHR16151, 1 hit
PfamiView protein in Pfam
PF14661 HAUS6_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHAUS6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7Z4H7
Secondary accession number(s): B3KPK4
, B4DX82, Q05CG1, Q14CB6, Q14CD9, Q2TA91, Q6IQ10, Q6NZX5, Q8IZQ4, Q96FN0, Q9H950, Q9H998, Q9HCJ8, Q9NXT8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: January 24, 2006
Last modified: October 16, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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